Imidazoles-derivatives

The Fairy Chemical Imidazole-4-carboxamide Inhibits the Expression of Axl, PD-L1, and PD-L2 and Improves Response to Cisplatin in Melanoma was written by Inoue, Chisa;Yasuma, Taro;D’Alessandro-Gabazza, Corina N.;Toda, Masaaki;Fridman D’Alessandro, Valeria;Inoue, Ryo;Fujimoto, Hajime;Kobori, Hajime;Tharavecharak, Suphachai;Takeshita, Atsuro;Nishihama, Kota;Okano, Yuko;Wu, Jing;Kobayashi, Tetsu;Yano, Yutaka;Kawagishi, Hirokazu;Gabazza, Esteban C.. And the article was included in Cells in 2022.Application In Synthesis of 1H-Imidazole-4-carboxamide This article mentions the following:

The leading cause of death worldwide is cancer. Many reports have proved the beneficial effect of mushrooms in cancer. However, the precise mechanism is not completely clear. In the present study, we focused on the medicinal properties of biomols. released by fairy ring-forming mushrooms. Fairy chems. generally stimulate or inhibit the growth of surrounding vegetation. In the present study, we evaluated whether fairy chems. (2-azahypoxanthine, 2-aza-8-oxohypoxanthine, and imidazole-4-carboxamide) exert anticancer activity by decreasing the expression of Axl and immune checkpoint mols. in melanoma cells. We used B16F10 melanoma cell lines and a melanoma xenograft model in the experiments Treatment of melanoma xenograft with cisplatin combined with imidazole-4-carboxamide significantly decreased the tumor volume compared to untreated mice or mice treated cisplatin alone. In addition, mice treated with cisplatin and imidazole-4-carboxamide showed increased peritumoral infiltration of T cells compared to mice treated with cisplatin alone. In vitro studies showed that all fairy chems., including imidazole-4-carboxamide, inhibit the expression of immune checkpoint mols. and Axl compared to controls. Imidazole-4-carboxamide also significantly blocks the cisplatin-induced upregulation of PD-L1. These observations point to the fairy chem. imidazole-4-carboxamide as a promising coadjuvant therapy with cisplatin in patients with cancer. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Application In Synthesis of 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effects of two kinds of ionic liquids on particle characterization of cassava was written by Luo, Zhigang;Li, Fuli. And the article was included in Shipin Yu Fajiao Gongye in 2010.Formula: C7H13ClN2 This article mentions the following:

The properties of cassava starch in two kinds of ionic liquid were evaluated by polarized microscope and SEM. The results showed that cassava starch dissolved in ionic liquids to form a clear and transparent homogeneous system. During the dissolution, polarized cross of starch gradually disappeared, the shape of starch particles were totally changed and the formation of irregular particles occurred. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Formula: C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Formula: C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

NHC-Catalyzed 1,2-Selective Hydroboration of Quinolines was written by Jeong, Jinseong;Heo, Joon;Kim, Dongwook;Chang, Sukbok. And the article was included in ACS Catalysis in 2020.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:

Selective dearomative transformation of readily available N-heteroarenes is a powerful tool accessing useful synthetic building units. Described herein is the NHC-catalyzed 1,2-selective hydroboration of quinolines with high functional group tolerance. Dihydroquinoline products, e.g. I, could be isolated as their amide derivatives upon in situ N-protection, thus offering high synthetic utility of the current procedure. Combined exptl. and computational studies revealed that the observed regioselectivity can be rationalized by proposing a six-membered transition state that collectively incorporates NHC catalyst, hydroborane reductant and protonated quinoline substrate. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The inflammasome signaling proteins ASC and IL-18 as biomarkers of psoriasis was written by Forouzandeh, Mahtab;Besen, Jaren;Keane, Robert W.;de Rivero Vaccari, Juan Pablo. And the article was included in Frontiers in Pharmacology in 2020.Formula: C33H34N6O6 This article mentions the following:

Inflammasome activation in the innate immune response plays a role in the pathogenesis of psoriasis largely due to the increased levels of pro-inflammatory cytokines. However, the precise role of inflammasomes in psoriasis (Ps) and psoriatic arthritis (PsA) is largely undefined. To establish the reliability of inflammasome signaling proteins as diagnostics and predictive biomarkers of clin. severity in this disease population, serum from healthy donors and patients with Ps/PsA were analyzed for the protein expression of caspase-1, apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC), interleukin (IL)-1β and IL-18 levels to determine cut-off points, pos. and neg. predictive values, and receiver operator characteristic (ROC) curves. Our data revealed that ASC and IL-18 proteins were significantly higher in the Ps group when compared to healthy controls. The area under the curve (AUC) for ASC was 0.9224 with a cut-off point of 321.8 pg/mL, while IL-18 had an AUC of 0.7818 and a cut-off point of 232.1 pg/mL. In addition, levels of IL-18 had a statistically significant linear correlation with that of ASC with an adjusted R squared of 0.2566, indicating that approx. 25% of IL-18 levels could be explained by ASC levels in serum. Our findings indicate that ASC and IL-18 play a significant role in the inflammatory response associated with the pathol. of Ps. These inflammasome proteins appear to be key biomarkers in determining diagnoses in this patient population. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Formula: C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Formula: C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Paclitaxel suppresses the viability of breast tumor MCF7 cells through the regulation of EF1α and FOXO3a by AMPK signaling was written by Kim, Ji Hae;Lee, Jung Ok;Kim, Nami;Lee, Hye Jeong;Lee, Yong Woo;Kim, Hyung Ip;Kim, Su Jin;Park, Sun Hwa;Kim, Hyeon Soo. And the article was included in International Journal of Oncology in 2015.Category: imidazoles-derivatives This article mentions the following:

Paclitaxel (Taxol), a potent drug of natural origin isolated from the bark of the Pacific yew, is widely used for treating ovarian, lung and breast cancers. Currently, there is little information regarding the specific mechanism underlying the anticancer activity of paclitaxel. In the present study, we found that 5-amino-1-β-D-ribofuranosyl-imidazole-4-carboxamide (AICAR), a well-known activator of adenosine monophosphate (AMP)-activated protein kinase (AMPK), downregulated the protein and mRNA levels of elongation factor 1 α (EF1α) in breast cancer MCF7 cells. Paclitaxel increased the phosphorylation of AMPK and also downregulated the expression of EF1α in MCF7 cells. In addition, paclitaxel increased the expression, as well as the phosphorylation of forkhead box O3a (FOXO3a). Phosphorylation of FOXO3a was suppressed in the presence of compound C, a specific AMPK inhibitor, suggesting the involvement of AMPK in paclitaxel-induced FOXO3a phosphorylation. The induction and phosphorylation of FOXO3a by paclitaxel were not observed in EF1a and AMPK knockdown cells. Co-treatment with AICAR resulted in increased susceptibility of cancer cells to paclitaxel-induced suppression of their viability and further enhanced paclitaxel-induced FOXO3a phosphorylation. These results suggest that the antitumor effects of paclitaxel in breast cancer are mediated by activation of the AMPK/EF1a/FOXO3a signaling pathway. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Category: imidazoles-derivatives).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Interaction studies between newly synthesized photosensitive polymer and ionic liquids was written by Kim, In Tae;Kwon, Gi-Chung;Choi, Eun Ha;Lee, Seung-Hyun;Kim, Young Sun;Kim, Jong Hyun;Cha, Ju Hyun;Kim, Sung Ho;Attri, Pankaj. And the article was included in International Journal of Polymer Science in 2015.Related Products of 35487-17-3 This article mentions the following:

In this information age, different kinds of photosensitive materials have been used in the manufacture of information storage devices. But these photosensitive materials have the bane of low diffraction efficiency. In order to solve this problem, we have synthesized a novel photosensitive polymer from epoxy-based azopolymers (with three types of azochromophores). Furthermore, we have studied the interaction between this newly synthesized azopolymer and ionic liquids (ILs). For this purpose, we have used the ammonium and imidazolium families of ILs, such as diethylammonium dihydrogen phosphate (DEAP), tributylammonium Me sulfate (TBMS), triethylammonium 4-aminotoluene-3-sulfonic acid (TASA), and 1-methylimidazolium chloride ([Mim]Cl). To investigate the mol. interaction between azopolymer and ILs, we have used the following spectroscopic methods of anal.: UV-visible spectroscopy, photoluminescence (PL) spectroscopy, Fourier transformed IR spectroscopy (FT-IR), and confocal Raman spectroscopy. In this study, we have developed new photosensitive materials by combining polymer with ILs. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Related Products of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Related Products of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of designed bleomycin models with different DNA recognition sites was written by Huang, Liren;Quada, James C. Jr.;Lown, J. William. And the article was included in Heterocyclic Communications in 1995.COA of Formula: C6H7N3O4 This article mentions the following:

The design and synthesis are described of compounds I (R = Q, X = N, CH, n = 1, 2, R = NHCOPr, H, Q¹; R = Q¹) that are functional models for the antitumor antibiotic bleomycin. These models contain peptidic heterocyclic moieties with various DNA sequence selectivities that have been incorporated as DNA binding sites. The multi-functional heterocyclic unit AMPHIS serves as the metal complexing subunit and chiral 1,2-trans-disubstituted cyclopropane are employed as linkers. In the experiment, the researchers used many compounds, for example, Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6COA of Formula: C6H7N3O4).

Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.COA of Formula: C6H7N3O4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Impedance sensing platform for 4,4′-dibromobiphenyl based on a molecularly imprinted polymerized ionic liquid film/gold nanoparticle-modified glassy carbon electrode was written by Wei, Qiuxi;Wu, Kangbing;Wang, Zhengguo;Ye, Xiaoxue;Li, Chunya;Wang, Yanying;Gan, Tian. And the article was included in Journal of Nanoparticle Research in 2018.Computed Properties of C9H15F6N2P This article mentions the following:

1-Vinyl-3-butyl-imidazolium hexafluorophosphate (VBimPF₆) was used as a functional monomer to fabricate an imprinted film onto a glassy carbon electrode modified with gold nanoparticle under the conditions applying 4,4′-dibromobiphenyl (DiBB) as a template, ethylene glycol dimethacrylate (EGDMA) as a cross-linker, and ammonium persulfate and N,N,N’,N’-tetramethylethylenediamine as initiators at room temperature After the fabrication process, the embedded DiBB template was removed to obtain a new electrochem. sensor with high specific recognition sites toward DiBB. The morphol. of the electrode surface was characterized with scanning electron microscope and at. force microscope. Electrochem. impedance spectroscopy was used to test the sensing performances of this newly developed electrode. The imprinted film exhibited high selectivity and sensitivity in the determination of DiBB. Under optimized conditions, the charge transfer resistance attributed to the interaction of DiBB with the electrode was found linearly related to the logarithm of DiBB concentration in the range from 0.005 to 10.0μM. The estimated detection limit is 0.001μM (S/N = 3). Therefore, this electrode shows great application potential for the determination of trace DiBB contents in soil samples. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Computed Properties of C9H15F6N2P).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Computed Properties of C9H15F6N2P

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of methylal from methanol and formaldehyde catalyzed by Bronsted acid ionic liquids with different alkyl groups was written by Sun, Jiahan;Li, Hansheng;Song, Haoran;Wu, Qin;Zhao, Yun;Jiao, Qingze. And the article was included in RSC Advances in 2015.Product Details of 21252-69-7 This article mentions the following:

The catalytic reaction of methanol with formaldehyde for the preparation of methylal was investigated in various Bronsted acid ionic liquids with different carbon chain length of alkyl groups. The structures, acidities and properties of ionic liquids were exptl. characterized and theor. analyzed. The Bronsted acidity-viscosity-activity correlation for the ionic liquids was studied. Among all these ionic liquids, [C₆ImBS][HSO₄] exhibited the best catalytic performance, which was ascribed to its strong Bronsted acidity and low viscosity. The catalytic activity of the ionic liquid was near that of concentrated sulfuric acid. The influences of ionic liquid dosage, reaction temperature and molar ratio of methanol to formaldehyde were explored using [C₆ImBS]HSO₄ as the catalyst. Under the optimal conditions of n(methanol) : n(formaldehyde) : n(ILs) = 2.5 : 1 : 0.0258, 60 °C, and 4 h, the conversion of formaldehyde can reach 63.37%. The ionic liquid [C₆ImBS]HSO₄ could be reused. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Product Details of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Product Details of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Organocatalytic Enantioselective Conjugate Alkynylation of β-Aminoenones: Access to Chiral β-Alkynyl-β-Amino Carbonyl Derivatives was written by Wang, Jian-Fei;Meng, Xin;Zhang, Chao-Huan;Yu, Chuan-Ming;Mao, Bin. And the article was included in Organic Letters in 2020.Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:

Readily available potassium alkynyltrifluoroborates were used for organocatalytic asym. conjugate alkynylation of β-enaminones. The interception of a modified binaphthol catalyst and in situ generated organodifluoroboranes proved important to access functionalized β-alkynyl-β-amino carbonyls and derivatives with improved chemo-reactivity and enantio-induction. Mechanistic studies revealed the impact of mol. sieves on efficiency and stereocontrol. The products undergo addnl. functionalization to yield a diverse set of valuable β-alkynyl-β-amino carbonyl scaffolds. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem