Imidazoles-derivatives

An efficient ICT based fluorescent turn-on dyad for selective detection of fluoride and carbon dioxide was written by Ali, Rashid;Razi, Syed S.;Gupta, Ramesh C.;Dwivedi, Sushil K.;Misra, Arvind. And the article was included in New Journal of Chemistry in 2016.Name: 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid This article mentions the following:

A new intramol. charge transfer (ICT) based fluorescent turn-on ratiometric probe 2 (D-蟺-A type) has been designed and synthesized by bridging imidazole (donor, D) and benzothiazole (acceptor, A) moieties through a Ph ring. The photophys. behavior of probe 2 in solvents of different polarities and at different pH values has been investigated. Upon interaction with different types of anions probe 2 showed selective high affinity for fluoride anions (F^–) in aqueous DMSO (20%) solution The ratiometric fluorescence turn-on behavior displayed by 2 with F^– is attributed to changes in the ICT process. Job’s plot anal. revealed a 1 : 1 binding stoichiometry for 2 + F^– interactions with a high binding constant and detection sensitivity (30 ppb). Moreover, a solution of 2 + F^– enabled the detection of CO₂ (鈭?00 ppb; 2.29 渭M) through enhanced emission. The mode of interaction has been confirmed by ¹H NMR titration studies which suggested the deprotonation of the -NH fragment of an imidazolyl unit in the presence of F^–. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Name: 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Name: 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Photoisomerization of indazoles to benzimidazoles was written by Tiefenthaler, H.;Dorscheln, W.;Goth, H.;Schmid, H.. And the article was included in Tetrahedron Letters in 1964.SDS of cas: 4887-83-6 This article mentions the following:

Indazole, 3-, 4-, 5-, 6-, or 7-methyl-, and 6-methoxyindazole irradiated with uv light (high pressure Hg lamp) in MeOH, EtOAc, or dioxane 3-20 hrs. at 25-90掳 were irreversibly converted in 9-31% yields to the corresponding benzimidazoles. The influence of solvent, reaction time, and temperature was tabulated. No isomerization was noted for 3-Ph-, 5-MeO-, 5-Cl-, and 6-Cl-substituted imidazoles. Pyrazole on irradiation in dioxane gave 12% imidazole. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6SDS of cas: 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-喂 was written by Sajan, Mini P.;Nimal, Sonali;Mastorides, Stephen;Acevedo-Duncan, Mildred;Kahn, C. Ronald;Fields, Alan P.;Braun, Ursula;Leitges, Michael;Farese, Robert V.. And the article was included in Metabolism, Clinical and Experimental in 2012.HPLC of Formula: 26832-08-6 This article mentions the following:

Excessive activity of hepatic atypical protein kinase (aPKC) is proposed to play a critical role in mediating lipid and carbohydrate abnormalities in obesity, the metabolic syndrome, and type 2 diabetes mellitus. In previous studies of rodent models of obesity and type 2 diabetes mellitus, adenoviral-mediated expression of kinase-inactive aPKC rapidly reversed or markedly improved most if not all metabolic abnormalities. Here, we examined effects of 2 newly developed small-mol. PKC-喂/位 inhibitors. We used the mouse model of heterozygous muscle-specific knockout of PKC-位, in which partial deficiency of muscle PKC-位 impairs glucose transport in muscle and thereby causes glucose intolerance and hyperinsulinemia, which, via hepatic aPKC activation, leads to abdominal obesity, hepatosteatosis, hypertriglyceridemia, and hypercholesterolemia. One inhibitor, 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl-[1R-(1a,2b,3b,4a)]], binds to the substrate-binding site of PKC-位/喂, but not other PKCs. The other inhibitor, aurothiomalate, binds to cysteine residues in the PB1-binding domains of aPKC-位/喂/味 and inhibits scaffolding. Treatment with either inhibitor for 7 days inhibited aPKC, but not Akt, in liver and concomitantly improved insulin signaling to Akt and aPKC in muscle and adipocytes. Moreover, both inhibitors diminished excessive expression of hepatic, aPKC-dependent lipogenic, proinflammatory, and gluconeogenic factors; and this was accompanied by reversal or marked improvements in hyperglycemia, hyperinsulinemia, abdominal obesity, hepatosteatosis, hypertriglyceridemia, and hypercholesterolemia. Our findings highlight the pathogenetic importance of insulin signaling to hepatic PKC-喂 in obesity, the metabolic syndrome, and type 2 diabetes mellitus and suggest that 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl-[1R-(1a,2b,3b,4a)]] and aurothiomalate or similar agents that selectively inhibit hepatic aPKC may be useful treatments. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6HPLC of Formula: 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic liquid-functionalized crystals of barium sulfate: A hybrid organic-inorganic material with tuned hydrophilicity and solid-liquid behavior was written by Kowacz, Magdalena;Marchel, Mateusz;Esperanca, Jose M. S. S.;Rebelo, Luis Paulo N.. And the article was included in Materials Chemistry and Physics in 2015.HPLC of Formula: 404001-48-5 This article mentions the following:

A hybrid organic-inorganic material composed of barium sulfate (BaSO₄) crystals embedded within a hydrophobic ionic liquid (ILs) matrix was synthesized. The contact between the inorganic solid and the organic coating is created by chem. interactions between the crystal surface and the ionic liquid The material exhibits higher affinity to lipophilic media than the nonmodified BaSO₄. Increased hydrophobicity is a property often sought for inorganic particles to be applied in nonpolar formulations. Immobilization of water-immiscible ILs on a hydrophilic solid carrier enables their application in aqueous solutions and the creation of appreciable hydrophobic-IL/water interfaces on the dispersion of solid-like material in aqueous media. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5HPLC of Formula: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.HPLC of Formula: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hierarchically Crosslinked Gels Containing Hydrophobic Ionic Liquids towards Reliable Sensing Applications was written by Chen, Xia-Chao;Sun, Pei-Ru;Liu, Hong-Liang. And the article was included in Chinese Journal of Polymer Science in 2020.Formula: C18H31F6N3O4S2 This article mentions the following:

Human skin can function steadily regardless of surrounding circumstances (dry or wet), while it is still a challenge for artificial ionic skins, which tend to release solvents in dry air and leach electrolytes in wetted state. Herein, a series of hierarchically crosslinked ionogels containing hydrophobic ionic liquids (ILs) is fabricated by combining a crystalline fluorinated copolymer with hydrophobic ILs. With a reasonable combination of nonvolatility, transparency, stretchablility, and sensitivity, such ionogels can work as reliable sensors for real-time monitoring human motions and operate steadily in complex environments as human skin does, which can contribute to the development of durable sensing devices with a simple design. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Formula: C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Formula: C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A Multiscale Simulation Study of Influence of Morphology on Ion Transport in Block Copolymeric Ionic Liquids was written by Zhang, Zidan;Krajniak, Jakub;Ganesan, Venkat. And the article was included in Macromolecules (Washington, DC, United States) in 2021.Synthetic Route of C9H15F6N2P This article mentions the following:

We present results of a multiscale simulation study involving coarse-graining and reverse-mapping steps probing at an atomistic resolution the influence of morphol. on ion transport in block copolymer polymeric ionic liquids We provide a detailed description of the multiscale simulation methodol. and then describe the results in the context of four microphase-separated morphologies: two lamella systems, a cylinder, and a gyroid morphol. For the framework adopted in this study (in which the total number of ions was maintained fixed), morphol. had little influence on the fraction of ions segregating to the interface and the coordination and hopping characteristics of such interfacially present ions. Such results manifested in anion mobilities being insensitive to the morphol. once the dimensionality of the morphol. was accounted for. Overall, our results are consistent with the hypothesis that the mobility of ions in such microphase-separated morphologies, after accounting for the dimensionality effects, can be roughly correlated to a linear superposition based on the fraction of bulk anions, which possess mobilities unperturbed from their values in the conducting homopolymers, and the interfacial anions, which exhibit much lower mobilities. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Synthetic Route of C9H15F6N2P).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Synthetic Route of C9H15F6N2P

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nano/microtribological properties of ultrathin functionalized imidazolium wear-resistant ionic liquid films on single crystal silicon was written by Mo, Yufei;Zhao, Wenjie;Zhu, Min;Bai, Mingwu. And the article was included in Tribology Letters in 2008.Computed Properties of C7H13ClN2 This article mentions the following:

Ionic liquids (ILs) are considered as a new kind of lubricant for micro/nanoelectromech. system (M/NEMS) due to their excellent thermal and elec. conductivity However, so far, only few reports have investigated the triboltribol. behavior of mol. thin films of various ILs. Evaluating the nanoscale tribol. performance of ILs when applied as a few nanometers-thick film on a substrate is a critical step for their application in MEMS/NEMS devices. To this end, four kinds of ionic liquid carrying Me, hydroxyl, nitrile, and carboxyl group were synthesized and these mol. thin films were prepared on single crystal silicon wafer by dip-coating method. Film thickness was determined by ellipsometric method. The chem. composition and morphol. were characterized by the means of multi-technique X-ray photoelectron spectrometric anal., and at. force microscopic (AFM) anal., resp. The nano- and microtribol. properties of the ionic liquid films were investigated. The morphologies of wear tracks of IL films were examined using a 3D non-contact interferometric microscope. The influence of temperature on friction and adhesion behavior at nanoscale, and the effect of sliding frequency and load on friction coefficient, load bearing capacity, and anti-wear durability at microscale were studied. Corresponding tribol. mechanisms of IL films were investigated by AFM and ball-on-plane microtribotester. Friction reduction, adhesion resistance, and durability of IL films were dependent on their cation chem. structures, wettability, and ambient environment. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Computed Properties of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Computed Properties of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cu-catalyzed amidation of halogenated imidazoles was written by Wang, Mo;Zhang, Zhenfeng;Xie, Fang;Zhang, Wanbin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Synthetic Route of C4H5BrN2 This article mentions the following:

An efficient methodol. involving the Cu-catalyzed amidation of halogenated imidazoles has been successfully developed. The amidated product of 5-bromo-1-alkylimidazole was further applied to the synthesis of a new chiral imidazole nucleophilic catalyst for the kinetic resolution of secondary alcs. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Synthetic Route of C4H5BrN2).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Synthetic Route of C4H5BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Amphiphilic multi-charged cyclodextrins and vitamin K co-assembly as a synergistic coagulant was written by Li, Pei-yu;Chen, Yong;Chen, Chang-hui;Liu, Yu. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Computed Properties of C11H20N2 This article mentions the following:

Balancing and neutralizing heparin dosing after surgeries and hemodialysis treatment is of great importance in medical and clin. fields. In this study, a series of new amphiphilic multi-charged cyclodextrins (AMCD)s as anti-heparin coagulants were designed and synthesized. The AMCD assembly was capable of selective heparin binding through multivalent bonding and showed a better neutralizing effect towards both unfractionated heparin and low mol. weight heparin than protamine in plasma. Meanwhile, an AMCD and vitamin K (VK) co-assembly was prepared to realize heparin-responsive VK release and provide a novel VK deficiency treatment for hemodialysis patients. This AMCD-VK co-assembly for heparin neutralization & vitamin K supplementation synergistic coagulation represents a promising candidate as a clin. anti-heparin coagulant. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Computed Properties of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Two-step redox systems. XV. Vinylogous bibenzimidazoles, bibenzoxazoles, and bibenzothiazoles and their aza derivatives was written by Huenig, Siegfried;Scheutzow, Dieter;Schlaf, Helmut;Schott, Albrecht. And the article was included in Justus Liebigs Annalen der Chemie in 1974.Recommanded Product: 3012-80-4 This article mentions the following:

The bibenzimidazoles and bibenzothiazoles I [Z = (CH:CH)n, n = 1-3, X = NMe or S, A- = e.g. BF4-] were prepared by two-fold ring closure of 2-HXC6H4NHMe with R1CO(CH:CH)nCOR1 (R1 = Cl or Me2CHCH2OCO2). Similarly prepared were I [X = S, Z = CH2(CH:CH)nCH2, n = 0-2]. I (X = O, Z = CH2CH2) was obtained by quaternization of the base. I (X = NMe, O, or S; Z = CH:NN:CH) were prepared by reaction of the heterocyclic aldehydes or the corresponding nitrones with N2H4 followed by quaternization. Coupling the hydrazono compounds II with glyoxal gave the tetraaza analogs III. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Recommanded Product: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem