Imidazoles-derivatives

Product class 4: benzimidazoles was written by Grimmett, M. R.. And the article was included in Science of Synthesis in 2002.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

Methods for preparing benzimidazoles are reviewed covering annulations to arenes, ring transformations, and aromatization. Modification of benzimidazole substituents are also included. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Free-radical polymerization and copolymerization of acrylonitrile in ionic liquids was written by Vygodskii, Ya. S.;Mel’nik, O. A.;Lozinskaya, E. I.;Shaplov, A. S.. And the article was included in Vysokomolekulyarnye Soedineniya, Seriya A i Seriya B in 2005.Synthetic Route of C7H13ClN2 This article mentions the following:

The free-radical polymerization of acrylonitrile and its copolymerization with Me methacrylate in ionic liquids based on 1,3-dialkyl-substituted imidazole were studied. It was shown that, in contrast to the case of common mol. solvents, the polymerization and copolymerization in liquid organic salts give high-mol.-mass polyacrylonitrile and copolymers with high yields, with the former polymer showing a higher onset temperature of degradation In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Synthetic Route of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Synthetic Route of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Langmuir films of 2-alkyl benzimidazoles on aqueous AgNO₃ subphase and the layer structures of the transferred films was written by Wu, Yi-Tian;Liu, Ming-Hua. And the article was included in Wuli Huaxue Xuebao in 2004.Formula: C15H22N2 This article mentions the following:

The formation of stable Langmuir films on the aqueous AgNO₃ subphase of 2-alkyl benzimidazoles(BzCn) with various chain lengths (from C5 to C15) and the layer structures of the transferred films were described. From the surface pressure-area isotherm, the true monolayer could be formed for the short chain derivatives, while multilayer structures for the long ones. All of the Langmuir films could be transferred to solid substrate. The measurement of the UV spectra of the transferred LB films confirmed the coordination between benzimidazole group and Ag(I) ion in the Langmuir films. The effect of the length of alkyl chains on the structure of the transferred LB films was revealed by application of at. force microscopy, FF-IR spectra and XRD measurement. Except for BzC15, a regular layer structure was formed. Characterization of the morphol. points to the formation of the neat LB film for the short derivatives and multilayer structure for BzC15. In the experiment, the researchers used many compounds, for example, 2-Octylbenzimidazole (cas: 13060-24-7Formula: C15H22N2).

2-Octylbenzimidazole (cas: 13060-24-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Formula: C15H22N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Exploitation of localized surface plasmon resonance of silver/gold nanoparticles for the fluorescence quantification of angiotensin II receptor antagonists in their tablets and bio-samples was written by Alarfaj, N. A.;Altamimi, S. A.;El-Tohamy, M. F.;Almahri, A. M.. And the article was included in New Journal of Chemistry in 2019.Product Details of 145040-37-5 This article mentions the following:

The present study suggested six different fluorometric systems for the determination of three angiotensin II receptor antagonists, candesartan cilexetil (CDC), valsartan (VAL) and telmisartan (TEL) in their bulk and pharmaceutical dosage forms. The fluorescence intensities (FIs) were recorded by measuring the high catalytic potential activity of silver or gold nanoparticles (AgNPs or AuNPs) at λ_ex 525, 420 and 330 nm and λ_em 555, 490 and 400 nm for CDC, VAL and TEL, resp. All exptl. measurements were carried out under optimum conditions using the CDC-Tb(III)-AgNPs, CDC-Tb(III)-AuNPs, VAL-Eu(III)-AgNPs, VAL-Eu(III)-AuNPs, TEL-SDS-AgNPs and TEL-SDS-AuNPs systems. The fluorescence (FL) signals displayed linear concentration ranges of 0.01-300, 0.02-120 and 2.0-30 ng mL^-1 for CDC, VAL and TEL in the presence of AgNPs, resp., and 0.05-60, 0.1-80 and 0.1-250 ng mL^-1 for the same drugs in the presence of AuNPs, resp. The influence of possible coexisting species and additives was tested. ICH guidelines were followed to validate the developed methods. All suggested FL systems were successfully used to monitor the studied drugs in bulk, tablets and bio-samples. The obtained data were compared with those of other reported methods revealing high agreement. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Product Details of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Product Details of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Characterization of the ionic liquid obtained by chlorosulfonation of 1-methylimidazole: 1-methyl-3-sulfonic acid imidazolium chloride, 1-methylimidazolium chlorosulfate or a zwitterionic salt? was written by Urban, Bela;Szalontai, Gabor;Papp, Mate;Feher, Csaba;Benyei, Attila C.;Skoda-Foldes, Rita. And the article was included in Journal of Molecular Liquids in 2021.Safety of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

A great number of organic reactions catalyzed by the ionic liquid product of chlorosulfonation of 1-methylimidazole have been reported recently. At the same time controversial assumptions have appeared on the real structure of the catalyst. In the present report the primarily formed chlorosulfonation product is proved to be 1-methylimidazolium chlorosulfate ([HMim]⁺[SO₃Cl]^–) instead of 1-methyl-3-sulfonic acid imidazolium chloride, reported previously. The former structure is confirmed by X-ray crystallog. and NMR spectroscopy, including ¹H-, ¹³C-, ¹⁷O- and ¹⁵N-¹H HSQC measurements. ¹H and ¹⁷O NMR experiments support fast hydrolysis of [HMim] [SO₃Cl] resulting in the formation of [HMim][HSO₄] in the presence of traces of water. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Safety of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Safety of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionization constants, and ultraviolet and infrared spectra of 4(7)- and 5(6)-halogenated benzimidazoles was written by Rabiger, D. J.;Joullie, M. M.. And the article was included in Journal of the Chemical Society in 1964.Reference of 83741-35-9 This article mentions the following:

For a series of 4(7)- and 5(6)-halogenated benzimidazoles, the ionization constants show that for compounds with a halogen atom in either the 4(7)- or the 5(6)-position the basicity decreases in the order F > I > Cl > Br. Attempts were made to correlate the effect of substituents on the pK_a values of benzimidazoles by means of the Hammett equation; no relation could be established for 5(6)-substituted compounds, presumably because of the tautomeric nature of the ring, but a satisfactory correlation was obtained for the 4(7)- halogenated benzimidazoles. The ultraviolet data indicate that the implied order of overall electron release for halogen atoms in both the 4(7)- and the 5(6)-position is I > Br > Cl > F. The infrared spectra of these halogenated benzimidazoles are discussed. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-benzoimidazole (cas: 83741-35-9Reference of 83741-35-9).

4-Bromo-1H-benzoimidazole (cas: 83741-35-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 83741-35-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Inhibition of bacterial growth and galactosyltransferase activity of WbwC by α, ω-bis(3-alkyl-1H-imidazolium)alkane salts: Effect of varying carbon content was written by Kocev, Alexander;Melamed, Jacob;Wang, Shuo;Kong, Xianqi;Vlahakis, Jason Z.;Xu, Yaozu;Szarek, Walter A.;Brockhausen, Inka. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Related Products of 21252-69-7 This article mentions the following:

A series of compounds was designed and synthesized having two imidazolium rings separated by a polymethylene spacer and having alkyl substituents on each of the imidazolium rings. The compounds were assayed for their effects on the activity of galactosyltransferase WbwC, and also on the growth of Gram-neg. and Gram-pos. bacteria, as well as human cells. The inhibition observed on enzyme activities and cell growth was dependent on the total number of carbons in the spacer and the alkyl substituents on the imidazolium rings. These readily synthesized, achiral compounds have potential as antimicrobial and antiseptic agents. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Related Products of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Related Products of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Oxidative alkylation of azoles: V. Synthesis of 1-chloro-4-nitroimidazole and its reaction with methyl iodide was written by Veretennikov, E. A.;Pevzner, M. S.. And the article was included in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) in 1997.Recommanded Product: 3034-41-1 This article mentions the following:

Chlorination of 4-nitroimidazole in alk. medium gave 1-chloro-4-nitroimidazole. The reaction of the latter with Me iodide results in liberation of iodine and formation of 4-nitroimidazole, isomeric 1-methyl-4-nitro- and 1-methyl-5-nitroimidazoles, and 1,3-dimethyl-4-nitroimidazolium triiodide. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Manganese-Catalyzed Asymmetric Hydrogenation of Quinolines Enabled by π-π Interaction** was written by Liu, Chenguang;Wang, Mingyang;Liu, Shihan;Wang, Yujie;Peng, Yong;Lan, Yu;Liu, Qiang. And the article was included in Angewandte Chemie, International Edition in 2021.Reference of 3012-80-4 This article mentions the following:

The non-noble metal-catalyzed asym. hydrogenation of N-heteroaromatics, quinolines, is reported. A new chiral pincer manganese catalyst showed outstanding catalytic activity in the asym. hydrogenation of quinolines, affording high yields and enantioselectivities (up to 97% ee). A turnover number of 3840 was reached at a low catalyst loading (S/C=4000), which is competitive with the activity of most effective noble metal catalysts for this reaction. The precise regulation of the enantioselectivity were ensured by a π-π interaction. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Reference of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ was written by Bubenik, Monica;Mader, Pavel;Mochirian, Philippe;Vallee, Frederic;Clark, Jillian;Truchon, Jean-Francois;Perryman, Alexander L.;Pau, Victor;Kurinov, Igor;Zahn, Karl E.;Leclaire, Marie-Eve;Papp, Robert;Mathieu, Marie-Claude;Hamel, Martine;Duffy, Nicole M.;Godbout, Claude;Casas-Selves, Matias;Falgueyret, Jean-Pierre;Baruah, Prasamit S.;Nicolas, Olivier;Stocco, Rino;Poirier, Hugo;Martino, Giovanni;Fortin, Alexanne Bonneau;Roulston, Anne;Chefson, Amandine;Dorich, Stephane;St-Onge, Miguel;Patel, Purvish;Pellerin, Charles;Ciblat, Stephane;Pinter, Thomas;Barabe, Francis;El Bakkouri, Majida;Parikh, Paranjay;Gervais, Christian;Sfeir, Agnel;Mamane, Yael;Morris, Stephen J.;Black, W. Cameron;Sicheri, Frank;Gallant, Michel. And the article was included in Journal of Medicinal Chemistry in 2022.Reference of 25676-75-9 This article mentions the following:

DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective inhibitor of human Polθ (encoded by POLQ). A high-throughput screening campaign of 350,000 compounds identified an 11 micromolar hit, giving rise to the N2-substituted fused pyrazolo series, which was validated by biophys. methods. Structure-based drug design efforts along with optimization of cellular potency and ADME ultimately led to the identification of RP-6685 (I): a potent, selective, and orally bioavailable Polθ inhibitor that showed in vivo efficacy in an HCT116 BRCA2^-/- mouse tumor xenograft model. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Reference of 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Reference of 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem