Imidazoles-derivatives

Aggregation of sodium dodecylbenzene sulfonate: Weak molecular interactions modulated by imidazolium cation of short alkyl chain length was written by Agudelo, Alvaro Javier Patino;Ferreira, Guilherme Max Dias;Ferreira, Gabriel Max Dias;Coelho, Yara Luiza;Hudson, Eliara Acipreste;Pires, Ana Clarissa dos Santos;Mendes da Silva, Luis Henrique. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2020.Electric Literature of C4H7ClN2 This article mentions the following:

Ionic liquids (ILs) can modify cooperative process in aqueous solutions to a large extent, including anionic surfactant aggregation. Here, the micellization of sodium dodecylbenzene sulfonate (SDBS) was evaluated in low concentrations of 1-alkyl-3-methylimidazolium chloride (C_nmimCl, n = 0, 2, and 4) aqueous solutions through fluorescence spectroscopy, isothermal titration calorimetry, dynamic light scattering, and conductometry. The thermodn. stability of SDBS aggregates strongly depended on the IL structure and concentration, following the order C₄mim⁺ > C₀mim⁺ ≈ C₂mim⁺. At 1.0 mmol L^-1 of the ILs, the increase of the hydrophobicity of the imidazolium cation decreased the enthalpic favorableness, changing ΔH^omic from -3.75 ± 0.07 kJ mol^-1, for C₀mim⁺, to -2.69 ± 0.01 kJ mol^-1, for C₄mim⁺. On the other hand, the entropic feasibility showed an opposite trend, i.e., the higher hydrophobicity of C₄mim⁺ overcame the kosmotropic effect of IL cations in the bulks. We suggested that the imidazolium cations interact with the SDBS monomers on the micellar surface, mainly through hydrophobic, π-π, and electrostatic interactions for C₄mim⁺ and C₂mim⁺, and through electrostatic interactions and hydrogen bonds for C₀mim⁺. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Electric Literature of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Understanding Cellulose Dissolution: Energetics of Interactions of Ionic Liquids and Cellobiose Revealed by Solution Microcalorimetry was written by Nunes de Oliveira, Heitor Fernando;Rinaldi, Roberto. And the article was included in ChemSusChem in 2015.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

In this report, the interactions between fifteen selected ionic liquids (ILs) and cellobiose (CB) were examined by high-precision solution microcalorimetry. The heat of mixing (Δ_mixH) of CB and ILs, or CB and IL/mol. solvent (MS) solutions, provides the first ever-published measure of the affinity of CB with ILs. Most importantly, we found that there is a very good correlation between the nature of the results found for Δ_mixH_(CB) and the solubility behavior of cellulose. This correlation suggests that Δ_mixH_(CB) offers a good estimate of the enthalpy of dissolution of cellulose even in solvents in which cellulose is insoluble Therefore, the current findings open up new horizons for unravelling the intricacies of the thermodn. factors accounting for the spontaneity of cellulose dissolution in ILs or IL/MS solutions In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Acylation of benzimidazole by the Regel-Buechel method. 2. Deacylation and dissociation of 1-methyl-3-acyl-2-(1-methyl-2-benzimidazolyl)benzimidazolin-4-ones was written by Khristich, B. I.;Bondarenko, E. V.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1987.Application of 3012-80-4 This article mentions the following:

1-Methyl-3-acyl-2-(1-methylbenzimidazol-2-yl)-2-benzimidazolines with an excess of acyl halide are transformed to unstable 1-methyl-3-acyl-2-(1-methyl-3-acyl-2-benzimidazolin-2-yl)benzimidazolium chlorides, which undergo intramol. oxidation-reduction-decomposition to give 1,1′-dimethyl-2,2′-bibenzimidazolyl and aldehyde, and dissociates at the C-C bond connecting the benzimidazole and benzimidazoline fragments to a carbene-ylide and 1-methyl-3-acylbenzimidazolium chloride. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Application of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quantum state-resolved molecular scattering of NO (²Π_1/2) at the gas-[C_nmim][Tf₂N] room temperature ionic liquid interface: Dependence on alkyl chain length, collision energy, and temperature was written by Zutz, Amelia;Nesbitt, David J.. And the article was included in AIP Advances in 2016.Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

Room temperature ionic liquids (RTILs) represent a promising class of chem. tunable, low vapor pressure solvents with myriad kinetic applications that depend sensitively on the nature of gas-mol. interactions at the liquid surface. This paper reports on rovibronically inelastic dynamics at the gas-RTIL interface, colliding supersonically cooled hyperthermal mol. beams of NO (²Π_1/2, N = 0) from 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (or [C_nmim][Tf₂N]) and probing the scattered NO mols. via laser induced fluorescence (LIF) from the A(²Σ) state. Specifically, inelastic energy transfer into NO rovibrational and electronic degrees of freedom is explored as a function of RTIL alkyl chain length (n), incident collision energy (E_inc) and surface temperature (T_s). At low collision energies (E_inc = 2.7(9) kcal/mol), the scattered NO mols. exhibit a rotational temperature (T_rot) systematically colder than T_s for all chain lengths, which signals the presence of non-equilibrium dynamics in the desorption channel. At high collision energies (E_inc = 20(2) kcal/mol), microscopic branching into trapping/desorption (TD) and impulsive scattering (IS) pathways is clearly evident, with the TD fraction (α) exhibiting a step-like increase between short (n = 2, 4) and long (n = 8, 12, 16) alkyl chains consistent with theor. predictions. For all hydrocarbon chain lengths and RTIL temperature conditions, NO rotational excitation in the IS channel yields hyperthermal albeit Boltzmann-like distributions well described by a “temperature” (T_IS = 900 -1200 K) that decreases systematically with increasing n. Non-adiabatic, collision induced hopping between ground and excited spin-orbit states is found to be independent of RTIL alkyl chain length and yet increase with collision energy. The scattering data confirm previous exptl. reports of an enhanced presence of the alkyl tail at the gas-RTIL interface with increasing n, as well as provide support for theor. predictions of an alkyl length dependent shift between chains oriented parallel vs. perpendicular to the surface normal. (c) 2016 American Institute of Physics. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Antimicrobial Activity and SAR Study of New Gemini Imidazolium-Based Chlorides was written by Palkowski, Lukasz;Blaszczynski, Jerzy;Skrzypczak, Andrzej;Blaszczak, Jan;Kozakowska, Karolina;Wroblewska, Joanna;Kozuszko, Sylwia;Gospodarek, Eugenia;Krysinski, Jerzy;Slowinski, Roman. And the article was included in Chemical Biology & Drug Design in 2014.Application In Synthesis of 1-Octyl-1H-imidazole This article mentions the following:

A series of seventy new 3,3′-(α,ω-dioxaalkyl)bis[1-(alkyl)imidazolium] chloride derivatives was prepared They were characterized with respect to surface active properties and antimicrobial activity against the following pathogens: Staphylococcus aureus, Enterococcus faecalis, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Candida krusei and Candida albicans. In this article, besides description of the synthesis, the authors characterize a set of features of these compounds, concerning their structure (described by the length of the dioxaalkane spacer and the length of the alkyl substituent in the aromatic ring) and surface active properties (critical micelle concentration, value of surface tension at critical micelle concentration, value of surface excess, mol. area of a single particle, and free energy of adsorption of mol.). Then, the authors present a SAR study for Staphylococcus aureus, as one of the most widespread pathogenic strains, conducted with the help of the Dominance-based Rough Set Approach (DRSA), that involves identification of relevant features and relevant combinations of features being in strong relationship with a high antimicrobial activity of the compounds The SAR study shows, moreover, that the antimicrobial activity is dependent on the type of substituents and their position at the chloride moiety, as well as on the surface active properties of the compounds The synthesis of the target compounds was achieved by a reaction of 1-(alkyl)-1H-imidazole derivatives with 1,5-bis(chloromethoxy)pentane, 1,6-bis(chloromethoxy)hexane, 1,3-bis(chloromethoxy)propane, etc. The title compounds thus formed included 1,1′-[1,2-ethanediylbis(oxymethylene)]bis[3-octyl-1H-imidazolium] dichloride and related substances, such as 1,1′-[1,4-butanediylbis(oxymethylene)]bis[3-octyl-1H-imidazolium] dichloride, [(alkanediyl)bis[(oxy)methylene]]bis[(alkyl)imidazolium] dichloride derivatives (imidazolium chloride dimers). In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application In Synthesis of 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Protic Ionic Liquid as Reagent, Catalyst, and Solvent: 1-Methylimidazolium Thiocyanate was written by Andreev, Ivan A.;Ratmanova, Nina K.;Augustin, Andre U.;Ivanova, Olga A.;Levina, Irina I.;Khrustalev, Victor N.;Werz, Daniel B.;Trushkov, Igor V.. And the article was included in Angewandte Chemie, International Edition in 2021.Application of 35487-17-3 This article mentions the following:

We propose a new concept of the triple role of protic ionic liquids with nucleophilic anions: (a) a regenerable solvent, (b) a Broensted acid inducing diverse transformations via general acid catalysis, and (c) a source of a nucleophile. The efficiency of this strategy was demonstrated using thiocyanate-based protic ionic liquids for the ring-opening of donor-acceptor cyclopropanes. A wide variety of activated cyclopropanes were found to react with 1-methylimidazolium thiocyanate under mild metal-free conditions via unusual nitrogen attack of the ambident thiocyanate ion on the electrophilic center of the three-membered ring affording pyrrolidine-2-thiones bearing donor and acceptor substituents at the C(5) and C(3) atoms, resp., in a single time-efficient step [e.g., I → II (81%)]. The ability of 1-methylimidazolium thiocyanate to serve as a triplex reagent was exemplarily illustrated by (4+2)-annulation with 1-acyl-2-(2-hydroxyphenyl)cyclopropane, epoxide ring-opening and other organic transformations. Safety: ammonia evolution in cation metathesis reactions → carry out in fume hood. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Application of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nitroimidazoles was written by Cosar, Charles;Crisan, Cornel;Horclois, Raymond;Jacob, Robert M.;Robert, Jacques;Tchelitcheff, Serge;Vaupre, Roger. And the article was included in Arzneimittel-Forschung in 1966.Application of 3034-41-1 This article mentions the following:

2-Alkyl 2-(4 or 5)nitroimidazoles were synthesized. Thus, 380 g. 2-methylimidazole was dissolved in 926 ml. 10N H2SO4, to obtain 2-methylimidazole acid sulfate (red oil) which was nitrated by treating with 550 ml. HNO3 (d. 1.38) and then 160 ml. HNO3 (d. 1.49) and 640 ml. H2SO4 (d. 1.83) with cooling at 18° to give 39% 2-methyl-4(5)-nitroimidazole (I, R = Me), m. 255°. Similarly were prepared the following I (R, m.p., and % yield given): H, 306° (2.5N HCl), 64; Et, 158° (H2O), 29; iso-Pr, 180° (H2O), 31. II were prepared from I by alternate methods. Method A: 38.1 g. I (R = Me) was mixed with 25.2 g. EtOK (18% in EtOH) and 100 ml. HCONMe2, EtOH was distilled, the residue was diluted with 200 ml. HCONMe2 and 37.8 g. Me2SO4 added dropwise, and the mixture heated 3 hrs. at 100° to give 62% 1,2-dimethyl-4-nitroimidazole, m. 183° (iso-PrOH). Method B: 13 g. Et2SO4 was added dropwise to a mixture of 17 g. 4-nitroimidazole, 90 ml. 2.5N NaOH, and heated 20 min. at 45°; after cooling a new addition of 90 ml. NaOH and 13 g. Et2SO4 was made, and the mixture heated 45 min. at 45°. Extraction with CHCl3 gave 27% 5.8 g. 1-ethyl-4-nitroimidazole, m. 40°. Method C: By heating 2 hrs. at 140-5° a mixture of 12.7 g. I and 22.6 g. PhCH2Cl, there was obtained 57% 1-benzyl-2-methyl-4-nitroimidazole, m. 106°. Similarly were prepared the II in the first table. [TABLE OMITTED] 2-Methyl-5-nitroimidazole (635 g.) and 3.22 kg. HO-CH2CH2Cl was refluxed 24 hrs. to yield 41% 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, m. 160°. Similarly were prepared the III in the 2nd table. Esters of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole (IV) were prepared by reaction of acid chloride and C5H5N with the IV (R = H). Thus were prepared the following IV (R, m.p., and % yield given): Ac, 74°, 60; COCHCl2 87°, 51; COCMe3, 39°, 26; palmitoyl, 55°, 68; stearoyl, 51°, 34; CO-(CH2)2CO2H, 109°, 89; neutral succinate, 129°, 39; COCH:CHPh, 100°, 44; Bz, 102°, 89; COC6H4Cl-o, 104°, 61; COC6H4-OH-o, 154°, 15; COC6H4OMe-p, 102°, 56; COC6H2(OMe)3-3,4,5, 116°, 45; COC6H4NO2-p, 166°, 22; neutral phthalate, 130°, 13. Derivatives of 2-nitroimidazole were prepared: 1-methyl-2-nitroimidazole, m. 105°, and 1-(2-hydroxyethyl)-2-nitroimidazole, m. 116°. The NO2 in position 4 or 5 was studied by ir spectroscopy. The influence of the position of the nitro group and the nature of the other substituents on the antitrichomonas activity was studied. The 5-nitro derivatives were always found to be more active than derivatives of 4-nitroimidazole. In the 5-nitroimidazole series, the best products are those carrying a Me group in the 2-position and in the 1-position; a short saturated aliphatic chain being optionally substituted, and the presence of a hydroxy group decreasing considerably the toxicity of the product. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Application of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Benzimidazolium-acridine-based silver N-heterocyclic carbene complexes as potential anti-bacterial and anti-cancer drug was written by Sharhan, Olla;Heidelberg, Thorsten;Hashim, Najihah Mohd.;Al-Madhagi, Wafa M.;Ali, Hapipah Mohd.. And the article was included in Inorganica Chimica Acta in 2020.Computed Properties of C8H8N2 This article mentions the following:

A series of N-alkylated benzimidazolium salts based on 9-substituted acridine has been synthesized and subsequently converted into the corresponding Ag(I) carbene complexes. The compounds were characterized by IR, ¹H and ¹³C NMR spectroscopy. Identity and purity were confirmed by HRMS and elemental anal., resp. Both, ligands and complexes, were evaluated on their antibacterial and anticancer potential. All complexes exhibited higher activity against both Gram pos. and Gram neg. bacterial strains than the corresponding ligands. Human cell line experiments indicated low in-vitro cytotoxicity, while some of the complexes showed promising activity against breast cancer cells. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Computed Properties of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Irreversible Humidity-Responsive Phosphorescence Materials from Cellulose for Advanced Anti-Counterfeiting and Environmental Monitoring was written by Zhang, Xin;Cheng, Yaohui;You, Jingxuan;Zhang, Jinming;Wang, Yirong;Zhang, Jun. And the article was included in ACS Applied Materials & Interfaces in 2022.Electric Literature of C11H20N2 This article mentions the following:

Organic phosphorescence materials have many unique advantages, such as a large Stokes shift, high signal-to-noise ratio, and no interference from background fluorescence and scattered light. But, they generally lack responsiveness. Herein, we developed a new type of biopolymer-based phosphorescence materials with excellent processability and irreversible humidity-responsiveness, via introducing the imidazolium cation to cellulose chain. In the resultant cellulose derivatives, the imidazolium cation promotes the intersystem crossing, meanwhile the cation, chloride anion, and hydroxyl group form multiple hydrogen bonding interactions and electrostatic attraction interactions, which successfully inhibit the nonradiative transitions. As a result, the ionic cellulose derivatives exhibit green phosphorescence at room temperature and can be processed into phosphorescent films, coatings, and patterns. More interestingly, their phosphorescence emission changes when the different processing solvents are used. The ionic cellulose derivatives processed with acetone have a negligible phosphorescence, while they give an irreversible humidity-responsive phosphorescence, which means that the ionic cellulose derivatives processed with acetone exhibit significantly enhanced phosphorescence once they meet water vapor. Such novel irreversible responsive phosphorescence materials have huge potential in advanced anticounterfeiting, information encryption, mol. logic gates, smart tags, and process monitoring. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Electric Literature of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Protic Imidazolium Cation-Based Ionic Liquids Show Unexpected Interfacial Properties was written by Chen, Zhichao;Morales-Collazo, Oscar;Brennecke, Joan F.. And the article was included in Langmuir in 2020.Electric Literature of C11H20N2 This article mentions the following:

Virtually, every investigation and application of ionic liquids (ILs) involves gas-liquid, liquid-liquid, and liquid-solid interactions. Therefore, understanding the behavior of ILs at those interfaces is critical In this work, we studied the interfacial properties of protic and aprotic ILs with N-alkylimidazolium and 1-alkyl-3-methylimidazolium as cations and bis(trifluoromethylsulfonyl)imide, methanesulfonate, and trifluoromethanesulfonate as anions. The surface tension of these ILs is measured with the pendant drop method in a temperature range of 293.15-343.15 K and at atm. pressure. The contact angle measurements are performed at 293.15 K on three solid substrates: polytetrafluoroethylene, glassy carbon, and platinum. Dispersive and nondispersive components of the IL surface energy are determined from the exptl. data using Fowkes theory. The most interesting result is that the protic ILs have lower surface tension and smaller contact angles than the equivalent aprotic ILs, despite the presence of high charge d. on the proton associated with one of the nitrogens of the cation. Higher charge d. on the anion results in a higher surface tension, and decreasing surface tension and contact angles are observed for increasing alkyl chain length on the cation. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Electric Literature of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem