Tag: 100-200

In 1973,Journal of General Microbiology included an article by Stutzenberger, F. J.; Parle, J. N.. Application In Synthesis of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol. The article was titled 《Effect of 2-substituted benzimidazoles on the fungus Pithomyces chartarum》. The information in the text is summarized as follows:

The inhibition of germ-tube elongation in P. chartarum conidia by 2-substituted benzimidazoles varied markedly with the substituted group, 2-(4-thiazolyl)benzimidazole (I) [148-79-8] being the most active. I inhibition of germ-tube elongation was partially eliminated by high concentrations of vitamin B12 [68-19-9], suggesting that I may act as a precursor in the formation of an inactive vitamin B12 coenzyme analog. The inhibition of respiration in germinating spores exposed to I for 3-4 hr appeared to be an indirect effect of I, since I did not affect O uptake or respiratory control of isolated mitochondria. In the experiment, the researchers used 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Application In Synthesis of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol)

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Application In Synthesis of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Zeolitic Imidazolate Frameworks for Kinetic Separation of Propane and Propene》 was written by Li, Kunhao; Olson, David H.; Seidel, Jonathan; Emge, Thomas J.; Gong, Hongwei; Zeng, Heping; Li, Jing. Reference of 2-Bromo-1H-imidazoleThis research focused onzinc imidazolate zeolitic framework propane propene separation. The article conveys some information:

Propane/propene separation by cryogenic distillation is one of the most energy and cost intensive industrial processes. Adsorptive separation is a more energy-efficient alternative. Three isostructural zinc imidazolate zeolitic framework materials are found, for the first time, to be promising in the separation of propene and propane based on their different diffusion rates. Fine-tuning of the pore opening size is critical for this type of separation The results came from multiple reactions, including the reaction of 2-Bromo-1H-imidazole(cas: 16681-56-4Reference of 2-Bromo-1H-imidazole)

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Reference of 2-Bromo-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthesis of bridgehead nitrogen compounds which contain the benzimidazole moiety. 2,3-Dihydro-1H-pyrrolo[1,2-a]benzimidazoles》 was published in Journal of Heterocyclic Chemistry in 1966. These research results belong to Freedman, Allan R.; Payne, Delbert S.; Day, Allan R.. Recommanded Product: 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol The article mentions the following:

An improved synthetic procedure has been developed for the preparation of the title compounds (I). Of the monosubstituted derivatives, only chloro-2,8-dihydro-1H-pyrrolo[1,2-a]benzimidazole was shown to be a mixture of the 6- and 7-isomers. In the part of experimental materials, we found many familiar compounds, such as 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Recommanded Product: 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol)

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Recommanded Product: 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition》 was written by Reich, Siegfried H.; Sprengeler, Paul A.; Chiang, Gary G.; Appleman, James R.; Chen, Joan; Clarine, Jeff; Eam, Boreth; Ernst, Justin T.; Han, Qing; Goel, Vikas K.; Han, Edward Z. R.; Huang, Vera; Hung, Ivy N. J.; Jemison, Adrianna; Jessen, Katti A.; Molter, Jolene; Murphy, Douglas; Neal, Melissa; Parker, Gregory S.; Shaghafi, Michael; Sperry, Samuel; Staunton, Jocelyn; Stumpf, Craig R.; Thompson, Peggy A.; Tran, Chinh; Webber, Stephen E.; Wegerski, Christopher J.; Zheng, Hong; Webster, Kevin R.. Quality Control of Imidazo[1,2-a]pyridine-8-carbonitrile And the article was included in Journal of Medicinal Chemistry on April 26 ,2018. The article conveys some information:

Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated protein kinase interacting kinases (MNK)1/2 are key regulators of mRNA translation integrating signals from oncogenic and immune signaling pathways through phosphorylation of eIF4E and other mRNA binding proteins. Modulation of these key effector proteins regulates mRNA, which controls tumor/stromal cell signaling. Compound 23 (eFT508, 6′-((6-aminopyrimidin-4-yl)amino)-8′-methyl-2’H-spiro-[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione hydrochloride), an exquisitely selective, potent dual MNK1/2 inhibitor, was designed to assess the potential for control of oncogene signaling at the level of mRNA translation. The crystal structure-guided design leverages stereoelectronic interactions unique to MNK culminating in a novel pyridone-aminal structure described for the first time in the kinase literature. Compound 23 has potent in vivo antitumor activity in models of diffuse large cell B-cell lymphoma and solid tumors, suggesting that controlling dysregulated translation has real therapeutic potential. Compound 23 is currently being evaluated in Phase 2 clin. trials in solid tumors and lymphoma. Compound 23 is the first highly selective dual MNK inhibitor targeting dysregulated translation being assessed clin. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9Quality Control of Imidazo[1,2-a]pyridine-8-carbonitrile)

Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Quality Control of Imidazo[1,2-a]pyridine-8-carbonitrile Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 530-62-1In 2019 ,《Harnessing Secondary Coordination Sphere Interactions That Enable the Selective Amidation of Benzylic C-H Bonds》 was published in Journal of the American Chemical Society. The article was written by Jung, Hoimin; Schrader, Malte; Kim, Dongwook; Baik, Mu-Hyun; Park, Yoonsu; Chang, Sukbok. The article contains the following contents:

Engineering site-selectivity is highly desirable especially in C-H functionalization reactions. We report a new catalyst platform that is highly selective for the amidation of benzylic C-H bonds controlled by π-π interactions in the secondary coordination sphere. Mechanistic understanding of the previously developed iridium catalysts that showed poor regioselectivity gave rise to the recognition that the π-cloud of an aromatic fragment on the substrate can act as a formal directing group through an attractive noncovalent interaction with the bidentate ligand of the catalyst. On the basis of this mechanism-driven strategy, we developed a cationic (η5-C5H5)Ru(II) catalyst with a neutral polypyridyl ligand to obtain record-setting benzylic selectivity in an intramol. C-H lactamization in the presence of tertiary C-H bonds at the same distance. Exptl. and computational techniques were integrated to identify the origin of this unprecedented benzylic selectivity, and robust linear free energy relationship between solvent polarity index and the measured site-selectivity was found to clearly corroborate that the solvophobic effect drives the selectivity. Generality of the reaction scope and applicability toward versatile γ-lactam synthesis were demonstrated.Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Related Products of 530-62-1) was used in this study.

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Related Products of 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Category: imidazoles-derivativesIn 2019 ,《Green, effective and chromatography free synthesis of benzoimidazo[1,2-a]pyrimidine and tetrahydrobenzo [4,5]imidazo [1,2-d]quinazolin-1(2H)-one and their pyrazolyl moiety using Fe3O4@SiO2@L-proline reusable catalyst in aqueous media》 appeared in Journal of Organometallic Chemistry. The author of the article were Fekri, Leila Zare; Nikpassand, Mohammad; Khakshoor, Samira Nazari. The article conveys some information:

L-proline-functionalized silica-coated Fe3O4 nanoparticle was synthesized and characterized using Fourier Transform IR spectroscopy, X-ray diffraction, field emission SEM, transmission electron microscopy, energy dispersive X-ray spectroscopy, thermogravimetric anal., Zeta potential and a vibrating sample magnetometer. The Fe3O4@SiO2@L-proline nanoparticles in aqueous media were used as a green avenue for the mild and efficient multicomponent synthesis of new derivatives of benzoimidazo[1,2-a]pyrimidines and tetrahydrobenzo[4,5]imidazo-[1,2-d]quinazolin-1(2H)-ones in excellent yields. Furthermore, the recovery and reuse of the catalyst was demonstrated 10 times without a detectable loss in activity. Eco-friendliness, high purity of the desired products, short reaction time and easy workup was mentioned as the other advantages of this method. The results came from multiple reactions, including the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Category: imidazoles-derivatives)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of C7H7N3In 2020 ,《Copper-Catalyzed Synthesis of Trinuclear N-Fused Hybrid Scaffolds by Double C(sp2)-N Bond Formation between 2-(2-Bromoaryl)indoles and 2-Aminoazoles》 appeared in European Journal of Organic Chemistry. The author of the article were Diep, Thi Duyen; Pham, Duy Quang Dao; Ho, Son Long; Cho, Chan Sik. The article conveys some information:

2-(2-Bromoaryl)indoles react with 2-aminoazoles by microwave irradiation in DMF in the presence of a catalytic amount of CuI and a base to produce trinuclear N-fused hybrid scaffolds, benzo[4,5]imidazo[1,2-a]indolo[1,2-c]quinazolines and imidazo[1,2-a]indolo[1,2-c]quinazolines in moderate to good yields [e.g., 2-(2-bromophenyl)indole + 2-aminobenzimidazole → I (74%) in presence of CuI and K3PO4 in DMF]. The reaction seems to proceed via copper-catalyzed C(sp2)-N coupling and subsequent intramol. cyclocondensation accompanied by ammonia evolution. Complete regioselective C-N cyclization is observed with the reaction of 2-(2-bromophenyl)indole with 2-aminoazoles. In the part of experimental materials, we found many familiar compounds, such as 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Electric Literature of C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Electric Literature of C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bay, Anna V.; Fitzpatrick, Keegan P.; Gonzalez-Montiel, Gisela A.; Farah, Abdikani Omar; Cheong, Paul Ha-Yeon; Scheidt, Karl A. published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Light-Driven Carbene Catalysis for the Synthesis of Aliphatic and α-Amino Ketones》.HPLC of Formula: 530-62-1 The article contains the following contents:

Single-electron N-heterocyclic carbene (NHC) catalysis has gained attention recently for the synthesis of C-C bonds. Guided by d. functional theory and mechanistic analyses, authors report the light-driven synthesis of aliphatic and α-amino ketones using single-electron NHC operators. Computational and exptl. results reveal that the reactivity of the key radical intermediate is substrate-dependent and can be modulated through steric and electronic parameters of the NHC. Catalyst potential is harnessed in the visible-light driven generation of an acyl azolium radical species that underwent selective coupling with various radical partners to afford diverse ketone products. This methodol. is showcased in the direct late-stage functionalization of amino acids and pharmaceutical compounds, highlighting the utility of single-electron NHC operators. In the experiment, the researchers used many compounds, for example, Di(1H-imidazol-1-yl)methanone(cas: 530-62-1HPLC of Formula: 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.HPLC of Formula: 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids》 was written by Bay, Anna V.; Fitzpatrick, Keegan P.; Betori, Rick C.; Scheidt, Karl A.. Application of 530-62-1 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

As a key element in the construction of complex organic scaffolds, the formation of C-C bonds remains a challenge in the field of synthetic organic chem. Recent advancements in single-electron chem. have enabled new methods for the formation of various C-C bonds. Disclosed herein is the development of a novel single-electron reduction of acyl azoliums for the formation of ketones from carboxylic acids. Facile construction of the acyl azolium in situ followed by a radical-radical coupling was made possible merging N-heterocyclic carbene (NHC) and photoredox catalysis. The utility of this protocol in synthesis was showcased in the late-stage functionalization of a variety of pharmaceutical compounds Preliminary studies using chiral NHCs demonstrate that enantioselectivity can be achieved, showcasing the advantages of this protocol over alternative methodologies. The experimental process involved the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Application of 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Application of 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《A synthetic, transiently thermoresponsive homopolymer with UCST behaviour within a physiologically relevant window》 was written by Zhang, Zhiyue; Li, Hui; Kasmi, Sabah; Van Herck, Simon; Deswarte, Kim; Lambrecht, Bart N.; Hoogenboom, Richard; Nuhn, Lutz; De Geest, Bruno G.. Reference of Di(1H-imidazol-1-yl)methanoneThis research focused onUCST polymer hydroxypropylmethacrylamide stimulus responsive biomaterial sustained release; UCST; degradable polymers; gels; protein delivery; responsive polymers. The article conveys some information:

Interactive materials that can respond to a trigger by changing their morphol., but that can also gradually degrade into a fully soluble state, are attractive building blocks for the next generation of biomaterials. Herein, we design such transiently responsive polymers that exhibit UCST behavior while gradually losing this property in response to a hydrolysis reaction in the polymer side chains. The polymers operate within a physiol. relevant window in terms of temperature, pH, and ionic strength. Whereas such behavior has been reported earlier for LCST systems, it is at present unexplored for UCST polymers. Furthermore, we demonstrate that, in contrast to LCST polymers, in aqueous medium the UCST polymer forms a coacervate phase below the UCST, which can entrap a hydrophilic model protein, as well as a hydrophobic dye. Because of their non-toxicity, we also provide in vivo proof of concept of the use of this coacervate as a protein depot, in view of sustained-release applications. The experimental process involved the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Reference of Di(1H-imidazol-1-yl)methanone)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Reference of Di(1H-imidazol-1-yl)methanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem