Tag: 100-200

On January 31, 1992, Debnath, Asim Kumar; Lopez de Compadre, Rosa L.; Shusterman, Alan J.; Hansch, Corwin published an article.Electric Literature of 5709-67-1 The title of the article was Quantitative structure-activity relationship investigation of the role of hydrophobicity in regulating mutagenicity in the Ames test: 2: Mutagenicity of aromatic and heteroaromatic nitro compounds in Salmonella typhimurium TA100. And the article contained the following:

A quant. structure-activity relationship (QSAR) is derived for the mutagenic activity of 117 aromatic and heteroaromatic nitro compounds acting on S. typhimurium TA100. Relative mutagenic activity is bilinearly dependent on hydrophobicity, with an optimal log P of 5.44, and is linearly dependent on the energy of the LUMO of the nitro compound The dependence of mutagenic activity on hydrophobicity and electronic effects is very similar for TA98 and TA100. Mutagenic activity in TA100 does not depend on the size of the aromatic ring system, as its does in TA98. The effect of the choice of assay organism, TA98 vs. TA100, on nitroarene QSAR is similar to the effect previously found for aminoarenes. Lateral verification of QSARs is presented as a tool for establishing the significance of a new QSAR. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Electric Literature of 5709-67-1

The Article related to hydrophobicity qsar mutagenicity heteroaromatic nitro compound, structure aromatic nitro compound mutagenicity hydrophobicity, salmonella aromatic nitro compound mutagenicity structure and other aspects.Electric Literature of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 15, 2020, Huo, Siqi; Yang, Shuang; Wang, Jun; Cheng, Jianwen; Zhang, Qianqian; Hu, Yefa; Ding, Guoping; Zhang, Qiaoxin; Song, Pingan published an article.Name: N-(3-Aminopropyl)-imidazole The title of the article was Liquid phosphorus-containing imidazole derivative as flame-retardant curing agent for epoxy resin with enhanced thermal latency, mechanical, and flame-retardant performances. And the article contained the following:

The development of phosphorus-containing flame retardants combining good compatibility with matrix, low curing temperature, and mech. reinforcing effect has remained a major challenge. Herein, we reported the synthesis of a liquid flame-retardant curing agent (DA) via the nucleophilic substitution between diphenylphosphinic chloride and 1-(3-aminopropyl)-imidazole (AI). DA exhibited good blending and latency towards epoxy resin (EP) at room temperature According to DSC studies, DA could rapidly cure EP at moderate temperature Compared with EP/AI sample, EP/DA samples displayed comparable or higher glass transition temperature (Tg) and enhanced mech. properties due to the introduction of rigid diphenylphosphinyl group and improved crosslinking d. Moreover, DA improved the flame-retardant performances of EP thermoset. For instance, the LOI and UL94 rating of EP/DA-16 sample achieved 37.2% and V-0, resp. In addition, the peak of heat release rate (PHRR), average of heat release rate (AHRR), fire growth rate (FIGRA), and total heat release (THR) for EP/DA-16 sample reduced by 32%, 42%, 28% and 27% in comparison to EP/AI sample, resp. DA was characterized by its good compatibility with EP, moderate curing temperature, fast curing rate, suitable thermal latency, mech. reinforcing and flame-retardant effects, and thus it had a broad application prospect in various industrial fields. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Name: N-(3-Aminopropyl)-imidazole

The Article related to epoxy resin liquid phosphorus imidazole thermal latency flame retardancy, epoxy resin, flame retardancy, liquid phosphorus-containing imidazole, mechanical properties, thermal latency and other aspects.Name: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 15, 2022, Liu, Lin; Wu, Yan; Song, Ru; Zhang, Yu; Ma, Yafei; Wan, Jun; Zhang, Meili; Cui, Huali; Yang, Hua; Chen, Xiaoli; Wang, Jijiang published an article.Formula: C6H11N3 The title of the article was Morphology engineering and photothermal effect derived from perylene diimide based derivative for boosting photocatalytic hydrogen evolution of ZnIn2S4. And the article contained the following:

The construction of excellent photocatalysts for splitting water into hydrogen is highly desirable to realize carbon neutralization. In this work, an innovative and well-designed S-scheme photocatalyst composed of ultrathin ZnIn2S4 (ZIS) nanosheets uniformly anchored on the surface of organic semiconductor PDIIM is successfully fabricated. Within the heterojunction, perylene diimide with an imidazole group (PDIIM) is strategically applied as a structure template, which plays a crucial role in optimizing the morphol., increasing the active sites of sulfur vacancies, providing the addnl. photothermal effect, and promoting photogenerated charge separation of the catalyst. The photocatalytic H2 generation rate of the ZIS/PDIIM heterojunction with an optimized mass ratio reaches up to 13.04 mmol/g/h, which is 2.64 times and 14.02 times higher than that of pristine ZIS and PDIIM, resp. The outstanding photocatalytic activity is attributed to the synergistic effect of the above advantages. Importantly, the photothermal effect induced by PDIIM belonging to the perylene diimide-based derivative was discovered to accelerate photocatalytic H2 generation for the first time. This work provides valuable insight into the utilization of perylene diimide-based derivatives in the construction of multi-effect enhancement photocatalysts and their application in photothermal-assisted photocatalytic hydrogen evolution. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Formula: C6H11N3

The Article related to indium zinc sulfide perylene diimide hydrogen evolution reaction catalyst, organic semiconductor, perylene diimide, photocatalytic hydrogen evolution, photothermal effect, znin(2)s(4) and other aspects.Formula: C6H11N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 15, 2020, Wang, Yixuan; Zhou, Rui; Quan, Yanni; Chen, Shumin; Shi, Xingpeng; Li, Yanping; Cen, Shan published an article.Safety of N-(3-Aminopropyl)-imidazole The title of the article was Design, synthesis, and evaluation of novel 4-amino-2-(4-benzylpiperazin-1-yl)methylbenzonitrile compounds as Zika inhibitors. And the article contained the following:

The prevalence of Zika virus (ZIKV) has become widespread in recent years. ZIKV infection is associated with severe congenital CNS malformations in both newborns and adults. However, neither vaccines nor therapeutics are available to control ZIKV infection until now. The authors started by hit screening the authors’ inhouse small mol. library, then designed, synthesized, and evaluated a new class of 1,4-bibenzyl-substituted piperazine derivatives for their cytopathic effect (CPE) protection effect in a ZIKV-infected Vero E6 cellular assay. A preliminary structure-activity relation study identified five novel 4-amino-2-(4-benzylpiperazin-1-yl)methylbenzonitrile analogs with obvious CPE reduction effects against ZIKV at micromolar concentrations Moreover, 2-((4-(2-chlorobenzyl)piperazin-1-yl)methyl)-4-((2(dimethylamino)ethyl)(methyl)amino)benzonitrile exerted a significant antiviral effect on both Zika RNA replication and virus protein expression in a dose-dependent manner at low micromolar concentrations This study demonstrated the potential of a novel 4-amino-2-(4-benzylpiperazin-1-yl)methylbenzonitrile scaffold for the development of anti-ZIKV candidates. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to aminobenzylpiperazinylmethylbenzonitrile preparation zika inhibitor, 4-amino-2-(4-benzylpiperazin-1-yl)methylbenzonitrile, antiviral, cytopathic effect, structure-activity relationship, synthesis, zika virus inhibitors and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 29, 2020, Darwish, Ghinwa H.; Asselin, Jeremie; Tran, Michael V.; Gupta, Rupsa; Kim, Hyungki; Boudreau, Denis; Algar, W. Russ published an article.Synthetic Route of 5036-48-6 The title of the article was Fully Self-Assembled Silica Nanoparticle-Semiconductor Quantum Dot Supra-Nanoparticles and Immunoconjugates for Enhanced Cellular Imaging by Microscopy and Smartphone Camera. And the article contained the following:

There is a growing need for brighter luminescent materials to improve the detection and imaging of biomarkers. Relevant contexts include low-abundance biomarkers and technol.-limited applications, where an example of the latter is the emerging use of smartphones and other nonoptimal but low-cost and portable devices for point-of-care diagnostics. One approach to achieving brighter luminescent materials is incorporating multiple copies of a luminescent material into a larger supra-nanoparticle (supra-NP) assembly. Here, the authors present a facile method for the preparation and immunoconjugation of supra-NP assemblies (SiO2@QDs) that comprised many quantum dots (QDs) around a central silica nanoparticle (SiO2 NP). The assembly was entirely driven by spontaneous affinity interactions between the constituent materials, which included imidazoline-functionalized silica nanoparticles, ligand-coated QDs, imidazole-functionalized dextran, and tetrameric antibody complexes (TACs). The phys. and optical properties of the SiO2@QDs were characterized at both the ensemble and single-particle levels. Notably, the optical properties of the QDs were preserved upon assembly into supra-NPs, and single SiO2@QDs were approx. an order of magnitude brighter than single QDs and nonblinking. In proof-of-concept applications, including selective immunolabeling of breast cancer cells, the SiO2@QDs provided higher sensitivity and superior signal-to-background ratios whether using research-grade fluorescence microscopy or smartphone-based imaging. Overall, the SiO2@QDs are promising materials for enhanced bioanal. and imaging. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to silica nanoparticle semiconductor quantum dot immunoconjugate cell imaging smartphone, cellular imaging, immunolabeling, quantum dots, self-assembly, silica nanoparticles, smartphone device, tetrameric antibody complex and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Floresta, Giuseppe; Fallica, Antonino Nicolo; Patamia, Vincenzo; Sorrenti, Valeria; Greish, Khaled; Rescifina, Antonio; Pittala, Valeria published an article in 2021, the title of the article was From Far West to East: Joining the Molecular Architecture of Imidazole-like Ligands in HO-1 Complexes.Safety of N-(3-Aminopropyl)-imidazole And the article contains the following content:

HO-1 overexpression has been reported in several cases/types of human malignancies. Unfortunately, poor clin. outcomes are reported in most of these cases, and the inhibition of HO-1 is considered a valuable and proven anticancer approach. To identify novel hit compounds suitable as HO-1 inhibitors, a fragment-based approach where ligand joining experiments were used was reported. The two most important parts of the classical structure of the HO-1 inhibitors were used as a starting point, and 1000 novel compounds were generated and then virtually evaluated by structure and ligand-based approaches. The joining experiments led to a novel series of indole-based compds I (R1 = Me, OMe, PhCH2O; R2 = H, OMe; R3 = Me, OMe, PhCH2). A synthetic pathway for eight selected mols. I was designed, and the compounds were synthesized. The biol. activity revealed that some mols. I reach the micromolar activity, whereas mol. I (R1 = PhCH2O; R2 = H; R3 = Me) inhibits the HO-1 with an IC50 of 1.03μM. This study suggested that joining approach was successful, and a novel hit compound I was generated. These results are ongoing for further development. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to imidazolyl indole carboxamide preparation sar heme oxygenase inhibitor docking, ho-1 inhibitors, fragment growing, fragment-based ligand design, heme oxygenase, imidazole, ligand joining, structure-based drug design and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Frey, Felice; Sandakly, Jawdat; Ghannam, Mirna; Doueiry, Caren; Hugosson, Fredrik; Berlandi, Johannes; Ismail, Joy N.; Gayden, Tenzin; Hasselblatt, Martin; Jabado, Nada; Shirinian, Margret published an article in 2022, the title of the article was Drosophila tet is required for maintaining glial homeostasis in developing and adult fly brains.SDS of cas: 443-72-1 And the article contains the following content:

Ten-eleven translocation (TET) proteins are crucial epigenetic regulators highly conserved in multicellular organisms. TETs’ enzymic function in demethylating 5-Me cytosine in DNA is required for proper development and TETs are frequently mutated in cancer. Recently, Drosophila melanogaster Tet (dTet) was shown to be highly expressed in developing fly brains and discovered to play an important role in brain and muscle development as well as fly behavior. Furthermore, dTet was shown to have different substrate specificity compared with mammals. However, the exact role dTet plays in glial cells and how ectopic TET expression in glial cells contributes to tumorigenesis and glioma is still not clear. Here, we report a novel role for dTet specifically in glial cell organization and number We show that loss of dTet affects the organization of a specific glia population in the optic lobe, the “optic chiasm” glia. Addnl., we find irregularities in axon patterns in the ventral nerve cord (VNC) both, in the midline and longitudinal axons. These morphol. glia and axonal defects were accompanied by locomotor defects in developing larvae escalating to immobility in adult flies. Furthermore, glia homeostasis was disturbed in dTet-deficient brains manifesting in gain of glial cell numbers and increased proliferation. Finally, we establish a Drosophila model to understand the impact of human TET3 in glia and find that ectopic expression of hTET3 in dTet-expressing cells causes glia expansion in larval brains and affects sleep/rest behavior and the circadian clock in adult flies. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).SDS of cas: 443-72-1

The Article related to drosophila melanogaster tet glial homeostasis fly brain development, 6ma dna demethylation, drosophila ten-eleven translocation (tet), drosophila brain, brain tumor, human tet drosophila model, optic chiasm glia and other aspects.SDS of cas: 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zhang, Zhongwang; Wang, Lidong published an article in 2022, the title of the article was Using Chou’ s 5-steps rule to identify N6-methyladenine sites by ensemble learning combined with multiple feature extraction methods.Formula: C6H7N5 And the article contains the following content:

N6-methyladenine (m6A), a type of modification mostly affecting the downstream biol. functions and determining the levels of gene expression, is mediated by the methylation of adenine in nucleic acids. It is also a key factor for influencing biol. processes and has attracted attention as a target for treating diseases. Here, an ensemble predictor named as TL-Methy, was developed to identify m6A sites across the genome. TL-Methy is a 2-level machine learning method developed by combining the support vector machine model and multiple features extraction methods, including nucleic acid composition, di-nucleotide composition, tri-nucleotide composition, position-specific trinucleotide propensity, Bi-profile Bayes, binary encoding, and accumulated nucleotide frequency. For Homo sapiens, TL-Methy method reached the accuracy of 91.68% on jackknife test and of 92.23% on 10-fold cross validation test; For Mus musculus, TL-Methy method achieved the accuracy of 93.66% on jackknife test and of 97.07% on 10-fold cross validation test; For Saccharomyces cerevisiae, TL-Methy method obtained the accuracy of 81.57% on jackknife test and of 82.54% on 10-fold cross validation test; For rice genome, TL-Methy method achieved the accuracy of 91.87% on jackknife test and of 93.04% on 10-fold cross validation test. The results via these two test approaches demonstrated the robustness and practicality of our TL-Methy model. The TL-Methy model may be as a potential method for m6A site identification.Communicated by Ramaswamy H. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Formula: C6H7N5

The Article related to saccharomyces cerevisiae mus musculus methyladenine jackknife test feature extraction, 10-fold cross validation test, 2-level method, n6-methyladenine, feature extraction, jackknife test, support vector machine and other aspects.Formula: C6H7N5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 28, 2022, Wang, Dong-En; You, Shangqi; Huo, Wenjing; Han, Xiang; Xu, Huiyun published an article.Safety of N-(3-Aminopropyl)-imidazole The title of the article was Colorimetric detection of alkaline phosphatase activity based on pyridoxal phosphate-induced chromatic switch of polydiacetylene nanoliposomes. And the article contained the following:

A colorimetric assay based on polydiacetylenes (PDA) nano-liposomes is reported for facile and sensitive detection of alk. phosphatase (ALP) activity. The critical basis of this method is that the interaction of pyridoxal phosphate (PLP) with nitrogenous group functionalized PDA nano-liposomes induces distinct blue-to-red color changes of PDA nano-liposomes. In the presence of ALP, as a nature substrate, PLP is enzymically hydrolyzed to form pyridoxal, which cannot interact with PDA nano-liposomes. As a result, the concentration of PLP is reduced and the color change of PDA nano-liposomes is retarded, which is associated with ALP level. Under optimal conditions, the proposed method showed good linear relationship with ALP activity in the range 10-200 U/L with a limit of detection of 2.8 U/L. The detection process could be vividly observed with the naked eye. Addnl. attempts by using the method for the evaluation of inhibitor efficiency were also achieved with satisfying results. The method was further challenged with real human serum samples, showing consistent results when compared with a com. standard assay kit. Such simple and easy-to-use approach may provide a new alternative for clin. and biol. detection of ALP. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to polydiacetylene nanoliposome chromatic switch pyridoxal phosphate alk phosphatase colorimetry, alkaline phosphatase, colorimetric assay, conjugated polymer, nano-liposomes, polydiacetylene, pyridoxal phosphate and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 2021, Xue, Tian; Zhang, Shengli; Qiao, Huijuan published an article.Recommanded Product: 443-72-1 The title of the article was i6mA-VC: A Multi-Classifier Voting Method for the Computational Identification of DNA N6-methyladenine Sites. And the article contained the following:

Abstract: DNA N6-methyladenine (6 mA), as an essential component of epigenetic modification, cannot be neglected in genetic regulation mechanism. Most of the established machine learning methods have a single dataset. Although some of them have achieved cross-species prediction, their results are not satisfactory. Therefore, we designed a novel statistical model called i6mA-VC to improve the accuracy for 6 mA sites. On the one hand, kmer and binary encoding are applied to extract features, and then gradient boosting decision tree (GBDT) embedded method is applied as the feature selection strategy. After fusing the two optimal features, a voting classifier based on gradient boosting decision tree (GBDT), light gradient boosting machine (LightGBM) and multilayer perceptron classifier (MLPC) is constructed for final classification and prediction. The accuracy of Rice dataset and M.musculus dataset with five-fold cross-validation are 0.888 and 0.967, resp. The cross-species dataset is selected as independent testing dataset, and the accuracy reaches 0.848. Through rigorous experiments, it is demonstrated that the proposed predictor is convincing and applicable. The development of i6mA-VC predictor will become an effective way for the recognition of N6-methyladenine sites, and it will also be beneficial for biol. geneticists to further study gene expression and DNA modification. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Recommanded Product: 443-72-1

The Article related to n6methyladenine machine learning dna sequence genetics, dna n6-methyladenine sites, light gradient boosting machine, multilayer perceptron classifier, ring-function-hydrogen-chemical properties, voting and other aspects.Recommanded Product: 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem