Imidazoles-derivatives

Unusual synthesis of stable pyridinium dinitromethylides was written by Andreasson, Eva;Newton, Christopher G.;Ollis, W. David;Rees, Charles W.;Smith, David I.;Wright, Derek E.. And the article was included in Journal of the Chemical Society, Chemical Communications in 1983.Formula: C9H8N2O2 This article mentions the following:

Nitration of imidazo[1,2-a]pyridines with concentrated HNO₃ and H₂SO₄ at room temperature gave pyridinium dinitromethylides in 51-85% yield; these compounds have orthogonal pyridinium and dinitromethylide groups. E.g., treatment of ester I with fuming HNO₃-concentrated H₂SO₄ at room temperature gave 61% ylide II. Reaction mechanisms involving sequential nitration and ring cleavage are discussed. In the experiment, the researchers used many compounds, for example, Methyl imidazo[1,2-a]pyridine-5-carboxylate (cas: 88047-55-6Formula: C9H8N2O2).

Methyl imidazo[1,2-a]pyridine-5-carboxylate (cas: 88047-55-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Formula: C9H8N2O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic molecules for disruption of the MYC protein-protein interface was written by Jacob, Nicholas T.;Miranda, Pedro O.;Shirey, Ryan J.;Gautam, Ritika;Zhou, Bin;de Orbe Izquierdo, M. Elena;Hixon, Mark S.;Hart, Jonathan R.;Ueno, Lynn;Vogt, Peter K.;Janda, Kim D.. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Synthetic Route of C6H8N2O This article mentions the following:

MYC is a key transcriptional regulator involved in cellular proliferation and has established roles in transcriptional elongation and initiation, microRNA regulation, apoptosis, and pluripotency. Despite this prevalence, functional chem. probes of MYC function at the protein level have been limited. Previously, we discovered 5a, that binds to MYC with potency and specificity, downregulates the transcriptional activities of MYC and shows efficacy in vivo. However, this scaffold posed intrinsic pharmacokinetic liabilities, namely, poor solubility that precluded biophys. interrogation. Here, we developed a screening platform based on field-effect transistor anal. (Bio-FET), surface plasmon resonance (SPR), and a microtumor formation assay to analyze a series of new compounds aimed at improving these properties. This blind SAR campaign has produced a new lead compound of significantly increased in vivo stability and solubility for a 40-fold increase in exposure. This probe represents a significant advancement that will not only enable biophys. characterization of this interaction and further SAR, but also contribute to advances in understanding of MYC biol. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Synthetic Route of C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Synthetic Route of C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Controlling selectivity for cycloadditions of nitrones and alkenes tethered by benzimidazoles: combining experiment and theory was written by Meng, Liping;Wang, Selina C.;Fettinger, James C.;Kurth, Mark J.;Tantillo, Dean J.. And the article was included in European Journal of Organic Chemistry in 2009.Related Products of 3012-80-4 This article mentions the following:

A combined exptl./theor. study on the effects of substituents on regio- and stereoselectivity in intramol. 1,3-dipolar cycloadditions of nitrones and alkenes tethered by benzimidazoles. By employing a large substituent at position R² or R³, complete selectivity was achieved for either the fused or bridged cycloadduct, resp. In addition, these cycloadducts were formed as single diastereomers in all of the cycloadditions examined In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Related Products of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Related Products of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of temperature on the interactions between low bandgap polymer and ionic liquids was written by Attri, Pankaj;Lee, Seung-Hyun;Hwang, Sun Woo;Kim, Joong Il;Jang, Won;Kim, Young Beom;Park, Jung Ho;Kwon, Gi-Chung;Choi, Eun Ha;Kim, In Tae. And the article was included in Thermochimica Acta in 2014.Synthetic Route of C4H7ClN2 This article mentions the following:

In this paper, we have examined the effect of temperature on the interactions between imidazolium and ammonium based ionic liquids (ILs) and the low bandgap polymer (poly(2-heptadecyl-4-vinylthieno[3,4-d]thiazole) (PHVTT)). With the aim of exploring the utility of low bandgap polymers, we have carried out the interaction studies of the polymer with the ILs and investigated the behavior of polymer in the presence of ILs as the function of temperature Recently, ILs have attracted extensive attention in polymer sciences. In this work, we have studied the temperature dependent interactions between the protic IL (1-methylimidazolium chloride ([Mim]Cl) from imidazolium family) and aprotic ILs (tributylmethylammonium Me sulfate ([N₁₄₄₄][MeSO₄]) from ammonium family and 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) from imidazolium family) with a low bandgap polymer. Our exptl. data of UV-vis spectroscopy, photoluminescence (PL) spectroscopy, FT-IR spectroscopy, d. (ρ) and speed of sound (u) as a function of temperature from 25 to 40° with the interval of 5°, clearly reveal that even at high temperature, [Bmim]Cl interacts strongly with the polymer as compared to other studied ILs. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Synthetic Route of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The effect of an electron-withdrawing group in the imidazolium cation: the case of nitro-functionalized imidazolium salts as acidic catalysts for the acetylation of glycerol was written by Morais, Eduardo M.;Grillo, Igor B.;Stassen, Hubert K.;Seferin, Marcus;Scholten, Jackson D.. And the article was included in New Journal of Chemistry in 2018.COA of Formula: C4H5N3O2 This article mentions the following:

The acetylation of glycerol was achieved with high conversion and selectivity towards triacetin at low temperatures and short reaction times by using acidic imidazolium salts as catalysts. Moreover, the addition of a nitro group to the imidazolium cation affords a much more competent catalyst, indicating a significant effect provided by the simple electronic change in the imidazolium cation. Theor. calculations revealed increased polarization of the acidic hydrogen bond on the nitrated salts, which may be related to their superior catalytic behavior when compared to the non-functionalized salts. Combining the preliminary exptl. and theor. results, it is possible to suppose that the catalytic activity of acidic imidazolium salts may be better comprehended by its Bronsted acidities, but other parameters such as hardness, electronegativity, electrophilicity and ion-pair binding energy were also evaluated in order to investigate their effects in the acetylation of glycerol promoted by these acidic imidazolium salts. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1COA of Formula: C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. COA of Formula: C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mechanochemical and conformational study of N-heterocyclic carbonyl-oxime transformations was written by Primozic, Ines;Hrenar, Tomica;Baumann, Kresimir;Kristo, Lucija;Krizic, Ivana;Tomic, Srdanka. And the article was included in Croatica Chemica Acta in 2014.Related Products of 3012-80-4 This article mentions the following:

New mechanochem. pathways for the transformation of six N-heterocyclic carbonyl compounds into oximes using hydroxylamine hydrochloride were explored. Reactions were performed first without any base since the heterocyclic moieties (imidazole, benzimidazole, pyridine and quinuclidine) have an intrinsic basic nitrogen atom. This green, solvent free method was suitable for all compounds (up to quant. yields) except for N-benzyl substituted imidazole and benzimidazole-2-carbaldehyde. For the slower reacting aldehydes, reactions with liquid assisted grinding and addition of sodium hydroxide were performed as well. Conformational anal. and quantum-chem. calculations revealed steric and electronic reasons for the lower reactivity of N-benzyl substituted derivatives In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Related Products of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Related Products of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

peri-Substituted imidazo[1,2-a]pyridines. A new reductive elimination reaction was written by Rees, Charles W.;Smith, David I.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1987.Safety of 5-Bromoimidazo[1,2-a]pyridine This article mentions the following:

A new reductive elimination reaction of 3,5-disubstituted imidazo[1,2-a]pyridines I (R, R¹ = Br, NO₂) with N₂H₄ in hot EtOH is reported. A mechanism based on the conjugated relationship of these peri-substituents is proposed and used to explain the reported conversion of 1,3,5-trichloro-2,4,6-trinitrobenzene into 1,3-dichloro-4,6-dinitrobenzene. A variety of other 3-nitro-5-substituted imidazo[1,2-a]pyridines I (R = NO₂, R¹ = CO₂Me, CONHNH₂, CON₃, NH₂, NHCO₂Me, N₃, etc.) are described, but these could not be cyclized. The 3-amino-5-methoxycarbonyl derivative I (R = NH₂, R¹ = CO₂Me) cyclizes to the imidazoindazole II with NaOMe. In the experiment, the researchers used many compounds, for example, 5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1Safety of 5-Bromoimidazo[1,2-a]pyridine).

5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Safety of 5-Bromoimidazo[1,2-a]pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bronsted acidic ionic liquids for cellulose hydrolysis in an aqueous medium: structural effects on acidity and glucose yield was written by Suzuki, Shiori;Takeoka, Yuko;Rikukawa, Masahiro;Yoshizawa-Fujita, Masahiro. And the article was included in RSC Advances in 2018.Product Details of 35487-17-3 This article mentions the following:

The conversion of cellulose into valuable chems. has attracted much attention, due to the concern about depletion of fossil fuels. The hydrolysis of cellulose is a key step in this conversion, for which Bronsted acidic ionic liquids (BAILs) have been considered promising acid catalysts. In this study, using BAILs with various structures, their acidic catalytic activity for cellulose hydrolysis assisted by microwave irradiation was assessed using the Hammett acidity function (H₀) and theor. calculations The glucose yields exceeded 10% when the H₀ values of the BAIL aqueous solutions were below 1.5. The highest glucose yield was about 36% in 1-(1-octyl-3-imidazolio)propane-3-sulfonate (Oimps)/sulfuric acid (H₂SO₄) aqueous solution A long alkyl side chain on the imidazolium cation, which increased the hydrophobicity of the BAILs, enhanced the glucose yield. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Product Details of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Product Details of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Catalytic pyrolysis of liquorice (Glycyrrhiza glabra L.) in a fixed-bed reactor: Effects of pyrolysis parameters on product yields and character was written by Aysu, Tevfik;Durak, Halil. And the article was included in Journal of Analytical and Applied Pyrolysis in 2015.COA of Formula: C4H5N3O This article mentions the following:

Pyrolysis of liquorice (Glycyrrhiza glabra L.) stalks were performed in a fixed-bed tubular reactor with (ZnO, FeCl₃, K₂CO₃, Al₂O₃, Na₂B₄O₇·10H₂O) and without catalyst at three different temperatures (350, 450, 550 °C) with a constant heating rate of 40 °C/min. The amounts of bio-char, bio-oil and gas produced, as well as the compositions of the resulting bio-oils were determined by GC-MS. The effects of pyrolysis parameters on product yields were investigated. The results indicate that both temperature and catalysts effect the conversions of G. glabra L. into solid, liquid and gaseous products. The highest conversion of 74.50% and liquid yield of 34.35% were obtained with Na₂B₄O₇·10H₂O catalyst at 550 °C temperature when 0.224 > Dp > 0.150 mm particle sized samples and 100 mL/min of sweeping gas flow rate were used. Liquid products (bio-oils) obtained at 350 and 550 °C were analyzed by elemental anal. and gas chromatog./mass spectrometry (GC-MS). 133 and 148 different compounds were identified by GC-MS in the bio-oils obtained at 350 and 550 °C, resp. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6COA of Formula: C4H5N3O).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C4H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Antibacterial Activity of Imidazolium-Based Ionic Liquids Investigated by QSAR Modeling and Experimental Studies was written by Hodyna, Diana;Kovalishyn, Vasyl;Rogalsky, Sergiy;Blagodatnyi, Volodymyr;Petko, Kirill;Metelytsia, Larisa. And the article was included in Chemical Biology & Drug Design in 2016.Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

Predictive QSAR models for the inhibitors of B. subtilis and Ps. aeruginosa among imidazolium-based ionic liquids were developed using literary data. The regression QSAR models were created through Artificial Neural Network and k-nearest neighbor procedures. The classification QSAR models were constructed using WEKA-RF (random forest) method. The predictive ability of the models was tested by fivefold cross-validation; giving q² = 0.77-0.92 for regression models and accuracy 83-88% for classification models. Twenty synthesized samples of 1,3-dialkylimidazolium ionic liquids with predictive value of activity level of antimicrobial potential were evaluated. For all asym. 1,3-dialkylimidazolium ionic liquids, only compounds containing at least one radical with alkyl chain length of 12 carbon atoms showed high antibacterial activity. However, the activity of sym. 1,3-dialkylimidazolium salts was found to have opposite relationship with the length of aliphatic radical being maximum for compounds based on 1,3-dioctylimidazolium cation. The obtained exptl. results suggested that the application of classification QSAR models is more accurate for the prediction of activity of new imidazolium-based ILs as potential antibacterials. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem