Tag: 100-200

DNA-based asymmetric catalysis: role of ionic solvents and glymes was written by Zhao, Hua;Shen, Kai. And the article was included in RSC Advances in 2014.Recommanded Product: 85692-37-1 This article mentions the following:

Stereoselective Michael addition reactions were performed between imidazolylphenylpropenones and di-Me malonate using DNA-based hybrid metal catalyst in ionic liquids, inorganic salts, DES, glymes and glycols as co-solvents (or additives). The unique chiral structure of DNA allowed the hybrid catalysts to catalyze various asym. synthesis reactions. In general, these additives induced indistinguishable changes to the DNA B-form duplex conformation as suggested by CD (CD) spectroscopy, but imposed a significant influence on the catalytic efficiency of the DNA-based hybrid catalyst. Most ILs and inorganic salts caused the deactivation of the hybrid catalyst except 0.2 M [BMIM][CF₃COO] (95.4% ee and 93% yield) and 0.2 M [BMIM]Cl (93.7% ee and 89% yield). Several other additives were found to improve the catalytic efficiency of the DNA-based hybrid catalyst (control reaction without additive gives >99% ee and 87% yield), 0.4 M glycerol (>99% ee and 96% yield at 5 °C or 96.2% ee and 83% yield at room temperature), 0.2 M choline chloride-glycerol (1 : 2) (92.4% ee and 90% yield at 5 °C or 94.0% ee and 88% yield at room temperature), and 0.5 M dipropylene glycol di-Me ether (>99% ee and 87% yield at room temperature). A brief pre-sonication (5 min) of DNA in MOPS buffer prior to the reaction improved the performance of the DNA-based hybrid catalyst. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Recommanded Product: 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Production of reducing sugar from macroalgae saccharina japonica using ionic liquid catalyst was written by Park, Don-Hee;Jeong, Gwi-Taek. And the article was included in Hwahak Konghak in 2013.Safety of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

In this work, we investigated 20 kinds of ionic liquids as catalyst during the hydrolysis of Saccharina japonica. Three kinds of ionic liquid, 1 -ethyl-3-methylimidazolium tetrafluoroborate, n-butyl-4-methylpyridinium tetrafluoroborate, and n-methylmorpholine [HSO₄], are selected, and then investigated the effect of reaction temperature, catalyst amount and reaction time. The hydrolysis of S. japonica was increased by the increasing of reaction temperature and ionic liquid amount Also, the hydrolysis presented the linear increase by the increasing of reaction time. After 90 min of reaction, the concentrations of reducing sugar of 1 -ethyl-3-methylimidazolium tetrafluoroborate, n-butyl-4-methylpyridinium tetrafluoroborate, and n-methylmorpholine [HSO₄] are reached to 6.2 g/L, 6.4 g/L and 6.0 g/L, resp. As an overall result, we obtained the possibility of hydrolysis of marine biomass using ionic liquids In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Safety of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

N-alkylation of N-H compounds in N, N-dimethylformamide dialkyl acetal was written by Zhao, Hui;Zhu, Xiaoyun;Hu, Xiaoxia;Liu, Yan-ge;Tang, Chunlei;Feng, Bainian. And the article was included in Youji Huaxue in 2019.Synthetic Route of C4H5N3O2 This article mentions the following:

The N, N-dimethylformamide dialkyl acetal was used as the alkyl source to achieve different nitrogen alkylation reactions of N-H compounds The reaction has the advantages of cheap raw materials, easy operation, mild reaction conditions, broad substrate scope and no metal participation. By studying the effects of solvents, temperature, reaction time, and the amount of N, N-dimethylformamide dialkyl acetal on the reaction, the optimal reaction conditions were obtained. The effect of different N, N-dimethylformamide dialkyl acetals on the alkylation ability of the substrate was investigated. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Synthetic Route of C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Synthetic Route of C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Heterocyclic ambident nucleophiles. V. Alkylation of benzimidazoles was written by Howell, John R.;Rasmussen, Malcolm. And the article was included in Australian Journal of Chemistry in 1993.Reference of 4887-83-6 This article mentions the following:

Alkylation of 5-substituted benzimidazole anions with a variety of primary alkyl halides in both protic and aprotic solvents showed only small regioselectivity, with a slight preference for reaction at N(1) for 5-nitro and N(3) for 5-methoxy systems. With 4-substituted benzimidazole anions, alkylation gave more divergent results, with the N(1) to N(3) regioselectivity varying between 100:0 and 29:71. These alkylation patterns are interpreted as deriving from an interplay of electrostatic, thermodn., steric and associative control factors within the variable S_N2 transition state structures involved. In the 4-substituted series, proximity effects, both electrostatic field and steric non-bonded, are clearly dominant. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Reference of 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Reference of 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ligand effect on ethylene trimerisation with [NNN]-heteroscorpionate pyrazolyl Cr(III) catalysts was written by Zhang, Jun;Li, Aifang;Hor, T. S. Andy. And the article was included in Dalton Transactions in 2009.Quality Control of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

Cr(III) complexes with [NNN]-heteroscorpionate pyrazolyl ligands of the type Pz’₂CHX (Pz’ = pyrazol-1-yl (Pz), or 3,5-dimethylpyrazol-1-yl (Pz^Me); X = N-containing heterocyclic ring or amine CH₂NR¹R²; R¹, R² = H or alkyl) have been prepared Upon activation with MAO, they are active for selective ethylene trimerization to 1-hexene. The effects of the hetero-functional group and chelate ring size on the catalytic performance have been examined The pre-catalysts with an N-heterocycle substituent show highest activity [32,400-53,000 g/(g/Cr/h^-1)] and total C₆ selectivities (>97.6%) as well as 1-hexene selectivity (>96.0%) among hexenes. The X-ray single-crystal crystallog. anal. of CrCl₃[Pz^Me₂CH₂NCH₂Ph] and CrCl₃[Pz^Me₂CH₂NCH₂Fc] (Fc = ferrocenyl) shows a tridentate coordination on the fac-octahedral Cr(III) sphere with the Cr-N bond length dependent on the N-substituent. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Quality Control of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Quality Control of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Optimized scale up of 3-pyrimidinylpyrazolo[1,5-a]pyridine via Suzuki coupling; a general method of accessing a range of 3-(hetero)arylpyrazolo[1,5-a]pyridines was written by Bethel, Paul A.;Campbell, Andrew D.;Goldberg, Frederick W.;Kemmitt, Paul D.;Lamont, Gillian M.;Suleman, Abid. And the article was included in Tetrahedron in 2012.Product Details of 25676-75-9 This article mentions the following:

We have developed an improved synthesis of 3-(hetero)aryl pyrazolo[1,5-a]pyridines [such as 3-(2,5-dichloropyrimidin-4-yl)pyrazolo[1,5-a]pyridine (I)] via an optimized synthesis and Suzuki coupling of 3-pyrazolo[1,5-a]pyridine boronic ester (II). These conditions are applicable to both high throughput chem. and large scale synthesis of these medicinally important compounds The scope of this chem. has been further extended to include the synthesis and coupling of a novel boronic ester, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Product Details of 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Product Details of 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

N-alkylation of N-H compounds in N, N-dimethylformamide dialkyl acetal was written by Zhao, Hui;Zhu, Xiaoyun;Hu, Xiaoxia;Liu, Yan-ge;Tang, Chunlei;Feng, Bainian. And the article was included in Youji Huaxue in 2019.Quality Control of 4-Bromo-1-methylimidazole This article mentions the following:

The N, N-dimethylformamide dialkyl acetal was used as the alkyl source to achieve different nitrogen alkylation reactions of N-H compounds The reaction has the advantages of cheap raw materials, easy operation, mild reaction conditions, broad substrate scope and no metal participation. By studying the effects of solvents, temperature, reaction time, and the amount of N, N-dimethylformamide dialkyl acetal on the reaction, the optimal reaction conditions were obtained. The effect of different N, N-dimethylformamide dialkyl acetals on the alkylation ability of the substrate was investigated. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Quality Control of 4-Bromo-1-methylimidazole).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Quality Control of 4-Bromo-1-methylimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The accumulation of 4-amino-5-imidazolecarboxamide in Escherichia coli was written by Alimchandani, H. R.;Sreenivasan, A.. And the article was included in Journal of Bacteriology in 1957.COA of Formula: C4H5N3O This article mentions the following:

The effects of pteroylglutamic acid (I), leucovorin (II), vitamin B₁₂ (III), and methionine (IV) on the accumulation of 4-amino-5-imidazolecarboxamide by E. coli during sulfadiazine (V) bacteriostasis were studied. I and II were ineffective in reversing V growth inhibition or in influencing amine accumulation per unit growth to different degrees, III being the more effective. Amine accumulation, when expressed as a variable against growth, was more in the presence of IV and least in the control set without added III or IV, the III effect being intermediate. These observations are interpreted to mean that the primary effects of III or IV are on the growth and other aspects of cell metabolism that are interfered with by sulfonamides. Their involvement in amine to purine conversion is only indirect. Ethionine and a III oxidation product depressed growth, but no amine accumulation was observed. The inability of an E. coli mutant to accumulate the amine under conditions of deficiency of III or IV also suggested that these 2 metabolites are involved only indirectly in purine synthesis. 27 references. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6COA of Formula: C4H5N3O).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C4H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Heptadentate, Octadentate, Or Even Nonadentate? Denticity in the Unexpected Formation of an All-Carbon Donor-Atom Ligand in Rh^III(Cp*)(Anthracenyl-NHC) Complexes was written by Lee, Betty Y. T.;Phillips, Andrew D.;Hanif, Muhammad;Tong, Kelvin K. H.;Sohnel, Tilo;Hartinger, Christian G.. And the article was included in Inorganic Chemistry in 2021.Computed Properties of C8H8N2 This article mentions the following:

Investigations on incorporating an N-flanking anthracenyl moiety to [Rh(Cp*)(NHC)Cl₂] complexes surprisingly led to the formation of an intramol. C-C bond between the Cp* and anthracenyl moieties, with addnl. auxiliary interactions between the metal and the anthracenyl ring system. In silico modeling supports a reaction mechanism whereby Rh(η⁴-tetramethylfulvene) intermediates undergo metallocycloaddn. and the abstraction of a chlorido ligand, affording unique cationic complexes that feature Rh centers coordinated by a nonadentate ligand with exclusively carbon donor atoms. Some Rh-C interactions were extremely weak but nevertheless exhibited covalent bonding character. These weak Rh-C interactions were readily displaced by stronger electron donors, and the nonadentate ligand reverted to the heptadentate coordination mode observed in the intermediate. As far as we are aware, this study provides the first conclusive evidence of complexes bearing a single nonadentate κ⁹-coordinating ligand that features only carbon donors bound to a metal center. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Computed Properties of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Facile fabrication of Sc-BiOBr photocatalyst immobilized on palm bark with enhanced visible light photocatalytic performance for estradiol degradation was written by Yang, Qiuping;Zhai, Yubo;Xu, Ting;Zhao, Kexian;Li, Huizhi. And the article was included in Journal of Physics and Chemistry of Solids in 2019.Application of 35487-17-3 This article mentions the following:

A novel Sc-BiOBr photocatalyst was innovatively prepared via the dispersion of Sc-BiOBr onto the surface of palm bark with the utilization of 1-Me imidazolium chloride ionic liquid as the solvent. The crystalline phase, morphol., chem. composition and optical property of the photocatalyst were investigated by X-ray diffraction (XRD), XPS, scanning electron microscope (SEM) attached with energy dispersive spectrometer (EDS), transmittance electron microscopy (TEM), Fourier transform IR (FT-IR) spectrometry, Brunauer-Emmett-Teller (BET) surface area, photoluminescence (PL) spectra and UV-vis diffuse reflectance spectroscopy (DRS). Photocatalytic activity was evaluated by the photodegradation of estradiol. The photodegradation rate of estradiol over Sc-BiOBr/palm bark photocatalyst was 99.9% under visible light irradiation, which exhibited excellent photocatalytic efficiency than pure BiOBr. The kinetics of estradiol photodegradation catalyzed by Sc-BiOBr/palm bark photocatalyst was investigated by fitting the data with the data with pseudo-first-order model. The apparent rate constant of Sc-BiOBr/palm bark photocatalyst was 1.88 and 1.27 times higher than that of pure BiOBr and Sc-BiOBr. Meanwhile, the effect of photocatalyst loading and initial estradiol concentration was also investigated. The recycling experiments revealed that the Sc-BiOBr/palm bark photocatalyst still exhibited excellent photocatalytic activity after five recycling runs. The radical quenching experiments verified that •O^–₂ and h⁺ were the dominant reactive species. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Application of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem