Tag: 100-200

Karuvalam, Ranjith P.; Haridas, Karickal R.; Shetty, Suchetha N. published an article in Journal of the Chilean Chemical Society. The title of the article was 《Trimethylsilyl chloride-catalyzed synthesis of substituted benzimidazoles using two phase system under microwave conditions, and their antimicrobial studies》.Recommanded Product: 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol The author mentioned the following in the article:

A convenient method using Me3SiCl (20 mol %) and microwave-induced technique for the synthesis of various benzimidazole is described. This reduced the reaction time drastically as well as improved the yield when compared to conventional heating. The synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities against four strains each. Some of the compounds indicated very good antimicrobial activity, comparable to the first line standard drugs. The most effective compounds exhibited activity at MIC of 6.25 μg/mL. In the experiment, the researchers used 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Recommanded Product: 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol)

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Recommanded Product: 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of C10H12N2OOn October 20, 2010 ,《Tetra butyl ammonium chloride catalyzed synthesis of substituted benzimidazoles under microwave conditions》 was published in Journal of the Korean Chemical Society. The article was written by Karuvalam, Ranjith. P.; Siji, M.; Divia., N.; Haridas, Karickal. R.. The article contains the following contents:

Tetrabutylammonium chloride (10 mol%) was a useful catalyst for the synthesis of substituted benzimidazoles from o-phenylenediamines with benzoic acids. The method was simple, convenient and the product was isolated with good yield. In addition to this study using 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol, there are many other studies that have used 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Electric Literature of C10H12N2O) was used in this study.

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Electric Literature of C10H12N2O Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Name: Di(1H-imidazol-1-yl)methanoneIn 2021 ,《Postmodulation of the Metal-Organic Framework Precursor toward the Vacancy-Rich CuxO Transducer for Sensitivity Boost: Synthesis, Catalysis, and H2O2 Sensing》 appeared in Analytical Chemistry (Washington, DC, United States). The author of the article were Li, Junji; Xin, Wen-Li; Dai, Yu-Xuan; Shu, Guofang; Zhang, Xue-Ji; Marks, Robert S.; Cosnier, Serge; Shan, Dan. The article conveys some information:

Metal-organic frameworks (MOFs) act as versatile coordinators for the subsequent synthesis of high-performance catalysts by providing dispersed metal-ion distribution, initial coordination condition, dopant atom ratios, and so on. In this work, a crystalline MOF trans-[Cu(NO3)2(Him)4] was synthesized as the novel precursor of a redox-alternating CuxO electrochem. catalyst. Through simple temperature modulation, the gradual transformation toward a highly active nanocomposite was characterized to ascertain the signal enhancing mechanism in H2O2 reduction Owing to the proprietary structure of the transducer material and its ensuing high activity, a proof-of-principle sensor was able to provide an amplified sensitivity of 2330μA mM-1 cm-2. The facile one-pot preparation and intrinsic nonenzymic nature also suggests its wide potentials in medical settings. In the part of experimental materials, we found many familiar compounds, such as Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Name: Di(1H-imidazol-1-yl)methanone)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Name: Di(1H-imidazol-1-yl)methanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Mechanochemical green synthesis of hyper-crosslinked cyclodextrin polymers》 was published in Beilstein Journal of Organic Chemistry in 2020. These research results belong to Pedrazzo, Alberto Rubin; Caldera, Fabrizio; Zanetti, Marco; Appleton, Silvia Lucia; Dahkar, Nilesh Kumar; Trotta, Francesco. Product Details of 530-62-1 The article mentions the following:

Cyclodextrin nanosponges (CD-NS) are nanostructured crosslinked polymers made up of cyclodextrins. The reactive hydroxy groups of CDs allow them to act as multifunctional monomers capable of crosslinking to bi- or multifunctional chems. The most common NS synthetic pathway consists in dissolving the chosen CD and an appropriate crosslinker in organic polar aprotic liquids (e.g., N,N-dimethylformamide or DMSO), which affect the final result, especially for potential biomedical applications. This article describes a new, green synthetic pathway through mechanochem., in particular via ball milling and using 1,1-carbonyldiimidazole as the crosslinker. The polymer obtained exhibited the same characteristics as a CD-based carbonate NS synthesized in a solvent. Moreover, after the synthesis, the polymer was easily functionalized through the reaction of the nucleophilic carboxylic group with three different organic dyes (fluorescein, methyl red, and rhodamine B) and the still reactive imidazoyl carbonyl group of the NS. In the experiment, the researchers used Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Product Details of 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Product Details of 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quality Control of 1H-Benzo[d]imidazol-2-amineIn 2020 ,《Synthesis, characterization and antibacterial studies of Schiff base with 2-amino benzimidazole and 5-methyl-thiophene-2-carboxaldehyde》 was published in Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences. The article was written by Kanthamma, D. Lakshmi; Kumar, N. Sathish; Imran, K.; Seshaiah, K.. The article contains the following contents:

A new Schiff base has been synthesized by condensation of 2-Amino benzimidazole and 5-methyl-thiophene-2-carboxaldehyde. The compound was characterized by FT-IR, 1H NMR Spectroscopy, 13C NMR Spectroscopyto confirm the structure of Schiff base. The Cu(II) and Zn(II) complexes were prepared using the Schiff base. The Schiff base and its metal complexes have been studied for antibacterial activity against the strains such as Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa, Escherichia coli.The metal complexes of Schiff base exhibited more antibacterial activity as compared to Schiff base ligand. The experimental process involved the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Quality Control of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Quality Control of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Elmali, A.; Elerman, Y.; Eren, G.; Guemues, F.; Svoboda, I. published an article on February 28 ,2005. The article was titled 《The crystal structures of 2-(3′-hydroxypropyl)benzimidazolium hexa- and tetrachloroplatinate》, and you may find the article in Zeitschrift fuer Naturforschung, B: Chemical Sciences.Quality Control of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol The information in the text is summarized as follows:

2-(3′-Hydroxypropyl)benzimidazolium (Hhpb) hexa- and tetrachloroplatinate (Co10H13N2O)2·[PtCl6] (I) and (C10H13N2O)2·[PtCl4] (II) were synthesized and their crystal structures determined I is monoclinic, space group P21/n, a 8.800(1), b 14.389(2), c 10.264(2) Å, β 98.540(10)°, and Z = 2. II is triclinic, space group P1̅, a 7.8480(10), b 9.0460(10), c 9.6980(10) Å, α 65.420(10), β 68.810(10), γ 76.770(1)°, and Z = 1. In both compounds, the Pt atoms reside at a center of inversion. I and II are comprised of 2-(3′-hydroxypropyl)benzimidazolium (Hhpb)+:(C10H12N2O)+ and [PtCl6]2- and [PtCl4]2- ions, resp., linked by intermol. H bonds N···Cl [range from 3.428(3) to 3.584(4) Å], N···O [2.769(5) Å] and O···Cl [3.338(4) and 3.321(3) Å] for I, and N···Cl [3.162(7) Å], N···O [2.749(8) Å] and O···Cl [3.289(6) Å] for II. The experimental part of the paper was very detailed, including the reaction process of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Quality Control of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol)

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
However, the application of imidazoles is not limited to the field of peptides and peptidomimetics. Quality Control of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Selective C-H trifluoromethylation of benzimidazoles through photoredox catalysis》 was written by Gao, Guo-Lin; Yang, Chao; Xia, Wujiong. Category: imidazoles-derivativesThis research focused ontrifluoromethyl benzoimidazole preparation; benzimidazole trifluoromethylation photoredox catalyst togni reagent. The article conveys some information:

A new strategy for the preparation of trifluoromethyl benzimidazoles I (R = H, 5,6-di-Me, 5-Cl, etc.; R1 = H, CH3, C6H5CH2, etc.; X = H, CH2OCH3, pyridin-2-yl, etc.) via visible light induced C-H trifluoromethylation at C4 of benzimidazoles II using Togni’s reagent in the presence of fac-Ir(ppy)3 has been presented. Its advantages are operational simplicity, mild reaction conditions, low catalyst loading and wide substrate scope, in which electron-withdrawing, electron-donating groups and different protecting groups are tolerated. After reading the article, we found that the author used 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Category: imidazoles-derivatives)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

V., Paleri Sandhya; V., Kakkotakath Muhammad Niyas; R., Karickal Haridas published their research in Research Journal of Chemistry and Environment in 2021. The article was titled 《Microwave assisted synthesis of benzimidazole derivatives using tetra butyl ammonium chloride as phase transfer catalyst, characterization, biological activities and molecular docking studies》.HPLC of Formula: 4857-06-1 The article contains the following contents:

Benzimidazole and its derivatives are of wide interest because of their diverse biol. activity and clin. applications. The heterocyclic imidazole core is a common moiety in a large number of natural products and pharmacol. active compounds and because of that they are possessing inhibitory activity as well as favorable selectivity ratio. Benzimidazoles exhibit significant activities like anti-microbial, anti-viral, anti-diabetic, anti-cancer activity, numerous antioxidants, anti-parasitic, anti-helmintics, antiproliferative, anti-HIV, anti-convulsant, anti-inflammatory, anti-hypertensive, anti-neoplastic, proton pump inhibitor and anti-trichinellosis. The synthesis of benzimidazole derivatives remains a focus of medicinal research. Here benzimidazole derivatives were synthesized using two phase system under microwave conditions using the phase transfer catalyst tetra Bu ammonium chloride (10% mol) in good yield. The mol. docking study against 4GQQ protein with synthesized benzimidazole derivatives was performed to see the necessary interactions responsible for anti-bacterial activity. The experimental process involved the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1HPLC of Formula: 4857-06-1)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.HPLC of Formula: 4857-06-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Ru(II)-Catalyzed and acidity-controlled tunable [5+1]/[5+2] annulation for building ring-fused quinazolines and 1,3-benzodiazepines》 was written by Yang, Yurong; Zhang, Kaixin; Yang, Jian; Zhu, Guoxun; Chen, Weijie; Zhang, Chao; Zhou, Zhi; Yi, Wei. Related Products of 4857-06-1 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

The Ru(II)-catalyzed tunable [5+1]/[5+2] annulation of N-benzo[d]imidazole indolines with propargyl carbonates was realized for the divergent synthesis of ring-fused quinazolines and 1,3-benzodiazepines bearing various functional groups. These transformations represented an efficient and practical strategy in constructing complex heterocycles via diversified C-H functionalization. A distinctive acidity-controlled reaction manner was clarified to account for the chemoselectivity. In the experiment, the researchers used many compounds, for example, 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Related Products of 4857-06-1)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Related Products of 4857-06-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Intracellular Drug Delivery with Anodic Titanium Dioxide Nanotubes and Nanocylinders》 was written by Kafshgari, Morteza Hasanzadeh; Mazare, Anca; Distaso, Monica; Goldmann, Wolfgang H.; Peukert, Wolfgang; Fabry, Ben; Schmuki, Patrik. Electric Literature of C7H6N4OThis research focused ontitanium dioxide nanotube nanocylinder drug carrier; electrochemical anodization; intracellular drug delivery; nanocylinders; nanotubes; titanium dioxide. The article conveys some information:

Titanium dioxide (TiO2) holds remarkable promises for developing current theranostic strategies. Anodic TiO2 nanostructures as a porous scaffold have offered a broad range of useful theranostic properties; however, previous attempts to generate single and uniform TiO2 one-dimensional nanocarriers from anodic nanotube arrays have resulted in a broad cluster size distribution of arbitrarily broken tubes that are unsuitable for therapeutic delivery systems due to poor bio-distribution and the risk of introducing tissue inflammation. Here, we achieve well-separated, uniformly shaped anodic TiO2 nanotubes and nanocylinders through a time-varying electrochem. anodization protocol that leads to the generation of planar sheets of weakly connected nanotubes with a defined fracture point near the base. Subsequent sonication cleanly detaches the nanotubes from the base. Depending on the position of the fracture point, we can fabricate single anodic nanocylinders that are open on both ends, or nanotubes that are closed on one end. We go on to show that anodic nanotubes and nanocylinders are non-toxic at therapeutic concentrations When conjugated with the anticancer drug doxorubicin using a pH-responsive linker, they are readily internalized by cells and subsequently release their drug cargo into acidic intracellular compartments. Our results demonstrate that uniformly sized anodic TiO2 nanotubes and nanocylinders are suitable for subcellular delivery of therapeutic agents in cancer therapy. In the part of experimental materials, we found many familiar compounds, such as Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Electric Literature of C7H6N4O)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Electric Literature of C7H6N4O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem