Imidazoles-derivatives

Correlation and prediction of ionic liquid viscosity using Valderrama-Patel-Teja cubic equation of state and the geometric similitude concept. Part I: Pure ionic liquids was written by Valderrama, Jose O.;Cardona, Luis F.;Rojas, Roberto E.. And the article was included in Fluid Phase Equilibria in 2019.Reference of 404001-48-5 This article mentions the following:

A generalized viscosity equation of state including a single adjustable parameter for correlating and estimating the viscosity of ionic liquids at different temperatures and pressures is proposed. The similar shape and form of the curves (isotherms and saturation lines) observed in a d.-pressure-temperature plot and in a viscosity-pressure-temperature plot (ρTP and μTP plots), known as geometrical similitude, is the basis of the proposed model. Viscosity data available in the literature has been gathered, analyzed, and selected to finally construct a database of consistent data to obtain a general model. The generalized equation of state model includes a number of parameters that are determined by fitting the model using the selected exptl. viscosity data of different types of ionic liquids In total, 3857 viscosity data for 187 ionic liquids in the temperature range of 253-573 K and pressures from 1.0 up to 1500 bar have been considered. The generalized viscosity model has been compared with other existing approaches and results show that the new viscosity cubic equation of state model provides accurate and consistent results taking in account the simplicity of the generalized expressions, which contains only one adjustable parameter for each ionic liquid In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Reference of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Reference of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of cyclodextrin based hydrogel nanocarriers for enhanced solubility of candesartan cilexetil was written by Aslam, Afeefa;Bashir, Sajid;Sarfraz, Rai M.;Ahmad, Shahbaz. And the article was included in Latin American Journal of Pharmacy in 2019.COA of Formula: C33H34N6O6 This article mentions the following:

Nanoparticles are considered a useful tool for improving properties of poorly soluble active ingredients. In this work, successful efforts have been performed for solubility enhancement of candesartan. pH-sensitive hydroxypropyl β-cyclodextrin-poly acrylic acid (HPβCD-pAA) hydrogel nanoparticles were developed. Candesartan cilexetil, practically insoluble in water, was used as a model drug. Different formulations were prepared by free radical polymerization Developed nanoparticles were subjected to FTIR, DSC, TGA, PXRD, SEM, size anal., equilibrium swelling ratio (q), solubility studies, and in vitro drug release studies. pH dependent higher swelling and drug release was observed at pH 6.8 in less than 3 h. Solubility was improved up to 167.4 and 233.1 μg/mL in distilled water and PBS (pH 6.8) as compared to pure drug. The efficient preparation, high solubility, improved dissolution and pH responsive nature of prepared hydrogel nanoparticles can be a potential approach for delivery of poorly soluble drugs. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5COA of Formula: C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quantitative estimation of intra-subject variability in bioequivalence studies of generic solid oral dosage forms by multiple regression analysis was written by Wada, Shigenori;Kagatani, Seiya;Nakagami, Hiroaki. And the article was included in Journal of Drug Delivery Science and Technology in 2021.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

Intra-subject variability (CVintra), which determines the 90% confidence intervals and the number of subjects needed for assessment in bioequivalence studies, is generally investigated by using pilot study Results. However, conducting pilot studies greatly affects the speed and cost of drug development. In this study, we performed multiple regression anal. of the major factors that predict the extent of the CVintra of pharmacokinetic parameters by using 4 quant. variables (drug solubility, variability of the peak drug concentration [Cmax] or area under the drug plasma concentration vs. time curve [AUC], bioavailability, and elimination half-life), which were obtained from a database of the results of bioequivalence studies conducted by Nihon Generic Co., Ltd. A total of 77 studies [34 components] were included. From this anal., we confirmed that multiple regression equations can be used to estimate 3 kinds of %CVintra values with high correlation coefficients (r = 0.8971 for the Cmax of all drug types, r = 0.9739 for the AUC of renal excretion-type drugs, and r = 0.5368 for the AUC of non-renal excretion-type drugs). When the predicted equations were applied to newly planned bioequivalence studies (2 studies [2 components]) without pilot studies, it was verified that the %CVintra of the Cmax and AUC could be estimated with a predicted value of ±5. Further, both formulations were found to be bioequivalent in term of the Cmax and AUC, with 90% confidence intervals of sufficient power. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates was written by Sadowsky, Jack D.;Pillow, Thomas H.;Chen, Jinhua;Fan, Fang;He, Changrong;Wang, Yanli;Yan, Gang;Yao, Hui;Xu, Zijin;Martin, Shanique;Zhang, Donglu;Chu, Phillip;dela Cruz-Chuh, Josefa;ODonohue, Aimee;Li, Guangmin;Del Rosario, Geoffrey;He, Jintang;Liu, Luna;Ng, Carl;Su, Dian;Lewis Phillips, Gail D.;Kozak, Katherine R.;Yu, Shang-Fan;Xu, Keyang;Leipold, Douglas;Wai, John. And the article was included in Bioconjugate Chemistry in 2017.Formula: C6H8N2O2S This article mentions the following:

Conjugation of small mol. payloads to specific cysteine residues on proteins via a disulfide bond represents an attractive strategy to generate redox-sensitive bioconjugates, which have value as potential diagnostic reagents or therapeutics. Advancement of such “direct-disulfide” bioconjugates to the clinic necessitates chem. methods to form disulfide connections efficiently, without byproducts. The disulfide connection must also be resistant to premature cleavage by thiols prior to arrival at the targeted tissue. We show here that commonly-employed methods to generate direct disulfide-linked bioconjugates are inadequate for addressing these challenges. We describe our efforts to optimize direct-disulfide conjugation chem., focusing on the generation of conjugates between cytotoxic payloads and cysteine-engineered antibodies (i.e., THIOMAB antibody-drug conjugates, or TDCs). This work culminates in the development of novel, high-yielding conjugation chem. for creating direct payload disulfide connections to any of several Cys mutation sites in THIOMAB antibodies or to Cys sites in other biomols. (e.g., human serum albumin and cell-penetrating peptides). We conclude by demonstrating that hindered direct disulfide TDCs with two Me groups adjacent to the disulfide, which have heretofore not been described for any bioconjugate, are more stable and more efficacious in mouse tumor xenograft studies than less hindered analogs. In the experiment, the researchers used many compounds, for example, Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8Formula: C6H8N2O2S).

Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Formula: C6H8N2O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Analytical method development and validation of Ramipril and Candesartan cilexetil in synthetic mixture was written by Nagar, Akhil;Deore, Sumit;Bendale, Atul;Kakade, Rajanikant;Sonawane, Chetankumar. And the article was included in Innovations in Pharmaceuticals and Pharmacotherapy in 2020.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

The aim of the study was to develop a rapid, accurate, and precise ratio spectra derivative spectroscopic high-performance liquid chromatog. method and validated for the estimation of Ramipril (RAM) and Candesartan cilexetil (CAN) in synthetic mixture The estimation of RAM, CAN (6μg/mL) was used as a devisor and for the estimation of CAN, RAM (5μg/mL) used as a devisor. The wavelengths selected for quant. estimation were 331 nm for RAM and 231 nm and for CAN. Results: The result for validation shows that linearity of the developed method was 0.9976 and 0.9994 in the range of 5-10μg/mL and 6-16μg/mL for RAM and CAN, resp. Phenomenex C18 column (250 mmx4.6 mm, 5μm particle size) column was used. Acetonitrile:water (0.5% TEA, pH 4.5 adjusted with 10% orthophosphoric acid) (85:15 volume/volume) as a mobile phase, flow rate 1 mL/min and detection carried out at 220 nm. The retention time of RAM and CAN was 3.607 and 5.613 min, resp. Linearity of the developed method was found to be 0.9956 and 0.9974 in the range of 0.5-0.9μg/mL and 1.60-2.88μg/mL for RAM and CAN, resp. From the mentioned results, we can conclude that the developed methods were validated successfully as per the ICH guideline and are accurate, robust, and precise. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enhanced Anti-Bacterial Activity of Non-Antibacterial Drug Candesartan Cilexetil by Delivery through Polymeric Micelles was written by Kareem, Faheem;Abdul-Karim, Rubina;Maharjan, Rukesh;Shah, Muhammad Raza;Simjee, Shabana U.;Khan, Khalid M.;Malik, Muhammad Imran. And the article was included in ChemistrySelect in 2020.Electric Literature of C33H34N6O6 This article mentions the following:

Candesartan Cilexetil (CC) is a prodrug of candesartan and an angiotensin II receptor antagonist. It is used as a drug for different diseases like myocardial infarction, hypertension, and heart failure. The applicability of CC is impeded due to its poor water solubility, low permeability, and low bioavailability. This study is targeted to improve the efficacy and bioavailability of CC by its delivery through MeO-PEO_5K-PCL micelles. The effect of length of hydrophobic block (PCL) on size of the micelles, drug encapsulation efficiency, and drug release behavior is evaluated. MeO-PEO_5K-PCL based micelles were prepared by solvent evaporation method. The size of PMs was determined by dynamic light scattering, morphol. by at. force microscopy, and critical micelles concentration by fluorescence method. Encapsulation efficiency and drug release behaviors of MeO-PEO_5K-PCL based PMs were evaluated by UV-visible spectroscopy and dispersion method, resp. The size of micelles increased and drug release rate decreased with increase in the length of PCL block. Maximum encapsulation efficiency of 96.42% for CC is achieved with ABCs having equal PEO and PCL block lengths. A comparison of antibacterial activity of CC in pure form and encapsulated in PMs against MRSA is conducted. The MIC₅₀ for CC loaded PMs has decreased to more than half in comparison to pure drug. AFM based morphol. anal. also confirmed the decrease in MIC₅₀ by delivery through PMs. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Herpes Simplex Virus-1 DNA Primase: A Remarkably Inaccurate yet Selective Polymerase was written by Urban, Milan;Joubert, Nicolas;Hocek, Michal;Alexander, Richard E.;Kuchta, Robert D.. And the article was included in Biochemistry in 2009.Related Products of 4887-83-6 This article mentions the following:

Herpes simplex virus-1 primase misincorporates the natural NTPs at frequencies of around one error per 30 NTPs polymerized, making it one of the least accurate polymerases known. We used a series of nucleotide analogs to further test the hypothesis that primase requires Watson-Crick hydrogen bond formation to efficiently polymerize a NTP. Primase could not generate base pairs containing a complete set of hydrogen bonds in an altered arrangement (isoguanine/isocytosine) and did not efficiently polymerize dNTPs completely incapable of forming Watson-Crick hydrogen bonds opposite templating bases incapable of forming Watson-Crick hydrogen bonds. Similarly, primase did not incorporate most NTPs containing hydrophobic bases incapable of Watson-Crick hydrogen bonding opposite natural template bases. However, 2-pyridone NTP and 4-methyl-2-pyridone NTP provided striking exceptions to this rule. The effects of removing single Watson-Crick hydrogen bonding groups from either the NTP or templating bases varied from almost no effect to completely blocking polymerization depending both on the parental base pair (G/C vs. A/T/U) and which base pair of the growing primer (second, third, or fourth) was examined Thus, primase does not absolutely need to form Watson-Crick hydrogen bonds to efficiently polymerize a NTP. Addnl., we found that herpes primase can misincorporate nucleotides both by misreading the template and by a primer-template slippage mechanism. The mechanistic and biol. implications of these results are discussed. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Related Products of 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Experimental memory disorders and their pharmacological correction was written by Shabanov, P. D.. And the article was included in Vestnik Akademii Meditsinskikh Nauk SSSR in 1985.Name: 1H-Imidazole-4-carboxamide This article mentions the following:

The antiamnesic action of a variety of neurotropic drugs on 2 models of memory disorders (electronconvulsive shock and mech. brain injury) was studied in rats. GABA (200 mg/kg) and 1-methyl-3,4-di-(N-methylcarbamoyl)-pyrazole (10 μg/kg) were the most potent drugs inhibiting amnesia for passive avoidance. Piracetam (100 mg/kg) and etimazole (1.5 mg/kg) were compared for effects on learning and memory of the drinking conditioned reflex under conditions of RNA synthesis inhibition by actinomycin D. Neither compound affected learning but facilitated it after actinomycin D administration. Both drugs also increased memory retention. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Name: 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results was written by Boulmier, Amandine;Feng, Xinxin;Oms, Olivier;Mialane, Pierre;Riviere, Eric;Shin, Christopher J.;Yao, Jiaqi;Kubo, Tadahiko;Furuta, Taisuke;Oldfield, Eric;Dolbecq, Anne. And the article was included in Inorganic Chemistry in 2017.Application In Synthesis of 1-Octyl-1H-imidazole This article mentions the following:

The authors synthesized a series of polyoxometalate-bisphosphonate complexes containing Mo^VIO₆ octahedra, zoledronate, or an N-alkyl (n-C₆ or n-C₈) zoledronate analog, and in two cases, Mn as a heterometal. Mo₆L₂ (L = Zol, ZolC₆, ZolC₈) and Mo₄L₂Mn (L = Zol, ZolC₈) were characterized by using single-crystal x-ray crystallog. and/or IR spectroscopy, elemental and energy dispersive x-ray anal. and ³¹P NMR. The authors found promising activity against human non-small cell lung cancer (NCI-H460) cells with IC₅₀ values for growth inhibition of ∼5 μM per bisphosphonate ligand. The effects of bisphosphonate complexation on IC₅₀ decreased with increasing bisphosphonate chain length: C₀ ≈ 6.1×, C₆ ≈ 3.4×, and C₈ ≈ 1.1×. The authors then determined the activity of one of the most potent compounds in the series, Mo₄Zol₂Mn(III), against SK-ES-1 sarcoma cells in a mouse xenograft system finding a ∼5× decrease in tumor volume than found with the parent compound zoledronate at the same compound dosing (5 μg/mouse). Overall, the results are of interest since the authors show for the first time that heteropolyoxomolybdate-bisphosphonate hybrids kill tumor cells in vitro and significantly decrease tumor growth, in vivo, opening up new possibilities for targeting both Ras as well as epidermal growth factor receptor driven cancers. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application In Synthesis of 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application In Synthesis of 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Studies on the solubility of terephthalic acid in ionic liquids was written by Matuszek, Karolina;Pankalla, Ewa;Grymel, Aleksander;Latos, Piotr;Chrobok, Anna. And the article was included in Molecules in 2020.Synthetic Route of C4H7ClN2 This article mentions the following:

Low solubility of terephthalic acid in common solvents makes its industrial production very difficult and not environmentally benign. Ionic liquids are known for their extraordinary solvent properties, with capability to dissolve a wide variety of materials, from common solvents to cellulose, opening new possibilities to find more suitable solvents for terephthalic acid. This work presents studies on the solubility of terephthalic acid in ionic liquids, and demonstrates that terephthalic acid is soluble in ionic liquids, such as 1-ethyl-3-methylimidazolium diethylphosphate, 1-butyl-3-methylimidazolium acetate, and dialkylimidazolium chlorides up to four times higher than in DMSO. Addnl., the temperature effect and correlation of ionic liquid structure with solubility efficiency are discussed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Synthetic Route of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Synthetic Route of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem