Tag: 100-200

On May 5, 2022, Slassi, Siham; Aarjane, Mohammed; Amine, Amina published an article.Synthetic Route of 5036-48-6 The title of the article was Synthesis, spectroscopic characterization (FT-IR, NMR, UV-Vis), DFT study, antibacterial and antioxidant in-vitro investigations of 4,6-bis((E)-1-((3-(1H-imidazol-1-yl)propyl)imino)ethyl)benzene-1,3-diol. And the article contained the following:

A new bis-Schiff base, I derived from N-(3-aminopropyl)imidazole and 4,6-diacetylresorcinol was obtained. The bis Schiff base I was characterized through mass spectrometry, elemental anal., IR, UV-Vis, 1H and 13C NMR spectroscopy. The B3LYP method was used to calculate the optimized structure of the mol. through d. functional of theory (DFT) using the 6-31G (d, p) basis set. The 1H and 13C NMR chem. shifts with respect to TMS were calculated using the (GIAO) method in DMSO-d6 and compared with the exptl. data. In addition, the frontier MOs, electronic properties and the mol. electrostatic potential (MEP) of RS were investigated using DFT calculations The compound showed significant antibacterial activity against Staphylococcus aureus. The DPPH free radical scavenging assay was used to evaluate the antioxidant activity. The effective concentration (EC50) showed that the compound has a good antioxidant activity. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to bis imidazolyl propyl imino ethyl benzenediol preparation schiff base, antibacterial antioxidant surface electrostatic potential, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 1984, Middleton, Richard W.; Monney, Hugh; Parrick, John published an article.Electric Literature of 5709-67-1 The title of the article was N-Methylation of heterocycles with dimethylformamide dimethyl acetal. And the article contained the following:

Benzimidazoles I (R = H, CF3), II (R1 = H, Me), and III (R2 = H, Me) were prepared 4,7-Dimethoxybenzimidazole was heated with HC(OMe)2NMe2 in PhMe to give I (R = H). 4,7-Dimethoxybenzimidazoline-2-thione gave III (R2 = H) and III (R2 = Me). The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Electric Literature of 5709-67-1

The Article related to methylbenzimidazole, methylation benzimidazole dmf methyl acetal, benzimidazolinone methylation dmf methyl acetal, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Electric Literature of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 31, 1997, Kang, Seok Ho; Kim, Jaheon; Kim, Jinho; Hahn, Jong Hoon; Kim, Kimoon published an article.Synthetic Route of 5709-67-1 The title of the article was Syntheses, x-ray structures and second harmonic generation efficiencies of fused ring heterocycles. And the article contained the following:

Second harmonic generation efficiencies of a number of fused ring heterocyclic compounds bearing a nitro group were measured using the Kurtz powder method. Among them, 5-nitroindole has the highest SHG efficiency, 20 times as high as that of urea reference Several 5-nitroindole derivatives were synthesized in the hope of improving the SHG efficiency. None of the derivatives, however, exhibited higher SHG efficiency than the mother compound X-ray crystal structures of some of these compounds as well as that of 5-nitroindole itself were determined In the crystal structure of 5-nitroindole the angle (θ) between the mol. charge transfer axis and the polar axis of the crystal is 52.72°, which is close to the optimum value 54.74° predicted by theory. On the other hand, crystal structures of 1,2-dimethyl-5-nitroindole and 1-ethyl-5-nitroindole revealed θ values far from the optimum one, which is consistent with their low SHG efficiencies. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Synthetic Route of 5709-67-1

The Article related to fused heterocycle preparation crystal mol structure, second harmonic generation efficiency fused heterocycle, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Synthetic Route of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gupta, Rajender P.; Larroquette, Cynthia A.; Agrawal, Krishna C. published an article in 1982, the title of the article was Potential radiosensitizing agents. 5. 2-Substituted benzimidazole derivatives.Recommanded Product: 5709-67-1 And the article contains the following content:

Benzimidazoles I [R = CH2CH(OH)CH2OMe, CH2CO2Et; R1 = CONH2, Ac, CF3, CN, SO2Me, NO2; R2, R3 = H, NO2] were prepared, e.g., by alkylation of I (R = H) with 1,2-epoxy-3-methoxypropane in the presence of K2CO3. Reaction of I (R1 = NO2, SO2Me) with the epoxide also yielded a benzimidazo[2,1-b]oxazole derivative I (R1 = NO2) showed the highest radiosensitizing activity against Chinese hamster cells (V-79) in culture. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Recommanded Product: 5709-67-1

The Article related to benzimidazole nitro preparation radiosensitizer, radiosensitizer nitrobenzimidazole derivative, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Recommanded Product: 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 28, 1992, Li, M. J.; Li, S. Z.; Zhuang, X. L.; Chen, A.; Zhang, H. Q.; Pang, X. C.; Hu, B. published an article.Application of 5709-67-1 The title of the article was Synthesis and radiosensitizing activity of benzimidazoles. And the article contained the following:

Reaction of 2-nitrobenzimidazole with Et chloroformate yielded Et (2-nitrobenzimidazol-1-yl)formate or Et (2-hydroxybenzimidazol-1-yl)formate, depending upon the solvents used. Reaction of 2-nitrobenzimidazole with 1,2-epoxy-3-chloropropane gave a cyclized compound I. In an attempt to increase hydrophilicity, 1-substituted 2-(3′-pyridyl)-5-nitrobenzimidazoles were prepared by reaction of 2-(3′-pyridyl)-5(6)-nitrobenzimidazole with alkyl epoxides or Et chloroacetate. Some of the compounds synthesized were tested for radiosensitizing activity in Ehrlich ascites carcinoma-bearing mice. Preliminary results showed that some compounds have radiosensitizing activity. The radiosensitizing enhancement ratio (SER) of compounds I and II (R = H, Me) were 1.50, 1.52 and 1.65 resp. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Application of 5709-67-1

The Article related to benzimidazole preparation radiosensitizer, nitrobenzimidazole preparation radiosensitizer, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 13, 2019, Aspnes, Gary Erik; Bagley, Scott W.; Curto, John M.; Edmonds, David James; Flanagan, Mark E.; Futatsugi, Kentaro; Griffith, David A.; Huard, Kim; Lian, Yajing; Limberakis, Chris; Londregan, Allyn T.; Mathiowetz, Alan M.; Piotrowski, David W.; Riggeri, Roger B. published a patent.Category: imidazoles-derivatives The title of the patent was Preparation of 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists for the treatment of diseases. And the patent contained the following:

Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof. The example compound (I) was prepared by multistep synthesis (procedure given). The compounds of the invention were evaluated for their biol. activity (data given). The compounds of the invention can be used in treatment of diseases, such as NASH, diabetes, obesity and like. The experimental process involved the reaction of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride(cas: 1255717-13-5).Category: imidazoles-derivatives

The Article related to benzimidazole carboxylic acid salt preparation glp1r agonist disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 25, 2021, Forrest, Michael D. published a patent.Related Products of 50743-01-6 The title of the patent was Therapeutic modifiers of the reverse mode of ATP synthase for treating diseases. And the patent contained the following:

Compounds that slow the ATP-hydrolyzing mode of ATP synthase are useful for treating various diseases and disorders including cancer, particularly cancers that utilize the Warburg effect. The experimental process involved the reaction of 5-Bromo-1H-imidazole-4-carbaldehyde(cas: 50743-01-6).Related Products of 50743-01-6

The Article related to atp synthase reverse mode modifier disease treatment, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Related Products of 50743-01-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 1, 2020, Hilton-Proctor, J. P.; Ilyichova, O.; Zheng, Z.; Jennings, I. G.; Johnstone, R. W.; Shortt, J.; Mountford, S. J.; Scanlon, M. J.; Thompson, P. E. published an article.Formula: C6H11N3 The title of the article was Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors. And the article contained the following:

The synthesis of a 4-Ph substituted analog – 1-methyl-4-phenylpyrrolidin-2-one – and the use of aryl substitution reactions as a divergent route for derivatives I (R = H, Br, Ph, 2-phenylethyl, etc.; R1 = 2-Br, 4-Ph, morpholine-4-sulfonyl, etc.) were described. Ultimately, this has led to structurally complex, chiral compounds (R/S)-II (R2 = H, Me; R3 = H, 3,4-dimethoxyphenyl; R4 = H, N,N-diethylsulfamoyl) with progressively improved affinity as inhibitors of bromodomain-containing protein 4. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Formula: C6H11N3

The Article related to methyl phenylpyrrolidinone preparation bromodomain inhibitor, brd4, bromodomain, epigenetics, fragment-based drug design, k-ac, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.Formula: C6H11N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 10, 2010, Kent, Perry; Nguyen, Truong published a patent.Related Products of 5709-67-1 The title of the patent was High temperature thermal cutoff device. And the patent contained the following:

The present disclosure provides high temperature thermal cutoff devices having a high-temperature thermal pellet with a transition temperature of greater than or equal to ∼240° and comprising at least one organic compound The pellet is disposed in a housing, which is sealed with a high-temperature seal that provides substantial sealing up to at least the transition temperature The high-temperature TCO also has a current interruption assembly, which establishes elec. continuity in a 1st operating condition corresponding to an operating temperature of less than said transition temperature and discontinues elec. continuity when the operating temperature exceeds the transition temperature Methods of making such high-temperature thermal cut off devices are also provided. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Related Products of 5709-67-1

The Article related to thermal cutoff device high temperature organic compound, tco, Electric Phenomena: Conductors, Semiconductors, Resistors, Contacts and other aspects.Related Products of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 31, 1982, Rastogi, Rashmi; Sharma, Satyavan published an article.Computed Properties of 5709-67-1 The title of the article was Synthesis of 2-substituted benzofurans as potential anthelmintics. And the article contained the following:

Thirteen title compounds, e.g. I (R = 2-O2NC6H4, 2-H2NC6H4, 2-benzimidazolyl) and II (X = NH, S), were prepared starting from 2-benzofurancarbonyl chloride. The title compounds were tested as anthelmintics, bactericides, and fungicides and found to be inactive. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Computed Properties of 5709-67-1

The Article related to benzofuran substituted preparation anthelmintic, bactericide substituted benzofuran, fungicide substituted benzofuran, benzimidazolylbenzofuran, benzothiazolylbenzofuran, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Computed Properties of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem