Imidazoles-derivatives

Accuracy of Algorithm to Non-Invasively Predict Core Body Temperature Using the Kenzen Wearable Device. was written by Moyen, Nicole E;Bapat, Rohit C;Tan, Beverly;Hunt, Lindsey A;Jay, Ollie;Mündel, Toby. And the article was included in International journal of environmental research and public health in 2021.Recommanded Product: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

With climate change increasing global temperatures, more workers are exposed to hotter ambient temperatures that exacerbate risk for heat injury and illness. Continuously monitoring core body temperature (T_C) can help workers avoid reaching unsafe T_C. However, continuous T_C measurements are currently cost-prohibitive or invasive for daily use. Here, we show that Kenzen’s wearable device can accurately predict T_C compared to gold standard T_C measurements (rectal probe or gastrointestinal pill). Data from four different studies (n = 52 trials; 27 unique subjects; >4000 min data) were used to develop and validate Kenzen’s machine learning T_C algorithm, which uses subject’s real-time physiological data combined with baseline anthropometric data. We show Kenzen’s T_C algorithm meets pre-established accuracy criteria compared to gold standard T_C: mean absolute error = 0.25 °C, root mean squared error = 0.30 °C, Pearson r correlation = 0.94, standard error of the measurement = 0.18 °C, and mean bias = 0.07 °C. Overall, the Kenzen T_C algorithm is accurate for a wide range of T_C, environmental temperatures (13-43 °C), light to vigorous heart rate zones, and both biological sexes. To our knowledge, this is the first study demonstrating a wearable device can accurately predict T_C in real-time, thus offering workers protection from heat injuries and illnesses. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Recommanded Product: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Structure of Alkylimidazolium-Based Ionic Liquids at the Interface with Vacuum and Water-A Molecular Dynamics Study was written by Konieczny, Jan K.;Szefczyk, Borys. And the article was included in Journal of Physical Chemistry B in 2015.Electric Literature of C18H31F6N3O4S2 This article mentions the following:

Ionic liquid (IL) interfaces with vacuum and water are studied by means of classical mol. dynamics simulations. Five ILs are compared: [C₂mim][TfO], [C₁₂mim][TfO], [C₂mim][NTf₂], [C₈mim][NTf₂] and [C₁₂mim][NTf₂], where [C₂mim], [C₈mim] and [C₁₂mim] stand for 1-ethyl-, 1-octyl- and 1-dodecyl-3-methylimidazolium cation. Phys. properties – d., thermal expansion coefficient, compressibility, surface tension, heat of vaporization, self-diffusion coefficient, elec. conductivity and viscosity – are calculated and validated against exptl. values. The structure of the interfaces is compared in terms of the orientation of the mols. and segregation into layers. It is observed that ILs with short alkyl chains orient at the surface; however, there is no single preferred orientation. ILs with longer chains, on the other hand, orient with alkyl chains protruding into the vacuum at the IL/vacuum interface and into the bulk IL, at the IL/water interface. Anions and water mols. tend to associate with polar imidazolium groups. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Electric Literature of C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study was written by Wang, Li;Bao, Bo-Bo;Song, Guo-Qing;Chen, Cheng;Zhang, Xu-Meng;Lu, Wei;Wang, Zefang;Cai, Yan;Li, Shuang;Fu, Sheng;Song, Fu-Hang;Yang, Haitao;Wang, Jian-Guo. And the article was included in European Journal of Medicinal Chemistry in 2017.Quality Control of Ethyl 2-mercapto-1H-imidazole-4-carboxylate This article mentions the following:

The worldwide outbreak of severe acute respiratory syndrome (SARS) in 2003 had caused a high rate of mortality. Main protease (M^pro) of SARS-associated coronavirus (SARS-CoV) is an important target to discover pharmaceutical compounds for the therapy of this life-threatening disease. During the course of screening new anti-SARS agents, a series of unsym. aromatic disulfides inhibited SARS-CoV M^pro significantly for the first time have been identified. Novel unsym. aromatic disulfides R¹SSR² [R¹ = 1,3-thiazol-2-ylsulfanyl, 1,3,4-oxadiazol-2-ylsulfanyl, pyrimidin-2-ylsulfanyl, etc.; R² = phenylsulfanyl, 4-bromophenylsulfanyl, [2-(methoxycarbonyl)phenyl]sulfanyl, etc.] were synthesized chem. and their biol. activities were evaluated in vitro against SARS-CoV Mpro. These novel compounds displayed excellent IC₅₀ data in the range of 0.516-5.954 μM. Preliminary studies indicated that these disulfides are reversible and competitive inhibitors. A possible binding mode was generated via mol. docking simulation and a comparative field anal. (CoMFA) model was constructed to understand the structure-activity relationships. The present research therefore has provided some meaningful guidance to design and identify anti-SARS drugs with totally new chem. structures. In the experiment, the researchers used many compounds, for example, Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8Quality Control of Ethyl 2-mercapto-1H-imidazole-4-carboxylate).

Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of Ethyl 2-mercapto-1H-imidazole-4-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparatory study for the synthesis of the starfish alkaloid imbricatine. Syntheses of 5-arylthio-3-methyl-L-histidines was written by Ohba, Masashi;Mukaihira, Takafumi;Fujii, Tozo. And the article was included in Chemical & Pharmaceutical Bulletin in 1994.SDS of cas: 25676-75-9 This article mentions the following:

Chiral syntheses of 3-methyl-5-(arylthio)-L-histidines I (R = Ph, 1-naphthyl), selected as models for the asteroid alkaloid imbricatine, have been accomplished through a 10-step route starting from 4(5)-bromoimidazole (II). The key steps involved were methylation of II, hydroxymethylation of 4-bromo-1-methyl-1H-imidazole, replacement of the 4-bromo group by an arylthio group, and introduction of a chiral α-amino acid moiety into the chlorides III by the bislactim ether method. The synthesis of 4-(4-methoxybenzyl)thio analog III (R = 4-MeOC₆H₄CH₂), carried out in a similar manner, concluded formal syntheses of ovothiols A and C. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9SDS of cas: 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. SDS of cas: 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Self-Supporting, Hydrophobic, Ionic Liquid-Based Reference Electrodes Prepared by Polymerization-Induced Microphase Separation was written by Chopade, Sujay A.;Anderson, Evan L.;Schmidt, Peter W.;Lodge, Timothy P.;Hillmyer, Marc A.;Buhlmann, Philippe. And the article was included in ACS Sensors in 2017.SDS of cas: 404001-48-5 This article mentions the following:

Interfaces of ionic liquids and aqueous solutions exhibit stable elec. potentials over a wide range of aqueous electrolyte concentrations This makes ionic liquids suitable as bridge materials that sep. in electroanal. measurements the reference electrode from samples with low and/or unknown ionic strengths. However, methods for the preparation of ionic liquid-based reference electrodes were not explored widely. The authors have designed a convenient and reliable synthesis of ionic liquid-based reference electrodes by polymerization-induced microphase separation This technique allows for a facile, single-pot synthesis of ready-to-use reference electrodes that incorporate ion conducting nanochannels filled with either 1-octyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide or 1-dodecyl-3-methylimidazolium bis(trifluoromethyl sulfonyl)imide as ionic liquid, supported by a mech. robust cross-linked polystyrene phase. This synthesis procedure allows for the straightforward design of various reference electrode geometries. These reference electrodes exhibit a low resistance as well as good reference potential stability and reproducibility when immersed into aqueous solutions varying from deionized, purified H₂O to 100 mM KCl, while requiring no correction for liquid junction potentials. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5SDS of cas: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.SDS of cas: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Significant effect of 5,10,15,20-meso-tetraarylporphyrinatoiron(III) chloride/triflate and acidic/neutral/basic imidazolium ionic liquids in catalytic oxidation of phenols was written by Ahmad, Sohail;Gautam, Renu;Singhal, Anchal;Chauhan, S. M. S.. And the article was included in Journal of Molecular Liquids in 2018.Category: imidazoles-derivatives This article mentions the following:

The influence of acidic, neutral and basic ionic liquids and their binary mixture with dichloromethane on the reactivity of iron(III) porphyrins was investigated during oxidation of phenols with hydrogen peroxide catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chloride and 5,10,15,20-tetraarylporphyrinatoiron(III) triflate. The generation of different intermediates of iron(III) porphyrin in different ILs was studied through viscosity, d., UV-Vis and ¹H NMR spectroscopy. The heterolytic cleavage efficiency of (TAP)Fe^III-OOH and formation of quinone using iron(III)porphyrin (TAP)Fe^IIICl with Cl atom as an axial ligand, is influenced by the structure of imidazolium moiety and the counter-anion following the order [(CH₂)₄SO₃HMIm]CF₃COO > [Hmim]CF₃COO > [bmim]TFA >>>> negligible amount in [bmim]CF₃SO₃, [Hmim]CF₃SO₃, [bmim]BF₄, [bmim]PF₆ and [bmim]Cl. On the other hand, the heterolytic cleavage efficiency of (TAP)Fe^III-OOH with iron(III)porphyrin (TAP)Fe^IIICF₃SO₃ with triflate as an axial ligand, was found in the following order [(CH₂)₄SO₃HMIm]CF₃SO₃ > [Hmim]CF₃SO₃ > [(CH₂)₄SO₃HMIm]CF₃COO > [Hmim]CF₃COO > [bmim] CF₃COO > [bmim]PF₆ â‰?[bmim]BF₄ â‰?[bmim]CF₃SO₃, while epoxidation and polymerization were mainly observed in basic and neutral ILs. The reactive intermediates formed by the reaction of monooxygen donors with (TAP)Fe^IIICl varied with ILs, as (TAP)^+·Fe^IV = O intermediate was dominated in acidic ILs, while (TAP)Fe^IV = O was formed in neutral ILs and (TAP)Fe^III-OO^– was formed in basic ILs. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Category: imidazoles-derivatives).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazolium based ionic liquids as solvents for cellulose chemistry was written by Vitz, Juergen;Erdmenger, Tina;Schubert, Ulrich S.. And the article was included in ACS Symposium Series in 2010.HPLC of Formula: 79917-89-8 This article mentions the following:

In recent years, ionic liquids developed to advantageous solvents for the dissolution and homogeneous processing of cellulose. Even if ionic liquids were already known for their capability of efficiently dissolving cellulose for a long time, significant efforts were made in the last years. New candidates were found, but it could be shown, that some ionic liquids are involved in side reactions, too. With the aim for gaining a better insight on the dissolution properties, we screened a wide range of potentially suitable ionic liquids Remarkable results were obtained, for example an odd-even effect was found for different alkyl side chain lengths, both linear and branched, for the imidazolium based ionic liquids with chloride counterions. Furthermore, 1-ethyl-3-methylimidazolium di-Et phosphate showed promising properties for the dissolution of cellulose, e.g. a lower degradation of cellulose than for other ILs, a low m.p., and a low viscosity of the cellulose solution, simplifying the handling. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8HPLC of Formula: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A Versatile Approach to Ullmann C-N Couplings at Room Temperature: New Families of Nucleophiles and Electrophiles for Photoinduced, Copper-Catalyzed Processes was written by Ziegler, Daniel T.;Choi, Junwon;Munoz-Molina, Jose Maria;Bissember, Alex C.;Peters, Jonas C.;Fu, Gregory C.. And the article was included in Journal of the American Chemical Society in 2013.Formula: C8H8N2 This article mentions the following:

The use of light to facilitate copper-catalyzed cross-couplings of nitrogen nucleophiles can enable C-N bond formation to occur under unusually mild conditions. In this study, we substantially expand the scope of such processes, establishing that this approach is not limited to reactions of carbazoles with iodobenzene and alkyl halides. Specifically, we demonstrate for the first time that other nitrogen nucleophiles (e.g., common pharmacophores such as indoles, benzimidazoles, and imidazoles) as well as other electrophiles (e.g., hindered/deactivated/heterocyclic aryl iodides, an aryl bromide, an activated aryl chloride, alkenyl halides, and an alkynyl bromide) serve as suitable partners. Photoinduced C-N bond formation can be achieved at room temperature using a common procedure with an inexpensive catalyst (CuI) that does not require a ligand coadditive and is tolerant of moisture and a variety of functional groups. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Formula: C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and Toxicity Evaluation of New Pyrroles Obtained by the Reaction of Activated Alkynes with 1-Methyl-3-(cyanomethyl)benzimidazolium Bromide was written by Ivan, Beatrice-Cristina;Dumitrascu, Florea;Anghel, Adriana Iuliana;Ancuceanu, Robert Viorel;Shova, Sergiu;Dumitrescu, Denisa;Draghici, Constantin;Olaru, Octavian Tudorel;Nitulescu, George Mihai;Dinu, Mihaela;Barbuceanu, Stefania-Felicia. And the article was included in Molecules in 2021.Category: imidazoles-derivatives This article mentions the following:

A series of new pyrrole derivatives I (R = H, methoxycarbonyl, ethoxycarbonyl; R¹ = Bz, methoxycarbonyl, ethoxycarbonyl, (propan-2-yloxy)carbonyl) were designed as chem. analogs of the 1,4-dihydropyridines drugs in order to develop future new calcium channel blockers. The new tri- and tetra-substituted N-arylpyrroles I were synthesized by the one-pot reaction of 1-methyl-3-cyanomethyl benzimidazolium bromide with substituted alkynes RCCR¹ having at least one electron-withdrawing substituent, in 1,2-epoxybutane, acting both as the solvent and reagent to generate the corresponding benzimidazolium N3-ylide. The structural characterization of the new substituted pyrroles I was based on IR, NMR spectroscopy as well as on single crystal X-ray anal. The toxicity of the new compounds was assessed on the plant cell using Triticum aestivum L. species and on the animal cell using Artemia franciscana Kellogg and Daphnia magna Straus crustaceans. The compounds showed minimal phytotoxicity on Triticum rootlets and virtually no acute toxicity on Artemia nauplii, while on Daphnia magna, it induced moderate to high toxicity, similar to nifedipine. This research indicates that the newly synthesized pyrrole derivatives are promising mols. with biol. activity and low acute toxicity. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lithium chloride-imidazolium chloride melts for the coupling reactions of propylene oxide and CO₂ was written by Nguyen, Ly Vinh;Lee, Bora;Nguyen, Dinh Quan;Kang, Min-Jung;Lee, Hyunjoo;Ryu, Seol;Kim, Hoon Sik;Lee, Je Seung. And the article was included in Bulletin of the Korean Chemical Society in 2008.Formula: C7H13ClN2 This article mentions the following:

A series of lithium chloride-imidazolium chloride (LiCl-[imidazolium]Cl) melts were prepared and their catalytic activities were evaluated for the coupling reactions of propylene oxide and CO₂. At the constant mole of LiCl, the catalytic activities of LiCl-[imidazolium]Cl melts increased with increasing molar ratio of [imidazolium]Cl/LiCl up to 2, but thereafter decreased rapidly. The variation of alkyl groups on the imidazolium ring showed a negligible effect on the catalytic activity, but the number of alkyl groups present on the imidazolium cation exerts a pronounced effect. Catalysis and electrospray ionization tandem mass spectral anal. results of LiCl-[imidazolium]Cl melts imply that the activity of the melt is strongly related to the amount of LiCl₂^– generated from the melt. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Formula: C7H13ClN2).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Formula: C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem