Tag: 100-200

On December 31, 2022, Takahashi, Yusuke; Shoura, Massa; Fire, Andrew; Morishita, Shinichi published an article.SDS of cas: 443-72-1 The title of the article was Context-dependent DNA polymerization effects can masquerade as DNA modification signals. And the article contained the following:

Single mol. measurements of DNA polymerization kinetics provide a sensitive means to detect both secondary structures in DNA and deviations from primary chem. structure as a result of modified bases. In one approach to such anal., deviations can be inferred by monitoring the behavior of DNA polymerase using single-mol., real-time sequencing with zero-mode waveguide. This approach uses a Single Mol. Real Time (SMRT)-sequencing measurement of time between fluorescence pulse signals from consecutive nucleosides incorporated during DNA replication, called the interpulse duration (IPD). In this paper we present an anal. of loci with high IPDs in two genomes, a bacterial genome (E. coli) and a eukaryotic genome (C. elegans). To distinguish the potential effects of DNA modification on DNA polymerization speed, we paired an anal. of native genomic DNA with whole-genome amplified (WGA) material in which DNA modifications were effectively removed. Adenine modification sites for E. coli are known and we observed the expected IPD shifts at these sites in the native but not WGA samples. For C. elegans, such differences were not observed Instead, we found a number of novel sequence contexts where IPDs were raised relative to the average IPDs for each of the four nucleotides, but for which the raised IPD was present in both native and WGA samples. The latter results argue strongly against DNA modification as the underlying driver for high IPD segments for C. elegans, and provide a framework for separating effects of DNA modification from context-dependent DNA polymerase kinetic patterns inherent in underlying DNA sequence for a complex eukaryotic genome. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).SDS of cas: 443-72-1

The Article related to dna polymerization effect masquerade modification signal, dna n6-methyladenine, dna modification, dna polymerization, non-b dna, single-molecule real-time (smrt) sequencing, whole genome amplification and other aspects.SDS of cas: 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 31, 2021, Geng, Chengbao; Fan, Lu-an; Niu, Hongyan; Liu, Lijia; Zhao, Fangbo; Zhang, Jiaming; Dong, Hongxing; Yu, Shuili published an article.Category: imidazoles-derivatives The title of the article was Improved anti-organic fouling and antibacterial properties of PVDF ultrafiltration membrane by one-step grafting imidazole-functionalized graphene oxide. And the article contained the following:

At present, membrane fouling is a thorny issue that limits the development of polyvinylidene fluoride (PVDF) composite membrane, which seriously affects its separation performance and service lifespan. Herein, an imidazole-functionalized graphene oxide (Im-GO) with hydrophilicity and antibacterial performance was synthesized, and it was used as a modifier to improve the anti-organic fouling and antibacterial properties of PVDF membrane. The anti-organic fouling test showed that the maximum flux recovery ratios against bovine serum albumin and humic acid were 88.9% and 94.5%, resp. Conspicuously, the grafted imidazole groups could effectively prevent the bacteria from growing on the membrane surface. It was gratifying that the antibacterial modifier Im-GO was almost not lost from the hybrid membranes even by the ultrasonic treatment, which was different from the conventional release-killing antibacterial agents. Owing to the long-term anti-organic fouling and antibacterial properties, Im-GO/PVDF hybrid membranes exhibit a great application potential in the fields of rough separation and concentration of biomedical products. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Category: imidazoles-derivatives

The Article related to escherichia pvdf imidazole graphene oxide humic acid hydrophilicity antibacterial, anti-organic fouling, antibacterial, hydrophilicity, imidazole-functionalized graphene oxide, polyvinylidene fluoride and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rehman, Mobeen Ur; Chong, Kil To published an article in 2020, the title of the article was DNA6mA-MINT: DNA-6mA modification identification neural tool.Recommanded Product: N-Methyl-7H-purin-6-amine And the article contains the following content:

DNA N6-methyladenine (6mA) is part of numerous biol. processes including DNA repair, DNA replication, and DNA transcription. The 6mA modification sites hold a great impact when their biol. function is under consideration. Research in biochem. experiments for this purpose is carried out and they have demonstrated good results. However, they proved not to be a practical solution when accessed under cost and time parameters. This led researchers to develop computational models to fulfill the requirement of modification identification. In consensus, we have developed a computational model recommended by Chou’s 5-steps rule. The Neural Network (NN) model uses convolution layers to extract the high-level features from the encoded binary sequence. These extracted features were given an optimal interpretation by using a Long Short-Term Memory (LSTM) layer. The proposed architecture showed higher performance compared to state-of-the-art techniques. The proposed model is evaluated on Mus musculus, Rice, and “Combined-species” genomes with 5- and 10-fold cross-validation. Further, with access to a user-friendly web server, publicly available can be accessed freely. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Recommanded Product: N-Methyl-7H-purin-6-amine

The Article related to n6 methyladenine genome dna replication convolutional neural network, chou’s 5-steps rule, convolution neural network (cnn), dna n6-methyladenine, long short-term memory (lstm), computational biology and other aspects.Recommanded Product: N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 31, 2021, Wang, Keyan; Li, Yiping; Qiang, Tingting; Chen, Jie; Wang, Xiaolong published an article.HPLC of Formula: 443-72-1 The title of the article was Role of epigenetic regulation in myocardial ischemia/reperfusion injury. And the article contained the following:

A review. Nowadays acute myocardial infarction (AMI) is a serious cardiovascular disease threatening the human life and health worldwide. The most effective treatment is to quickly restore coronary blood flow through revascularization. However, timely revascularization may lead to reperfusion injury, thereby reducing the clin. benefits of revascularization. At present, no effective treatment is available for myocardial ischemia/reperfusion injury. Emerging evidence indicates that epigenetic regulation is closely related to the pathogenesis of myocardial ischemia/reperfusion injury, indicating that epigenetics may serve as a novel therapeutic target to ameliorate or prevent ischemia/reperfusion injury. This aimed to briefly summarize the role of histone modification, DNA methylation, noncoding RNAs, and N6-methyladenosine (m6A) methylation in myocardial ischemia/reperfusion injury, with a view to providing new methods and ideas for the research and treatment of myocardial ischemia/reperfusion injury. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).HPLC of Formula: 443-72-1

The Article related to cardiovascular disease, coronary circulation, dna methylation, epigenetics, histones role: thu (therapeutic use), biol (biological study), uses (uses), homo sapiens, human, ischemia-reperfusion injury, myocardial infarction, non-coding rna role: thu (therapeutic use), biol (biological study), uses (uses) and other aspects.HPLC of Formula: 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 30, 1991, Seela, F.; Rosemeyer, H.; Gumbiowski, R.; Mersmann, K.; Muth, H. P.; Roeling, A. published an article.Formula: C6H4ClN3O The title of the article was Base-modified purine 2′,3′-dideoxyribonucleosides: synthesis via deoxygenation or direct nucleobase anion glycosylation. And the article contained the following:

A symposium report. 5-Aza-7-deazapurine, 5-aza-1,7-dideazapurine, and 8-azapurine 2′,3′-dideoxy-D-ribonucleosides were synthesized and inhibitory activity against HIV reverse transcriptase and DNA-polymerases was evaluated. The experimental process involved the reaction of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one(cas: 57473-33-3).Formula: C6H4ClN3O

The Article related to purine dideoxyribonucleoside base modified symposium, deoxygenation nucleoside symposium, nucleobase anion glycosylation symposium, hiv reverse transcriptase inhibitor symposium, dna polymerase inhibitor symposium, aids inhibitor purine dideoxyribonucleoside symposium, azadeazapurine dideoxyribonucleoside symposium and other aspects.Formula: C6H4ClN3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 31, 2008, Meira, Lisiane B.; Bugni, James M.; Green, Stephanie L.; Lee, Chung-Wei; Pang, Bo; Borenshtein, Diana; Rickman, Barry H.; Rogers, Arlin B.; Moroski-Erkul, Catherine A.; McFaline, Jose L.; Schauer, David B.; Dedon, Peter C.; Fox, James G.; Samson, Leona D. published an article.Application of 55662-66-3 The title of the article was DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. And the article contained the following:

Chronic inflammation increases cancer risk. While it is clear that cell signaling elicited by inflammatory cytokines promotes tumor development, the impact of DNA damage production resulting from inflammation-associated reactive oxygen and nitrogen species (RONS) on tumor development was not directly tested. RONS induce DNA damage that can be recognized by alkyladenine DNA glycosylase (Aag) to initiate base excision repair. Using a mouse model of episodic inflammatory bowel disease by repeated administration of dextran sulfate Na in the drinking water, we show that Aag-mediated DNA repair prevents colonic epithelial damage and reduces the severity of dextran sulfate sodium-induced colon tumorigenesis. Importantly, DNA base lesions expected to be induced by RONS and recognized by Aag accumulated to higher levels in Aag-deficient animals following stimulation of colonic inflammation. Finally, as a test of the generality of this effect we show that Aag-deficient animals display more severe gastric lesions that are precursors of gastric cancer after chronic infection with Helicobacter pylori. These data demonstrate that the repair of DNA lesions formed by RONS during chronic inflammation is important for protection against colon carcinogenesis. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Application of 55662-66-3

The Article related to dextran sulfate sodium colon inflammation carcinogenesis dna damage, alkyladenine dna glycosylase colon inflammation carcinogenesis dna damage, reactive oxygen species colon inflammation carcinogenesis dna damage, nitrogen reactive species colon inflammation carcinogenesis dna damage and other aspects.Application of 55662-66-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 1, 2022, Nikitin, E. A.; Shpakovsky, D. B.; Tyurin, V. Yu; Kazak, A. A.; Gracheva, Yu A.; Vasilichin, V. A.; Pavlyukov, M. S.; Mironova, E. M.; Gontcharenko, V. E.; Lyssenko, K. A.; Antonets, A. A.; Dubova, L. G.; Shevtsov, P. N.; Shevtsova, E. F.; Shamraeva, M. A.; Shtil, A. A.; Milaeva, E. R. published an article.Recommanded Product: 5036-48-6 The title of the article was Novel organotin complexes with phenol and imidazole moieties for optimized antitumor properties. And the article contained the following:

A series of novel imidazole-containing ligands and their organotin complexes were synthesized and characterized by NMR, IR, MALDI and elemental anal. Redox behavior was studied by cyclic voltammetry (CV). Antioxidant properties were estimated in model reactions of single-electron reduction (CUPRAC-test), scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and O-.2 radical anion, enzymic oxidation of linoleic acid by lipoxygenase and Fe3+-induced lipid peroxidation of rat liver homogenates. It was found that ligands and complexes both possess radical scavenging activity of prolonged action type. Compounds exhibited notable antioxidant activity in lipid peroxidation Cytotoxicity was estimated in standard MTT-test on multiple cell lines. Compounds demonstrated high toxicity on colon carcinoma and breast cancer cells and based on obtained data, lead compound was proposed. Addnl. assays were carried out for the lead compound, including regular MTT-test on cancer cells possessing various resistant mechanisms and modified MTT-test on tumor tissue samples, obtained from patients as well as apoptosis and cell cycle studies. All organotin complexes were also studied for their influence on tubulin polymerization It was demonstrated that obtained compounds demonstrate unorthodox activity, promoting microtubules assembly rate instead of inhibiting it. Significant influence of compound 5 on G2/M phase of cell cycle is in accordance with influence on tubulin polymerization and lets us to mark synthesized compounds as mitotic poisons. The results open up the scopes for the search of novel antitumor agents for treatment of advanced forms of cancer. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: 5036-48-6

The Article related to organotin complex phenol imidazole human antitumor breast colon ovary, electrochem preparation organotin complex phenol imidazole, cytotoxicity antioxidant organotin complex phenol imidazole preparation, crystal structure mol optimized organotin complex phenol imidazole moiety and other aspects.Recommanded Product: 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 31, 2020, Ding, Wen; Yu, Tao; Du, Yingxiang; Sun, Xiaodong; Feng, Zijie; Zhao, Shiyuan; Ma, Xiaofei; Ma, Mingxuan; Chen, Cheng published an article.Product Details of 5036-48-6 The title of the article was A metal organic framework-functionalized monolithic column for enantioseparation of six basic chiral drugs by capillary electrochromatography. And the article contained the following:

Poly(glycidyl methacrylate)-co-(ethylene dimethacrylate) [poly(GMA-co-EDMA)] monoliths were used as a support to grow a zeolitic imidazolate framework-8 (ZIF-8) via layer-by-layer self-assembly. Pepsin, acting as as chiral selector, was covalently linked to the surface of the amino-modified ZIF-8 through the Schiff base method. The material was characterized by SEM, thermogravimetric anal., X-ray diffraction, Fourier transform IR spectroscopy and elemental anal. The pepsin-ZIF-8-poly(GMA-co-EDMA) column was utilized to the enantioseparation of the racemic forms of hydroxychloroquine (HCQ), chloroquine (CHQ), hydroxyzine (HXY), nefopam (NEF), clenbuterol (CLE) and amlodipine (AML). In comparison with a pepsin-poly(GMA-co-EDMA) monolithic column (without self-assembled ZIF-8 nanoparticles), the resolution is strongly enhanced (HCQ: 0.34 → 2.50; CHQ: 0.45 → 1.97; HXY: 0.39 → 1.43; NEF: 0.27 → 0.81; CLE: 0 → 0.81; AML: 0.16 → 0.72). Effects of self-assembly layers of ZIF-8, pepsin concentration, buffer pH values and applied voltage were investigated with hydroxychloroquine as the model analyte. The reproducibility of run-to-run, day-to-day and column-to-column were explored, and found to be satisfactory. [Figure not available: see fulltext.]. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to metal organic framework monolithic column enantioseparation capillary electrochromatog, basic drugs, capillary electrochromatography, enantioseparation, glycidyl methacrylate, metal-organic framework, monolithic column, nanoparticles, pepsin, self assembly, zif-8 and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 31, 2020, Currie, Sarah; Kim, Seungil; Gu, Xiaochen; Ren, Xiaoou; Lin, Francis; Liu, Shangxi; Yang, Chengbo; Kim, Ji-Heung; Liu, Song published an article.Quality Control of N-(3-Aminopropyl)-imidazole The title of the article was Mucus-penetrating PEGylated polysuccinimide-based nanocarrier for intravaginal delivery of siRNA battling sexually transmitted infections. And the article contained the following:

Intravaginal delivery of siRNA for prevention of sexually transmitted infections faces obstacles such as the acidic environment and vaginal mucus barrier. To achieve effective protection and delivery of siRNA, we developed a polysuccinimide (PSI)-based nanocarrier (PSI-PEG-API-PMA, PPAP) by conjugating methoxy polyethylene glycol amine (Me-PEG-NH2, Mw 5000), 1-(3-aminopropyl)imidazole (API), and 1-pyrenemethylamine hydrochloride (PMA) to PSI. PPAP demonstrated a spherical self-assembled nanostructure before and after encapsulation of a model siRNA. Variable electrostatic interaction between API and siRNA at acidic vs. neutral pH accomplished significantly lower burst release at pH 4.2 (4 ± 1%) than pH 7.0 (26 ± 5%) within 1 h. PEGylation enabled siRNA-PPAP to achieve higher mucus penetration efficiency (64 ± 17%) than free siRNA (27 ± 5%) for 24 h. Moreover, in vitro study showed minimal toxicity, successful internalization of siRNA-PPAP in HeLa cells and improved gene knockdown (97.5 ± 0.4%). Overall, PPAP is promising for developing preventative treatments for battling sexually transmitted infections. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Quality Control of N-(3-Aminopropyl)-imidazole

The Article related to pegylated polysuccinimide nanocarrier intravaginal sirna sexually transmitted infections mucus, hsv-2 prevention, intravaginal nanomedicine, mucus-penetrating sirna nanocarrier, polysuccinimide (psi)-based nanocarrier, preventing sexually transmitted infections and other aspects.Quality Control of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 6, 2021, Martin-Montes, Alvaro; Kolodova, Kristina; Marin, Clotilde; Rosales-Lombardo, Maria Jose; Sanchez-Moreno, Manuel; de Andres-Gordo, Lucia; Cano, Carmen; Campayo, Lucrecia; Gomez-Munoz, Alberto; Sanz, Ana M.; Yunta, Maria J. R. published an article.Recommanded Product: N-(3-Aminopropyl)-imidazole The title of the article was In vitro Leishmanicidal and Trypanosomicidal Properties of Imidazole-Containing Azine and Benzoazine Derivatives. And the article contained the following:

Leishmaniasis and Chagas diseases are two of the most important parasitic diseases in the world. Both belong to the category of Neglected Tropical Diseases, and they cannot be prevented by vaccination. Their treatments are founded in outdated drugs that possess many pernicious side-effects and they’re not easy to administer. With the aim of discovering new compounds that could serve as anti-trypanosomal drugs, an antiparasitic study of a synthetic compound family has been conducted. A series of new 1,4-bis(alkylamino)- and 1-alkylamino-4-chloroazine and benzoazine derivatives 1-4 containing imidazole rings have been synthesized and identified. Their structures showed a possible interest based on previous work. Their in vitro anti-Leishmania infantum, anti-L. braziliensis, anti-L. donovani and anti-T. cruzi activity were tested, as well as the inhibition of Fe-SOD enzymes. It was found that some of them exhibited quite relevant values indicative of being worthy of future more detailed studies, as most of them showed activity to more than only one parasite species, especially compound 3 c was active for the three studied Leishmania species and also for T. cruzi, which is a very interesting trait as it covers a wide spectrum. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: N-(3-Aminopropyl)-imidazole

The Article related to imidazole containing azine benzoazine derivative preparation, azine benzoazine leishmanicidal trypanosomicidal property structure activity relationship, azines and benzoazines, fe-sod inhibition, imidazole, in vitro trypanosomicidal and leishmanicidal activity and other aspects.Recommanded Product: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem