Tag: 100-200

Srivastava, Shivansh; Mahor, Alok; Singh, Gyanendra; Bansal, Kuldeep; Singh, Prem Prakash; Gupta, Rishikesh; Dutt, Rohit; Alanazi, Amer M.; Khan, Azmat Ali; Kesharwani, Prashant published their research in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2021. The article was titled 《Formulation Development, In Vitro and In Vivo Evaluation of Topical Hydrogel Formulation of Econazole Nitrate-Loaded β-Cyclodextrin Nanosponges》.Recommanded Product: Di(1H-imidazol-1-yl)methanone The article contains the following contents:

Econazole nitrate, an antifungal drug used in the handling of skin ailments, is com. not efficient as these ailments typically require a more elevated concentration of the drug to offer an effective pharmacol. retort. Like so, it is proposed to assess the effectiveness of the topical hydrogel of econazole-loaded nanosponge in the management of skin ailment(s). Econazole nitrate-laden β-cyclodextrin nanosponges were developed by employing the melt method using β-cyclodextrin as the organic polymer and N,N-carbonyldiimidazole as the crosslinker. The critical factors disturbing the quality of the formulation were uniquely identified by the Ishikawa diagram, and they were optimized by the statistical experiment design concept. β-cyclodextrin loaded nanosponges were uniquely designed using the Placket-Burman approach and optimized utilizing the Box-Behnken method. The optimized nanosponges (EN-CDN) were 421.37 ± 6.19 nm in size with an entrapment efficiency of 70.13% ± 5.73%. The topical hydrogel of nanosponges (EN-TG) was prepared using carbopol 934 and pyrrolidone as permeation enhancers. In vitro skin permeation studies affirmed the improved transport crosswise the goatskin for topical hydrogel in comparison to the marketed product. EN-TG was able to control the fungal infection in the selected animal model in comparison to the marketed preparation Stability studies reported favorably that nanogel remained stable under normal and accelerated settings. In the experimental materials used by the author, we found Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Recommanded Product: Di(1H-imidazol-1-yl)methanone)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Recommanded Product: Di(1H-imidazol-1-yl)methanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Dioxothietanylation of heterocycles 2*. Imidazoles and benzimidazoles》 were Makarova, Nadezhda N.; Klen, Elena E.; Khaliullin, Ferkat A.. And the article was published in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2019. Synthetic Route of C7H5ClN2 The author mentioned the following in the article:

The 1-(1,1-dioxidothietan-3-yl)-1H-benzimidazoles I (R = H, Cl, CH3, C6H5CH2, CH3S, CH3CH2S) and 1-(1,1-dioxidothietan-3-yl)-1H-imidazoles II (R1 = H, CH3; R2 = H, NO2) were synthesized in the reaction of 3,5-dibromo-1-(1,1-dioxidothietan-3-yl)-1H-1,2,4-triazole with the sodium salts of benzimidazoles III and imidazoles IV. The reaction involves addition of azoles to thiete 1,1-dioxide formed in situ, which acts as a Michael acceptor. The effect of pKa values of benzimidazoles III and imidazoles IV on their reactivity is shown. The results came from multiple reactions, including the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Synthetic Route of C7H5ClN2)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Synthetic Route of C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rakhmonova, Dilnoza; Kadirova, Zukhra; Torambetov, Batirbay; Kadirova, Shakhnoza; Ashurov, Jamshid; Shishkina, Svitlana published an article in Acta Crystallographica, Section E: Crystallographic Communications. The title of the article was 《The molecular and crystal structures of 2-(3-hydroxypropyl)benzimidazole and its nitrate salt》.Reference of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol The author mentioned the following in the article:

2-(3-Hydroxypropyl)-1H-benzimidazole, C10H12N2O, which has potential biol. activity, can be used as a ligand for complexation with metals. This compound is an electron donor, due to the lone pair of the nitrogen atom in the imidazole ring. This nitrogen atom also acts as a proton acceptor. In the crystalline phase, the nitrate salt, namely, 2-(3-hydroxypropyl)-1H-benzimidazol-3-ium nitrate, C10H13N2O+·NO3-, has been studied. The protonation of the 2-(3-hydroxypropyl)benzimidazole unit results in significant delocalization of the electron d. within the imidazole ring. The salt formation leads to variations in the intermol. interactions, which were studied by anal. of the Hirshfeld surfaces and two-dimensional fingerprint plots.3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Reference of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol) was used in this study.

3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
However, the application of imidazoles is not limited to the field of peptides and peptidomimetics. Reference of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy included an article by Tekuri, Venkatadri; Sahoo, Suban K.; Trivedi, Darshak R.. Recommanded Product: 934-32-7. The article was titled 《Hg2+ induced hydrolysis of thiazole amine based Schiff base: Colorimetric and fluorogenic chemodosimeter for Hg2+ ions in an aqueous medium》. The information in the text is summarized as follows:

Simple pyrene-based chemosensors 1 to 3, were synthesized from pyrene-1-carboxaldehyde and they were characterized using various spectroscopic techniques like UV-Vis, FT-IR, Mass, 1H NMR and 13C NMR. Among synthesized receptors, the receptor 1 shows high selectivity towards Hg2+ ions. Further, the high selectivity of receptor 1 towards Hg2+ ions in the presence of various other interfering metal ions like Ni2+, Zn2+, Mn2+, Co2+, Cu2+, Cr3+, Fe3+, Al3+, Ag+, Fe2+, Cd2+, Mg2+, Pb2+, Ca2+, Na+, K+ was confirmed by UV-Vis and fluorescence methods. The detection limit for Hg2+ ions was found to be 0.270 μM. The chemodosimetric irreversible hydrolysis of the receptor 1 in the presence of Hg2+ was studied by UV/Vis, fluorescence, FT-IR, LC-MS, 1H NMR and theor. DFT study. Further, the real life applications of receptor 1 for the determination of Hg2+ ions were demonstrated by UV-Vis method. The results came from multiple reactions, including the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Recommanded Product: 934-32-7)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Recommanded Product: 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recommanded Product: 65039-09-0《Highly efficient absorption of HCl in deep eutectic solvents and their corresponding ethylene glycol blends》 was published in 2022. The authors were Pan, Yi;Liu, Yu;Tu, Zhuoheng;Zhang, Xiaomin;Wu, Youting;Hu, Xingbang, and the article was included in《Chemical Engineering Journal (Amsterdam, Netherlands)》. The author mentioned the following in the article:

Effective separation of byproduct HCl is of great importance for its recovery and high-value utilization. Herein, a novel strategy for highly efficient and reversible absorption of HCl using deep eutectic solvents (DESs) and their corresponding ethylene glycol blends (DES/EG blends) was reported. HCl uptakes (up to 0.881 g/g) higher than that of water (0.67 g/g) were achieved. The d., viscosity, thermal decomposition temperatures, m.ps. and the HCl uptakes (0-1.0 bar, 293.2-328.2 K) of DESs or DES/EG blends were systematically determined Almost pure HCl (greater than 99.5%) could be easily stripped out at elevated temperature and reduced pressure. Spectroscopic characterizations paired with theor. calculations were applied to characterize the interaction mechanism of HCl in DESs or DES/EG blends. It is the densified hydrogen bond networks in DESs or DES/EG blends that can lower the energy level of systems and induce the superior absorption of HCl. This work provides novel insights into high-performance DESs or DES/EG blends for the absorption of HCl. To complete the study, the researchers used 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Recommanded Product: 65039-09-0

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kiefer, Rudolf;Elhi, Fred;Puust, Laurits;Peikolainen, Anna-Liisa;Tamm, Tarmo published 《Dual function composite fibers of cellulose with activated carbon aerogel and carbide derived carbon》. The research results were published in《Journal of Applied Polymer Science》 in 2022.HPLC of Formula: 65039-09-0 The article conveys some information:

Polymers of natural origin, especially cellulose, have risen to the focus of smart materials, and also energy storage materials’ research as sustainable matrix alternatives. In this work, novel composites of cellulose with activated carbon aerogel (ACA) and carbide-derived carbon (CDC) are demonstrated. The composites were formulated as fibers from regenerated cellulose (Cell). The electromech. response as linear actuation in stress and strain of the fibers was studied in an organic electrolyte at low applied potentials in range of 0.55 to -0.8 V. Cyclic voltammetry and square wave potential steps were performed revealing for both composite fibers expansion at pos. charging. The Cell-ACA fibers showed a stronger response compared with Cell-CDC, largely due to the particle structure, reflected in higher electronic conductivity The chronopotentiometric measurements showed that Cell-ACA also had the higher specific capacitance of the two of 47.5 F g^-1. The dual-function of Cell-ACA and Cell-CDC of electromech. activity and energy storage capability can have potential in smart clothing applications. The experimental procedure involved many compounds, such as 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.HPLC of Formula: 65039-09-0

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

de Sousa, Kenia Marcatti;Lima, Thailan Souza Pereira;de Souza, Ranyere Lucena;Nerli, Bibiana Beatriz;Pereira, Matheus M.;Soares, Cleide Mara Faria;Lima, Alvaro Silva published 《Liquid-liquid equilibrium data for the ternary system based on ionic liquid + organic solvents + water at 298 K and atmospheric pressure applied in antidepressant partitioning》. The research results were published in《Separation and Purification Technology》 in 2022.HPLC of Formula: 65039-09-0 The article conveys some information:

Antidepressants are drugs widely used in nervous disorders, such as anxiety, depression, and panic, and are eliminated through the urinary system. In bodies of water, they present high persistence and toxicity, even at low concentrations, conforming to the classification of emerging micropollutants. This work addresses the construction of phase diagrams for different biphasic systems, based on ionic liquids (ILs) and organic solvents, and their subsequent application in the partitioning of antidepressants such as fluoxetine hydrochloride, paroxetine hydrochloride and sertraline hydrochloride. The phase diagrams were measured gravimetrically at 298.15 ± 1.00 K and atm. pressure using the turbidity method. The ILs of the imidazolium family, with shorter chain length [C₂mim]⁺, were the only ones able to form biphasic systems using 1,3-dioxolane. The driving force for phase separation is the comparison of hydrophobic/hydrophilic characteristics between the constituents. In this sense, the pair of constituents [C₂min][OAc] and 1,3-dioxolane provided the phase diagram with the largest biphasic area. The partitioning of antidepressants was studied in systems formed by IL (25%) + 1,3-dioxolane (50%) + water (25%) containing 1.05μg·L^-1 of fluoxetine hydrochloride, 1.42μg·L^-1 of paroxetine hydrochloride or 0.23μg·L^-1 sertraline hydrochloride at 298.15 ± 1.00 K and atm. pressure. The partitioning followed the characteristics of antidepressant σ-profiles generated through COSMO-RS. The recoveries were high, and the proposed systems were shown to promote the selective isolation of pairs of these antidepressants. To complete the study, the researchers used 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.HPLC of Formula: 65039-09-0

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Doelle, Anja;Adhikari, Bikash;Kraemer, Andreas;Weckesser, Janik;Berner, Nicola;Berger, Lena-Marie;Diebold, Mathias;Szewczyk, Magdalena M.;Barsyte-Lovejoy, Dalia;Arrowsmith, Cheryl H.;Gebel, Jakob;Loehr, Frank;Doetsch, Volker;Eilers, Martin;Heinzlmeir, Stephanie;Kuster, Bernhard;Sotriffer, Christoph;Wolf, Elmar;Knapp, Stefan published 《Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders》. The research results were published in《Journal of Medicinal Chemistry》 in 2021.Electric Literature of C6H7BrN2 The article conveys some information:

Histone H3K4 methylation serves as a post-translational hallmark of actively transcribed genes and is introduced by histone methyltransferase (HMT) and its regulatory scaffolding proteins. One of these is the WD-repeat-containing protein 5 (WDR5) that has also been associated with controlling long noncoding RNAs and transcription factors including MYC. The wide influence of dysfunctional HMT complexes and the typically upregulated MYC levels in diverse tumor types suggested WDR5 as an attractive drug target. Indeed, protein-protein interface inhibitors for two protein interaction interfaces on WDR5 have been developed. While such compounds only inhibit a subset of WDR5 interactions, chem. induced proteasomal degradation of WDR5 might represent an elegant way to target all oncogenic functions. This study presents the design, synthesis, and evaluation of two diverse WDR5 degrader series based on two WIN site binding scaffolds and shows that linker nature and length strongly influence degradation efficacy.2-Bromo-5H,6H,7H-pyrrolo[1,2-a]imidazole (cas: 1525619-20-8) were involved in the experimental procedure.

Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Electric Literature of C6H7BrN2Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wong, John L.;Fuchs, David S. published 《Reactivities and electronic aspects of nucleic acid heterocycles. III. Hydrolytic behavior of 6-methoxypurines》 in 1974. The article was appeared in 《Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999)》. They have made some progress in their research.Formula: C7H11N3O2 The article mentions the following:

Aqueous acidic hydrolysis of the methoxypurine I (0.1M) gave Me 5-amino-1-methylimidazole-4-carboxylate and 9-methylhypoxanthine (7:3). II and III behaved analogously. At >0.2M concentrations of the methoxypurines, O to N methyl migration became competitive. The hydrolysis proceeded via purine dications. The results indicated that no O-methylated pyrimidines or purines could survive the acidic conditions used prevalently in the chem. hydrolysis of nucleic acids. And Ethyl 5-amino-1-methyl-1H-imidazole-4-carboxylate (cas: 54147-04-5) was used in the research process.

Ethyl 5-amino-1-methyl-1H-imidazole-4-carboxylate (cas: 54147-04-5 Formula: C7H11N3O2) is a synthetic retinoid that has been shown to be effective in the treatment of psoriasis. It inhibits the activation of histone lysine residues and increases the terminal half life of endogenous synthesis.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of C6H11ClN2In 2022, Elterman, V. A.;Shevelin, P. Yu.;Yolshina, L. A.;Borozdin, A. V. published 《Features of aluminum electrodeposition from 1,3-dialkylimidazolium chloride chloroaluminate ionic liquids》. 《Journal of Molecular Liquids》published the findings. The article contains the following contents:

The mechanism of aluminum electrodeposition from acidic 1-butyl-3-methylimidazolium chloride chloroaluminate ionic liquids ([BMIm]Cl ILs) is studied over a wide range of the molar ratio of AlCl₃ to [BMIm]Cl (N) at 30°C. The findings for AlCl₃-[BMIm]Cl and AlCl₃-1-ethyl-3-methylimidazolium chloride ([EMIm]Cl) are analyzed and compared in order to identify dependences common for 1,3-dialkylimidazolium chloride ILs. Limiting currents were detected on the cathodic polarization curves at the aluminum | ionic liquid interface. Limiting currents are caused by the Al₂Cl^–₇ anions diffusion to the electrode surface. The limiting c.d. values for AlCl₃-[BMIm]Cl are lower (i_lim, 1.1 ≤ N leq 2.0 = 1.17 – 12.36 mA•cm^-2) than for AlCl₃-[EMIm]Cl (i_lim, 1.1 ≤ N leq 2.0 = 1.81 – 25.37 mA·cm^-2). It is shown that anion AlCl-4 can be reduced to metallic aluminum at cathodic overpotentials above 1.5 V. The diffusion coefficient of Al₂Cl-7 in AlCl₃-[BMIm]Cl (7.4•10-7 cm²•s^-1) is lower than in AlCl₃-[EMIm]Cl (9.3•10-7 cm²•s^-1) and is unaffected by aluminum chloride concentration in either system. The experimental procedure involved many compounds, such as 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Synthetic Route of C6H11ClN2

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem