Tag: 100-200

Wang, Ying-Ying; Liu, Man; Dong, Lin published an article in 2021. The article was titled 《Rh(III)-Catalyzed multi-site-selective C-H bond functionalization: condition-controlled synthesis of diverse fused polycyclic benzimidazole derivatives》, and you may find the article in Organic Chemistry Frontiers.Synthetic Route of C7H5ClN2 The information in the text is summarized as follows:

Novel fused polycyclic- and multi-substituted 2-oxyl naphthalene benzimidazole derivatives were selectively synthesized via Rh(III)-catalyzed tandem C-H activation/cyclization. The efficient strategy for the construction of diverse annulation products was precisely controlled by changing the reaction conditions. The experimental process involved the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Synthetic Route of C7H5ClN2)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Synthetic Route of C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lafzi, Ferruh; Kilic, Deryanur; Yildiz, Melike; Saracoglu, Nurullah published an article in 2021. The article was titled 《Design, synthesis, antimicrobial evaluation, and molecular docking of novel chiral urea/thiourea derivatives bearing indole, benzimidazole, and benzothiazole scaffolds》, and you may find the article in Journal of Molecular Structure.Reference of 1H-Benzo[d]imidazol-2-amine The information in the text is summarized as follows:

Urea/thiourea derivatives with heteroaromatic scaffolds such as indole I [X = O, S], benzimidazole II, and benzothiazole were designed, synthesized and evaluated for their potential antimicrobial activity in vitro assays to establish against B. cereus, S. aureus, E. coli, and P. aeruginosa. Results indicated that compounds were only active in gram-pos. bacteria. Mol. docking studies were carried out for the most efficient compounds to understand the interactions with proteins involved in peptidoglycan synthesis. ADME calculations indicated that these compounds were more likely to be taken via the oral route. In summary, these findings may contribute to the design and development of candidates for more effective therapeutics in biol. systems. In the experimental materials used by the author, we found 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Reference of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Reference of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fan, Guang-Gao; Jiang, Bo-Wen; Sang, Wei; Cheng, Hua; Zhang, Rui; Yu, Bao-Yi; Yuan, Ye; Chen, Cheng; Verpoort, Francis published an article in 2021. The article was titled 《Metal-Free Synthesis of Heteroaryl Amines or Their Hydrochlorides via an External-Base-Free and Solvent-Free C-N Coupling Protocol》, and you may find the article in Journal of Organic Chemistry.Computed Properties of C7H5ClN2 The information in the text is summarized as follows:

Herein, a metal-free and solvent-free protocol was developed for the C-N coupling of heteroaryl halides and amines, which afforded numerous heteroaryl amines or their hydrochlorides without any external base. Further investigations elucidated that the basicity of amines and specific interactions derived from the X-ray crystallog. anal. of 1-Methyl-N-phenyl-1H-benzo[d]imidazol-2-amine hydrochloride played pivotal roles in the reactions. Moreover, this protocol was scalable to gram scales and applicable to drug mols., which demonstrated its practical value for further applications. The experimental process involved the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Computed Properties of C7H5ClN2)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Computed Properties of C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zhang, Chenlu; Zhu, Hai; Gang, Kaiyue; Tao, Minli; Ma, Ning; Zhang, Wenqin published their research in Reactive & Functional Polymers in 2021. The article was titled 《Immobilization of copper(II) into polyacrylonitrile fiber toward efficient and recyclable catalyst in Chan-Lam coupling reactions》.Application In Synthesis of 1H-Benzo[d]imidazol-2-amine The article contains the following contents:

A series of polyacrylonitrile fiber (PANF)-supported copper(II) catalysts were prepared through the immobilization of Cu(II) into prolinamide-modified PANF (PANPA-2F) and subsequently used for the synthesis of diverse N-arylimidazoles from arylboronic acids and imidazole. The prepared Cu(II)@PANPA-2Fs were well characterized by mech. strength, FT-IR, XRD, XPS and SEM. Among them, CuCl2@PANPA-2F exhibited excellent catalytic performance and its activity was significantly affected by the Cu loading. This catalytic system also displayed good activity in the synthesis of N-arylsulfonamides from arylboronic acids and tosyl azide. The catalyst was highly efficient in gram-scale reactions and could be reused five times. The advantages of low cost, easy preparation, good durability, and facile recovery made the fiber catalyst attractive. The results came from multiple reactions, including the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Application In Synthesis of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Application In Synthesis of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Cyclic Voltammetry as an Electroanalytical Tool for Analysing the Reaction Mechanisms of Copper in Chloride Solution Containing Different Azole Compounds》 was published in Current Analytical Chemistry in 2020. These research results belong to Finsgar, Matjaz; Xhanari, Klodian; Curkovic, Helena O.. Electric Literature of C7H7N3 The article mentions the following:

Cyclic voltammetry is widely employed in electroanal.studies because it provides fast information about the redox potentials of the electroactive species and the influence of the medium on the redox processes. Azole compoundshave been found to be effective corrosion inhibitors for copper in chloride-containingsolutions The aim of this work was to investigate in detail the influence of the addition of various azole compoundson the oxidationmechanism of copper in chloride-containingsolutions, using cyclic voltammetry. The influence of thirteen azole compounds, at three different concentrationson the electrochem./ chem. reactions of pure copper immersed in 3 weight% NaCl solutionwas studied using cyclic voltammetry at different scan rates. The change of the peak current and potential with the scan rate were investigated. The possible linearity was compared with the theor.derived mechanism. The possible reaction mechanisms were discussed based on the linearity of these parameters (peak current and potential) with the scan rate compared to theor.derived models. Both the peak current and peak potential of the copper samples immersed in chloridecontaining solutionswith additionsof the majority of azole compoundsshowed linearity with the square root of the scan rate, suggesting that copper follows the Muller-Calandra passivation model. The same behavior was also found for copper in chloride-containing solutions without additionsof azole compounds A linear variation of the peak potential with the natural logarithm of the scan rate and linear variation of the peak potential with the square root of the scan rate was observed for the copper samples immersed in chloride-containing solutions with the addition of 10 mM of 2-mercapto-1- methylimidazole, imidazole, or 2-aminobenzimidazole. This suggests that copper follows irreversible redox reactions under a diffusion controlled process. No other linear relations of the peak current and peak potential with the scan rate were found. Copper oxidationin chloride-containingsolutionsis controlled by passivation (following the Muller-Calandra passivation model) upon the addition of the majority of the selected azoles. In the minority of cases, irreversible redox reactions that follow a diffusion-controlled process were identified. None of the systems followed an adsorption-controlled process. Moreover, none of the tested systems underwent reversible redox reactions that followed a diffusion controlled process. In the part of experimental materials, we found many familiar compounds, such as 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Electric Literature of C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Electric Literature of C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254)》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Yang, Bin; Hird, Alexander W.; Bodnarchuk, Michael S.; Zheng, Xiaolan; Dakin, Les; Su, Qibin; Daly, Kevin; Godin, Robert; Hattersley, Maureen M.; Brassil, Patrick; Redmond, Sean; John Russell, Daniel; Janetka, James W.. Category: imidazoles-derivatives The article mentions the following:

Aberrant hedgehog (Hh) pathway signaling is implicated in multiple cancer types and targeting the Smoothened (SMO) receptor, a key protein of the Hh pathway, has proven effective in treating metastasized basal cell carcinoma. Our lead optimization effort focused on a series of heteroarylamides. We observed that a Me substitution ortho to the heteroaryl groups on an aniline core significantly improved the potency of this series of compounds These findings predated the availability of SMO crystal structure in 2013. Here we retrospectively applied quantum mechanics calculations to demonstrate the o-Me substitution favors the bioactive conformation by inducing a dihedral twist between the heteroaryl rings and the core aniline. The o-Me also makes favorable hydrophobic interactions with key residue side chains in the binding pocket. From this effort, two compounds (AZD8542 and AZD7254) showed excellent pharmacokinetics across multiple preclin. species and demonstrated in vivo activity in abrogating the Hh paracrine pathway as well as anti- tumor effects. After reading the article, we found that the author used 2-Bromo-1H-imidazole(cas: 16681-56-4Category: imidazoles-derivatives)

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Mechanistic studies of the influence of halogen substituents on the corrosion inhibitive efficiency of selected imidazole molecules: A synergistic computational and experimental approach》 were Abdulazeez, Ismail; Zeino, Aasem; Kee, Choon Wee; Al-Saadi, Abdulaziz A.; Khaled, Mazen; Wong, Ming Wah; Al-Sunaidi, Abdullah A.. And the article was published in Applied Surface Science in 2019. COA of Formula: C3H3BrN2 The author mentioned the following in the article:

Adsorption behavior and corrosion inhibition mechanism of imidazole and its C2-halogenated analogs (with the halogen atoms being Cl, Br or I) on Fe(1 0 0) surface were investigated by DFT periodic slab calculations and electrochem. techniques. DFT calculations revealed that C2-halogenated imidazoles adopt the tilted conformation on Fe surface with a significantly lengthened C-halogen bond and readily undergo facile dissociation at the halo-substitution with calculated adsorption energies -3.95, -3.76 and -3.48 eV for 2-I-Imz, 2-Br-Imz and 2-Cl-Imz, resp. Electrochem. evaluations supported with surface characterization studies showed that the inhibitor mols. adsorb onto mild steel with 2-I-Imz having the highest inhibition efficiency of 83.5%. The trend of observed inhibition efficiencies correlates with adsorption energies and kinetic behavior predicted by the MD approach. The strength of adsorption in the order I >Br > Cl. The present study therefore provides a thorough mechanistic understanding of the role halogen substituents could play on the corrosion inhibitive performance of small organic systems. In addition to this study using 2-Bromo-1H-imidazole, there are many other studies that have used 2-Bromo-1H-imidazole(cas: 16681-56-4COA of Formula: C3H3BrN2) was used in this study.

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. COA of Formula: C3H3BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Polymers (Basel, Switzerland) included an article by Vu-Quang, Hieu; Vinding, Mads Sloth; Nielsen, Thomas; Ullisch, Marcus Goerge; Nielsen, Niels Chr.; Nguyen, Dinh-Truong; Kjems, Jorgen. Application In Synthesis of Di(1H-imidazol-1-yl)methanone. The article was titled 《Pluronic F127-folate coated super paramagenic iron oxide nanoparticles as contrast agent for cancer diagnosis in magnetic resonance imaging》. The information in the text is summarized as follows:

Contrast agents have been widely used in medicine to enhance contrast in magnetic resonance imaging (MRI). Among them, super paramagnetic iron oxide nanoparticles (SPION) have been reported to have low risk in clin. use. In our study, F127-Folate coated SPION was fabricated in order to efficiently target tumors and provide imaging contrast in MRI. SPION alone have an average core size of 15 nm. After stabilizing with Pluronic F127, the nanoparticles reached a hydrodynamic size of 180 nm and dispersed well in various kinds of media. The F127-Folate coated SPION were shown to specifically target folate receptor expressing cancer cells by flow cytometry anal., confocal laser scanning microscope, as well as in vitro MRI. Furthermore, in vivo MRI images have shown the enhanced neg. contrast from the F127-Folate coated SPION in tumor-bearing mice. In conclusion, our F127-Folate coated SPION have shown great potential as a contrast agent in MRI, as well as in the combination with drug delivery for cancer therapy. In the experimental materials used by the author, we found Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Application In Synthesis of Di(1H-imidazol-1-yl)methanone)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Application In Synthesis of Di(1H-imidazol-1-yl)methanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels》 was published in British Journal of Pharmacology in 2015. These research results belong to Zhu, Yingmin; Lu, Yungang; Qu, Chunrong; Miller, Melissa; Tian, Jinbin; Thakur, Dhananjay P.; Zhu, Jinmei; Deng, Zixin; Hu, Xianming; Wu, Meng; McManus, Owen B.; Li, Min; Hong, Xuechuan; Zhu, Michael X.; Luo, Huai-Rong. COA of Formula: C10H12N2O The article mentions the following:

Background and Purpose : Transient receptor potential canonical (TRPC) channels play important roles in a broad array of physiol. functions and are involved in various diseases. However, due to a lack of potent subtype-specific inhibitors the exact roles of TRPC channels in physiol. and pathophysiol. conditions have not been elucidated. Exptl. Approach : Using fluorescence membrane potential and Ca2+ assays and electrophysiol. recordings, we characterized new 2-aminobenzimidazole-based small mol. inhibitors of TRPC4 and TRPC5 channels identified from cell-based fluorescence high-throughput screening. Key Results : The original compound, M084, was a potent inhibitor of both TRPC4 and TRPC5, but was also a weak inhibitor of TRPC3. Structural modifications of the lead compound resulted in the identification of analogs with improved potency and selectivity for TRPC4 and TRPC5 channels. The aminobenzimidazole derivatives rapidly inhibited the TRPC4- and TRPC5-mediated currents when applied from the extracellular side and this inhibition was independent of the mode of activation of these channels. The compounds effectively blocked the plateau potential mediated by TRPC4-containing channels in mouse lateral septal neurons, but did not affect the activity of heterologously expressed TRPA1, TRPM8, TRPV1 or TRPV3 channels or that of the native voltage-gated Na+, K+ and Ca2+ channels in dissociated neurons. Conclusions and Implications : The TRPC4/C5-selective inhibitors developed here represent novel and useful pharmaceutical tools for investigation of physiol. and pathophysiol. functions of TRPC4/C5 channels.3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9COA of Formula: C10H12N2O) was used in this study.

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
COA of Formula: C10H12N2O However, the application of imidazoles is not limited to the field of peptides and peptidomimetics.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Functionalized ZIF-7/Pebax 2533 mixed matrix membranes for CO2/N2 separation》 was written by Gao, Jie; Mao, Haizhuo; Jin, Hua; Chen, Chen; Feldhoff, Armin; Li, Yanshuo. Category: imidazoles-derivativesThis research focused onzeolite mixed matrix membrane carbon dioxide nitrogen separation. The article conveys some information:

Membrane-based separation technol. has evolved as a competitive approach for CO2 capture from flue gas (mainly N2). To achieve high separation performance, three partially NH2-, OH- and CH3OH- functionalized mixed-linker-ZIF-7 were successfully synthesized, and incorporated into polyether-block-amide (Pebax 2533) polymer to form mixed-matrix membranes (MMMs). As evidenced by the CO2 adsorption isotherms, introducing functional groups in the ZIF-7 framework was indeed beneficial for CO2 adsorption. All MMMs composed of ZIF-7-NH2, ZIF-7-OH and ZIF-7-CH3OH offered better CO2/N2 separation performance than the parent ZIF-7-Pebax 2533 membrane, suggesting the pos. effect of functionalized ZIF-7 fillers on the gas separation performance. Among the three functionalized ZIF-7 based MMMs, the ZIF-7-OH-Pebax MMMs exhibited the best performance for CO2/N2 separation, which might be ascribed to the highest adsorption selectivity of CO2 over N2 predicted by ideal adsorbed solution theory (IAST) for ZIF-7-OH fillers. The 14% ZIF-7-OH-Pebax MMM showed high CO2 permeability of 273 Barrer and CO2/N2 separation factor of 38, which increased by 60% and 145% as compared with the neat Pebax membrane. The strategy of preparing functionalized MOFs with strong affinity for CO2 provides an effective method to develop MMMs for highly efficient CO2 separation In the experiment, the researchers used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Category: imidazoles-derivatives)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem