Imidazoles-derivatives

Carbon-13, nitrogen-14, nitrogen-15, and oxygen-17 NMR spectra of nitropyrroles and nitroimidazoles was written by Lippmaa, E.;Magi, M.;Novikov, S. S.;Khmelnitski, L. I.;Prihodko, A. S.;Lebedev, O. V.;Epishina, L. V.. And the article was included in Organic Magnetic Resonance in 1972.Recommanded Product: 3034-41-1 This article mentions the following:

C, N, and O NMR spectra of nitro derivatives of pyrrole and imidazole are investigated. The 13C chem. shifts of para-C atoms and the 17O chem. shifts of the nitro group correlate qual. with the electron ds. on these C and O atoms, which in turn depend upon the degree of conjugation of the nitro groups with the heterocyclic ring. Conjugation of several nitro groups with the benzene ring is not impaired by mutual interactions and the 13C shifts are additive. Additivity is much worse in pyrrole and imidazole derivatives Taken together with the diamagnetic nature of these deviations from additivity, this leads to a possible conclusion about the less pronounced conjugation of the nitro groups with the heterocyclic ring in heterocyclic dinitro derivatives In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Self-Assembly and Complexation of Cellulose/Ionic Liquid at High Cellulose Concentration: Anion Dependence was written by Endo, Takatsugu;Yoshida, Shota;Kimura, Yoshifumi. And the article was included in Crystal Growth & Design in 2020.COA of Formula: C7H13ClN2 This article mentions the following:

The authors studied the state of cellulose that was dissolved in ionic liquid (IL) consisting of 1-Me-3-propylimdiazolium cation ([C₃mim]⁺) paired with acetate ([OAc]^–), dimethylphospate ([DMP]^–), or chloride (Cl^–) anions using wide-angle x-ray scattering (WAXS), particularly focusing on the high cellulose concentration region (10-80 mol %). The anion species considerably altered the WAXS pattern of the cellulose/IL mixtures [C₃mim][OAc] deconstructed cellulose crystal structure up to the 40 mol % cellulose concentration Similar to the previously reported cellulose/1-Et-3-methylimidazolium acetate system ([C₂mim][OAc]), the mixtures of cellulose/[C₃mim][OAc] at 25-60 mol % induced a low angle peak, which corresponds to the self-assembly of the system. For [C₃mim][DMP] and [C₃mim]Cl mixtures, sharp Bragg peaks were observed, which demonstrated the formation of the complex crystal of cellulose/IL. The presence of moisture eventually deconstructed these crystal structures; while for [C₃mim]Cl, an intermediate complex crystal containing H₂O mols. emerged. This work contributes to understanding the cellulose state dissolved in IL at high concentrations and to the development of crystal engineering on this most abundant and recalcitrant biopolymer. Complex crystals formed when cellulose was simply mixed with a certain ionic liquid at high concentrations The complex crystals are sensitive to H₂O; they transformed into a different complex crystal or an amorphous state, depending on anion types used and H₂O concentration contained. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8COA of Formula: C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hydrogenation sequence of acetophenone on commercial platinum catalyst AP-64 was written by Smirnova, N. A.;Adamyan, V. L.;Edigarova, E. I.. And the article was included in Azerbaidzhanskii Khimicheskii Zhurnal in 1987.Formula: C6H8N2O This article mentions the following:

Cyclohexyl Me carbinol formation from PhCOMe in the title reaction at 100-155° proceeded by parallel formation and hydrogenation of PhCHMeOH (I) and cyclohexyl Me ketone. Small amounts of I were also reduced to PhEt and then to ethylcyclohexane. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Highly selective biocatalytic synthesis of monoacylglycerides in sponge-like ionic liquids was written by Lozano, Pedro;Gomez, Celia;Nieto, Susana;Sanchez-Gomez, Gregorio;Garcia-Verdugo, Eduardo;Luis, Santiago V.. And the article was included in Green Chemistry in 2017.Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

The biocatalytic synthesis of monoacylglycerides (MAGs) was carried out by the direct esterification of fatty acids (i.e. capric, lauric, myristic, palmitic and oleic acids, resp.) with glycerol in different ionic liquids (ILs) based on cations with long alkyl side-chains (e.g. 1-hexadecyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [C₁₆mim][NTf₂], 1-dodecyl-3-methylimidazolium tetrafluoroborate [C₁₂mim][BF₄], etc.). Although all ILs have been shown as suitable reaction media for Novozym 435-catalyzed esterification of glycerol with free fatty acids, a high selectivity of MAGs was only observed in the [C₁₂mim][BF₄] case (e.g. up to 100% selectivity and 100% yield for monolaurin). Furthermore, as these ILs are temperature switchable ionic liquid/solid phases that behave as sponge-like systems, a straightforward protocol for IL-free MAG recovery, based on iterative centrifugations at controlled temperature, has been developed. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Oxone-DMSO Triggered Methylene Insertion and C(sp²)-C(sp³)-H-C(sp²) Bond Formation to Access Functional Bis-Heterocycles was written by Kour, Jaspreet;Venkateswarlu, Vunnam;Verma, Praveen K.;Hussain, Yaseen;Dubey, Gurudutt;Bharatam, Prasad V.;Sahoo, Subash C.;Sawant, Sanghapal D.. And the article was included in Journal of Organic Chemistry in 2020.Reference of 1632-83-3 This article mentions the following:

Metal-free insertion of a methylene group was achieved for the construction of a new C(sp²)-C(sp³)-H-C(sp²) bond in order to prepare novel bis-heterocyclic scaffolds. The complete mechanistic investigations included exptl. study and DFT calculations, and various sym. and unsym. bis-pyrazoles as well as other pyrazole-based bis-heterocyclic mols. were prepared in moderate to high yields. Further modification of the bridged methylene group in the unsym. pyrazoles generated a chiral center to extend the scope of this method. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Reference of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation and Characterization of Titanium Tetrachloride-Based Ionic Liquids was written by Gao, Lixia;Wang, Lina;Qi, Tao;Chu, Jinglong;Qu, Jingkui. And the article was included in Journal of the Electrochemical Society in 2009.Application of 79917-89-8 This article mentions the following:

TiCl₄-based ionic liquids (ILs) were synthesized by mixing TiCl₄ with quaternary ammonium, pyridinium, and imidazolium chlorogenated salt, resp. The structure and composition of the ILs were studied with Fourier transform ICR mass spectrometry, IR, and Raman spectra. The primary anions of the TiCl₄-based ILs were Ti₂Cl₉^– and TiCl₆^2-, whose amounts were different by variation of the molar ratio of TiCl₄ to organic halogenated salt. The phys. properties such as the phase transition behavior, surface tension, d., viscosity, and conductivity of these ILs were also studied. Temperature-dependent viscosity and conductivity of the ILs followed the Vogel-Tammann-Fulcher equation, and the best-fit parameters had been estimated, together with the linear fitting parameters for the d. The conductivity and viscosity of the TiCl₄-based ILs were controlled by the ion mobility and the availability of voids with suitable dimensions. Hole theory could well explain the physicochem. properties of the TiCl₄-based ILs. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Application of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Uncoupling of photophosphorylation by 2-alkylbenzimidazoles was written by Trebst, A.;Pistorius, E.;Buechel, K. H.. And the article was included in Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie in 1966.Recommanded Product: 13060-24-7 This article mentions the following:

2-Alkylbenzimidazoles exhibited little or no inhibition of the Hill reaction in isolated spinach chloroplasts, but were effective uncouplers of photophosphorylation. 2-Alkylbenzimidazoles, with side chains, of from 8 to 14 C atoms, uncoupled noncyclic and cyclic photophosphorylation at <10^-5M. 2-Decylbenzimidazole was the most potent uncoupler. 2-Undecylbenzimidazole stimulated the Hill reaction in the absence of the phosphorylation system and shifted the pH optimum to a lower value. 25 references. In the experiment, the researchers used many compounds, for example, 2-Octylbenzimidazole (cas: 13060-24-7Recommanded Product: 13060-24-7).

2-Octylbenzimidazole (cas: 13060-24-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 13060-24-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Green synthesis of acetylated maize starch in different imidazolium carboxylate and choline carboxylate ionic liquids was written by Ren, Fei;Wang, Jinwei;Yu, Jinglin;Zhong, Cheng;Xie, Fengwei;Wang, Shujun. And the article was included in Carbohydrate Polymers in 2022.Recommanded Product: 79917-89-8 This article mentions the following:

This work demonstrates that acetylated maize starches (AMS) with varied degree of substitution (DS, 0.26-2.63) was synthesized in ionic liquids (ILs) (imidazolium chloride, imidazolium carboxylate and choline carboxylate) at 85°C without catalyst. The DS of AMS and reaction efficiency increased with decreasing alkyl chain length of cations or anions, while decreased as the choline cation replaced the imidazolium cation and the chloride anion replaced the acetate anion. The AMS synthesized in imidazolium-based ILs exhibited much higher hydrophobicity and thermal stability than the native starch. Rheol. properties of ILs and ATR-FTIR anal. of acetic anhydride/ILs mixtures indicated that a shorter alkyl side chain or the combination of an imidazolium cation and an acetate anion gave ILs lower viscosities and weaker interactions between acetic anhydride mols., which favored the acetylation of starch. These findings provide insights into the design of green processes to modify starch and the application of acetylated starch. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Recommanded Product: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of Well-Defined Adenosine Diphosphate Ribose Oligomers was written by Kistemaker, Hans A. V.;Lameijer, Lucien N.;Meeuwenoord, Nico J.;Overkleeft, Herman S.;van der Marel, Gijsbert A.;Filippov, Dmitri V.. And the article was included in Angewandte Chemie, International Edition in 2015.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

The post-translational modification of proteins that is known as ADP ribosylation (ADPr) regulates a wide variety of important biol. processes, such as DNA-damage repair and cellular metabolism This modification is also involved in carcinogenesis and the process of aging. Therefore, a better understanding of the function of ADP-ribosylation is crucial for the development of novel therapeutics. To facilitate the elucidation of the biol. of ADPr, the availability of well-defined fragments of poly(ADP-ribose) is essential. Herein we report a solid-phase synthetic approach for the preparation of ADP-ribose oligomers of exactly defined length. The methodol. is exemplified by the first reported synthesis of an ADP-ribose dimer and trimer. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Evaluation of lophine derivatives as chemiluminogens by a flow-injection method was written by Nakashima, Kenichiro;Yamasaki, Hiromi;Kuroda, Naotaka;Akiyama, Shuzo. And the article was included in Analytica Chimica Acta in 1995.Quality Control of 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid This article mentions the following:

A rapid and convenient method for the evaluation of lophine (2,4,5-triphenylimidazole) derivatives as to their chemiluminescence efficiency was developed by using a flow-injection technique. Standard solutions of lophine derivatives were injected into a flow line containing a carrier solution (1.5 × 10^-4 M cobalt(II) containing 0.2% hydroxylammonium chloride in 75% methanol), which was successively combined with a flow line containing 100 mM hydrogen peroxide in H₂O and a flow line containing 1.0M KOH in H₂O, and the chemiluminescence generated was monitored. Addition of hydroxylammonium chloride into a carrier solution resulted in a significant increase in chemiluminescence. Calibration graphs for eighteen derivatives were prepared and the relative chemiluminescence intensities were estimated from the slopes of these graphs. Among the derivatives, the compounds substituted by OMe at the 2- and 3-positions, and COOH, COCl, CONHNH₂ and CONHNHCO(CH₂)₄Me at the 4-position on the Ph ring at the 2-position of the imidazole skeleton showed large chemiluminescence intensities which are comparable to that of lophine. The detection limit of lophine was 72 fmol per injection at a signal-to-noise ratio of 2. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Quality Control of 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Quality Control of 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem