Tag: 100-200

《Solvent-mediated Highly Efficient Synthesis of [1,2,4]triazolo/benzimidazoloquinazolinone Derivatives》 was written by Malamiri, Fatemeh; Khaksar, Samad; Badri, Rashid; Tahanpesar, Elham. Safety of 1H-Benzo[d]imidazol-2-amineThis research focused ontriazoloquinazolinone preparation; aminotriazole dimedone benzaldehyde cyclocondensation trifluoroethanol mediated; benzimidazoloquinazolinone preparation; aminobenzimidazole dimedone benzaldehyde cyclocondensation trifluoroethanol mediated; Fluorinated alcohols; anticancer; green chemistry; heterocyclic; multicomponent; triazole. The article conveys some information:

An efficient and catalyst-free procedure for the synthesis of triazoloquinazolinones I [Ar = Ph, 4-MeC6H4, 2,4-di-ClC6H3, etc.] and benzimidazoloquinazolinones II [R = Ph, 4-ClC6H4, 4-O2NC6H4, etc.] was developed in 2,2,2-trifluoroethanol or deep eutectic solvent(DESs) as a clean and reusable media. Various products were obtained in good to excellent yields under reaction conditions. The results came from multiple reactions, including the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Safety of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Safety of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis》 was written by Devine, William G.; Diaz-Gonzalez, Rosario; Ceballos-Perez, Gloria; Rojas, Domingo; Satoh, Takashi; Tear, Westley; Ranade, Ranae M.; Barros-Alvarez, Ximena; Hol, Wim G. J.; Buckner, Frederick S.; Navarro, Miguel; Pollastri, Michael P.. Recommanded Product: 2-Chloro-1H-benzo[d]imidazoleThis research focused ontrypanosomiasis trypanosomicide Trypanosoma; crystal structure; Trypanosoma brucei; medicinal chemistry; methionyl-tRNA synthetase. The article conveys some information:

Human African Trypanosomiasis is a neglected tropical disease that is lethal if left untreated. Existing therapeutics have limited efficacy and severe associated toxicities. NEU-1053 I has recently been identified from a high throughput screen of >42,000 compounds as a highly potent and fast acting trypanocidal agent capable of curing a blood stream infection of T. brucei in mice. The authors have designed a library of analogs to probe the SAR and improve the predicted CNS exposure of NEU-1053. The authors report the activity of these inhibitors of Trypanosoma brucei, the efficacy of NEU-1053 in a murine CNS model of infection, and identification of the target of NEU-1053 via x-ray crystallog. The results came from multiple reactions, including the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Recommanded Product: 2-Chloro-1H-benzo[d]imidazole)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Recommanded Product: 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 934-32-7In 2020 ,《Synthesis, spectral, DFT calculation, sensor, antimicrobial and DNA binding studies of Co(II), Cu(II) and Zn(II) metal complexes with 2-amino benzimidazole Schiff base》 appeared in Journal of Molecular Structure. The author of the article were Kalarani, R.; Sankarganesh, M.; Kumar, G. G. Vinoth; Kalanithi, M.. The article conveys some information:

Synthesis of Co(II), Cu(II) and Zn(II) complexes of bidentate Schiff base ligand (L) 2-(1H-Benzo [d]imidazole-4-ylimmino) Me phenol is presented here. The Schiff base and its metal (II) complexes were characterized by micro anal. and spectral techniques such as AAS, UV-visible, FTIR, NMR, molar conductance and magnetic moment measurements. Molar conductance reveals the non electrolytic nature of the complexes. From the anal. and spectral anal., octahedral geometry is proposed to the synthesized metal (II) complexes. DFT calculations were done for Schiff base and metal (II) complexes to confirm the geometry of the complexes. The sensor activity of Schiff base towards calcium and magnesium ions was studied by absorption spectroscopy. Electrochem. nature of the copper(II) complex was studied by cyclic voltammetry technique and indicates the reversible nature of Cu(II)/Cu(I) couple. The antimicrobial activity of the Schiff base and its metal (II) complexes showed good potency against various microorganism such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. DNA binding properties of the metal complexes were studied using UV-visible absorption spectroscopy and found that the Cu(II) complex has more binding ability than L, Co(II) and Zn(II) complexes. After reading the article, we found that the author used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Related Products of 934-32-7)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Related Products of 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Nanosilk increases the strength of diabetic skin and delivers CNP-miR146a to improve wound healing》 was written by Niemiec, Stephen M.; Louiselle, Amanda E.; Hilton, Sarah A.; Dewberry, Lindel C.; Zhang, Liping; Azeltine, Mark; Xu, Junwang; Singh, Sushant; Sakthivel, Tamil S.; Seal, Sudipta; Liechty, Kenneth W.; Zgheib, Carlos. Electric Literature of C7H6N4O And the article was included in Frontiers in Immunology in 2020. The article conveys some information:

Diabetes mellitus is a metabolic disorder associated with properties and an increased risk of chronic wounds due to sustained pro-inflammatory response. We have previously of radical scavenging cerium oxide nanoparticles (CNP) conjugated to the anti-inflammatory microRNA (miR)-146a, termed CNP-miR146a, improves diabetic wound healing by synergistically lowering oxidative stress and inflammation, and we sought to evaluate this treatment in a topical application. Silk fibroin is a biocompatible polymer that can be fabricated into nanostructures, termed nanosilk. Nanosilk is characterized by a high strength-to-d. ratio and an ability to exhibit strain hardening. We therefore hypothesized that nanosilk would strengthen the biomech. properties of diabetic skin and that nanosilk solution could effectively deliver CNP-miR146a to improve diabetic wound healing. The ability of nanosilk to deliver CNP-miR146a to murine diabetic wounds and improve healing was assessed by the rate of wound closure and inflammatory gene expression, as well as histol. anal. The effect of nanosilk on the properties of human diabetic skin was evaluated by testing the biomech. properties following topical application of a 7% nanosilk solution Diabetic murine wounds treated with topical nanosilk and CNP-miR146a healed by day 14.5 compared to day 16.8 in controls (p = 0.0321). Wounds treated with CNP-miR146a had higher collagen levels than controls (p = 0.0126) with higher pro-fibrotic gene expression of TGFβ-1 (p = 0.0092), Col3α1 (p = 0.0369), and Col1α2 (p = 0.0454). Treatment with CNP-miR146a lowered pro-inflammatory gene expression of lL-6 (p = 0.0488) and lL-8 (p = 0.0009). Treatment of human diabetic skin with 7% nanosilk solution resulted in significant improvement in maximum load and modulus (p < 0.05). Nanosilk solution is able to strengthen the biomech. properties of diabetic skin and can successfully deliver CNP-miR146a to improve diabetic wound healing through inhibition of pro-infl ammatory gene signaling and promotion of pro-fi brotic processes. In the experimental materials used by the author, we found Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Electric Literature of C7H6N4O)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Electric Literature of C7H6N4O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

HPLC of Formula: 16681-56-4In 2012 ,《Fluorous Oxime Palladacycle: A Precatalyst for Carbon-Carbon Coupling Reactions in Aqueous and Organic Medium》 appeared in Journal of Organic Chemistry. The author of the article were Susanto, Woen; Chu, Chi-Yuan; Ang, Wei Jie; Chou, Tzyy-Chao; Lo, Lee-Chiang; Lam, Yulin. The article conveys some information:

To facilitate precatalyst recovery and reuse, fluorous, oxime-based palladacycle I was developed, and it was demonstrated that it is a very efficient and versatile precatalyst for a wide range of carbon-carbon bond formation reactions (Suzuki-Miyaura, Sonogashira, Stille, Heck, Glaser-type, and Kumada) in either aqueous or organic medium under microwave irradiation Palladacycle I could be recovered through F-SPE in various coupling reactions with recovery ranging from 84 to 95% for the first cycle. Inductively coupled plasma optical emission spectrometry (ICP-OES) analyses of the Pd content in the crude product from each class of transformation indicated extremely low levels of leaching and the palladacycle could be reused four to five times without significant loss of activity.2-Bromo-1H-imidazole(cas: 16681-56-4HPLC of Formula: 16681-56-4) was used in this study.

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. HPLC of Formula: 16681-56-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Computed Properties of C7H5ClN2In 2022 ,《Cross dehydrogenation coupling reaction of purine derivatives with thioethers》 appeared in Organic & Biomolecular Chemistry. The author of the article were Li, Xinjie; Qi, Peng; Du, Hongguang. The article conveys some information:

A metal-free cross-dehydrogenation coupling method was established to synthesize N9 alkylated purine derivatives Using PhI(OAc)2 as the oxidant, versatile thioethers were successfully employed as alkylation reagents. Under the optimized conditions, a variety of alkylated purine derivatives and other aromatic N-heterocycles were obtained in moderate to good yields. The regioselectivity of this protocol which involves the reaction of unsym. thioethers with purine derivatives was also studied. In addition to this study using 2-Chloro-1H-benzo[d]imidazole, there are many other studies that have used 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Computed Properties of C7H5ClN2) was used in this study.

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Computed Properties of C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Martynova, Ekaterina A.; Scattolin, Thomas; Cavarzerani, Enrico; Peng, Min; Van Hecke, Kristof; Rizzolio, Flavio; Nolan, Steven P. published an article in Dalton Transactions. The title of the article was 《A simple synthetic entryway into new families of NHC-gold-amido complexes and their in vitro antitumor activity》.Recommanded Product: 4857-06-1 The author mentioned the following in the article:

A simple synthetic pathway to Au-NHC amido complexes is described. Syntheses and isolation of [Au(NHC)(NR1R2)] complexes, bearing various NHC ligands and NH-containing heterocycles under mild conditions are reported. The in vitro anticancer activity of these gold-complexes was investigated on three human cancer cell lines. A number of these show comparable or even better antiproliferative activity than cisplatin. Noteworthy is the non-toxicity of most of the complexes on normal cells. In the experimental materials used by the author, we found 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Recommanded Product: 4857-06-1)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Recommanded Product: 4857-06-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Wang, Pengzhi; Fitzpatrick, Keegan P.; Scheidt, Karl A. published an article in Advanced Synthesis & Catalysis. The title of the article was 《Combined Photoredox and Carbene Catalysis for the Synthesis of γ-Aryloxy Ketones》.Product Details of 530-62-1 The author mentioned the following in the article:

N-heterocyclic carbenes (NHCs) have emerged as catalysts for the construction of C-C bonds in the synthesis of substituted ketones under single-electron processes. Despite these recent reports, there still remains a need to increase the utility and practicality of these reactions by exploring new radical coupling partners. Herein, authors report the synthesis of γ-aryloxyketones via combined NHC/photoredox catalysis. In this reaction, an α-aryloxymethyl radical is generated via oxidation of an aryloxymethyl potassium trifluoroborate salt, which is then added into styrene derivatives to provide a stabilized benzylic radical. Subsequent radical-radical coupling reaction with an azolium radical affords the γ-aryloxy ketone products.Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Product Details of 530-62-1) was used in this study.

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Product Details of 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Kimpel, Joost; He, Waner; Cheng, Ye; Michinobu, Tsuyoshi published an article in Journal of Organic Chemistry. The title of the article was 《A Route to Conjugated Monomers and Polymers Incorporating 2,5-Connected Oxazole in the Backbone》.Safety of 2-Bromo-1H-imidazole The author mentioned the following in the article:

Joining of imidazole, pyrimidine, and oxazole to other conjugated core units was explored in pursuit of yielding monomers to synthesize organic semiconducting polymers. Regioregular oxazole-flanked thiophene, benzothiadiazole, naphthalene diimide (NDI), and thienopyrroledione (TPD) were successfully isolated via stannylation of oxazole and the Stille coupling of brominated core units (overall yields ranging from ca. 40 to 60%). From subsequent direct arylation polymerization, NDI/oxazole/TPD-containing regioisomeric polymers were obtained with optical and electrochem. orbital energetics in the semiconducting regime. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-1H-imidazole(cas: 16681-56-4Safety of 2-Bromo-1H-imidazole)

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Safety of 2-Bromo-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Wu, Wen-Long; Wen, Ze-Yu; Qian, Jing-Jing; Zou, Jing-Pei; Liu, Shan-Ming; Yang, Shun; Qin, Tian; Yang, Qun; Liu, Yu-Han; Liu, Wei-Wei; Wang, Jing; Shi, Li-Ying; Shi, Da-Hua published an article in Journal of Molecular Structure. The title of the article was 《Design, synthesis, characterization and evaluation of 1,3,5-triazine-benzimidazole hybrids as multifunctional acetylcholinesterases inhibitors》.SDS of cas: 4857-06-1 The author mentioned the following in the article:

A series of triazine-benzimidazole hybrids I [R = NEt2, NPr2, N(Bn)Et, etc.; n = 0, 1] were designed and synthesized and evaluated as multi-target agents for the treatment of Alzheimer’s disease. Compounds I were designed, synthesized and identified by NMR, IR, HRMS and single-crystal X-ray diffraction studies. The compound I [R = N(n-Bu)2, n = 0] had the crystal system of orthorhombic and the space group of P212121. The cholinesterase inhibitory activity of synthesized compounds I was measured using colorimetric Ellman’s method. Most 1,3,5-triazine-benzimidazole hybrids I showed potent acetylcholinesterase-inhibition activities and weak butyrylcholinesterase inhibitory activities. Compound I [R = N(Cy)Me, n = 1] possessed the best acetylcholinesterase inhibitory activity with the IC50 of 0.044μM, which was better than donepezil (0.052μM). Mol. docking and mol. dynamics simulations demonstrated that there was a stable interaction between compound I [R = N(Cy)Me, n = 1] and acetylcholinesterase. Simultaneously, experiments have also proved that compound I [R = N(Cy)Me, n = 1] has good metal chelating properties. ADMET in silico prediction results suggest the compound can pass through the blood-brain barrier well and have good drug similarity. So, compound I [R = N(Cy)Me, n = 1] could be a multi-target agent for the treatment of Alzheimer’s disease.2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1SDS of cas: 4857-06-1) was used in this study.

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.SDS of cas: 4857-06-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem