Imidazoles-derivatives

High-throughput photocapture approach for reaction discovery was written by Bayly, Alison A.;McDonald, Benjamin R.;Mrksich, Milan;Scheidt, Karl A.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2020.Electric Literature of C8H8N2 This article mentions the following:

Modern organic reaction discovery and development relies on the rapid assessment of large arrays of hypothesis-driven experiments The time-intensive nature of reaction anal. presents the greatest practical barrier for the execution of this iterative process that underpins the development of new bioactive agents. Toward addressing this critical bottleneck, the authors report herein a high-throughput anal. (HTA) method of reaction mixtures by photocapture on a 384-spot diazirine-terminated self-assembled monolayer, and self-assembled monolayers for matrix-assisted laser desorption/ionization mass spectrometry (SAMDI-MS) anal. This anal. platform has been applied to the identification of a single-electron-promoted reductive coupling of acyl azolium species. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Comparative effects of amlodipine and candesartan on blood pressure and metabolic profile in non-diabetic hypertensive patients was written by Althanoon, Zeina A.;Thanoon, Imad AJ. And the article was included in Pharmacognosy Journal in 2022.Electric Literature of C33H34N6O6 This article mentions the following:

Introduction: The present study aimed to compare the effects of the angiotensin II receptor blocker candesartan and the calcium channel blocker amlodipine on blood pressure and metabolic profile in non-diabetic hypertensive patients. Methods: The study involved non-diabetic patients with mild to moderate hypertension. They were randomly assigned to receive candesartan or amlodipine for 24 wk, parameters were evaluated at baseline and after 12 wk and 24 wk for each patient group. Results: Candesartan and amlodipine both reduced blood pressure and the HOMA-IR index significantly (P < 0.05, 24 wk vs. baseline). Candesartan was more effective than amlodipine in lowering blood pressure and HOMA-IR, although the difference was not significant statistically. Conclusion: Both candesartan and amlodipine are extremely effective at reducing blood pressure in moderate hypertension patients. Candesartan cilexetil has a major benefit in terms of tolerability, as it reduces the risk of developing metabolic dysregulation. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Polybenzimidazoles based on methylated benzene tetraamines was written by Korshak, V. V.;Teplyakov, M. M.;Fedorova, R. D.. And the article was included in Vysokomolekulyarnye Soedineniya, Seriya B: Kratkie Soobshcheniya in 1967.Product Details of 4887-83-6 This article mentions the following:

3,3′-Diaminotolidine (I) and 2,3′,4,4′-tetraaminoditolylmethane (II) were synthesized and were used to prepare polybenzimidazoles with di-Ph isophthalate (III), di-Ph terephthalate (IV), di-Ph adipate (V), and di-Ph sebacate (VI). The polybenzimidazoles obtained had the following properties (amine, ester, intrinsic viscosity in HCO2H, and decomposition temperature given): I, V, 0.76, -; I, VI, 0.80, -; I, III, 0.40, 490°; I, IV, 0.42, 500°; II, III-IV, 0.51, 490°; II, III, 0.64, -; II, III, 0.47, 400°; II, IV, 0.41, 450°. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Product Details of 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Product Details of 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of new ionic liquids based on dicationic imidazolium and their anti-corrosion performances was written by Zaky, M. T.;Nessim, M. I.;Deyab, M. A.. And the article was included in Journal of Molecular Liquids in 2019.Synthetic Route of C11H20N2 This article mentions the following:

Ionic liquids with high environmental value and adsorption properties are a requirement for the new trend for corrosion inhibitors. Here, we synthesis three new ionic liquids based on dicationic imidazolium (IL1, IL2 and IL3) to produce green inhibitors for stainless steel corrosion in acidic environment. The anionic portion of all prepared ionic liquids is BF-4. New ionic liquids were recognized by means of element inspection, FT-IR, TGA and 1H NMR spectroscopy. All prepared ionic liquids work as good corrosion inhibitors. Where their efficiencies are 91.5%, 98.4% and 83.3% for IL1, IL2 and IL3, resp. at 100 ppm. The counter portion of ILs (BF-4) has a great role in the adsorption process. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Synthetic Route of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Synthetic Route of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Structure-Activity Relationships of a Novel Capsid Targeted Inhibitor of HIV-1 Replication was written by Kortagere, Sandhya;Xu, Jimmy P.;Mankowski, Marie K.;Ptak, Roger G.;Cocklin, Simon. And the article was included in Journal of Chemical Information and Modeling in 2014.Recommanded Product: 5496-35-5 This article mentions the following:

Despite the considerable successes of highly active antiretroviral therapy (HAART) for the treatment of HIV/AIDS, cumulative drug toxicities and the development of multidrug-resistant virus necessitate the search for new classes of antiretroviral agents with novel modes of action. The HIV-1 capsid (CA) protein has been structurally and functionally characterized as a druggable target. We have recently designed a novel small mol. inhibitor I-XW-053 using the hybrid structure based method to block the interface between CA N-terminal domains (NTD-NTD interface) with micromolar affinity. In an effort to optimize and improve the efficacy of I-XW-053, we have developed the structure activity relationship of I-XW-053 compound series using ligand efficiency methods. Fifty-six analogs of I-XW-053 were designed that could be subclassified into four different core domains based on their ligand efficiency values computed as the ratio of binding efficiency (BEI) and surface efficiency (SEI) indexes. Compound 34 belonging to subcore-3 showed an 11-fold improvement over I-XW-053 in blocking HIV-1 replication in primary human peripheral blood mononuclear cells (PBMCs). Surface plasmon resonance experiments confirmed the binding of compound 34 to purified HIV-1 CA protein. Mol. docking studies on compound 34 and I-XW-053 to HIV-1 CA protein suggested that they both bind to NTD-NTD interface region but with different binding modes, which was further validated using site-directed mutagenesis studies. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Recommanded Product: 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Semi-heterogeneous photo-Cu-dual-catalytic cross-coupling reactions using polymeric carbon nitrides was written by Zhang, Zhaofei;Xu, Yangsen;Zhang, Qitao;Fang, Shaofan;Sun, Hongli;Ou, Wei;Su, Chenliang. And the article was included in Science Bulletin in 2022.Safety of 1-Methylbenzimidazole This article mentions the following:

A merger of copper catalysis and semiconductor photocatalysis using polymeric carbon nitride (PCN) for multi-type cross-coupling reactions was developed. This dual catalytic system enables mild C-H arylation, chalcogenation, and C-N cross-coupling reactions under visible light irradiation with a broad substrate scope. Good to excellent yields were obtained with appreciable site selectivity and functional group tolerance. Metal-free and low-cost PCN photocatalyst can easily be recovered and reused several times. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Safety of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Safety of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Poly(ionic liquid)-Coated Meshes with Opposite Wettability for Continuous Oil/Water Separation was written by Deng, Xi;Zhang, Jingshun;Zhang, Liren;Cheng, Guiren;Chen, Bihua;Zhang, Yongya;Gao, Guohua. And the article was included in Industrial & Engineering Chemistry Research in 2020.Application of 915358-85-9 This article mentions the following:

A series of oil/water separation membranes with tunable surface wettability based on poly(ionic liquid)s (PILs) were prepared via a facile one-step photopolymerization of N-vinylimidazolium ionic liquids and divinylbenzene on meshes. The wettability of PIL-based membranes (PILMs) was adjusted by the structures of PILs, specifically the alkyl chain length of imidazolium (Bu and octyl) and anion species (acrylic anion, Br^–, and PF₆^–). Tunability of wettability resulted in the hydrophilic or hydrophobic property of PILMs. The hydrophilic poly(1-vinyl-3-butylimidazolium acrylate)-based membrane (PILM-1) transported water and intercepted oil, while the hydrophobic poly(1-vinyl-3-octylimidazolium hexafluorophosphate)-based membrane (PILM-5) removed oil and rejected water. The two membranes with opposite wettability showed excellent oil/water separation efficiency (above 99%) in batch processes. Continuous oil/water separation was also achieved by assembling PILM-1 and PILM-5 on the fabricated devices. A T-type device could sep. various oil/water mixtures continuously, and a tank-type device could sep. dispersed oil/water mixtures, with a handling capacity of 46 L within 12 h. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Application of 915358-85-9).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application of 915358-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Selective CO₂ Reduction to Ethylene Using Imidazolium-Functionalized Copper was written by Cheng, Banggui;Du, Jiehao;Yuan, Huiqing;Tao, Yuan;Chen, Ya;Lei, Jingxiang;Han, Zhiji. And the article was included in ACS Applied Materials & Interfaces in 2022.Reference of 21252-69-7 This article mentions the following:

Electrochem. CO₂ reduction is a promising approach to obtain sustainable chems. in energy conversion. Improving the selectivity of CO₂ reduction toward a particular C₂ product such as ethylene remains a significant challenge. Herein, we report a series of imidazolium hexafluorophosphate compounds as surface modifiers for planar Cu foils to boost the Faradaic efficiency (FE) of ethylene from 5 to 73%, which is among the highest reported using polycrystalline Cu. The modified electrodes are convenient to prepare The structure-function study demonstrates that varying the alkyl or aromatic substituents on the imidazolium nitrogen atoms has significant effects on the morphol. of the deposited films and the product selectivity of CO₂ reduction Exptl. FE_Câ‰?, FE_C2H4, ln(FE_Câ‰?/FE_CH4), and ln(FE_C2H4/FE_C2H5OH) values show generally linear relationships with FE_H2 while using different imidazolium modifiers, suggesting that factors governing proton reduction may also be directly related to both overall C_â‰? generation and ethylene selectivity. This work presents an effective and practical way in tailoring the active sites of metallic surface for selective CO₂ reduction In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Leaching separation of taurine and sodium sulfate solid mixture using ionic liquids was written by Gu, Yanlong;Shi, Feng;Yang, Hongzhou;Deng, Youquan. And the article was included in Separation and Purification Technology in 2004.HPLC of Formula: 79917-89-8 This article mentions the following:

The solubilities of taurine [2-aminoethanesulfonic acid (H₂NCH₂CH₂SO₃H)] and sodium sulfate in a series of room temperature ionic liquids were examined, and a novel and greener separation method combined with chlorinated dialkylimidazolium ionic liquid as leaching reagent and organic solvent as precipitating reagent was developed. Using such a process, selective separation of taurine from a solid mixture containing a large amount of sodium sulfate could be realized with 67-98.5% of single separation yield. Recycling of ionic liquid and organic solvent used in this separation process is possible. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8HPLC of Formula: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.HPLC of Formula: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Novel synthetic methods for N-cyano-1H-imidazole-4-carboxamides and their fungicidal activity was written by Yang, Wen-Chao;Li, Jing;Li, Jun;Chen, Qiong;Yang, Guang-Fu. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Related Products of 26832-08-6 This article mentions the following:

A novel synthetic method for N-cyanoimidazolecarboxamides has been developed with advantages of mild reaction conditions, simpler procedure, and easy reactant-product isolation compared with the existing methods. Thus, a one-step or two-step alkylation of 8-methylimidazo[1,5-d][1,2,4]triazin-1-(2H)-one gave N-cyanocarboxamides. Using this novel method, 16 new N-cyano-1H-imidazole-4-carboxamide derivatives were synthesized and their structures were characterized by spectrum anal. Further antifungal activity study showed that most of the newly synthesized compounds have good antifungal activity selectively against Rhizoctonia solani among the six fungi tested. Particularly, compound I was identified as the most promising candidate with an EC₅₀ of 2.63 μg/mL against R. solani. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Related Products of 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Related Products of 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem