Imidazoles-derivatives

Alkylation of 4(5)-substituted imidazoles was written by Benjes, Paul;Grimmett, Ross. And the article was included in Heterocycles in 1994.Category: imidazoles-derivatives This article mentions the following:

4(5)-Substituted imidazoles were alkylated under “neutral” and alk. conditions to give mixtures of isomers in ratios which depended on the reaction conditions, and the nature of the substituent and alkylating agents. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Category: imidazoles-derivatives).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Substituent effects on proton affinities: through bonds or through space mechanism? was written by Catalan, Javier;Perez, Pilar;Elguero, Jose. And the article was included in Heterocycles in 1983.SDS of cas: 3034-41-1 This article mentions the following:

INDO calculations of the protonation energies and lone pair orbital energies of twenty pyrazoles and twenty imidazoles have been carried out in order to ascertain the mechanism of the substituent effect; Me, cyano, fluoro, amino, and nitro substituents have been examined The nitro group shows a special behavior. The importance of optimizing the geometry and the reasons for the anomaly shown by the nitro derivatives are discussed. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1SDS of cas: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Model reactions for enzymic catalysis. I. Nonenzymic transamination between α-amino acids and 2-formylimidazoles was written by Gebert, Ulrich;Von Kerekjarto, Bela. And the article was included in Justus Liebigs Annalen der Chemie in 1968.SDS of cas: 22600-77-7 This article mentions the following:

2-Formylimidazole and 1-benzyl-2-formylimidazole transaminated, in the presence of Ni2+, Co2+, and Cu2+, α-amino acids into α-keto acids. The pH optimum was 8.5 for the Ni2+- and Co2+-catalyzed reactions, while the Cu2+-catalyzed reactions showed no pH dependence. In the experiment, the researchers used many compounds, for example, (1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7SDS of cas: 22600-77-7).

(1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.SDS of cas: 22600-77-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Photorelease of Pyridines Using a Metal-Free Photoremovable Protecting Group was written by Tang, Xiao-Jun;Wu, Yayun;Zhao, Rong;Kou, Xiaolong;Dong, Zaizai;Zhou, Wei;Zhang, Zhen;Tan, Weihong;Fang, Xiaohong. And the article was included in Angewandte Chemie, International Edition in 2020.Product Details of 25676-75-9 This article mentions the following:

The photorelease of bioactive mols. has emerged as a valuable tool in biochem. Nevertheless, many important bioactive mols., such as pyridine derivatives, cannot benefit from currently available organic photoremovable protecting groups (PPGs). The inefficient photorelease of pyridines is attributed to intramol. photoinduced electron transfer (PET) from PPGs to pyridinium ions. To alleviate PET, the authors rationally designed a strategy to drive the excited state of PPG from S₁ to T₁ with a heavy atom, and synthesized a new PPG by substitution of the H atom at the 3-position of 7-dietheylamino-coumarin-4-Me (DEACM) with Br or I. This resulted in an improved photolytic efficiency of the pyridinium ion by hundreds-fold in aqueous solution The PPG can be applied to various pyridine derivatives The successful photorelease of a microtubule inhibitor, indibulin, in living cells was demonstrated for the potential application of this strategy in biochem. research. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Product Details of 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Alkylation of 4(5)-substituted imidazoles was written by Benjes, Paul;Grimmett, Ross. And the article was included in Heterocycles in 1994.Product Details of 3034-41-1 This article mentions the following:

4(5)-Substituted imidazoles were alkylated under “neutral” and alk. conditions to give mixtures of isomers in ratios which depended on the reaction conditions, and the nature of the substituent and alkylating agents. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Product Details of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chlorodifluoromethane as a C1 Synthon in the Assembly of N-Containing Compounds was written by Ma, Xingxing;Su, Jianke;Zhang, Xingang;Song, Qiuling. And the article was included in iScience in 2019.Electric Literature of C8H8N2 This article mentions the following:

A quadruple cleavage of chlorodifluoromethane to yield a C1 source, which was successfully employed in the construction of various N-containing compounds e.g., C₆H₅N(CH₃)CH=NC₆H₅ especially with pharmaceutical mols. under mild conditions was reported. This strategy provides a useful method for late-stage modification of pharmaceutical compounds Four bonds in ClCF₂H were orderly cleaved under basic conditions in the absence of transition metals. Preliminary mechanistic studies revealed that (E)-N-phenylformimidoyl fluoride intermediate is involved in this process by in situ ¹H NMR studies and control experiments In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Relationship between the structural specialties and morphologies based on a group of luminescent imidazole derivatives with sensing properties was written by Wang, Qianming;Zhou, Zhan;Zheng, Yuhui;Zheng, Junke;Zhang, Cheng Cheng. And the article was included in Science of Advanced Materials in 2014.Application of 5496-35-5 This article mentions the following:

A group of low mol. weight imidazole derivatives have been prepared They have two sensitive features including ultra-violet absorption and fluorescence spectra to detect fluoride anions. Particularly, compound 5 had a special side chain moiety effect in the assembly of microstructures. Regular and densely packed 1D morphologies can be found and easily formed in the presence of water and other conventional organic solvents. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Application of 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application of 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mechanisms of hydrogen bond formation between ionic liquids and cellulose and the influence of water content was written by Rabideau, Brooks D.;Ismail, Ahmed E.. And the article was included in Physical Chemistry Chemical Physics in 2015.Electric Literature of C7H13ClN2 This article mentions the following:

We study the dynamics of the formation of multiple hydrogen bonds between ionic liquid anions and cellulose using mol. dynamics simulations. We examine fifteen different ionic liquids composed of 1-alkyl-3-methylimidazolium cations ([C_nmim], n = 1, 2, 3, 4, 5) paired with either chloride, acetate or dimethylphosphate. We map the transitions of anions hydrogen bonded to cellulose into different bonding states. We find that increased tail length in the ionic liquids has only a very minor effect on these transitions, tending to slow the dynamics of the transitions and increasing the hydrogen bond lifetimes. Each anion can form up to four hydrogen bonds with cellulose. We find that this hydrogen bond “redundancy” leads to multiply bonded anions having lifetimes three to four times that of singly bound anions. Such redundant hydrogen bonds account for roughly half of all anion-cellulose hydrogen bonds. Addnl. simulations for [C₂mim]Cl, [C₂mim]Ac and [C₂mim]DMP were performed at different water concentrations between 70 mol% and 90 mol%. It was found that water crowds the hydrogen bond-accepting sites of the anions, preventing interactions with cellulose. The more water that is present in the system, the more crowded these sites become. Thus, if a hydrogen bond between an anion and cellulose breaks, the likelihood that it will be replaced by a nearby water mol. increases as well. We show that the formation of these “redundant” hydrogen bonding states is greatly affected by the presence of water, leading to steep drops in hydrogen bonding between the anions and cellulose. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Electric Literature of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Electric Literature of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Iridium-catalyzed Synthesis of Saturated N-Heterocycles from Aldehydes and SnAP Reagents with Continuous Flow Photochemistry was written by Jindakun, Chalupat;Hsieh, Sheng-Ying;Bode, Jeffrey W.. And the article was included in Organic Letters in 2018.Synthetic Route of C9H8N2O This article mentions the following:

Com. available tin amine protocol (SnAP) reagents provide a simple approach to the synthesis of a wide variety of saturated N-heterocycles from aldehydes. In this report, we disclose that the copper(II) promoter and hexafluoroisopropanol can be replaced by photocatalytic conditions using Ir[dF(CF₃)ppy]₂(dtbbpy)PF₆ in CH₃CN. Continuous flow photochem. conditions provide a clean, scalable approach to valuable products including morpholines, piperazines, thiomorpholines, diazepanes, and oxazepanes from aldehyde starting materials. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Synthetic Route of C9H8N2O).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C9H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Regulation of the Metal Center and Coordinating Anion of Mononuclear Ln(III) Complexes to Promote an Efficient Luminescence Response to Various Organic Solvents was written by Wang, Hui-Feng;Ma, Xiong-Feng;Zhu, Zhong-Hong;Zou, Hua-Hong;Liang, Fu-Pei. And the article was included in Langmuir in 2020.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

A series of mononuclear lanthanide complexes [Ln(L1)(NO₃)₃], (Ln = Dy(III), 1; Tb(III), 3; and Eu(III), 4; L1 = (N¹E,N²E)-N¹,N²-bis((1-methyl-1H-benzo[d]imidazol-2-yl)methylene)cyclohexane-1,2-diamine) is obtained by reacting N-methylbenzimidazole-2-carbaldehyde (L2) and 1,2-cyclohexanediamine (L3) with Ln(NO₃)₃·6H₂O under solvothermal conditions. L1 ligand is produced via an in situ Schiff base reaction of two mols. of L2 and one mol. of L3. The metal center Ln(III) is in a N₄O₆ environment formed by L1 and NO₃^–. NaSCN is added on the basis of 1 synthesis. One SCN^– replaces one of the three coordinated NO₃^– anions in the 1 structure, and the complex [Dy(L1)(NO₃)₂(SCN)]·CH₃CN (2) is synthesized. The complex 1 shows excellent luminescence response to petroleum ether (PET), an organic solvent. To the best of our knowledge, this study is the first to use a complex for sensing responses to PET. When the metal center is changed, the obtained mononuclear complexes 3 and 4 show an excellent luminescence response to THF. Lastly, 2 obtained by changing the coordinating anion shows an excellent luminescence response to dichloromethane. Herein, for the first time, we regulate the metal center and coordinating anion of lanthanide complexes to adjust the recognition and response of these complexes to different organic solvents. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem