Tag: 100-200

He, Liting; Xiong, Kai; Wang, Lili; Guan, Ruilin; Chen, Yu; Ji, Liangnian; Chao, Hui published an article in 2021, the title of the article was Iridium(III) complexes as mitochondrial topoisomerase inhibitors against cisplatin-resistant cancer cells.Formula: C6H11N3 And the article contains the following content:

Herein, we developed the first metal-based mitochondrial topoisomerase inhibitors to achieve an effective therapeutic outcome for the therapy of cisplatin-resistant tumor cells. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Formula: C6H11N3

The Article related to iridium complex mitochondrial topoisomerase inhibitor cisplatin resistant tumor cell, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Formula: C6H11N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 15, 2011, Lingaraju, Gondichatnahalli M.; Davis, C. Ainsley; Setser, Jeremy W.; Samson, Leona D.; Drennan, Catherine L. published an article.Reference of Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was Structural Basis for the Inhibition of Human Alkyladenine DNA Glycosylase (AAG) by 3,N4-Ethenocytosine-containing DNA. And the article contained the following:

Reactive oxygen and nitrogen species, generated by neutrophils and macrophages in chronically inflamed tissues, readily damage DNA, producing a variety of potentially genotoxic etheno base lesions; such inflammation-related DNA damage is now known to contribute to carcinogenesis. Although the human alkyladenine DNA glycosylase (AAG) can specifically bind DNA containing either 1,N6-ethenoadenine (εA) lesions or 3,N4-ethenocytosine (εC) lesions, it can only excise εA lesions. AAG binds very tightly to DNA containing εC lesions, forming an abortive protein-DNA complex; such binding not only shields εC from repair by other enzymes but also inhibits AAG from acting on other DNA lesions. To understand the structural basis for inhibition, we have characterized the binding of AAG to DNA containing εC lesions and have solved a crystal structure of AAG bound to a DNA duplex containing the εC lesion. This study provides the first structure of a DNA glycosylase in complex with an inhibitory base lesion that is induced endogenously and that is also induced upon exposure to environmental agents such as vinyl chloride. We identify the primary cause of inhibition as a failure to activate the nucleotide base as an efficient leaving group and demonstrate that the higher binding affinity of AAG for εC vs. εA is achieved through formation of an addnl. hydrogen bond between Asn-169 in the active site pocket and the O2 of εC. This structure provides the basis for the design of AAG inhibitors currently being sought as an adjuvant for cancer chemotherapy. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Reference of Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to antitumor design ethenocytosine alkyladenine dna glycosylase inhibitor, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Reference of Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Klapoetke, Thomas M.; Preimesser, Andreas; Stierstorfer, Joerg published an article in 2015, the title of the article was Energetic Derivatives of 2-Nitrimino-5,6-dinitro-benzimidazole.Application of 5709-67-1 And the article contains the following content:

2-Nitrimino-5,6-dinitrobenzimidazole (1) was synthesized by nitration of 2-aminobenzimidazole at ambient temperature in good yield. In order to explore new insensitive explosives four energetic nitrogen-rich 1:1 salts such as the guanidinium (1a), aminoguanidinium (1b), triaminoguanidinium (1c) and hydroxylammonium (1d) were synthesized either by facile acid/base or in situ metathesis reaction. In addition 2-nitrobenzimidazole (2) was synthesized by the reaction of 2-aminobenzimidazole using potassium hyperoxide in THF. Different nitration methods were tested to obtain a theor. 2,4,5,6,7-pentanitrobenzimidazole but only the already known 4,5,6,7-tetranitrobenzimidazol-2-one (3) could be isolated. All synthesized compounds were characterized especially by low temperature X-ray diffraction, CHN elemental anal. and 1H and 13C NMR spectroscopy. The heat of formation of all new synthesized compounds was calculated using CBS-4M electronic enthalpies in combination with the atomization method to calculate their detonation parameters with the EXPLO 5 V5.05 computer code. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Application of 5709-67-1

The Article related to nitrimino dinitro benzimidazole energetic derivative, Propellants and Explosives: Explosives, Ignitors, and Detonators and other aspects.Application of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 21, 2019, Yang, Wenjin; Chang, Kai-Wei; Liu, Suying; Tsai, Cheng-Han published a patent.Reference of 5-Bromo-1H-imidazole-4-carbaldehyde The title of the patent was Preparation of imidazolidines as matrix metalloproteinase (MMP) inhibitors useful in treatment of diseases. And the patent contained the following:

The invention relates to preparation of hydantoin-based compounds (I) useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Compounds I wherein ring B is (un)substituted aryl or heteroaryl; ring C is aryl or heteroaryl; ring D is aryl or heteroaryl; each X, Y, and Z each independently is O, CH2, NH, etc.; R1 is H or alkyl; R2 is H, halo, OH, etc.; R3 is H, halo, alkyl, etc.; R4 is H or alkyl; R5 is H; m is 1-4; n is 1-5, are claimed. The example compound II was prepared by a synthetic procedure from the intermediate compound(also prepared) (procedure given). Compounds I were evaluated for their biol. activities including selective MMP inhibiting activity (data given). Compounds I and related compositions are selective inhibitors of MMP-12 and can be used in treatment of diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis. The experimental process involved the reaction of 5-Bromo-1H-imidazole-4-carbaldehyde(cas: 50743-01-6).Reference of 5-Bromo-1H-imidazole-4-carbaldehyde

The Article related to imidazolidine preparation selective mmp inhibitor disease treatment, hydantoin preparation selective macrophage elastase mmp12 inhibitor disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 5-Bromo-1H-imidazole-4-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Muljana, Henky; Remerie, Klaas; Boven, Gert; Picchioni, Francesco; Bose, Ranjita K. published an article in 2022, the title of the article was Crosslinking of Polypropylene with Thiophene and Imidazole.Safety of N-(3-Aminopropyl)-imidazole And the article contains the following content:

In this work, two novel routes to synthesis crosslinked polypropylene (PP) are introduced by using two different precursors (2-thiophenemethyl amine (TMA) and 1-(3 aminopropyl) imidazole (API)), both crosslinked with 1,1′-(methylenedi-4,1-phenylene) bismaleimide (BM) at two different annealing temperature values (T = 50°C and T = 150°C). Both Diels-Alder (DA) and Michael addition reactions were successfully performed with TMA and API, resp., albeit with different reactivity. Imidazole clearly shows a higher reactivity compared to thiophene. In addition, an increase in annealing temperature leads to a higher degree of crosslinking. The highest degree of crosslinking was obtained by the imidazole product after annealing at 150°C (IMG1A150) as evident from the highest complex viscosity (η*) value of IMG1A150. A difference in rheol. and thermal properties between the imidazole and thiophene crosslinked products was also observed However, both products have superior melt properties and thermal stability compared with the starting material. They show processability at high temperatures The melt flow behavior and de-crosslinking at higher temperatures can be tuned depending on the choice of imidazole or thiophene. This study shows an advance on the crosslinked PP processing and its product performances for further application on the com. scale. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to polypropylene thiophene imidazole crosslinking, diels–alder, cross-linked, imidazole-bismaleimide, polypropylene, thermo-reversible, thiophene-bismaleimide, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 14, 2021, Yang, Rui; Dai, Pei; Zhang, Shu; Xu, Ri-Wei; Hong, Song; Lin, Wen-Feng; Wu, Yi-Xian published an article.Product Details of 5036-48-6 The title of the article was In-situ synthesis of cross-linked imidazolium functionalized Poly(styrene-b-isobutylene-b-styrene) for anion exchange membranes. And the article contained the following:

The crosslinked imidazolium functionalized anion-exchange membranes is in-situ prepared via reaction of chloromethylated poly(styrene-b-isobutylene-b-styrene) with 1,1′-(1,6-hexanediyl)bisimidazole and N-methylimidazole. The composite membranes of cross-linked imidazolium poly(styrene-b-isobutylene-b-styrene) with a small amount of modified graphene oxide grafted with octadecyl and Pr Ph imidazolium could be further prepared These membranes exhibit significantly high chem. stability and ionic conductivity (σ), marked by low methanol permeability, together with improved dynamic mech. properties. The ionic conductivity of crosslinked imidazolium poly(styrene-b-isobutylene-b-styrene) reaches 2.09 x 10-2 S cm-1 at 80°C by introduction of 0.5 wt% loading of modified graphene oxide. This membrane also behaves an excellent chem. stability and σ can remain ca. 82% of the original value after immerged in strong alk. medium (2 M NaOH) at 60°C for 500 h, which is almost the same as that (ca. 82%) of com. Nafion 115 in acid medium (2 M H2SO4) at 60°C for 500 h. The cross-linked imidazolium poly(styrene-b-isobutylene-b-styrene) is characterized as a promising anion exchange membrane materials in fuel cell for its high ionic conductivity, chem. stability and low methanol permeability. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to crosslinked imidazolium functionalized polystyrene isobutylene triblock copolymer, anion exchange membrane, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 19, 2022, Santa Chalarca, Cristiam F.; Dalal, Rishad J.; Chapa, Alejandra; Hanson, Mckenna G.; Reineke, Therefsa M. published an article.Electric Literature of 5036-48-6 The title of the article was Cation Bulk and pKa Modulate Diblock Polymer Micelle Binding to pDNA. And the article contained the following:

Polymer-based gene delivery relies on the binding, protection, and final release of nucleic acid cargo using polycations. Engineering polymeric vectors, by exploring novel topologies and cationic moieties, is a promising avenue to improve their performance, which hinges on the development of simple synthetic methods that allow facile preparation In this work, we focus on cationic micelles formed from block polymers, which are examined as promising gene compaction agents and carriers. In this study, we report the synthesis and assembly of six amphiphilic poly(Bu acrylate)-b-poly(cationic acrylamide) diblock polymers with different types of cationic groups ((dialkyl)amine, morpholine, or imidazole) in their hydrophilic corona. The polycations were obtained through the parallel postpolymn. modification of a poly(Bu acrylate)-b-poly(pentafluorophenyl acrylate) reactive scaffold, which granted diblock polymers with equivalent ds.p. and subsequent quant. functionalization with cations of different pKa. Ultrasound-assisted direct dissolution of the polycations in different aqueous buffers (pH = 1-7) afforded micellar structures with low size dispersities and hydrodynamic radii below 100 nm. The formation and properties of micelle-DNA complexes (“micelleplexes”) were explored via DLS, zeta potential, and dye-exclusion assays revealing that binding is influenced by the cation type present in the micelle corona where bulkiness and pKa are the drivers of micelleplex formation. Combining parallel synthesis strategies with simple direct dissolution formulation opens opportunities to optimize and expand the range of micelle delivery vehicles available by facile tuning of the composition of the cationic micelle corona. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Electric Literature of 5036-48-6

The Article related to diblock fluoropolymer raft polymerization cationic micelle pdna complex polyplex, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.Electric Literature of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 5, 2022, Das, Mithun; Baran Bhattacharya, Asit; Rahman Parathodika, Arshad; Naskar, Kinsuk published an article.Synthetic Route of 5036-48-6 The title of the article was Room temperature Self-healable and extremely stretchable elastomer with improved mechanical Properties: Exploring a simplistic Metal-Ligand interaction. And the article contained the following:

The dynamic supramol. crosslinking reactions like imine bond formation, disulfide metathesis reactions, Diels Alder reactions, metal-ligand interactions, H-bonding, and ionic interactions are broadly used for the self-healing application of elastomers. Herein, we have developed a new self-healable and extremely stretchable elastomer based on robustness and dynamic metal-ligand coordination bonds between the API ligand and the Zn2+ metal ion moieties incorporated onto the XNBR rubber backbone. The FT-IR anal. confirmed the formation of amide linkage and metal-ligand coordination bonds into the XNBR rubber backbone. The healing performance and mech. properties of various rubber compounds depend on the dosages of metal ions and the type of crosslinking systems. The metal-ligand crosslink compounds exhibit excellent healing performance over the sulfur crosslinking system. Differential scanning calorimetry, rubber process analyzer, crosslinking d., and morphol. studies are indicated to characterize the metal-ligand interactions in the XNBR rubber matrix. The metal-ligand crosslinked XNBR rubber with 3 parts of Zn2+ metal ion demonstrates an excellent healing performance of 91.2%, with the tensile strength of 5.7±0.8 MPa at room temperature for 24 h is much higher than the covalently crosslinked elastomers. The metal-ligand coordination bonds are entirely dynamic and thermoreversible during the rebuilding process and obtain an excellent self-healing property than the sulfur curing system. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to carboxylated nitrile rubber metal ligand interaction self healing, Synthetic Elastomers and Natural Rubber: Physical Properties and Testing and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wei, Wei; Liu, Chao; Wang, Meng; Jiang, Wei; Wang, Caihong; Zhang, Shuqun published an article in 2022, the title of the article was Prognostic signature and tumor immune landscape of N7-methylguanosine-related lncRNAs in hepatocellular carcinoma.COA of Formula: C6H7N5 And the article contains the following content:

Despite great advances in the treatment of liver hepatocellular carcinoma (LIHC), such as immunotherapy, the prognosis remains extremely poor, and there is an urgent need to develop novel diagnostic and prognostic markers. Recently, RNA methylation-related long non-coding RNAs (lncRNAs) have been demonstrated to be novel potential biomarkers for tumor diagnosis and prognosis as well as immunotherapy response, such as N6- methyladenine (m6A) and 5-methylcytosine (m5C). N7-Methylguanosine (m7G) is a widespread RNA modification in eukaryotes, but the relationship between m7G-related lncRNAs and prognosis of LIHC patients as well as tumor immunotherapy response is still unknown. In this study, based on the LIHC patients’ clin. and transcriptomic data from TCGA database, a total of 992 m7G-related lncRNAs that co-expressed with 22 m7G regulatory genes were identified using Pearson correlation anal. Univariate regression anal. was used to screen prognostic m7G-related lncRNAs, and the least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression were applied to construct a 9-m7G-related-lncRNA risk model. The m7G-related lncRNA risk model was validated to exhibit good prognostic performance through Kaplan-Meier anal. and ROC anal. Together with the clinicopathol. features, the m7G-related lncRNA risk score was found to be an independent prognostic factor for LIHC. Furthermore, the high-risk group of LIHC patients was unveiled to have a higher tumor mutation burden (TMB), and their tumor microenvironment was more prone to the immunosuppressive state and exhibited a lower response rate to immunotherapy. In addition, 47 anti-cancer drugs were identified to exhibit a difference in drug sensitivity between the high-risk and low-risk groups. Taken together, the m7G-related lncRNA risk model might display potential value in predicting prognosis, immunotherapy response, and drug sensitivity in LIHC patients. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).COA of Formula: C6H7N5

The Article related to n methylguanosine lncrna hepatocellular carcinoma prognosis tumor immunity, lihc, immune response, lncrna, m7g methylation, prognostic model, Immunochemistry: Other (Immunity, Immune Suppression, Tolerance, etc.) and other aspects.COA of Formula: C6H7N5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 1, 2003, Hardeland, Ulrike; Bentele, Marc; Jiricny, Josef; Schaer, Primo published an article.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs. And the article contained the following:

Human thymine-DNA glycosylase (TDG) is well known to excise thymine and uracil from G·T and G·U mismatches, resp., and was therefore proposed to play a central role in the cellular defense against genetic mutation through spontaneous deamination of 5-methylcytosine and cytosine. In this study, we characterized two newly discovered orthologs of TDG, the Drosophila melanogaster Thd1p and the Schizosaccharomyces pombe Thp1p proteins, with an objective to address the function of this subfamily of uracil-DNA glycosylases from an evolutionary perspective. A systematic biochem. comparison of both enzymes with human TDG revealed a number of biol. significant facts. (i) All eukaryotic TDG orthologs have broad and species-specific substrate spectra that include a variety of damaged pyrimidine and purine bases; (ii) the common most efficiently processed substrates of all are uracil and 3,N4-ethenocytosine opposite guanine and 5-fluorouracil in any double-stranded DNA context; (iii) 5-methylcytosine and thymine derivatives are processed with an appreciable efficiency only by the human and the Drosophila enzymes; (iv) none of the proteins is able to hydrolyze a non-damaged 5′-methylcytosine opposite G; and (v) the double strand and mismatch dependency of the enzymes varies with the substrate and is not a stringent feature of this subfamily of DNA glycosylases. These findings advance our current view on the role of TDG proteins and document that they have evolved with high structural flexibility to counter a broad range of DNA base damage in accordance with the specific needs of individual species. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Name: Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to uracil thymine dna glycosylase human drosophila fission yeast, schizosaccharomyces uracil dna glycosylase, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem