Tag: 100-200

On September 30, 1983, Kashik, T. V.; Ponomareva, S. M.; Abramova, N. D.; Skvortsova, G. G. published an article.Computed Properties of 5709-67-1 The title of the article was Effect of meso-substituents on NH-acidity of benzimidazoles. And the article contained the following:

The pK2 values of I (R = Me, Et, H, Ph, OEt, COMe, SMe, SCH:CH2, Cl, NO2) decreased in the order stated, ranging from 26.43 to 18.75 in MeCN at 20°. A linear correlation with σm constants of R was obtained, and the following 2-parameter equation was obtained: pKa = 25.58-9.83σI – 3.86σC, where σI and σC are inductive and conjugation substituent constants The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Computed Properties of 5709-67-1

The Article related to benzimidazole acidity lfer, Physical Organic Chemistry: Acid-Base, Tautomerism, and Other Equilibrium Studies and other aspects.Computed Properties of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 31, 2021, AlNeyadi, Shaikha S.; Adem, Abdu; Amer, Naheed; Ghattas, Mohammad A.; Atatreh, Noor; Salem, Alaa A.; Abdou, Ibrahim M. published an article.COA of Formula: C6H11N3 The title of the article was Activation of the GLP-1 receptor by chloropyrimidine derivatives. And the article contained the following:

The anti-diabetic activities of a series of chloropyrimidine derviativeswere investigated after they were designed, synthesized, and docked against the GLP-1 receptor target. In comparison to exenatide, which was utilized as a reference drug, the three chloropyrimidine synthesized compounds I, II and III exhibited potent in vitro and in vivo antidiabetic activities. Interestingly, compounds I, II and III showed to be the most effective in lowering blood glucose levels and led to even higher glucose uptake than the reference drug, exenatide. Consistent with the in vitro and in vivo data, compounds II and III had the lowest docking energy scores (Glide-XP score = 5.1 kcal/mol) and the greatest ligand efficiency score (> – 0.40 kcal/mol) among all docked compounds These findings give up new possibilities for the development of high-efficacy compounds to treat hyperglycemia. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).COA of Formula: C6H11N3

The Article related to alkylated chloropyrimidine prpen antidiabetic sar mol docking glp receptor, aliphatic and aromatic amine nucleophilic substitution, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.COA of Formula: C6H11N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 7, 2015, Jansa, Josef; Lycka, Antonin; Ruzicka, Ales; Grepl, Martin; Vanecek, Jan published an article.Quality Control of Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was Synthesis, structure and rearrangement of iodinated imidazo[1,2-c]pyrimidine-5(6H)-ones derived from cytosine. And the article contained the following:

We describe mild and selective iodination of various 8-substituted imidazo[1,2-c]pyrimidine-5(6H)-ones (ethenocytosines). Starting ethenocytosines were obtained by cyclization of 5-halogenocytosines with chloroacetaldehyde or by subsequent Suzuki-Miyaura cross-coupling between 8-iodoimidazo[1,2-c]pyrimidine-5(6H)-one 1d and corresponding arylboronic acids. When imidazo[1,2-c]pyrimidine-5(6H)-one or 8-iodoimidazo[1,2-c]pyrimidine-5(6H)-one 1d was iodinated by N-iodosuccinimide (NIS) in DMF, pure 3,8-diiododerivative 2d was obtained. Under basic or acidic conditions, this mol. is subject to rearrangement into 2,8-diododerivative 3d, which can be subsequently iodinated to 2,3,8-triododerivative 4d. Since the positions of iodine atoms on the imidazole ring could not be determined convincingly from NMR spectra only, x-ray anal. of 2d was carried out with the aim of confirming the structure undoubtedly. The same sequence of reactions was applied to another eight ethenocytosines, providing excellent regioselectivity, easy rearrangement and high yields of iodinated products. All ethenocytosines were properly characterized by 1H, 13C and 15N NMR spectroscopy. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Quality Control of Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to cytosine cyclization suzuki miyaura coupling iodination dimroth rearrangement, iodinated imidazopyrimidine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yanai, Mitsuji; Takeda, Shigeko; Baba, Tsuyomi; Kitagawa, Koichi published an article in 1974, the title of the article was Heterocyclic compounds. XVIII. Synthesis of imidazo[1,2-c]- and pyrimido[1,2-c]pyrimidine derivatives.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one And the article contains the following content:

Reaction of the amino alcs. H2N(CH2)nOH (n = 2,3) and HN(CH2CH2OH)2 with the chloropyrimidines I (R = H, Me) and 4,6-dichloropyrimidine nII) gave the 4-substituted derivatives which, when treated with SOCl2 in THF, cyclized to give III, IV (R1 = H, Cl), V (R2 = H, Me, Cl; R3 = H, CH2CH2Cl), and VI. Treatment of V (R2 = Cl, R3 = CH2CH2Cl) with mild alk. solution gave the imidazolidines VII (R4 = H, CHO). Treatment of I and II with the amino acetal H2NCH2CH(OEt)2 gave the 4-(2,2-diethoxyethylamino) derivatives, which when treated with 6N HCl followed by concentrated H2SO4 gave III (R1 = H) and VIII resp. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Name: Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to imidazopyrimidine, pyrimidopyrimidine, amino alc chloropyrimidine cyclization, alc acetal chloropyrimidine cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 15, 2012, Lin, Hong; Erhard, Karl; Hardwicke, Mary Ann; Luengo, Juan I.; Mack, James F.; McSurdy-Freed, Jeanelle; Plant, Ramona; Raha, Kaushik; Rominger, Cynthia M.; Sanchez, Robert M.; Schaber, Michael D.; Schulz, Mark J.; Spengler, Michael D.; Tedesco, Rosanna; Xie, Ren; Zeng, Jin J.; Rivero, Ralph A. published an article.Quality Control of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one The title of the article was Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors. And the article contained the following:

A series of PI3K-beta selective inhibitors, imidazo[1,2-a]-pyrimidin-5(1H)-ones, has been rationally designed based on the docking model of the more potent R enantiomer of TGX-221, identified by a chiral separation, in a PI3K-beta homol. model. Synthesis and SAR of this novel chemotype are described. Several compounds in the series demonstrated potent growth inhibition in a PTEN-deficient breast cancer cell line MDA-MB-468 under anchorage independent conditions. The experimental process involved the reaction of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one(cas: 57473-33-3).Quality Control of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one

The Article related to phosphatidylinositol kinase isoform inhibitor imidazopyrimidinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

O’Harra, Kathryn E.; Noll, Danielle M.; Kammakakam, Irshad; DeVriese, Emily M.; Solis, Gala; Jackson, Enrique M.; Bara, Jason E. published an article in 2020, the title of the article was Designing imidazolium poly(amide-amide) and poly(amide-imide) ionenes and their interactions with mono- and tris(imidazolium) ionic liquids.Computed Properties of 5036-48-6 And the article contains the following content:

Here we introduce the synthesis and thermal properties of a series of sophisticated imidazolium ionenes with alternating amide-amide or amide-imide backbone functionality, and investigate the structural effects of mono(imidazolium) and unprecedented tris(imidazolium) ionic liquids (ILs) in these ionenes. The new set of poly(amide-amide) (PAA) and poly(amide-imide) (PAI) ionenes represent the intersection of conventional high-performance polymers with the ionene archetype-presenting polymers with alternating functional and ionic elements precisely sequenced along the backbone. The effects of polymer composition on the thermal properties and morphol. were analyzed. Five distinct polymer backbones were synthesized and combined with a stoichiometric equivalent of the IL 1-benzyl-3-methylimidazolium bistriflimide ([Bnmim][Tf2N]), which were studied to probe the self-assembly, structuring, and contributions of intermol. forces when IL is added. Furthermore, three polyamide (PA) or polyimide (PI) ionenes with simpler xylyl linkages were interfaced with [Bnmim][Tf2N] as well as a novel amide-linked tris(imidazolium) IL, to demonstrate the structural changes imparted by the inclusion of functional, ionic additives dispersed within the ionene matrix. This work highlights the possibilities for utilizing concepts from small mols. which exhibit supramol. self-assembly to guide creative design and manipulate the structuring of ionenes. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Computed Properties of 5036-48-6

The Article related to imidazolium polyamide amide imide ionene ionic liquid, composites, copolymers, ionenes, polyamides, polyelectrolytes, polyimides, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.Computed Properties of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 3, 2021, Cao, Jianhua; Su, Xuehui; Li, Chenghui; Cheng, Youwen; Liu, Saisai; Zhao, Yani; Song, Xiaodong published a patent.Category: imidazoles-derivatives The title of the patent was Metal complex with high luminous efficiency and application in organic electroluminescent device. And the patent contained the following:

An easy metal complex having deep red electroluminescence, high luminous efficiency, good thermal stability of the material, and very wide market prospect is provided. The metal complex with mol. formula is M(LA)X(LB)Y(LC)Z, which was characterized by the following chem. structural formula LAI, LAII and LAIII. The metal complex was used in an organic electroluminescent device, the organic electroluminescent device includes a substrate, an anode layer disposed on the substrate, a hole transport layer disposed on the anode layer, an organic light emitting layer disposed on the hole transport layer, an electron transport layer disposed on the organic light emitting layer, and a cathode layer disposed on the electron transport layer, wherein the material of the organic light emitting layer includes the metal complex. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Category: imidazoles-derivatives

The Article related to iridium platinum heterocyclic diketonate complex preparation oled, Organometallic and Organometalloidal Compounds: Group Viii – Co, Ni, Ru, Rh, Pd, Os, Ir, Pt and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Waleed, Hadeer Q.; Csecsi, Marcell; Hadjadj, Rachid; Thangaraj, Ravikumar; Pecsmany, Daniel; Owen, Michael; Szori, Milan; Fejes, Zsolt; Viskolcz, Bela; Fiser, Bela published an article in 2022, the title of the article was Computational Study of Catalytic Urethane Formation.Synthetic Route of 5036-48-6 And the article contains the following content:

Polyurethanes (PUs) are widely used in different applications, and thus various synthetic procedures including one or more catalysts are applied to prepare them. For PU foams, the most important catalysts are nitrogen-containing compounds Therefore, in this work, the catalytic effect of eight different nitrogen-containing catalysts on urethane formation will be examined The reactions of Ph isocyanate (PhNCO) and methanol without and in the presence of catalysts have been studied and discussed using the G3MP2BH and HLYP composite method. The solvent effects have also been considered by applying the SMD implicit solvent model. A general urethane formation mechanism has been proposed without and in the presence of the studied catalysts. The proton affinities (PA) were also examined The barrier height of the reaction significantly decreased (螖E0 > 100 kJ/mol) in the presence of the studied catalysts, which proves the important effect they have on urethane formation. The achieved results can be applied in catalyst design and development in the near future. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to urethane phenyl isocyanate proton affinity computational study, dft, catalyst-free, catalysts, composite method, proton affinities, urethane formation, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Catalytic Reactions and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Misztal, Tomasz; Kowalczyk, Pawel; Mlotkowska, Patrycja; Marciniak, Elzbieta published an article in 2020, the title of the article was The effect of allopregnanolone on enzymatic activity of the DNA base excision repair pathway in the sheep hippocampus and amygdala under natural and stressful conditions.Reference of Imidazo[1,2-c]pyrimidin-5(6H)-one And the article contains the following content:

The neurosteroid allopregnanolone (AL) has many beneficial functions in the brain. This study tested the hypothesis that AL administered for three days into the third brain ventricle would affect the enzymic activity of the DNA base excision repair (BER) pathway in the hippocampal CA1 and CA3 fields and the central amygdala in luteal-phase sheep under both natural and stressful conditions. Acute stressful stimuli, including isolation and partial movement restriction, were used on the last day of infusion. The results showed that stressful stimuli increased N-methylpurine DNA glycosylase (MPG), thymine DNA glycosylase (TDG), 8-oxoguanine glycosylase (OGG1), and AP-endonuclease 1 (APE1) mRNA expression, as well as repair activities for 1,N6 -ethenoadenine (蔚A), 3,N4 -ethenocytosine (蔚C), and 8-oxoguanine (8-oxoG) compared to controls. The stimulated events were lower in stressed and AL-treated sheep compared to sheep that were only stressed (except MPG mRNA expression in the CA1 and amygdala, as well as TDG mRNA expression in the CA1). AL alone reduced mRNA expression of all DNA repair enzymes (except TDG in the amygdala) relative to controls and other groups. DNA repair activities varied depending on the tissue-AL alone stimulated the excision of 蔚A in the amygdala, 蔚C in the CA3 and amygdala, and 8-oxoG in all tissues studied compared to controls. However, the excision efficiency of lesioned bases in the AL group was lower than in the stressed and stressed and AL-treated groups, with the exception of 蔚A in the amygdala. In conclusion, the presented modulating effect of AL on the synthesis of BER pathway enzymes and their repair capacity, both under natural and stressful conditions, indicates another functional role of this neurosteroid in brain structures. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Reference of Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to allopregnanolone neuroprotectant dna base excision repair psychol stress, dna glycosylases, allopregnanolone, amygdala, base excision repair, hippocampus, stress, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Reference of Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 30, 2021, Sarikaya, Ikbal; Bilgen, Selcuk; Unver, Yasemin; Inan Bektas, Kadriye; Akbas, Halide published an article.Recommanded Product: 5036-48-6 The title of the article was Preparation, characterization, antibacterial activity, and interfacial and micellar features of cationic gemini surfactants with different spacers. And the article contained the following:

In the present study, four novel imidazolium-based cationic gemini surfactants (IBCGS) have been synthesized, having same hydrocarbon chain lengths and different spacers. The impacts of type and nature of spacer on Krafft temperatures (TK) have been examined Micellization behaviors of IBCGS have been investigated at different temperatures above TK by both surface tension and specific conductivity measurements. Surface activity properties of aqueous systems have been calculated using the results of the measurement data. Critical micelle concentration (CMC), surface pressure at CMC (螤CMC), min. area of head group (Amin), degree of counterion binding (尾), degree of counterion dissociation (伪), and maximum surface excess (螕max) of IBCGS have been calculated with data of surface tension and specific conductivity IBCGS have low CMC values than other imidazole categories of gemini and monomeric cationic surfactants. Micelle aggregation number (Nagg) values have been determined with the steady-state fluorescence quenching method. The values of Nagg have been found in the range of 19-28. Addnl., the antibacterial activities of IBCGS on gram-pos. and gram-neg. bacteria have been investigated. IBCGS studied in this article have showed perfect antibacterial activity particularly against gram-pos. bacteria. The data obtained in this study may be benefical for the surfactant applications in different areas. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: 5036-48-6

The Article related to cationic gemini surfactant critical micelle concentration antibacterial activity, Surface Active Agents and Detergents: Preparation, Analysis, and Properties Of Surfactants Other Than Soaps and other aspects.Recommanded Product: 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem