Tag: 100-200

In 2022,Machado, R. M.; da Silva, S. W.; Bernardes, A. M.; Ferreira, J. Z. published an article in Journal of Environmental Management. The title of the article was 《Degradation of carbendazim in aqueous solution by different settings of photochemical and electrochemical oxidation processes》.Quality Control of 1H-Benzo[d]imidazol-2-amine The author mentioned the following in the article:

The present study analyzed the performance of photochem. and electrochem. techniques in the degradation and mineralization of the pesticide carbendazim (CBZ). Direct photolysis (DP), heterogeneous photocatalysis (HP), photoelectrocatalysis (PEC), and electrochem. oxidation (EO) were tested, and the influence of UV radiation, c.d. (j), and supporting electrolyte concentration were evaluated. The results suggest that CBZ is only degraded by DP when UV-C254nm is used. For HP, the CBZ degradation was observed both when UV-A365nm or UV-C254nm were used, which is related to the reactive oxygen species (ROS) formed by the photocatalytic activity (photon-ROS). Neither DP nor HP were able to mineralize CBZ, demonstrating its resistance to photomediated processes. For EO, regardless of the j, there were higher CBZ degradation and mineralization than those observed when using DP and HP. The increase in the supporting electrolyte concentration (Na2SO4) did not affect the levels of degradation and mineralization of CBZ. Concerning the PEC, a CBZ mineralization of 52.2% was accomplished. These findings demonstrate that the EO is the main pathway for CBZ mineralization, suggesting an addnl. effect of the electro-ROS on the photon-ROS and UV-C254nm. The values of mineralization, kinetics, and half-life show that PEC UV-C254nm with a j of 15 mA cm-2 was the best setting for the degradation and mineralization of CBZ. However, when the values of specific energy consumption were considered for industrial applications, the use of EO with a j of 3 mA cm-2 and 4 g L-1 of Na2SO2 becomes more attractive. The assessment of byproducts formed after this best cost-efficient treatment setting revealed the presence of aromatic and aliphatic compounds from CBZ degradation Acute phytotoxicity results showed that the presence of sodium sulfate can be a representative factor regarding the toxicity of samples treated in electrochem. systems. The experimental part of the paper was very detailed, including the reaction process of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Quality Control of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Quality Control of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Idayu Abdul Razak, Mas Amira; Abdul Hamid, Haslinda; Izawati Raja Othman, Raja Nor; Mohd Moktar, Shaik Alaudeen; Miskon, Azizi published an article in 2021. The article was titled 《Improved Drug Delivery System for Cancer Treatment by D-Glucose Conjugation with Eugenol From Natural Product》, and you may find the article in Current Drug Delivery.Related Products of 530-62-1 The information in the text is summarized as follows:

Bioconjugations are swiftly progressing and are being applied to solve several limitations of conventional Drug Delivery Systems (DDS) such as lack of water solubility, non-specific, and poor bioavailability. The main goals of DDS are to achieve greater drug effectiveness and minimize toxicity to the healthy tissues. In this study, D-glucose was conjugated with eugenol to target the cancer cells. To identify the implication of the anticancer effect, osteosarcoma (K7M2) cells were cultured and the anti-proliferative effect was performed using MTT [3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl tetrazolium bromide assay] test in order to evaluate the viability and toxicity on cells with various concentrations of eugenol and D-glucose-eugenol conjugate in 24-h incubation. It was found that, the successful confirmation of the conjugation between D-glucose and eugenol was obtained by 1H NMR spectroscopy. MTT assay showed inhibitory concentration (IC50 value) of D-glucose-eugenol was at 96.2 μg/mL and the decreased of osteosarcoma cell survival was 48%. These findings strongly indicate that K7M2 cells would be affected by toxicity of D-glucose- eugenol. Therefore, the present study suggests that D-glucose-eugenol has high potential to act as an anti-proliferative agent who may promise a new modality or approach as the drug delivery treatment for cancer or chemotherapeutic agent. In the experiment, the researchers used many compounds, for example, Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Related Products of 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Related Products of 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wannberg, Johan; Gising, Johan; Lindman, Jens; Salander, Jessica; Gutierrez-de-Teran, Hugo; Ablahad, Hanin; Hamid, Selin; Groenbladh, Alfhild; Spizzo, Iresha; Gaspari, Tracey A.; Widdop, Robert E.; Hallberg, Anders; Backlund, Maria; Lesniak, Anna; Hallberg, Mathias; Larhed, Mats published their research in Bioorganic & Medicinal Chemistry in 2021. The article was titled 《N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands》.Application In Synthesis of 2-Bromo-1H-imidazole The article contains the following contents:

A series of meta-substituted acetophenone derivatives, encompassing N-(alkyloxycarbonyl)thiophene sulfonamide fragments have been synthesized. Several selective AT2 receptor ligands were identified, among those a tert-butylimidazole derivative (20) with a Ki of 9.3 nM, that demonstrates a high stability in human liver microsomes (t1/2 = 62 min) and in human hepatocytes (t1/2 = 194 min). This methyloxycarbonylthiophene sulfonamide is a 20-fold more potent binder to the AT2 receptor and is considerably more stable in human liver microsomes, than a previously reported and broadly studied structurally related AT2R prototype antagonist 3 (C38). Ligand 20 acts as an AT2R agonist and caused an AT2R mediated concentration-dependent vasorelaxation of pre-contracted mouse aorta. Furthermore, in contrast to imidazole derivative C38, the tert-butylimidazole derivative 20 is a poor inhibitor of CYP3A4, CYP2D6 and CYP2C9. It is demonstrated herein that smaller alkyloxycarbonyl groups make the ligands in this series of AT2R selective compounds less prone to degradation and that a high AT2 receptor affinity can be retained after truncation of the alkyloxycarbonyl group. Binding modes of the most potent AT2R ligands were explored by docking calculations combined with mol. dynamics simulations. In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-1H-imidazole(cas: 16681-56-4Application In Synthesis of 2-Bromo-1H-imidazole)

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Application In Synthesis of 2-Bromo-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Preparation and characterization of cyclodextrin nanosponges for bortezomib delivery》 was published in Expert Opinion on Drug Delivery in 2020. These research results belong to Allahyari, Saeideh; Valizadeh, Hadi; Roshangar, Leila; Mahmoudian, Mohammad; Trotta, Francesco; Caldera, Fabrizio; Jelvehgari, Mitra; Zakeri-Milani, Parvin. Quality Control of Di(1H-imidazol-1-yl)methanone The article mentions the following:

Bortezomib (BTZ) as an anticancer drug has been used through the injection pathway. Research design and methodsTwo types of Cyclodextrin nanosponges (CDNSs) were synthesized and studied by DLS, TEM, FTIR, and DSC instruments for BTZ delivery. Both carriers were analyzed for loading efficiencies and in-vitro release. Cell studies and intestinal permeability of selected CDNS were determined using MTT and SPIP method, resp. Both types of CDNSs, encapsulated BTZ in their nano-porous structure, but better loading was shown in CDNS 1:4. FTIR and DSC results proved considerable encapsulation of BTZ into CDNSs. The slow and prolonged release profile was observed for CDNS 1:4 in comparison with CDNS 1:2. Based on in-vitro results, BTZ-CDNS 1:4 was chosen as a selected nanosystem for further anal. This nontoxic carrier revealed considerable uptake (93.9% in 3 h) against the MCF-7 cell line but indicated higher IC50 in comparison with the plain drug. This carrier also could improve the rat intestinal permeability of BTZ almost 5.8 times. CDNS 1:4 has the ability to be introduced as a nontoxic carrier for BTZ delivery with its high loading, controlled release manner, high cellular uptake, and permeability improvement characteristics. In addition to this study using Di(1H-imidazol-1-yl)methanone, there are many other studies that have used Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Quality Control of Di(1H-imidazol-1-yl)methanone) was used in this study.

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Quality Control of Di(1H-imidazol-1-yl)methanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Synthesis of Imidazolium and Benzimidazolium Triiodides》 were Shagun, L. G.; Dorofeev, I. A.; Zhilitskaya, L. V.; Yarosh, N. O.; Larina, L. I.. And the article was published in Russian Journal of Organic Chemistry in 2019. Name: 1H-Benzo[d]imidazol-2-amine The author mentioned the following in the article:

1,3-(Di)acetonylimidazolium and -benzimidazolium triiodides were synthesized in a one-pot fashion by reactions of imidazole, 3-(1H-imidazol-4-yl)prop-2-enoic acid, benzimidazole, benzimidazol-2-amine, and 2-ethylbenzimidazole with 1-iodopropan-2-one and mol. iodine under solvent-free conditions in the absence of a base and catalyst at room temperature The reaction of 1H-benzimidazole-2-thiol with 1-iodopropan-2-one and iodine afforded 2-(2-oxopropylsulfanyl)imidazolium triiodide. The reaction direction and yield did not change when 2-iodo-1-(thiophen-2-yl)ethanone was used instead of 1-iodopropan-2-one. After reading the article, we found that the author used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Name: 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Name: 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Iridium-Catalyzed Enantioselective C(sp3)-H Amidation Controlled by Attractive Noncovalent Interactions》 were Wang, Hao; Park, Yoonsu; Bai, Ziqian; Chang, Sukbok; He, Gang; Chen, Gong. And the article was published in Journal of the American Chemical Society in 2019. Recommanded Product: 530-62-1 The author mentioned the following in the article:

While remarkable progress was made over the past decade, new design strategies for chiral catalysts in enantioselective C(sp3)-H functionalization reactions are still highly desirable. In particular, the ability to use attractive noncovalent interactions for rate acceleration and enantiocontrol would significantly expand the current arsenal for asym. metal catalysis. Herein, the authors report the development of a highly enantioselective Ir(III)-catalyzed intramol. C(sp3)-H amidation reaction of dioxazolone substrates for synthesis of optically enriched γ-lactams using a newly designed α-amino-acid-based chiral ligand. This Ir-catalyzed reaction proceeds with excellent efficiency and with outstanding enantioselectivity for both activated and unactivated alkyl C(sp3)-H bonds under very mild conditions. It offers the first general route for asym. synthesis of γ-alkyl γ-lactams. Water is a unique cosolvent to achieve excellent enantioselectivity for γ-aryl lactam production Mechanistic studies revealed that the ligands form a well-defined groove-type chiral pocket around the Ir center. The hydrophobic effect of this pocket allows facile stereocontrolled binding of substrates in polar or aqueous media. Instead of capitalizing on steric repulsions as in the conventional approaches, this new Ir catalyst operates through an unprecedented enantiocontrol mechanism for intramol. nitrenoid C-H insertion featuring multiple attractive noncovalent interactions. The results came from multiple reactions, including the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Recommanded Product: 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Recommanded Product: 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Advanced Materials (Weinheim, Germany) included an article by Guo, Jiawei; Li, Dandan; Tao, Hui; Li, Gang; Liu, Renfeng; Dou, Yin; Jin, Taotao; Li, Lanlan; Huang, Jun; Hu, Houyuan; Zhang, Jianxiang. Recommanded Product: Di(1H-imidazol-1-yl)methanone. The article was titled 《Cyclodextrin-derived intrinsically bioactive nanoparticles for treatment of acute and chronic inflammatory diseases》. The information in the text is summarized as follows:

Inflammation is a common cause of many acute and chronic inflammatory diseases. A major limitation of existing anti-inflammatory therapeutics is that they cannot simultaneously regulate pro-inflammatory cytokine production, oxidative stress, and recruitment of neutrophils and macrophages. To overcome this limitation, nanoparticles (NPs) with multiple pharmacol. activities are synthesized, using a chem. modified cyclic oligosaccharide. The manufacture of this type of bioactive, saccharide material-based NPs (defined as LCD NP) is straight forward, cost-effective, and scalable. Functionally, LCD NP effectively inhibits inflammatory response, oxidative stress, and cell migration for both neutrophils and macrophages, two major players of inflammation. Therapeutically, LCD NP shows desirable efficacies for the treatment of acute and chronic inflammatory diseases in mouse models of peritonitis, acute lung injury, and atherosclerosis. Mechanistically, the therapeutic benefits of LCD NP are achieved by inhibiting neutrophil-mediated inflammatory macrophage recruitment and by preventing subsequent pro-inflammatory events. In addition, LCD NP shows good safety profile in a mouse model. Thus, LCD NP can serve as an effective anti-inflammatory nanotherapy for the treatment of inflammatory diseases mainly associated with neutrophil and macrophage infiltration. In addition to this study using Di(1H-imidazol-1-yl)methanone, there are many other studies that have used Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Recommanded Product: Di(1H-imidazol-1-yl)methanone) was used in this study.

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Recommanded Product: Di(1H-imidazol-1-yl)methanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Safety of Di(1H-imidazol-1-yl)methanoneIn 2019 ,《A Pyrene-Poly(acrylic acid)-Polyrotaxane Supramolecular Binder Network for High-Performance Silicon Negative Electrodes》 appeared in Advanced Materials (Weinheim, Germany). The author of the article were Cho, Yunshik; Kim, Jaemin; Elabd, Ahmed; Choi, Sunghun; Park, Kiho; Kwon, Tae-woo; Lee, Jungmin; Char, Kookheon; Coskun, Ali; Choi, Jang Wook. The article conveys some information:

Although being incorporated in com. lithium-ion batteries for a while, the weight portion of silicon monoxide (SiOx, x ≈ 1) is only < 10 wt% due to the insufficient cycle life. Along this line, polymeric binders that can assist in maintaining the mech. integrity and interfacial stability of SiOx electrodes are desired to realize higher contents of SiOx. Herein, a pyrene-poly(acrylic acid) (PAA)-polyrotaxane (PR) supramol. network is reported as a polymeric binder for SiOx with 100 wt%. The noncovalent functionalization of a carbon coating layer on the SiOx is achieved by using a hydroxylated pyrene derivative via the π-π stacking interaction, which simultaneously enables hydrogen bonding interactions with the PR-PAA network through its hydroxyl moiety. Moreover, the PR's ring sliding while being crosslinked to PAA endows a high elasticity to the entire polymer network, effectively buffering the volume expansion of SiOx and largely mitigating the electrode swelling. Based on these extraordinary physicochem. properties of the pyrene-PAA-PR supramol. binder, the robust cycling of SiOx electrodes is demonstrated at com. levels of areal loading in both half-cell and full-cell configurations. After reading the article, we found that the author used Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Safety of Di(1H-imidazol-1-yl)methanone)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Safety of Di(1H-imidazol-1-yl)methanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Steuer, Lena; Kaifer, Elisabeth; Himmel, Hans-Jorg published an article in European Journal of Organic Chemistry. The title of the article was 《Redox-Active Dendrimer-Like Oligoguanidines and Their Use in a Proton-Coupled Electron Transfer Reaction》.Reference of 2-Chloro-1H-benzo[d]imidazole The author mentioned the following in the article:

Redox-active organic dendrimers are of interest for a variety of applications, e. g. as components in optoelectronic devices and energy-storage (battery) materials, and were also used to model enzymic reactivity. Here, we report the first synthesis of redox-active dendrimer-like oligoguanidines, assembling six or twelve guanidino groups attached to aromatic cores in one mol. The novel oligoguanidines, being strong electron donors, are characterized in their stable (neutral and dicationic) redox states. Redox processes occur preferentially at the core, while the periphery provides highly Broensted basic sites. The combined electron and proton acceptor properties of the mols. in their stable oxidized dicationic redox state motivate applications in proton-coupled electron transfer (PCET) processes. In this work, we test their application in a representative intramol. oxidative aryl-aryl coupling reaction. The experimental process involved the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Reference of 2-Chloro-1H-benzo[d]imidazole)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.Reference of 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Saeedian Moghadam, Ebrahim; Al-Saadi, Abdullah Mohammed; Talebi, Meysam; Amanlou, Massoud; Amini, Mohsen; Abdel-Jalil, Raid published an article in Synthetic Communications. The title of the article was 《Design, synthesis, and bioactivity investigation of novel benzimidazole derivatives as potent urease inhibitors》.Product Details of 934-32-7 The author mentioned the following in the article:

Herein, we synthesized a series of novel benzimidazole derivatives and screened their bioactivity as potent urease inhibitors. The structure of the was elucidated using spectroscopic technics (1H-NMR, 13C-NMR, MS), elemental anal., and m.p. The urease inhibition activity was evaluated using the urease enzyme inhibition kit. All , except , showed higher urease inhibition activity (0.77 to 6.25 μM) in comparison to thiourea and hydroxyurea as standard (IC50: 22 and 100 μM resp.). and exhibited the best activity with the IC50 value of 0.77 and 1.26 μM resp. A mol. docking study showed the mode of interactions between the most active compound and enzyme active site. To investigate the cytotoxicity profile of the target compounds, an MTT assay was done on two different cell lines which showed all have IC50 values higher than 50 μM on both tested cell lines.1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Product Details of 934-32-7) was used in this study.

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Product Details of 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem