Imidazoles-derivatives

Liquid Nickel Salts: Synthesis, Crystal Structure Determination and Electrochemical Synthesis of Nickel Nanoparticles was written by Sniekers, Jeroen;Verguts, Ken;Brooks, Neil R.;Schaltin, Stijn;Phan, Thanh Hai;Trung Huynh, Thi Mien;Van Meervelt, Luc;De Feyter, Steven;Seo, Jin Won;Fransaer, Jan;Binnemans, Koen. And the article was included in Chemistry – A European Journal in 2016.Synthetic Route of C11H20N2 This article mentions the following:

New Ni-containing ionic liquids were synthesized, characterized and their electrochem. was studied. A mechanism for the electrochem. synthesis of nanoparticles from these compounds is proposed. In these so-called liquid metal salts, the Ni(II) cation is octahedrally coordinated by six N-alkylimidazole ligands. The different counteranions that were used are bis(trifluoromethanesulfonyl)imide (Tf₂N^–), trifluoromethanesulfonate (OTf^–) and methanesulfonate (OMs^–). Several different N-alkylimidazoles were considered, with the alkyl side-chain ranging in length from Me to dodecyl. The newly synthesized liquid metal salts were characterized by CHN anal., FTIR, DSC, TGA and viscosity measurements. An odd-even effect was observed for the melting temperatures and viscosities of the ionic liquids, with the complexes with an even number of C atoms in the alkyl chain of the imidazole having a higher melting temperature and a lower viscosity than the complexes with an odd number of carbons. The crystal structures of several of the Ni(II) complexes that are not liquid at room temperature were determined The electrochem. of the compounds with the lowest viscosities was studied. The Ni(II) cation could be reduced, but surprisingly no Ni deposits were obtained on the electrode. Instead, Ni nanoparticles were formed at 100% selectivity, as confirmed by TEM. The magnetic properties of these nanoparticles were studied by SQUID measurements. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Synthetic Route of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Synthetic Route of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles was written by Kang, Tengfei;Hou, Liuzhen;Ruan, Sai;Cao, Weidi;Liu, Xiaohua;Feng, Xiaoming. And the article was included in Nature Communications in 2020.Application of 85692-37-1 This article mentions the following:

A regioselective catalytic asym. tandem isomerization/α-Michael addition of β,γ-unsaturated 2-acyl imidazoles in the presence of chiral N,N’-dioxide metal complexes, delivering a broad range of optically pure 1,5-dicarbonyl compounds with two vicinal tertiary carbon stereocenters such as I [R = Et, Ph, 3-thienyl, etc.] in up to > 99% ee under mild conditions. Meanwhile, stereodivergent synthesis was disclosed to yield all four stereoisomers of products. Control experiments suggested an isomerization process involved in reaction and gave an insight into the role of NEt₃. In addition, Mannich reaction and sulfur-Michael addition of β,γ-unsaturated 2-acyl imidazoles proceeded smoothly as well under same catalytic systemto give functionalized carbonyl compounds II [R¹ = n-Pr, Ph, 4-ClC₆H₄, etc.; R² = n-Bu, CH₂CO₂Me, 2-naphthyl, etc.]. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Application of 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application of 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Europium-based ionic liquids as luminescent soft materials was written by Tang, S.;Babai, A.;Mudring, A.-V.. And the article was included in Angewandte Chemie, International Edition in 2008.SDS of cas: 79917-89-8 This article mentions the following:

Low melting, highly luminescent: [C₃mim][Eu(Tf₂N)₄] (1), [C₄mim][Eu(Tf₂N)₄], and [C₄mpyr]₂[Eu(Tf₂N)₅] (Tf₂N = bis(trifluoromethanesulfonyl)amide; C₃mim = 1-propyl-3-methylimidazolium; C₄mim = 1-butyl-3-methylimidazolium; C₄mpyr = 1-butyl-1-methylpyrrolidium) are the 1st lanthanide ionic liquids that do not need stabilization of the liquid state by neutral coligands. They show excellent photophys. properties, such as long lifetimes of luminescence at large Eu^III concentration, small line width, and high color purity (see emission spectrum of 1 and photograph of a sample under UV light). In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8SDS of cas: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).SDS of cas: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Thermoplastic deformation of poplar wood plasticized by ionic liquids measured by a nonisothermal compression technique was written by Ou, Rongxian;Xie, Yanjun;Wang, Qingwen;Sui, Shujuan;Wolcott, Michael P.. And the article was included in Holzforschung in 2014.Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride This article mentions the following:

The in situ thermoplasticization of poplar wood with ionic liquids (ILs) had been investigated. The thermoplastic deformation of wood samples treated with four types of ILs at various concentrations were determined through nonisothermal compression tests by means of a rotational rheometer. Results show that increasing the concentration of ILs reduced softening temperature and increased deformation compared to the untreated control. SEM revealed that plastic deformation of wood cells from the applied compression stress varied, depending on cell type, and occurred without cell wall fracture. X-ray diffraction anal. of compressed wood showed that wood treated with ILs exhibited a greater crystallinity index than the untreated control. The recovered strain in compressed samples decreased with increasing temperature and concentration of ILs to 18% weight percent gain (WPG) and then decreased slightly to 36% WPG. In treated samples, the combined wood/IL blends demonstrated less thermal stability than wood and ILs alone. Results also showed that plastic deformation of IL-treated wood resulted in viscous buckling of unfractured cell walls. This deformation mode likely resulted from the disintegration of intermol. and intramol. hydrogen bonding between cell wall polymers through the combined effect of ILs, pressure, and high temperature In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Concise and regioselective synthesis of 5H-imidazo[1,2-e][1,3,5]triazepines was written by Demydchuk, Bohdan A.;Mykhalchenko, Oleksandr A.;Rusanov, Eduard B.;Moskvina, Viktoriia S.;Brovarets, Volodymyr S.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2022.Application of 22600-77-7 This article mentions the following:

In this communication, a regioselective synthesis of novel 5H-imidazo[1,2-e][1,3,5]triazepines I (R = tert-Bu, Ph, 2-furyl, etc.) via the interaction of tetrachloro-2-aza-1,3-butadienes RC(Cl)=NC(Cl)=CCl₂ with (1H-imidazol-2-yl)methanamine was reported. The advantages of the presented method are mild reaction conditions, a simple work-up procedure, available reagents, and high yields. A possible mechanism is proposed for the synthesis of key products. The structure of one of the obtained products was proven with a single crystal X-ray diffraction-based structure. In the experiment, the researchers used many compounds, for example, (1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7Application of 22600-77-7).

(1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application of 22600-77-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A new method for separation and determination of Cr(III) and Cr(VI) in water samples by high-performance liquid chromatography based on anion exchange stationary phase of ionic liquid modified silica was written by Sadeghi, Susan;Moghaddam, Ali Zeraatkar. And the article was included in Environmental Monitoring and Assessment in 2015.HPLC of Formula: 35487-17-3 This article mentions the following:

In this work, N-methylimidazolium-chloride ionic liquid functionalized silica was prepared and used as an anion-exchange stationary phase for separation of chromium species by high-performance liquid chromatog. (HPLC) with UV detection at 200 nm. The Cr(VI) as HCr₂O₇^– and chelated Cr(III) with potassium hydrogen phthalate (PHP) as Cr(PHP)₂^– was retained on the prepared column and separated using a mobile phase composed of 5% methanol in 25 mM phosphate buffer at pH 6.5. Several variables affecting the chelation/separation steps were modeled by response surface methodol. (RSM) using Box-Behnken (BBD) design. The significance of the independent variables and their interactions were tested by the anal. of variances (ANOVA) with 95% confidence limit. Under the optimized conditions, the Cr(III) and Cr(VI) anionic species were well separated with a single peak for each Cr species at retention times of 2.3 and 4.3 min, resp. The relationship between the peak area and concentration was linear in the range of 0.025-30 for Cr(III) and 0.5-20 mg L^-1 for Cr(VI) with detection limits of 0.010 and 0.210 mg L^-1 for Cr(III) and Cr(VI), resp. The proposed method was validated by simultaneous separation and determination of the Cr species in tap and underground water samples without impose to any pretreatment. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3HPLC of Formula: 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.HPLC of Formula: 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

DNA-cellulose: an economical, fully recyclable and highly effective chiral biomaterial for asymmetric catalysis was written by Benedetti, Erica;Duchemin, Nicolas;Bethge, Lucas;Vonhoff, Stefan;Klussmann, Sven;Vasseur, Jean-Jacques;Cossy, Janine;Smietana, Michael;Arseniyadis, Stellios. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Category: imidazoles-derivatives This article mentions the following:

The challenge in DNA-based asym. catalysis is to perform a reaction in the vicinity of the helix by incorporating a small-mol. catalyst anchored to the DNA in a covalent, dative, or non-covalent yet stable fashion in order to ensure high levels of enantio-discrimination. Here, we report the first generation of a DNA-based catalyst bound to a cellulose matrix. The chiral biomaterial is com. available, trivial to use, fully recyclable and produces high levels of enantioselectivity in various Cu(II)-catalyzed asym. reactions including Friedel-Crafts alkylations and Michael additions A single-pass, continuous-flow process is also reported affording fast conversions and high enantioselectivities at low catalyst loadings thus offering a new benchmark in the field of DNA-based asym. catalysis. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Category: imidazoles-derivatives).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enantioselective Mukaiyama-Michael Reaction Catalyzed by a Chiral Rhodium Complex Based on Pinene-Modified Pyridine Ligands was written by Gong, Jun;Wan, Qian;Kang, Qiang. And the article was included in Chemistry – An Asian Journal in 2018.Name: 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:

The rhodium complex Λ-Rh1 containing chiral pinene-modified pyridine ligands was prepared through a two-step synthetic procedure; it exhibited excellent reactivity and enantiocontrol toward the enantioselective Mukaiyama-Michael reaction of α,β-unsaturated 2-acyl imidazoles with silyl enol ethers, affording enantioenriched 1,5-dicarbonyl compounds such as I [R = n-Bu, SEt, 4-FC₆H₄, etc.; R¹ = i-Pr, Me; R² = cyclopropyl, 2-thienyl, 4O₂NC₆H₄, etc.] in good yields (up to 99 %) with excellent enantioselectivities (up to 99 % ee). In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Name: 1-(1-Methyl-1H-imidazol-2-yl)ethanone).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 1-(1-Methyl-1H-imidazol-2-yl)ethanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Impact of substituents attached to N-heterocyclic carbenes on the catalytic activity of copper complexes in the reduction of carbonyl compounds with triethoxysilane was written by Peng, Jiajian;Chen, Lingzhen;Xu, Zheng;Hu, Yingqian;Li, Jiayun;Bai, Ying;Qiu, Huayu;Lai, Guoqiao. And the article was included in Chinese Journal of Chemistry in 2009.Synthetic Route of C9H15F6N2P This article mentions the following:

By using functionalized imidazolium salts such as 1-allyl-3-alkylimidazolium or 1-alkyl-3-vinylimidazolium salts as carbene ligand precursors, the reduction of aryl ketones with triethoxysilane catalyzed by copper salt/imidazolium salt/KO-tert-Bu systems was described. The functional substituents attached to the N-heterocyclic carbene serve to enhance the catalytic activity. Different copper salts also have an effect on the catalytic activity, with copper(II) acetate monohydrate being superior to copper(I) chloride. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Synthetic Route of C9H15F6N2P).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Synthetic Route of C9H15F6N2P

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Amphiphilic Pd^II-NHC Complexes on 1,3-Alternate p-tert-Butylthiacalix[4]arene Platform: Synthesis and Catalytic Activities in Coupling and Hydrogenation Reactions was written by Burilov, Vladimir A.;Gafiatullin, Bulat Kh.;Mironova, Diana A.;Sultanova, Elza D.;Evtugyn, Vladimir G.;Osin, Yuri N.;Islamov, Daut R.;Usachev, Konstantin S.;Solovieva, Svetlana E.;Antipin, Igor S.. And the article was included in European Journal of Organic Chemistry in 2020.Electric Literature of C8H8N2 This article mentions the following:

Herein the authors report the first example of amphiphilic Pd^II-NHC complexes on the thiacalix[4]arene backbone in 1,3-alternate configuration. Relative catalytic activity of synthesized Pd^II-NHC complexes in Suzuki-Miyaura coupling of haloarenes with phenylboronic acid was studied. A combination of micellar and metallocomplex catalysis was observed in Suzuki-Miyaura coupling upon going from pure DMF to water/DMF 3:1: the 2-fold increase of conversion of 4-bromoanisole unlike pure DMF was found. Interesting feature was found using chloroarene in DMF/water: the reaction selectivity changed from heterocoupling to homo coupling of phenylboronic acid. Pd^II-NHC complexes demonstrated a high activity in model hydrogenation reaction of p-nitrophenol using sodium borohydride. The most lipophilic Pd^II-NHC complex is most active, which can be attributed with addnl. p-nitrophenol preconcentration in the aggregates due to larger hydrophobic capacity of macrocycle. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem