Imidazoles-derivatives

Catalytic activity of styrene/divinylbenzene copolymeric support immobilized with imidazolium ionic liquids in disproportionation of trichlorosilane was written by Petukhov, A. N.;Vorotyntsev, A. V.;Razov, E. N.;Nyuchev, A.;Makarov, D. A.;Vorotyntsev, V. M.. And the article was included in Journal of Physics: Conference Series in 2018.Formula: C4H7ClN2 This article mentions the following:

For the first time, imidazolium chloride-based ionic liquids (namely 1-methylimidazolium chloride and 1-butyl-3-methylimidazolium chloride) immobilized into macroporous styrene-divinylbenzene copolymer support (5-25 weight% of ionic liquid) were studied as catalysts for trichlorosilane disproportionation in the gas phase in the 293 – 393 K temperature range. In the case of the catalyst containing 15 weight% of the ionic liquid the apparent energy of activation was found to be 67.44 K and the reaction rate constant was found to be 0.2 s^-1 at 393 K. This catalyst was found to be stable up to 408 K, further heating leads to thermal decomposition of the polymer matrix with chloroform as main gas product. The catalytic activity of the catalyst showed to be stable after 3 mo at 393 K. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Formula: C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formylation of 1-methylbenzimidazoles was written by Tertov, B. A.;Koblik, A. V.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1967.SDS of cas: 3012-80-4 This article mentions the following:

To 0.8 g. Na (activated with iso-amyl alc.) in 2.5 ml. HCONMe2 and 45 ml. C6H6, 4 g. 1-methylbenzimidazole was added and the whole stirred under N 1.5 hrs., 5 ml. AcOH in 20 ml. H2O added in one portion, and the mixture worked up to give 0.7 g. 1-methyl 2-formylbenzimidazole (I) m. 109-10°; oxime m. 215-16°. To obtain the Cu salt of 1-methylbenzimidazole-2-carboxylic acid a 5% solution of CuSO4 was added to the reaction mixture to which 80% EtOH was added instead of AcOH to destroy excess Na. From this, the free 1-methylbenzimidazole-2-carboxylic acid (II), m. 90-1°, was obtained. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4SDS of cas: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. SDS of cas: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Solution extraction of several lanthanides from nitric acid with isohexyl-BTP in [C_nmim][NTf₂] ionic liquid was written by Zhao, Long;Dong, Zhen;Ma, Guolong;Yuan, Weijin. And the article was included in Journal of Rare Earths in 2015.Product Details of 404001-48-5 This article mentions the following:

The extraction behavior of several lanthanides (La³⁺, Eu³⁺, Lu³⁺) from nitric acid (HNO₃) solution was studied using a novel extraction system based on 2,6-bis(5,6-dihexyl-1,2,4-triazin-3-yl) pyridine (isohexyl-BTP) as extractant in 1-alkyl-3-methylimidazolium bis(trifluoromethylsufonyl)imide ([C_nmim][NTf₂]) ionic liquid Isohexyl-BTP in ionic liquids exhibited remarkably better extraction performance for lanthanides than that in octanol-dodecane (3:7 volume/volume) system. Lower HNO₃ concentration and short alkyl chain length of [C_nmim]⁺ were more favorable for removal of lanthanides. Besides, it was confirmed that isohexyl-BTP in ILs formed a 1:3 complex [Ln(BTP)₃(NO₃)_n]^(3-n)+ (n=0, 1) by slope anal. In addition, [C₂mim][NTf₂] preferred to extract lanthanides via a cation exchange mechanism at lower acidity, which was proved via UV-Vis measurement. It was speculated that extraction mechanism shifted from cation exchange to neutral species extraction with increase in HNO₃ concentration and alkyl chain length of [C_nmim]⁺ due to the H⁺ completion, NO^–₃ inhibition and hydrophobicity of IL. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Product Details of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Product Details of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Asymmetric Synthesis of Heterocyclic Chloroamines and Aziridines by Enantioselective Protonation of Catalytically Generated Enamines was written by McLean, Liam A.;Ashford, Matthew W.;Fyfe, James W. B.;Slawin, Alexandra M. Z.;Leach, Andrew G.;Watson, Allan J. B.. And the article was included in Chemistry – A European Journal in 2022.Reference of 1632-83-3 This article mentions the following:

A method for the synthesis of chiral vicinal chloroamines RCH(Cl)CH₂NHR¹ [R = 2-quinolyl, quinazolin-2-yl, 1,3-benzothiazol-2-yl, etc.; R¹ = Ph, 4-MeC₆H₄, benzothiophen-5-yl, etc.] via asym. protonation of catalytically generated prochiral chloroenamines using chiral Bronsted acids was reported. The process was highly enantioselective, with the origin of asymmetry and catalyst substituent effects elucidated by DFT calculations The utility of the method showed as an approach to the synthesis of a broad range of heterocycle-substituted aziridines I [R² = 2-quinolyl, quinoxalin-2-yl, 5-cyano-2-pyridyl, etc.; Ar = Ph, 4-MeOC₆H₄, 3-BrC₆H₄, etc.] by treatment of the chloroamines with base in a one-pot process, as well as the utility of the process to allow access to vicinal diamines II [R³ = 4-tert-butoxycarbonylpiperazin-1-yl, morpholino, thiomorpholino]. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Reference of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of the Cation on the Interactions between Alkyl Methyl Imidazolium Chloride Ionic Liquids and Water was written by Khan, Imran;Taha, Mohamed;Ribeiro-Claro, Paulo;Pinho, Simao P.;Coutinho, Joao A. P.. And the article was included in Journal of Physical Chemistry B in 2014.COA of Formula: C4H7ClN2 This article mentions the following:

A systematic study of the interactions between water and alkyl Me imidazolium chloride ionic liquids at 298.2 K, based on activity coefficients estimated from water activity measurements in the entire solubility range, is presented. The results show that the activity coefficients of water in the studied ILs are controlled by the hydrophilicity of the cation and the cation-anion interaction. To achieve a deeper understanding on the interactions between water and the ILs, COSMO-RS and FTIR spectroscopy were also applied. COSMO-RS was used to predict the activity coefficient of water in the studied ionic liquids along with the excess enthalpies, suggesting the formation of complexes between three mols. of water and one IL mol. On the basis of quantum-chem. calculations, it is found that cation-anion interaction plays an important role upon the ability of the IL anion to interact with water. The changes in the peak positions/band areas of OH vibrational modes of water as a function of IL concentration were investigated, and the impact of the cation on the hydrogen-bonding network of water is identified and discussed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3COA of Formula: C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.COA of Formula: C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Density, Viscosity, and Conductivity of Lewis Acidic 1-Butyl- and 1-Hydrogen-3-methylimidazolium Chloroaluminate Ionic Liquids was written by Zheng, Yong;Dong, Kun;Wang, Qian;Zhang, Jianmin;Lu, Xingmei. And the article was included in Journal of Chemical & Engineering Data in 2013.Synthetic Route of C4H7ClN2 This article mentions the following:

To promote the development of Lewis acidic chloroaluminate ionic liquids, it is necessary to get a deeper insight into their physicochem. properties and mol. structure. In this work, the densities, viscosities, and conductivities of acidic 1-butyl- and 1-hydrogen-3-methylimidazolium chloroaluminate with different mole fractions of AlCl₃ were measured in the temperature range from (293.15 to 343.15) K. Meanwhile, excess molar volume and viscosity deviation values for the binary mixtures of 1-butyl-3-methylimidazolium chloroaluminate ionic liquids were also obtained. All of the exptl. data were well-fitted by the empirical equations. Based on the results of d. functional theory calculations, the differences in these properties are attributed to the mol. structure, cation-anion interaction, and hydrogen bonds of ionic liquids It is expected that the present study may be deemed useful for the application of Lewis acidic chloroaluminate ionic liquids in electrochem. and catalysis. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Synthetic Route of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Synthetic Route of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Efficient and convenient oxidation of sulfides to sulfones using H₂O₂ catalyzed by V₂O₅ in ionic liquid [C₁₂mim][HSO₄] was written by Hu, Yu-Lin;Liu, Xiao-Bing;Fang, Dong. And the article was included in Catalysis Science & Technology in 2014.Electric Literature of C18H31F6N3O4S2 This article mentions the following:

A simple, efficient, and eco-friendly procedure for the oxidation of sulfides to sulfones using H₂O₂ catalyzed by V₂O₅ in ionic liquid [C₁₂mim][HSO₄] has been developed. This atom-economical protocol affords the target products in good to high yields. The products can be separated by a simple extraction with organic solvent, and the catalytic system can be recycled and reused without loss of catalytic activity. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Electric Literature of C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Product control by halide ions of ionic liquids in the ionothermal syntheses of Ni-(H)BTC metal-organic frameworks was written by Xu, Ling;Yan, Shihai;Choi, Eun-Young;Lee, Jin Yong;Kwon, Young-Uk. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2009.Quality Control of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Ni(OAc)₂-H₃BTC (1,3,5-benzenetricarboxylic acid) system in various imidazolium ionic liquids, [RMI]X (R = Et, Pr, n-butyl; X = Cl, Br, I), produced five MOFs in two structure types; [RMI]₂[Ni₃(BTC)₂(OAc)₂] and [RMI]₂[Ni₃(HBTC)₄(H₂O)₂][RMI]₂. Their relative thermodn. stability varies with the cation size of RMI⁺, and the X^– ions govern the kinetic factors so that their combination effects determine the final product. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Quality Control of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Quality Control of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of 5-fluorouracil, ftorafur and imidazolecarboxamide on the kinetics of the primary immune response in mice was written by Matveev, A. B.;Kudryashov, V. M.. And the article was included in Farmakologiya i Toksikologiya (Moscow) in 1981.SDS of cas: 26832-08-6 This article mentions the following:

Treatment of mice with 5-fluorouracil [51-21-8], ftorafur [17902-23-7], or imidazolecarboxamide [26832-08-6] at 48 or 72 h following immunization with sheep erythrocytes caused an oscillatory-type of response in splenic antibody-forming cells. Each pattern of increases-decreases lasted 8-16 h. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6SDS of cas: 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formulation and development of candesartan cilexetil fast dissolving tablets by sublimation technique was written by Priya, Hunashal Sarah;Patil, Basawaraj S.;Jeevanagi, Ravindra S.. And the article was included in American Journal of PharmTech Research in 2019.Reference of 145040-37-5 This article mentions the following:

Candesartan cilexetil is a prodrug of candesartan – a compound that inhibits binding of angiotensin II to the AT1 – receptor. It is mainly used in the treatment of hypertension. In the present work attempts were mase to prepare fast dissolving tablets of candesartan cilexetil by sublimation technique. The prepared formulations were evaluated for pre-compressional and postcompressional parameters. The compatibility of drug with other ingredients was checked by FTIR studies, these results revealed that there was no interaction between dug and other excipients. The values of pre-compressional parameters were within prescribed limits and indicated good free flowing properties. In all the formulations the hardness test indicates good mech. strength. Friability of all formulations was less than 1. Drug content was found to be high (≥ 100.27%) and uniform in all the formulations. The tablet thickness was found to be 3.14 – 3.47. The weight variation results revealed that average percentage deviation was less then ± 7.5%, which provides good uniformity in all formulations. The disintegration time of the tablets decreased significantly with increase in the concentration of subliming agent. The formulations CSC3, CSM3, CSA3, and CSU3 50% of drug released in 1.38, 2.55, 4.00 and 3.57 min, and 90% of drug released in 3.39, 6.04, 7.50 and 7.18 min. The formulation CS (control) released 42.16% in 60 min. Stability study carried out as per ICH guidelines for three months and results revealed that upon storage disintegration time of tablets decreased significantly (p<0.05). The results concluded that by adopting a systemic formulation approach, an optimum point could be reached in the shortest time with min. efforts. Sublimation technique would be an effective alternative approach compared with the use of more expensive adjuvants in the formulations of fast dissolving tablets. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Reference of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem