Tag: 100-200

Synthetic Route of C7H7N3In 2020 ,《Efficient Synthesis of Pyrimido[1,2-a]Benzimidazoles and Ethyl Pyrimido[1,2-a]Benzimidazole-3-Carboxylates Using Bronsted Acidic Ionic Liquid Supported on Nanoporous Na+-Montmorillonite》 appeared in Polycyclic Aromatic Compounds. The author of the article were Makhsous, Masoumeh; Shirini, Farhad; Seddighi, Mohadeseh; Mazloumi, Masoumeh. The article conveys some information:

Nanoporous sodium montmorillonite clay (Na+-MMT) was successfully modified with 1-methyl-3-(trimethoxysilylpropyl)-imidazolium hydrogen sulfate (Na+-MMT-[pmim]HSO4). This immobilized acidic ionic liquid showed excellent catalytic activity for the synthesis of pyrimido[1,2-a]benzimidazoles and Et pyrimido[1,2-a]benzimidazole-3-carboxylates via three-component reactions between aldehydes, 2-aminobenzimidazole and malononitrile or β-dicarbonyl compounds The procedure gave the products in high yields in very short reaction times at 100° under solvent-free conditions. Also, this catalyst can be reused for five times without loss of its catalytic activity. The experimental process involved the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Synthetic Route of C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Synthetic Route of C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,St-Jean, Frederic; Angelaud, Remy; Bachmann, Stephan; Carrera, Diane E.; Remarchuk, Travis; Piechowicz, Katarzyna A.; Niedermann, Katrin; Iding, Hans; Meier, Roland; Hou, Haiyun; Sirois, Lauren E.; Xu, Jie; Olbrich, Martin; Rege, Pankaj; Guillemot-Plass, Maud; Gosselin, Francis published an article in Journal of Organic Chemistry. The title of the article was 《Stereoselective Synthesis of the IDO Inhibitor Navoximod》.COA of Formula: C3H3BrN2 The author mentioned the following in the article:

A highly efficient asym. synthesis of the IDO inhibitor navoximod, featuring the stereoselective installation of two relative and two absolute stereocenters from an advanced racemic intermediate, was described. The stereocenters were set via a crystallization-induced dynamic resolution along with two selective ketone reductions: one via a biocatalytic ketoreductase transformation and one via substrate-controlled hydride delivery from LiAlH(Ot-Bu)3. Following this strategy, navoximod were synthesized in 10 steps from 2-fluorobenzaldehyde and isolated in 23% overall yield with 99.8% ee and high purity. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-1H-imidazole(cas: 16681-56-4COA of Formula: C3H3BrN2)

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. COA of Formula: C3H3BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chen, Nan; Yang, Hao; Li, Qing; Song, Lijun; Gopinath, Subash C. B.; Wu, Di published an article in 2021. The article was titled 《An interdigitated aptasensor to detect interleukin-6 for diagnosing rheumatoid arthritis in serum》, and you may find the article in Biotechnology and Applied Biochemistry.HPLC of Formula: 530-62-1 The information in the text is summarized as follows:

Rheumatoid arthritis (RA) is an autoimmune disorder causing chronic inflammation in the small joints of the articular bone and destruction of articular cartilage. RA causes stiffness, pain, joint destruction, substantial comorbidity, and functional disability. Early-stage diagnosis of RA can help in the treatment of the disease and expand the patient life span. Interleukins are a group of inflammatory cytokines; in particular, an abundance of interleukin-6 (IL-6) was found in the synovial fluid and serum. In RA patients, the levels of IL-6 have been found to be correlated with the disease, and this work focused on detecting IL-6 by its aptamer with the help of a biotin-streptavidin strategy on an interdigitated electrode. A sensitivity of 1 fM (0.021 pg/mL) and a limit of detection of 10 fM (0.21 pg/mL) were found by a linear regression [y = 0.6413x – 0.6249; R2 = 0.952] of the linear range from 1 fM to 100 pM. This method enhanced the immobilization of higher aptamer mols. for recognizing RA in serum-containing samples and is applicable to other diseases. In the experimental materials used by the author, we found Di(1H-imidazol-1-yl)methanone(cas: 530-62-1HPLC of Formula: 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.HPLC of Formula: 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Qian, Junfeng; Wu, Tingting; Shi, Jianqun; Chang, Hao; Liu, Donghui; Pan, Yichang published an article in 2021. The article was titled 《Improved CO2/CH4 separation performance of mixed-matrix membrane by adding ZIF-7-NH2 nanocrystals》, and you may find the article in Journal of Applied Polymer Science.Electric Literature of C7H7N3 The information in the text is summarized as follows:

Membrane-based technol. is an attractive alternative in terms of CO2 separation Pebax-based membranes are regarded as potential candidates for CO2 separation due to the favorable interaction between its poly(ethylene oxide) chains with CO2 mols. and inorganic fillers. However, the separation performance for CO2/CH4 mixture is still suffered from the moderate gas permeability and selectivity. To overcome this problem, in this work, amino-functionalized zeolite imidazolate framework (ZIF-7-NH2) nanocrystals were used as fillers to blend with Pebax 1657 for fabricating mixed-matrix membranes (MMMs). XRD, Brunauer-Emmett-Teller (BET), scanning electron microscope, and 1H NMR characterization indicated that ZIF-7-NH2 with the highest crystallinity was synthesized. Fourier transform IR spectroscopy, thermogravimetric anal., differential scanning calorimetry (DSC), and Young’s modulus showed that it has good interfacial interaction. Gas separation test results showed that both the CO2 permeability and CO2/CH4 selectivity of the 31 wt% ZIF-7-NH2/Pebax MMMs increased by 80 and 170%, resp. The improved performance is attributed to the addition of ZIF-7-NH2 nanocrystals and the favorable interfacial interactions between the polymer and ZIF-7-NH2 nanocrystals. Furthermore, the polyvinylidene fluoride supported hollow fiber composite membranes also exhibit the long-term stability for CO2/CH4 separation In addition to this study using 1H-Benzo[d]imidazol-2-amine, there are many other studies that have used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Electric Literature of C7H7N3) was used in this study.

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Electric Literature of C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Aliabadi, Alireza; Hakimi, Mohammad; Hosseinabadi, Fatemeh; Motieiyan, Elham; Rodrigues, Vitor Hugo Nunes; Ghadermazi, Mohammad; Marabello, Domenica; Abdolmaleki, Sara published an article in 2021. The article was titled 《Investigation of X-ray crystal structure and in vitro cytotoxicity of two Ga(III) complexes containing pyridine dicarboxylic acid derivatives and 2-aminobenzimidazole》, and you may find the article in Journal of Molecular Structure.SDS of cas: 934-32-7 The information in the text is summarized as follows:

Two new coordination complexes were synthesized using the reaction of two organic salts with gallium(III) nitrate octahydrate. The salts were prepared and used as ligand from the reaction of 2-aminobenzimidazole with pyridine-2,6-dicarboxylic acid and 4-hydroxypyridine-2,6-dicarboxylic acid, resp. All compounds were identified by spectroscopic methods and their crystal structures determined by single crystal x-ray diffraction. The investigations showed that the two complexes were isostructural. Moreover, thermal anal. was carried out to study the decomposition steps of the complexes. The inhibition properties of the compounds were studied in vitro using oxaliplatin as a standard against five cell lines including a human breast cancer, a prostate cancer, a human liver hepatocellular carcinoma, a colorectal carcinoma and a human foreskin fibroblast. The anti-proliferative activity of the complexes is similar in the majority of cell lines except for the prostate cancer cells. The most remarkable cytotoxicity effect of both complexes appeared on the human breast cancer cells. Determination of mitochondrial membrane potential and reactive oxygen species in this cell line suggested that apoptosis may be the main pathway for the death of the cells. The experimental part of the paper was very detailed, including the reaction process of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7SDS of cas: 934-32-7)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.SDS of cas: 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Micellar nanocarriers from dendritic macromolecules containing fluorescent coumarin moieties》 was written by Concellon, Alberto; Anselmo, Maria San; Hernandez-Ainsa, Silvia; Romero, Pilar; Marcos, Mercedes; Serrano, Jose Luis. HPLC of Formula: 530-62-1 And the article was included in Polymers (Basel, Switzerland) in 2020. The article conveys some information:

The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with bisMPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic mols., and at the same time provided fluorescent traceability due to the presence of coumarin units in their chem. structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications. In the experiment, the researchers used many compounds, for example, Di(1H-imidazol-1-yl)methanone(cas: 530-62-1HPLC of Formula: 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.HPLC of Formula: 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthesis, spectroscopic characterizations, DFT, molecular docking and molecular dynamics simulations of a novel 2-methyl-3H-benzimidazolo[1,2-b][1,2,4]triazepin-4(5H)-one》 was written by El Bakri, Youness; Anouar, El Hassane; Subramani, Karthikeyan; Ben-Yahya, Ali; Essassi, El Mokhtar. COA of Formula: C7H7N3 And the article was included in Journal of Molecular Structure in 2020. The article conveys some information:

A novel compound named 2-methyl-3H-benzimidazolo[1,2-b][1,2,4]triazepin-4(5H)-one I was synthesized and characterized by spectroscopic techniques (FT-IR), UV-Vis, 1H NMR, 13C NMR and mass spectra. The optimized mol. structure anal., vibrational wave numbers, 13C and 1H NMR chem. shifts of the title mol. had been performed at DFT/B3LYP method with 6-31 + G(d,p) basis set. The electronic absorption wavelengths computed using B3LYP, B3P86 and PBE0 hybrid functional. The scaled vibrational modes and the predicted 13C NMR and 1H NMR chem. shifts were relatively in good agreement with the corresponding exptl. ones. However, B3LYP, B3P86 and PBE0 hybrid functional failed in reproduction of exptl. λMAX of the tilted compound and it was underestimated by the tested hybrid functionals with deviations to the exptl. values of 30, 34 and 40 nm for B3LYP, B3P86 and PBE0, resp. In addition, mol. docking and mol. dynamics simulations of titled compound were carried out to determine its binding modes and stability within the leucine-rich repeat kinase 2 active site. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7COA of Formula: C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.COA of Formula: C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Amino-functional ZIF-8 nanocrystals by microemulsion based mixed linker strategy and the enhanced CO2/N2 separation》 was published in Separation and Purification Technology in 2020. These research results belong to Ding, Rui; Zheng, Wenji; Yang, Kai; Dai, Yan; Ruan, Xuehua; Yan, Xiaoming; He, Gaohong. Electric Literature of C7H7N3 The article mentions the following:

High permeability and selectivity are desirable for mixed matrix membranes (MMMs) based CO2 separation Herein, a microemulsion based mixed linker strategy is proposed to introduce amino groups during the growth of ZIF-8. Compared to post-synthetic modification, this method presents a less reduction in SBET of ZIF-8, which is beneficial for CO2 adsorption. By controlling the ratio of 2-methylimidazole to 2-aminobenzimidazole, NH2-ZIF-8 with various morphologies and sizes were synthesized and serve as the filler to fabricate the MMMs for CO2 capture. From the SEM, no obvious agglomerations or defects are observed in ZIF-8/Pebax MMMs, due to the amino groups in ZIF-8 can interact with the amide in Pebax chain, which can improve compatibility between ZIF-8 and Pebax. With the amino groups, NH2-ZIF-8 shows higher affinity with CO2 than that of non-amine-functionalized ZIF-8, leading to an enhancement in the separation performances. When the MMM doped with 6 weight% of NH2-ZIF-8(10), the CO2 permeability reaches up to 163.8 Barrer, which increases by around 53% and 107.6% in contrast with the ZIF-8/Pebax MMM and pure Pebax membrane. Besides, the CO2/N2 selectivity is enhanced by around 10% and 27%, resp. These results indicate that amine-functional modification by mixed ligands is a useful way to construct MOFs-based MMMs with high performance for CO2/N2 separation The experimental part of the paper was very detailed, including the reaction process of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Electric Literature of C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Electric Literature of C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Journal of Saudi Chemical Society included an article by Karimi, Maryam; Naimi-Jamal, M. R.. Application In Synthesis of 1H-Benzo[d]imidazol-2-amine. The article was titled 《Carboxymethyl cellulose as a green and biodegradable catalyst for the solvent-free synthesis of benzimidazoloquinazolinone derivatives》. The information in the text is summarized as follows:

CM-cellulose (CMC) was used as an efficient, and environmentally friendly catalyst for the solvent-free three-component synthesis of quinazolinone derivatives by condensation of 2-aminobenzimidazole, dimedone or 1,3-cyclohexanedione, and different aldehydes. The catalyst was recovered easily, and reused without significant loss of its activity. Solvent-free and mild reaction conditions, nontoxic-, biodegradable-, and inexpensive catalyst, environmentally benign method, and high to excellent yields are some important features of this protocol. In addition to this study using 1H-Benzo[d]imidazol-2-amine, there are many other studies that have used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Application In Synthesis of 1H-Benzo[d]imidazol-2-amine) was used in this study.

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Application In Synthesis of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Organic & Biomolecular Chemistry included an article by Saha, Abhishek; Akhtar, Nasim; Kumar, Vishnu; Kumar, Suresh; Srivastava, Hemant Kumar; Kumar, Sachin; Manna, Debasis. COA of Formula: C7H5ClN2. The article was titled 《pH-regulated anion transport activities of bis(iminourea) derivatives across the cell and vesicle membrane》. The information in the text is summarized as follows:

Recently, synthetic anion transporters have gained considerable attention because of their ability to disrupt cellular anion homeostasis and promote cell death. Herein, we report the development of bis(iminourea) derivatives as a new class of selective Cl- ion carrier. The bis(iminourea) derivatives were synthesized via a one-pot approach under mild reaction conditions. The presence of iminourea moieties suggests that the bis(iminourea) derivatives can be considered as unique guanidine mimics, indicating that the protonated framework could have much stronger anion recognition properties. The cooperative interactions of H+ and Cl- ions with these iminourea moieties results in the efficient transport of HCl across the lipid bilayer in an acidic environment. Under physiol. conditions these compounds weakly transport Cl- ions via an antiport exchange mechanism. This pH-dependent gating/switching behavior (9-fold) within a narrow window could be due to the apparent pKa values (6.2-6.7) of the compounds within the lipid bilayer. The disruption of ionic homeostasis by the potent compounds was found to induce cell death. In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1COA of Formula: C7H5ClN2)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.COA of Formula: C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem