Tag: 100-200

Bridge-functionalized bisimidazolium bromides as catalysts for the conversion of epoxides to cyclic carbonates with CO₂ was written by Li, Yuanhui;Dominelli, Bruno;Reich, Robert M.;Liu, Boping;Kuhn, Fritz E.. And the article was included in Catalysis Communications in 2019.Recommanded Product: 1-Octyl-1H-imidazole This article mentions the following:

Six novel bridge-functionalized bisimidazolium bromides were synthesized and applied as catalysts for the cycloaddition of carbon dioxide and epoxides to give cyclic carbonates. Addnl., the influence of the hydrogen-bond donors, the N-wing-tip-substituents and the chain length of the connecting carbon bridges on the catalytic activity were studied. Catalyst bis[(trimethylphenyl)imidazoliumyl]methylpropanoic acid dibromide proved to be slightly more active than the reference catalyst bis(octylimidazoliumyl)propanol dibromide for the addition of carbon dioxide to various epoxides and could be analogously recycled from propylene carbonate for at least six times without distinct loss of activity. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Recommanded Product: 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cadmium(II) and lead(II) extraction and transport through polymer inclusion membranes with 1-alkylimidazole was written by Radzyminska-Lenarcik, Elzbieta;Pyszka, Ilona;Urbaniak, Wlodzimierz. And the article was included in Desalination and Water Treatment in 2021.COA of Formula: C11H20N2 This article mentions the following:

The formation of cadmium(II) complexes with hydrophobic 1-alkylimidazoles (1-hexylimidazole (1), 1-heptylimidazole (2), 1-octylimidazole (3), 1-decylimidazole (4) was tested by liquid-liquid partition method. On the basis of the extraction data, stability constants of cadmium(II) and Pb(II) complexes were determined It had been assumed that differences in the formation of cadmium(II) and lead(II) complexes with alkylimidazoles could be used to sep. those ions. The possibility of cadmium(II) and lead(II) ion separation in the transport through polymer inclusion membranes (PIMs) was examined PIMs comprising of cellulose triacetate, o-nitrophenylpentyl ether, and alkylimidazole (1-4) were used. The membranes were characterized using at. force microscopy (AFM). The results have shown that cadmium(II) ions are effectively transported through PIMs. The best result achieved for cadmium(II) removal from Cd(II)-Pb(II) solution for PIMs with (4) was 95.5% after 24 h. For this membrane, the separation coefficients for Cd(II)/Pb(II) were 1.62. Best Cd(II)/Pb(II) selectivity coefficients equal to 2.94 were found for (1). The influence of the basicity of carrier mols. on transport kinetics was discussed as well. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7COA of Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.COA of Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Influence of the Surface Chemistry of Metal-Organic Polyhedra in Their Assembly into Ultrathin Films for Gas Separation was written by Tejedor, Ines;Andres, Miguel A.;Carne-Sanchez, Arnau;Arjona, Monica;Perez-Miana, Marta;Sanchez-Lainez, Javier;Coronas, Joaquin;Fontaine, Philippe;Goldmann, Michel;Roubeau, Olivier;Maspoch, Daniel;Gascon, Ignacio. And the article was included in ACS Applied Materials & Interfaces in 2022.Formula: C11H20N2 This article mentions the following:

The formation of ultrathin films of Rh-based porous metal-organic polyhedra (Rh-MOPs) by the Langmuir-Blodgett method has been explored. Homogeneous and dense monolayer films were formed at the air-water interface either using two different coordinatively alkyl-functionalized Rh-MOPs (HRhMOP(diz)₁₂ and HRhMOP(oiz)₁₂) or by in situ incorporation of aliphatic chains to the axial sites of dirhodium paddlewheels of another Rh-MOP (OHRhMOP) at the air-liquid interface. All these Rh-MOP monolayers were successively deposited onto different substrates in order to obtain multilayer films with controllable thicknesses. Aliphatic chains were partially removed from HRhMOP(diz)₁₂ films post-synthetically by a simple acid treatment, resulting in a relevant modification of the film hydrophobicity. Moreover, the CO₂/N₂ separation performance of Rh-MOP-supported membranes was also evaluated, proving that they can be used as selective layers for efficient CO₂ separation In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazolium Based Ionic Liquids: Impact of the Cation Symmetry and Alkyl Chain Length on the Enthalpy of Vaporization was written by Yermalayeu, Andrei V.;Zaitsau, Dzmitry H.;Loor, Manuel;Schaumann, Julian;Emel’yanenko, Vladimir N.;Schulz, Stephan;Verevkin, Sergey P.. And the article was included in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2017.Synthetic Route of C11H20N2 This article mentions the following:

The vaporization thermodn. of sym. imidazolium based ionic liquids of the general formula [C_nC_nIm][Br] with the chains length n = 4, 5, 6, and 8 were investigated using a combination of DSC, TGA, and QCM methods with quantum chem. calculations Comparison of vaporization enthalpies for the sym. ([C_nC_nIm][Br]) and asym. imidazolium based ILs ([C_nmim][Br]) revealed a general trend with the lower vaporization enthalpies of the sym. species indicating a significant decrease of the Coulombic interactions affecting energetics of vaporization. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Synthetic Route of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Synthetic Route of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Room-temperature silver-containing liquid metal salts with nitrate anions was written by Schaltin, Stijn;Brooks, Neil R.;Sniekers, Jeroen;Depuydt, Daphne;Van Meervelt, Luc;Binnemans, Koen;Fransaer, Jan. And the article was included in Physical Chemistry Chemical Physics in 2013.Reference of 21252-69-7 This article mentions the following:

The synthesis, structural, thermal and electrochem. properties of F-free Ag-containing ionic liquids are presented. The ionic liquid cations are formed by a Ag(I) ion surrounded by two 1-alkylimidazole ligands, with the counteranions being nitrate ions. Depending on the alkyl chain length, the complexes are liquids at room temperature or melting slightly above this. For the solid compounds it was possible to elucidate the structure by single crystal x-ray anal. The ionic liquids are electroactive, have good mass transport properties and can be used for the electrodeposition of Ag at high current densities. The thermal properties and stability of these compounds were tested by DSC and TGA. The viscosity of the ionic liquids follows a Vogel-Tamman-Fulcher relation as a function of temperature The electrochem. properties of the complexes were tested by cyclic voltammetry and the resulting electrodeposits were examined using SEM and at. force microscopy. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nanocage formation and structural anomalies in imidazolium ionic liquid glasses governed by alkyl chains of cations was written by Bakulina, Olga D.;Ivanov, Mikhail Yu.;Prikhod’ko, Sergey A.;Pylaeva, Svetlana;Zaytseva, Irina V.;Surovtsev, Nikolay V.;Adonin, Nicolay Yu.;Fedin, Matvey V.. And the article was included in Nanoscale in 2020.Synthetic Route of C7H13ClN2 This article mentions the following:

Intriguing nanostructuring anomalies have been recently observed in imidazolium ionic liquids (ILs) near their glass transition points, where local d. around a nanocaged solute progressively grows up with temperature Herewith, we for the first time demonstrate exptl. and theor., that these anomalies are governed by alkyl chains of cations and crucially depend on their length. ESR spectroscopy on a series of ILs [C_nmim]BF₄ (n = 0-12) shows that only the chains with n = 3-10 favor anomaly. Moreover, remarkable even vs. odd n peculiarities were systematically observed Finally, similar anomaly was for the first time observed for a non-IL glass of di-Bu phthalate, which structurally mimics cations of imidazolium ILs. Therefore, such anomalous d. behavior in a glassy state nanocage goes far beyond ILs and proves to be a more general phenomenon, which can be structurally tuned and rationally adjusted for various potential applications in nanoscale materials. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Synthetic Route of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New (E)-1-alkyl-1H-benzo[d]imidazol-2-yl)methylene)indolin-2-ones: Synthesis, in vitro cytotoxicity evaluation and apoptosis inducing studies was written by Sharma, Pankaj;Thummuri, Dinesh;Reddy, T. Srinivasa;Senwar, Kishna Ram;Naidu, V. G. M.;Srinivasulu, Gannoju;Bharghava, Suresh K.;Shankaraiah, Nagula. And the article was included in European Journal of Medicinal Chemistry in 2016.Recommanded Product: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

A new series of (E)-[(benzo[d]imidazol-2-yl)methylene]indolin-2-one derivatives has been synthesized and evaluated for their in vitro cytotoxic activity against a panel of selected human cancer cell lines of prostate (PC-3 and DU-145) and breast (BT-549, MDA-MB-231, MCF-7, 4T1), non-small lung (A549) and gastric (HGC) cancer cells along with normal breast epithelial cells (MCF10A). Among the tested compounds, 8l (I) showed significant cytotoxic activity against MDA-MB-231 and 4T1 cancer cells with IC₅₀ values of 3.26 卤 0.24 渭M and 5.96 卤 0.67 渭M resp. The compounds 8f (II), 8i (III), 8l (I) and 8o (IV) were also screened on normal human breast epithelial cells (MCF10A) and found to be safer with lesser cytotoxicity. The treatment of MDA-MB-231 cells with 8l led to inhibition of cell migration ability through disruption of F-actin protein assembly. The flow-cytometry anal. reveals that the cells arrested in G0/G1 phase of the cell cycle. Further, the compound 8l induced apoptosis of MDA-MB-231 cells was characterized by different staining techniques such as Acridine Orange/Ethidium Bromide (AO/EB), DAPI, annexin V-FITC/PI, Rhodamine-123 and MitoSOX red assay. Western blot studies demonstrated that the compound 8l treatment led to activation of caspase-3, increased expression of cleaved PARP, increased expression of pro-apoptotic Bax and decreased expression of anti-apoptotic Bcl-2 in MDA-MB-231 cancer cells. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Recommanded Product: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Evaluations of imidazolium ionic liquids as novel skin permeation enhancers for drug transdermal delivery was written by Zhang, Ding;Wang, Huai-Ji;Cui, Xiu-Ming;Wang, Cheng-Xiao. And the article was included in Pharmaceutical Development and Technology in 2017.Category: imidazoles-derivatives This article mentions the following:

In this work, imidazolium ionic liquids (imidazolium ILs) were employed as the novel chem. permeation enhancers (CPEs) and their performances and mechanisms of action were deeply investigated. Testosterone was used as a model drug to investigate the transdermal delivery enhancement of twenty imdidazolium ILs. The results suggested that the promotion activity connected to the structure and composition of the ILs. The quant. structure-activity relationship (QSAR) model revealed a good linearity between the electronic properties of ILs and their enhancements. Furthermore, the transepidermal water loss (TEWL) and scanning laser confocal microscope (CLSM) examinations showed the strong improvement of ILs on skin barrier permeability, which were well correlated with the drug penetration profiles. The total reflection-Fourier transform IR spectroscopy (ATR-FTIR) and at. force microscope (AFM) evaluations of skins indicated that the ILs can disrupt the regular and compact arrangements of the corneocytes, change the surface properties of stratum corneum, and make the skin structure more permeable. Our work demonstrated the significant skin permeation promotion profiles of the imidazolium ILs, which are of great potential in transdermal drug delivery systems. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Category: imidazoles-derivatives).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent was written by Maroz, Andrej;Shinde, Sujata S.;Franzblau, Scott G.;Ma, Zhenkun;Denny, William A.;Palmer, Brian D.;Anderson, Robert F.. And the article was included in Organic & Biomolecular Chemistry in 2010.Reference of 3034-41-1 This article mentions the following:

The one-electron reduction chem. of the antituberculosis drug PA-824, together with a series of closely related compounds, has been investigated in irradiated anaerobic propan-2-ol solution The protic solvent, of low dielec. constant, was chosen to mimic the environment of a water-restricting active site of a model protein, which is capable of reducing the compounds Radiolytic reduction of the compounds containing electron donating substituents in the 2-position of the imidazole ring released nitrite, with compounds that are highly active against Mycobacterium tuberculosis exhibiting high yields of nitrite. The release of cytotoxic reactive nitrogen species through a one-electron pathway, by as yet unidentified proteins, may play a role in the activity of this class of compounds against TB. The described radiolytic quantification of nitrite release may have utility as a preliminary screening test for nitroarom. candidate drugs against the disease. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Reference of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A quantum mechanical study of alkylimidazolium halide ionic liquids was written by Li, Wei;Qi, Chuansong;Rong, Hua;Wu, Xinmin;Gong, Liangfa. And the article was included in Chemical Physics Letters in 2012.Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride This article mentions the following:

Thirty imidazolium (IM) halide compounds were studied using DFT methods (B3LYP, B3P86, and PBE1PBE1) methods. Geometry optimization and interaction energy calculations were performed using the B3LYP/6-311++G(d,p) method for ions composed of one alkylimidazolium cation and two or three halogen anions. The obtained structures were consistent with exptl. results. In addition, a linear correlation between m.ps. and interaction energies was obtained for the compounds studied, and this relationship was consistent with that obtained for amino acid cation based ionic liquids In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem