Imidazoles-derivatives

Double head-to-tail direct arylation as a viable strategy towards the synthesis of the aza-analog of dihydrocyclopenta[hi]aceanthrylene – an intriguing antiaromatic heterocycle was written by Firmansyah, Dikhi;Deperasinska, Irena;Vakuliuk, Olena;Banasiewicz, Marzena;Tasior, Mariusz;Makarewicz, Artur;Cyranski, Michal K.;Kozankiewicz, Boleslaw;Gryko, Daniel T.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Computed Properties of C7H5BrN2 This article mentions the following:

The first case of double head-to-tail direct arylation of aromatic compounds and the unusual photophys. properties of the resulting 2,2a^1,5b^1,7-tetraazacyclopenta[hi]aceanthrylene are reported. This mol., comprising of two imidazo[1,2-a]pyridine units, is antiarom. due to the changes in the efficiency of π-electron ring current and it belongs to a class of seldom encountered compounds with a dark lowest electronically excited singlet state. In the experiment, the researchers used many compounds, for example, 5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1Computed Properties of C7H5BrN2).

5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Computed Properties of C7H5BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The effects of cationic type ionic liquids on methane hydrate formation was written by Lu, Cui-ying. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2014.Electric Literature of C4H7ClN2 This article mentions the following:

The article has studied the effects of ionic liquids on the induction time of methane hydrate formation under different mass concentrations, temperatures and pressures. The results show: all the tested ionic liquids can postpone the induction time of hydrate forming. Among them, imimidazolium-based ones have the strongest ability; The concentrations of ionic liquids also have strong effects on the induction time, and 0.5% is optimal. In addition the inhibiting abilities of ionic liquid on the induction time change with different pressures and temperatures, but not obviously. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Electric Literature of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Electric Literature of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and antiaggregant and anticoagulant activity of new 1-(4-alkyloxybenzyl)-1H-azoles and 1-(adamantyl-1)-2-[4-(1H-azol-1-ylmethyl)-phenoxy]ethanones was written by Gurevich, K. G.;Urakov, A. L.;Basantsev, A. V.;Abzalilov, T. A.;Bashirov, I. I.;Danilin, A. A.;Purygin, P. P.;Golovanov, A. A.;Khayrzamanova, K. A.;Samorodov, A. V.. And the article was included in Pharmaceutical Chemistry Journal in 2021.Category: imidazoles-derivatives This article mentions the following:

The development and optimization of synthetic methods for alkyl esters of 4-[(1H-azol-1-yl)methyl]phenols I [R = n-octyl, n-hexadecyl, 1-adamantyl; Az = imidazol-1-ylmethyl, 1,2,4-triazol-1-ylmethyl, benzimidazol-1-ylmethyl, benzotriazol-1-ylmethyl] enabled the expansion of organic synthesis methodol., which is extremely important for designing new structures with various types of biol. activity, e.g., antiaggregant and anticoagulant. The present work studied O-alkylation of 4-[(1H-azol-1-yl)methyl]phenols with various alkylating agents, e.g., n-octyl bromide, n-hexadecyl bromide, and (adamantyl-1)bromomethylketone. The newly synthesized compounds were identified using elemental anal. and IR and PMR spectroscopy. Laboratory studies of blood isolated from healthy volunteers revealed compounds with antiaggregant and anticoagulant properties. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic Liquid-Liquid Separations Using Countercurrent Chromatography: A New General-Purpose Separation Methodology was written by Brown, Leslie;Earle, Martyn J.;Gilea, Manuela A.;Plechkova, Natalia V.;Seddon, Kenneth R.. And the article was included in Australian Journal of Chemistry in 2017.HPLC of Formula: 404001-48-5 This article mentions the following:

Liquid-liquid separations based on countercurrent chromatog., in which at least one phase contains an ionic liquid, represent a new empirical approach for the separation of organic, inorganic, or bio-based materials. A custom-designed instrument was developed and constructed specifically to perform separations (including transition metal salts, arenes, alkenes, alkanes, and sugars) with ionic liquids, and was demonstrated for use on the 0.1 to 10 g scale. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5HPLC of Formula: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.HPLC of Formula: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reactive-Atom Scattering from Liquid Crystals at the Liquid-Vacuum Interface: [C₁₂mim][BF₄] and 4-Cyano-4′-Octylbiphenyl (8CB) was written by Purcell, Simon M.;Tesa-Serrate, Maria A.;Marshall, Brooks C.;Bruce, Duncan W.;D’Andrea, Lucia;Costen, Matthew L.;Slattery, John M.;Smoll, Eric J.;Minton, Timothy K.;McKendrick, Kenneth G.. And the article was included in Langmuir in 2016.HPLC of Formula: 404001-48-5 This article mentions the following:

Two complementary approaches were used to study the liquid-vacuum interface of the liquid-crystalline ionic liquid 1-dodecyl-3-methylimidazolium tetrafluoroborate ([C₁₂mim][BF₄]) in the smectic A (SmA) and isotropic phases. O atoms with two distinct incident translational energies were scattered from the surface of [C₁₂mim][BF₄]. Angle-dependent time-of-flight distributions and OH yields, resp., were recorded from high- and low-energy O atoms. There were no significant changes in the measurements using either approach, nor the properties derived from them, accompanying the transition from the SmA to the isotropic phase. This indicates that the surface structure of [C₁₂mim][BF₄] remains essentially unchanged across the phase boundary, implying that the bulk order and surface structure are not strongly correlated for this material. This effect is ascribed to the strong propensity for the outer surfaces of ionic liquids to be dominated by alkyl chains, over an underlying layer rich in anions and cation head groups, whether or not the bulk material is a liquid crystal. In a comparative study, the OH yield from the surface of the liquid crystal, 8CB, was found to be affected by the bulk order, showing a surprising step increase at the SmA-nematic transition temperature, whose origin is the subject of speculation. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5HPLC of Formula: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. HPLC of Formula: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Manganese-Catalysed Deuterium Labelling of Anilines and Electron-Rich (Hetero)Arenes was written by Bourriquen, Florian;Rockstroh, Nils;Bartling, Stephan;Junge, Kathrin;Beller, Matthias. And the article was included in Angewandte Chemie, International Edition in 2022.Electric Literature of C8H8N2 This article mentions the following:

Here, a new class of heterogeneous catalysts was reported for practical deuterium incorporation in anilines, phenols, and heterocyclic substrates. The optimal material can be conveniently synthesized and allows for high deuterium incorporation using deuterium oxide as isotope source. This new catalyst was fully characterized and successfully applied to the labeling of natural products as well as marketed drugs. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Development of a Regioselective N-Methylation of (Benz)imidazoles Providing the More Sterically Hindered Isomer was written by Van Den Berge, Emilie;Robiette, Raphael. And the article was included in Journal of Organic Chemistry in 2013.Computed Properties of C8H8N2 This article mentions the following:

An efficient and highly regioselective N-methylation of (NH)-(benz)imidazoles furnishing the sterically more hindered, less stable, and usually minor regioisomer has been developed. The methodol. involves very mild reaction conditions and tolerates a wide range of functional groups. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Computed Properties of C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Computed Properties of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enhancement of the solubility and the dissolution rate of candesartan cilexetil using microsponge technology was written by Nazar, Shaimaa;Alhammid, Abd. And the article was included in Asian Journal of Pharmaceutical and Clinical Research in 2018.Application of 145040-37-5 This article mentions the following:

The aim of the present study is to enhance the dissolution rate of candesartan cilexetil (CC) using microsponges. Candesartan is therapeutically a potent antihypertensive agent, but it suffers a major drawback of poor oral bioavailability, which is estimated to be 15% due to its low solubility in the gastrointestinal fluids and hepatic first-pass metabolism Eudragit-based microsponges were prepared by quasi-emulsion solvent diffusion method using different drug-polymer ratios (1:1 to 1:6), stirring speeds (250-750 rpm), and emulsifier concentrations (polyvinyl alc.) (0.05%-0.083% w/v). Differential scanning calorimetry (DSC) and Fourier transform IR spectroscopy (FTIR) study for CC, phys. mixtures of drug-polymer, and selected formula were investigated to estimate compatibility of CC with other used ingredients. All formulations were evaluated for particle size, production yield, and loading efficiency. The in vitro drug release study of optimized formulation was performed in phosphate buffer pH 6.8. The obtained results indicated that formula F3 which contains eudragit RS100 at drug:polymer ratio (6:1) was showed the smallest particle size with higher production yield and loading efficiency. DSC and FTIR study of the phys. mixtures of drug and polymer revealed no drug-polymer interaction. The results clearly confirm that the percentage of CC released at 30 min from F3, CC powder, and self-made tablet was 54%, 20.325, and 38.9%, resp. Microsponges technique was considered as a promising system to enhance the solubility and dissolution rate of poor-water soluble CC. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Application of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites was written by Oba, Yasuhiro;Takano, Yoshinori;Furukawa, Yoshihiro;Koga, Toshiki;Glavin, Daniel P.;Dworkin, Jason P.;Naraoka, Hiroshi. And the article was included in Nature Communications in 2022.SDS of cas: 26832-08-6 This article mentions the following:

The lack of pyrimidine diversity in meteorites remains a mystery since prebiotic chem. models and laboratory experiments have predicted that these compounds can also be produced from chem. precursors found in meteorites. Here we report the detection of nucleobases in three carbonaceous meteorites using state-of-the-art anal. techniques optimized for small-scale quantification of nucleobases down to the range of parts per trillion (ppt). In addition to previously detected purine nucleobases in meteorites such as guanine and adenine, we identify various pyrimidine nucleobases such as cytosine, uracil, and thymine, and their structural isomers such as isocytosine, imidazole-4-carboxylic acid, and 6-methyluracil, resp. Given the similarity in the mol. distribution of pyrimidines in meteorites and those in photon-processed interstellar ice analogs, some of these derivatives could have been generated by photochem. reactions prevailing in the interstellar medium and later incorporated into asteroids during solar system formation. This study demonstrates that a diversity of meteoritic nucleobases could serve as building blocks of DNA and RNA on the early Earth. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6SDS of cas: 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Investigations on benzimidazole-absorption spectra and chromiferous properties was written by Mangini, Angelo;Montanari, Fernando;Passerini, Riccardo. And the article was included in Atti accad. nazl. Lincei, Rend. Classe sci. fis., mat. e. nat. in 1952.HPLC of Formula: 4887-83-6 This article mentions the following:

The results are tabulated of absorption-spectrum measurements of derivatives of benzimidazole substituted in either the 4 or 5 position by H, CH₃, Cl, Br, OCH₃, NH₂, or NO₂, and 2-phenylbenzimidazole substituted with various possible combinations of the above substituents in the 4 or 5 positions and in the o, m, or p positions in the phenyl group. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6HPLC of Formula: 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem