Tag: 100-200

《Concomitant polymorphic forms of 3-cyclopropyl-5-(2-hydrazinylpyridin-3-yl)-1,2,4-oxadiazole》 was published in Acta Crystallographica, Section C: Structural Chemistry in 2020. These research results belong to Shishkina, Svitlana V.; Konovalova, Irina S.; Karpina, Veronika R.; Kovalenko, Svitlana S.; Kovalenko, Sergiy M.; Bunyatyan, Natalya D.. Related Products of 530-62-1 The article mentions the following:

The dipharmacophore compound 3-cyclopropyl-5-(2-hydrazinylpyridin-3-yl)-1,2,4-oxadiazole, C10H11N5O, was studied on the assumption of its potential biol. activity. Two concomitant polymorphs were obtained on crystallization from isopropanol solution and these were thoroughly studied. Identical conformations of the mols. are found in both structures despite the low difference in energy between the four possible conformers. The two polymorphs differ crucially with respect to their crystal structures. A centrosym. dimer formed due to both stacking interactions of the ‘head-to-tail’ type and N-H…N(π) hydrogen bonds is the building unit in the triclinic structure. The dimeric building units form an isotropic packing. In the orthorhombic polymorphic structure, the mols. form stacking interactions of the ‘head-to-head’ type, which results in their organization in a column as the primary basic structural motif. The formation of N-H···N(lone pair) hydrogen bonds between two neighboring columns allows the formation of a double column as the main structural motif. The correct packing motifs in the two polymorphs could not be identified without calculations of the pairwise interaction energies. The triclinic structure has a higher d. and a lower (by 0.60 kcal mol-1) lattice energy according to periodic calculations compared to the orthorhombic structure. This allows us to presume that the triclinic form of 3-cyclopropyl-5-(2-hydrazinylpyridin-3-yl)-1,2,4-oxadiazole is the more stable. In the experiment, the researchers used Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Related Products of 530-62-1)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Related Products of 530-62-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Degradation kinetics of carbendazim by Klebsiella oxytoca, Flavobacterium johnsoniae, and Stenotrophomonas maltophilia strains》 was written by Alvarado-Gutierrez, Maria Luisa; Ruiz-Ordaz, Nora; Galindez-Mayer, Juvencio; Curiel-Quesada, Everardo; Santoyo-Tepole, Fortunata. HPLC of Formula: 934-32-7 And the article was included in Environmental Science and Pollution Research in 2020. The article conveys some information:

The fungicide carbendazim is an ecotoxic pollutant frequently found in water reservoirs. The ability of microorganisms to remove pollutants found in diverse environments, soil, water, or air is well documented. Although microbial communities have many advantages in bioremediation processes, in many cases, those with the desired capabilities may be slow-growing or have low pollutant degradation rates. In these cases, the manipulation of the microbial community through enrichment with specialized microbial strains showing high specific growth rates and high rates and efficiencies of pollutant degradation is desirable. In this work, bacteria of the genera Klebsiella, Flavobacterium, and Stenotrophomonas, isolated from the biofilm attached to the packed zones of a biofilm reactor, were able to grow individually in selective medium containing carbendazim. In the three bacteria studied, the mheI gene encoding the first enzyme involved in the degradation of the fungicide carbendazim was found. Studying the dynamics of growth and carbendazim degradation of the three bacteria, the effect of co-formulants was also evaluated. The pure compound and a com. formulation of carbendazim were used as substrates. Finally, the study made it possible to define the biokinetic advantages of these strains for amendment of microbial communities. In the experimental materials used by the author, we found 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7HPLC of Formula: 934-32-7)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.HPLC of Formula: 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,International Journal of Environmental Analytical Chemistry included an article by Mahdavi, Vahideh; Ghorbani-Paji, Fatemeh; Ramezani, Mohammad Kazem; Ghassempour, Alireza; Aboul-Enein, Hassan Y.. Product Details of 934-32-7. The article was titled 《Dissipation of carbendazim and its metabolites in cucumber using liquid chromatography tandem mass spectrometry》. The information in the text is summarized as follows:

Currently, there is growing interest in the degradation pathways of organic contaminants such as pesticides. In the case of pesticides, the determination of metabolites in agricultural products and environment is necessary as some of them could present similar toxicity to or even higher toxicity than the parent compound The development of anal. methodol. for the identification and quantification of carbendazim fungicide and its metabolites in cucumber was studied. Cucumber (cucumis sativus) is a global food in terms of economic importance and nutritional quality. Careful optimization of the liquid chromatog.-mass spectrometry (LC-MS)/MS parameters was achieved in order to attain a fast separation with the best sensitivity. The detection was carried out on an Ion-Trap tandem mass spectrometer (MS/MS) by electrospray ionisation in pos. ion mode (ESI+) with multiple reaction monitoring (MRM). In the experiment, the researchers used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Product Details of 934-32-7)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Product Details of 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Journal of Photochemistry and Photobiology, B: Biology included an article by Devipriya, Duraipandi; Roopan, Selvaraj Mohana. Formula: C7H7N3. The article was titled 《UV-light intervened synthesis of imidazo fused quinazoline and its solvatochromism, antioxidant, antifungal and luminescence properties》. The information in the text is summarized as follows:

The photochem. preparation of benzo[4,5]imidazo[2,1-b]quinazoline I, by reaction of 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one with 1H-benzo[d]imidazol-2-amine in presence of KOH/DMF, was assessed under the UV irradiation (312 nm) in shorter duration (2 h) and in higher yield of 96%. Solvatochromism impacts of the compound I was computed with different solvents (DCM < methanol< DMF < DMSO). The compound, I was presented to in-vitro free radical screening strategy and the standard ascorbic acid has less IC50 value - than compound I. Further, it was subjected to in-vitro fungicidal action against two Aspergillus species (A. flavus & niger). The anti-fungal activity of compound I addnl. demonstrated great action, when compared antifungal specialist Fluconazole. The results came from multiple reactions, including the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Formula: C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Formula: C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application In Synthesis of 2-Bromo-1H-imidazoleIn 1982 ,《Radiosensitization by non-nitro compounds》 appeared in International Journal of Radiation Oncology, Biology, Physics. The author of the article were Wardman, P.; Anderson, R. F.; Hodgkiss, R. J.; Parrick, J.; Smithen, C. E.; Wallace, R. G.; Watts, M. E.. The article conveys some information:

The effects of non-nitro compounds on the radiosensitivity of hypoxic Chinese hamster V79-379A or Escherichia coli AB 1157 cells in vitro are outlined. Imidazole derivatives substituted with several alternative electron-withdrawing groups are described; the dicyanovinyl function conferred considerable radiosensitizing activity. 2,4,5-Tribromoimidazole and 2,4-DNP may show unusual radiosensitizing activity because of interference with oxidative phosphorylation. Attempts to influence radiosensitivity by compounds potentially capable of depleting intracellular SH groups are also described.2-Bromo-1H-imidazole(cas: 16681-56-4Application In Synthesis of 2-Bromo-1H-imidazole) was used in this study.

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Application In Synthesis of 2-Bromo-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Preparation and characterization of cyclodextrin nanosponges for organic toxic molecule removal》 was published in International Journal of Pharmaceutics (Amsterdam, Netherlands) in 2020. These research results belong to Varan, Cem; Anceschi, Anastasia; Sevli, Serhat; Bruni, Natascia; Giraudo, Leonardo; Bilgic, Elif; Korkusuz, Petek; Iskit, Alper B.; Trotta, Francesco; Bilensoy, Erem. Synthetic Route of C7H6N4O The article mentions the following:

Cyclodextrin-based nanosponges (CD-NS) are considered as safe and biocompatible systems for removing toxic mols. from the body. Rapid removal of toxic mols. that are formed in the body from certain food constituents, is relevant especially for patients affected by chronic kidney disease. Within the scope of this study, innovative cyclodextrin polymers were synthesized to form nanosponges able to remove indole, before it could form the toxic indoxyl sulfate in the body. Furthermore, in vivo studies were carried out using the two optimal CD-NS formulations by assessing physicochem. properties, stability, indole adsorption capacity and in vitro cytotoxicity. NS prepared from β-cyclodextrin crosslinked with toluene diisocyanate was found to be the most effective NS with an in vitro indole adsorption capacity of over 90%. In addition, this derivative was more stable in gastrointestinal media. Animal studies further revealed that oral CD-NSs did not tend to accumulate and damage gastrointestinal tissues and are excreted from the GI tract with minimal absorption. In conclusion, this study suggests that CD-NS formulations are effective and safe in removing toxic mols. from the body. Their potential use in veterinary or human medicine could reduce dialysis frequency and avoid hepatic and cardiac toxicity avoiding the indole formation. The experimental process involved the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Synthetic Route of C7H6N4O)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Synthetic Route of C7H6N4O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2020,Journal of Materials Chemistry C: Materials for Optical and Electronic Devices included an article by Young, David C.; Tasior, Mariusz; Laurent, Adele D.; Dobrzycki, Lukasz; Cyranski, Michal K.; Tkachenko, Nikolai; Jacquemin, Denis; Gryko, Daniel T.. Application In Synthesis of Imidazo[1,2-a]pyridine-8-carbonitrile. The article was titled 《Photostable orange-red fluorescent unsymmetrical diketopyrrolopyrrole-BF2 hybrids》. The information in the text is summarized as follows:

The straightforward synthesis of structurally unique DPP-BODIPY hybrids was developed using unsym., imidazopyridine substituted diketopyrrolopyrroles (DPPs). These hybrids exhibit a superb combination of photophys. properties including high photostability, good fluorescence quantum yield as well as markedly bathochromically shifted absorption and emission compared to conventional diketopyrrolopyrroles. Increasing the size of the imidazopyridine substituent and/or the electron donating power of the other aryl substituent can further red shift both absorption and emission to reach ∼650 nm for the free-base and ∼700 nm for B-chelates. A strong intramol. H bond is responsible for the small change in geometry between the ground and excited states and hence relatively small differences in photophys. properties upon formation of B-chelates are observed The solvent dependence of the photophys. properties for the free base and DPP-BF2 complexes were studied and show strong fluorescence with long lifetimes in both nonpolar and polar aprotic environments. In addition to this study using Imidazo[1,2-a]pyridine-8-carbonitrile, there are many other studies that have used Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9Application In Synthesis of Imidazo[1,2-a]pyridine-8-carbonitrile) was used in this study.

Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Application In Synthesis of Imidazo[1,2-a]pyridine-8-carbonitrile Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recommanded Product: 934-32-7In 2021 ,《Using sulfate-functionalized Hf-based metal-organic frameworks as a heterogeneous catalyst for solvent-free synthesis of pyrimido[1,2-a]benzimidazoles via one-pot three-component reaction》 was published in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands). The article was written by Dinh Dang, Minh-Huy; Ho Thuy Nguyen, Linh; Thi Thu Nguyen, Trang; Xuan Dat Mai, Ngoc; Hoang Tran, Phuong; Le Hoang Doan, Tan. The article contains the following contents:

In this work, a sulfate-functionalized Hf-cluster-based metal-organic framework was prepared via sulfation of a Hf-MOF, named Hf-BTC, constructed by Hf6 clusters and 1,3,5-tricarboxylate linkers. The Hf-BTC-SO4 material was consequently demonstrated to be an efficiently reusable superacid catalyst for a one-pot three-component reaction of pyrimido[1,2-a]benzimidazoles synthesis. The reaction catalyzed by the sulfated Hf-BTC could be carried out under mild and solvent-free conditions and give superior performance in a wide range of substrates. According to detailed investigation, the good catalytic performance of the sulfated-functionalized MOF likely originates from the high-porosity framework and the high active sites of the functionalized clusters. Importantly, the catalyst was easy to recover and reuse the functionalized framework several times with minor changes in catalytic efficiency. The experimental process involved the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Recommanded Product: 934-32-7)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Recommanded Product: 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthesis and characterization of some heterocyclic compounds and evaluation of antibacterial activity》 was published in International Journal of Research in Pharmaceutical Sciences (Madurai, India) in 2020. These research results belong to Smaysem, Farah; Salim, Ahmed. Synthetic Route of C7H7N3 The article mentions the following:

In this study, heterocyclic compounds with two nitrogen atoms are prepared by reaction of 2-aminobenzimidazole with formic acid to give amide derivative, which underwent reaction with phenylhydrazine to give Ph hydrazone derivative and which further reacts with Et chloroacetate to obtain Et acetate derivative A number of Schiff bases are prepared by reacting 2-aminobenzimidazole with benzaldehyde derivatives Triazine, oxadiazole, triazole, tetrazoles are synthesized via cyclization of the Schiff base derivatives with Et chloroacetate and chloro acetyl chloride, benzoic acid, 4-nitrophenyl azide, sodium azide and Ph azide resp. Some prepared compounds exhibit antibacterial properties. In the experiment, the researchers used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Synthetic Route of C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Synthetic Route of C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2002,Carter, S. R.; Rimmer, S. published 《Smart hyperbranched polymers for the purification of biomolecules》.Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) published the findings.Product Details of 16681-56-4 The information in the text is summarized as follows:

The use of a SMART polymer such as polyNIPAM allows for a hyperbranched structure to respond to small changes in temperature, pH or ionic strength. A hyperbranched SMART polymer with ligands situated at chain-ends should allow for multi-point attachment to biomacromols. in response to a change in an external stimulus. The hyperbranched poly-NIPAM polymers, where the chain termini are functionalized with an imidazole group, was prepared using the radical addition fragmentation termination (RAFT) methodol. The RAFT technique allows for control over the degree of branching by varying the proportion of dithionate ester to NIPAM. The RAFT agent 4-vinylbenzylimidazole dithioate was synthesized from 4(5)-imidazoledithioic acid and 4-vinylbenzyl chloride in DMF solvent using cesium carbonate as base. The pure product was achieved in moderate yield (27%) by repeated column chromatog. using silica and alumina sorbents. The synthetic procedure developed allowed the production of several series of macro-ligands with various mol. sizes, distances between ligands and spatial arrangement of ligands. The polymers can form multi-point attachments to specific sites on a biomacromol. so that changes in these mol. parameters will be a means of selectively targeting particular biomols. In the experiment, the researchers used 2-Bromo-1H-imidazole(cas: 16681-56-4Product Details of 16681-56-4)

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Product Details of 16681-56-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem