Imidazoles-derivatives

Imidazolium-Catalyzed Formation of Bisphenol A Polycarbonate with a Reduced Level of Branching was written by Tay, Boonying;van Meurs, Martin;Tan, Jozel;Ye, Suming;Borgna, Armando;van Herk, Alexander M.;Selvaratnam, Selvasothi;Wang, Cun;Taniguchi, Shohei;Suzuki, Yousuke;Utsunomiya, Masaru;Ito, Mitsunobu;Monden, Toshiki;Shibata, Hiroki;Tomita, Shohei. And the article was included in Industrial & Engineering Chemistry Research in 2021.Electric Literature of C7H13ClN2 This article mentions the following:

The melt-phase polymerization of bisphenol A (BPA) and di-Ph carbonate (DPC) catalyzed by alk. metal catalysts produces polycarbonates with high branching, which impairs the product’s properties during weather resistance, ductility, and rheol. The use of an imidazolium-type catalyst can result in a reduced amount of branching relative to the benchmark Cs₂CO₃ catalyst. Modification of the imidazolium structure, especially by introducing a substitution at the C2 position, definitely improves the catalyst performance in enhancing the catalyst stability and reducing the branching level in the polycarbonate product. For the best catalyst identified (1,3-Ad₂-2-Ph-Im-BPA), we have shown that at a DPC/BPA ratio of 1.075 and a catalyst loading of 7 ppm, the specifications can be met at the laboratory scale: polymerization time = 125 min, M_n = 11.0 K, OH = 660 ppm, branching = 460 ppm (鈭?5% reduction relative to the Cs₂CO₃ benchmark), and yellowness index = 6.3. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Electric Literature of C7H13ClN2).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Substituent Effect of Imidazolium Ionic Liquid: A Potential Strategy for High Coulombic Efficiency Al Battery was written by Yang, Congrong;Wang, Suli;Zhang, Xiaoming;Zhang, Qiang;Ma, Wenjia;Yu, Shansheng;Sun, Gongquan. And the article was included in Journal of Physical Chemistry C in 2019.Name: 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

The chem. structure-effect relationship between imidazolium ion liquid and the properties of electrolyte or Al battery is first completely revealed. First, it is proved that there indeed exsits an interaction between imidazolium cation and chloroaluminate anions (active ions, Al₂Cl₇^– and AlCl₄^–), blocking their reaction in the anode or pos. electrode. Second, by introducing the substituent effect, which could enhance the steric hindrance and change the detailed electronic distribution of imidazolium cations, the intermol. force between imidazolium cations and chloroaluminate anions is effectively weakened. As a result, the electrodeposition achievement, electrodeposition/electrostripping reversibility of aluminum, and intercalation/deintercalation capacity of AlCl₄^– in the pos. electrode are significantly improved. Therefore, the as-assembled battery with AlCl₃/[MPIM]Cl electrolyte shows an 鈭?00% CE. This work provides a potential approach on how to enhance the performance of Al battery by designing the ionic liquid structure. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Name: 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Unusual temperature-promoted carbon dioxide capture in deep-eutectic solvents: the synergistic interactions was written by Shukla, Shashi Kant;Mikkola, Jyri-Pekka. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Formula: C4H7ClN2 This article mentions the following:

A series of novel ethylenediamine (EDA)-based deep-eutectic solvents (DESs) gave rise to unexpectedly large carbon dioxide (CO₂) capture capacities at higher temperatures owing to the “synergistic interaction” between the donor and acceptor moieties. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Formula: C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Inelastic neutron scattering study on boson peaks of imidazolium-based ionic liquids was written by Kofu, Maiko;Inamura, Yasuhiro;Moriya, Yosuke;Podlesnyak, Andrey;Ehlers, Georg;Yamamuro, Osamu. And the article was included in Journal of Molecular Liquids in 2015.Reference of 79917-89-8 This article mentions the following:

Low energy excitations of 1-alkyl-3-methylimidazolium ionic liquids (ILs) have been investigated by means of neutron spectroscopy. In the spectra of inelastic scattering, a broad excitation peak referred to as a “boson peak” appeared at 1-3 meV in all of the ILs measured. The intensity of the boson peak was enhanced at the Q positions corresponding to the diffraction peaks, reflecting the in-phase vibrational nature of the boson peak. Furthermore the boson peak energy (E_BP) was insensitive to the length of the alkyl-chain but changed depending on the radius of the anion. From the correlation among E_BP, the anion radius, and the glass transition temperature T_g, we conclude that both E_BP and T_g in ILs are predominantly governed by the inter-ionic Coulomb interaction which is less influenced by the alkyl-chain length. We also found that the E_BP is proportional to the inverse square root of the mol. weight as observed in mol. glasses. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Reference of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor was written by Griffith, David A.;Edmonds, David J.;Fortin, Jean-Philippe;Kalgutkar, Amit S.;Kuzmiski, J. Brent;Loria, Paula M.;Saxena, Aditi R.;Bagley, Scott W.;Buckeridge, Clare;Curto, John M.;Derksen, David R.;Dias, Joao M.;Griffor, Matthew C.;Han, Seungil;Jackson, V. Margaret;Landis, Margaret S.;Lettiere, Daniel;Limberakis, Chris;Liu, Yuhang;Mathiowetz, Alan M.;Patel, Jayesh C.;Piotrowski, David W.;Price, David A.;Ruggeri, Roger B.;Tess, David A.. And the article was included in Journal of Medicinal Chemistry in 2022.Recommanded Product: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized diabetes therapy, but their use has been limited because they require injection. Herein, we describe the discovery of the orally bioavailable, small-mol., GLP-1R agonist PF-06882961 (danuglipron). A sensitized high-throughput screen was used to identify 5-fluoropyrimidine-based GLP-1R agonists that were optimized to promote endogenous GLP-1R signaling with nanomolar potency. Incorporation of a carboxylic acid moiety provided considerable GLP-1R potency gains with improved off-target pharmacol. and reduced metabolic clearance, ultimately resulting in the identification of danuglipron. Danuglipron increased insulin levels in primates but not rodents, which was explained by receptor mutagenesis studies and a cryogenic electron microscope structure that revealed a binding pocket requiring a primate-specific tryptophan 33 residue. Oral administration of danuglipron to healthy humans produced dose-proportional increases in systemic exposure (NCT03309241). This opens an opportunity for oral small-mol. therapies that target the well-validated GLP-1R for metabolic health. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Recommanded Product: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Investigation on the Coordination Mode of IL-Supported Diols Used as Phosphine-Free Ligands for Palladium Catalyzed Heck Reaction was written by Cai, Yueqin;Song, Gonghua;Chen, Xiao. And the article was included in Chinese Journal of Chemistry in 2013.COA of Formula: C11H20N2 This article mentions the following:

The coordination mode of IL-supported diols used as phosphine-free ligands for palladium catalyzed Heck reaction was investigated by tuning their compositions The difference in coordination of these IL-supported diols with metal Pd in Heck reaction was related to the changes of the cation rings, leading to the different activities of Pd catalyst in the reaction. The exptl. results indicated that the activities of Pd catalyst were affected mainly by 蟺-electron d. of the cation rings. Compared to pyridinium and piperidinium cations, imidazolium cations showed the best coordination to metal Pd. In the meantime, C-2 hydrogen and the length of alkyl side chains had impacts on the coordination as well. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7COA of Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

2-Pyridyl P1′-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors (A-792611 and A-790742) with Potential for Convenient Dosing and Reduced Side Effects was written by De Goey, David A.;Grampovnik, David J.;Flentge, Charles A.;Flosi, William J.;Chen, Hui-ju;Yeung, Clinton M.;Randolph, John T.;Klein, Larry L.;Dekhtyar, Tatyana;Colletti, Lynn;Marsh, Kennan C.;Stoll, Vincent;Mamo, Mulugeta;Morfitt, David C.;Nguyen, Bach;Schmidt, James M.;Swanson, Sue J.;Mo, Hongmei;Kati, Warren M.;Molla, Akhteruzzaman;Kempf, Dale J.. And the article was included in Journal of Medicinal Chemistry in 2009.COA of Formula: C9H8N2O This article mentions the following:

A series of symmetry-based HIV protease inhibitors I (R¹ = 2-FC₆H₄, 3-MeC₆H₄, 2-H₂NC₆H₄, 6-methyl-2-pyridyl, 4-quinazolyl, 2-methyl-4-thiazolyl, 1-methyl-2-benzimidazolyl, etc.; R² = OH, R³ = H; R² = H, R³ = OH) was designed and synthesized. Modification of the core regiochem. and stereochem. significantly affected the potency, metabolic stability, and oral bioavailability of the inhibitors, as did the variation of a pendant arylmethyl P3 group. Optimization led to the selection of two compounds, (R)-I [R¹ = 6-(2-hydroxypropan-2-yl)-2-pyridyl; R² = OH; R³ = H] (A-790742) and (S)-I (R¹ = Ph; R² = OH; R³ = H) (A-792611), for advancement to preclin. studies. Both compounds displayed low nanomolar potency against wild type HIV in the presence of human serum, low rates of metabolism in human liver microsomes, and high oral bioavailability in animal models. The compounds were examined in a preclin. model for the hyperbilirubinemia observed with some HIV PIs, and both exhibited less bilirubin elevation than comparator compounds X-ray crystallog. analyses of the new cores were used to examine differences in their binding modes. The antiviral activity of the compounds against protease inhibitor resistant strains of HIV was also determined In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4COA of Formula: C9H8N2O).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C9H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Identification of parallel medicinal chemistry protocols to expand branched amine design space was written by Conn, Edward L.;Perry, Matthew A.;Shi, Kecheng;Wang, Guotao;Hoy, Susan;Sach, Neal W.;Qi, Wenying;Qu, Liqiang;Gao, Yu;Xu, Yan;Schmitt, Daniel C.. And the article was included in Organic & Biomolecular Chemistry in 2022.Product Details of 25676-75-9 This article mentions the following:

Methods for the synthesis of 伪-branched heteroaryl amines RCH(R¹)NH(R²) (R = tert-Bu, Ph, 1-methyl-1H-imidazol-4-yl, pyridin-2-yl, etc. R¹ = 1-methyl-1H-pyrazol-5-yl, pyridin-3-yl, 1-propyl-1H-pyrazol-4-yl, 4-bromo-2-hydroxyphenyl, etc.; R² = pyridin-2-yl, Ph, 4-phenylpyridin-2-yl, pyrazin-2-yl, etc.) via aldimine addition have been evaluated for compatibility with parallel synthesis. In situ activation of aliphatic carboxylic acids RC(O)OH as redox-active esters enables Zn-mediated decarboxylative radical imine R¹CH=NR² addition to access aliphatic-branched heterobenzylic amines. In situ activation of (hetero)aryl bromides RBr via Li-halogen exchange enables heteroaryl-lithium addition to imines to access (hetero)benzhydryl amines. Condensation of heteroaryl amines RNH₂ with heteroaryl aldehydes R¹CHO provides aldimines which may be intercepted with aryl Grignard reagents to provide modular access to (hetero)benzhydryl amines. These protocols minimize synthetic step count and maximize accessible design space, enhancing access to 伪-branched heteroaryl amines for medicinal chem. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Product Details of 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

BODIPY-BODIPY dyad: assessing the potential as a viscometer for molecular and ionic liquids was written by Kimball, Joseph D.;Raut, Sangram;Jameson, Laramie P.;Smith, Nicholas W.;Gryczynski, Zygmunt;Dzyuba, Sergei V.. And the article was included in RSC Advances in 2015.Product Details of 404001-48-5 This article mentions the following:

A sym. BODIPY-BODIPY dyad with a diyne linker was prepared in two steps; the lifetime decay of this rotor appeared to correlate with the viscosity of the media, thus making this dyad a suitable small mol. viscometer for mol. solvents. The potential of using the rotor to probe the viscosity of ionic liquids was also investigated. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Product Details of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Product Details of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dehydration of glucose and fructose into 5-hydroxymethylfurfural catalyzed by Lewis acid in ionic liquids was written by Tian, Yukui;Deng, Jin;Pan, Tao;Guo, Qingxiang;Fu, Yao. And the article was included in Cuihua Xuebao in 2011.Application of 79917-89-8 This article mentions the following:

A variety of Lewis acids have been examined for the transformation of glucose and fructose into 5-hydroxymethylfurfural (5-HMF) in ionic liquids (ILs). SnCl_n, and CrCl_n are effective catalysts for the isomerization, and Lewis acids with strong acidity can facilitate the dehydration of fructose. The influence of ILs structure, including the length of alkyl side chain and halide anions, on the conversion was also studied. A distinct odd-even carbon-atom-number effect is observed in the conversion of glucose to 5-HMF and the imidazolium bromides with short alkyl side-chains can provide a higher yield of 5-HMF from fructose. In the presence of 1-ethyl-3-methylimidazolium bromide ([C₂MIM]Br) and SnCl₂, the yields of 5-HMF are 65% and 73% from glucose and fructose, resp. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Application of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem