Tag: 100-200

Symmetry vs. asymmetry – Enthalpic differences in imidazolium-based ionic liquids was written by Yermalayeu, Andrei V.;Varfolomeev, Mikhail A.;Verevkin, Sergey P.. And the article was included in Journal of Molecular Liquids in 2020.HPLC of Formula: 21252-69-7 This article mentions the following:

Enthalpies of ionic liquids [C_nC_nIm][X] synthesis reactions were measured with help of differential scanning calorimetry. These results in combination with quantum-chem. calculations were used for estimation of vaporization enthalpies of sym. imidazolium based ionic liquids with X = Cl, Br, and I. Vaporization enthalpies of the sym. ([C_nC_nIm][X]) series were found to be systematically lower (of 5-8 kJ mol^-1) in comparison with the corresponding asym. imidazolium-based ILs ([C_nC₁Im][X]). This energetic difference was attributed to the intensity of dispersion interactions. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7HPLC of Formula: 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.HPLC of Formula: 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic liquid-regulated sulfamic acid. Chemoselective catalyst for the transesterification of β-ketoesters was written by Wang, Bo;Ming, Yang Li;Shuan, Suo Ji. And the article was included in Tetrahedron Letters in 2003.Reference of 79917-89-8 This article mentions the following:

1-Propyl-3-methylimidazolium chloride ([C₃MIm]Cl) ionic liquid and sulfamic acid (NH₂SO₃H), as a synergetic catalytic medium, were used for the transesterification of acetoacetate with alcs. of different structures. It shows the good ability for the chemoselective transesterification of β-ketoesters and maintains its catalytic activity in the reuse. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Reference of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Reference of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Stabilizing Au(III) in supported-ionic-liquid-phase (SILP) catalyst using CuCl₂ via a redox mechanism was written by Zhao, Jia;Yu, Yi;Xu, Xiaolong;Di, Shuxia;Wang, Bolin;Xu, Hao;Ni, Jun;Guo, Ling Ling;Pan, Zhiyan;Li, Xiaonian. And the article was included in Applied Catalysis, B: Environmental in 2017.Related Products of 79917-89-8 This article mentions the following:

High-valent Au(III) complexes have attracted much attention as catalysts in many reactions. Nevertheless Au(III) catalysts suffer from instability of the oxidized metal complexes during preparation and use. Herein, we demonstrated that Au(III) catalysts can be stabilized against reduction to metallic Au⁰ by modifying supported-ionic-liquid-phase-stabilized Au(III) catalyst with CuCl₂. It was found that the reduced Au⁰ could be re-oxidized in situ to Au³⁺ species by CuCl₂ during the reaction and further stabilized by the electron transfer from Cu to these active species. When evaluated in the acetylene hydrochlorination reaction, the Au-Cu-IL/AC catalyst displayed an excellent specific activity with the turnover frequency (TOF) as high as 168.5 h^-1 and more than 99.8% selectivity for the product, vinyl chloride (VCM). Furthermore, the Au-Cu-IL/AC catalyst demonstrated a stable catalytic performance with a negligible loss of C₂H₂ conversion after 500 h under typical industrial reaction conditions for acetylene hydrochlorination. Therefore, the findings of this work provide an efficient approach for designing stable high-valent metals for long-term operation, and also pave the way for the application of Au-Cu-IL/AC catalyst in industrial VCM production In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Related Products of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Related Products of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fractionation of corn stover into cellulose, hemicellulose and lignin using a series of ionic liquids was written by Zhang, Peng;Dong, Shi-Jia;Ma, Hui-Hui;Zhang, Bi-Xian;Wang, Yu-Fei;Hu, Xiao-Mei. And the article was included in Industrial Crops and Products in 2015.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

Lignocellulosic biomass is increasingly being promoted as an environmentally and economically sustainable fuel. However, the complex structure of lignocellulose makes it difficult to be fractionated, which limits its conversion into valuable products. In this work, a series of functional acidic ionic liquids (ILs) with a simple synthetic procedure were prepared Fractionation of corn stover into cellulose, hemicellulose and lignin was successfully performed in ultrasound-assisted ILs at a low reaction temperature of 70 °C for 3 h followed by alk. extraction IL-isolated lignin, alk. lignin, hemicellulose and cellulose were obtained in good yields and their chem. properties were analyzed by FTIR. Significantly, a good yield of IL-isolated lignin was obtained, which accounted for 60.48% of the original lignin. The IL-isolated lignin was S-G-H type indicating by ¹³C NMR and ¹³C-¹H correlation 2D NMR (HSQC) anal. Enzymic hydrolysis of cellulose was performed successfully. A high yield of 97.77% reducing sugar was achieved. Glucose and cellobiose were measured by HPLC anal., which accounted for 92.55% of cellulose conversion. Both of the hydrogen bond capability and the acidity of ILs contributed to achieve the effective fractionation. These ILs have a great potential for the preparation of biofuel. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enthalpic interactions in aqueous strong electrolytes upon addition of ionic liquids was written by Jain, Preeti;Kumar, Anil. And the article was included in Physical Chemistry Chemical Physics in 2018.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

The present study deals with the inter-ionic interactions between strong electrolytes and ionic liquids based on the thermodn. properties such as excess partial molar enthalpy, H^E_IL, relative apparent molar enthalpy, ϕ_L, and the enthalpic interaction parameters. The thermodn. properties of the systems are the key indicators to understand the interionic interactions. We have conducted a systematic investigation of the enthalpic behavior of aqueous solution of salts and ionic liquids and their mixtures The present study also emphasizes how the H^E_IL values for the mixture of aqueous solution of ionic liquids and salts deviate from linearity as compared to those of the constituent aqueous ionic liquid or salt. This deviation from linearity for the H^E_IL values has been discussed here. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Organic carbonate synthesis from CO₂ and alcohol over CeO₂ with 2-cyanopyridine: Scope and mechanistic studies was written by Honda, Masayoshi;Tamura, Masazumi;Nakagawa, Yoshinao;Nakao, Kenji;Suzuki, Kimihito;Tomishige, Keiichi. And the article was included in Journal of Catalysis in 2014.Formula: C4H5N3O This article mentions the following:

The combination system of CeO₂-catalyzed carboxylation and 2-cyanopyridine hydration (CeO₂ + 2-cyanopyridine system) is effective for the direct synthesis of organic carbonates from CO₂ and alcs. This catalyst system can be applied to various alcs. to afford the corresponding carbonates in high alc.-based yields. The hydration of 2-cyanopyridine over CeO₂ rapidly proceeds under the low concentration of water, which can remove the water from the reaction media. Since the reaction is limited by the chem. equilibrium, the removal of water remarkably shifts the chem. equilibrium to the carbonate side, leading to high carbonate yields. In addition, 2-picolinamide that is produced by hydration of 2-cyanopyridine forms an intramol. hydrogen bonding between H atom of the amide group and N atom of the pyridine ring, which weakens the adsorption of 2-picolinamide on CeO₂ by reduction of the acidity. The reaction mechanism of DMC formation in CeO₂ + 2-cyanopyridine system is also proposed. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Formula: C4H5N3O).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Formula: C4H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Successful Control of Aggregation and Folding Rates during Refolding of Denatured Lysozyme by Adding N-Methylimidazolium Cations with Various N’-Substituents was written by Yamaguchi, Satoshi;Yamamoto, Etsushi;Tsukiji, Shinya;Nagamune, Teruyuki. And the article was included in Biotechnology Progress in 2008.Formula: C7H13ClN2 This article mentions the following:

The present study aimed to obtain more effective refolding agents and to understand the influence of their chem. structures on their function as refolding agents. To achieve these aims, we investigated the effects of a large variety of N’-substituted N-methylimidazolium chlorides on the oxidative refolding of lysozyme in a high throughput manner. Among the mols. examined, N-methylimidazolium cations with a short N’-alkyl chain, such as an N’-Et or N’-Bu chain, significantly enhanced the refolding yield compared to conventional refolding additives such as arginine hydrochloride and Triton X-100. Detailed kinetic analyses revealed that the effective cations selectively decreased the aggregation rate constant (k_A) without any large decreases in the folding rate constant (k_N). However, when the hydrophobicity of the N’-substituent of the cations was increased, the desirable properties of the short N’-alkyl chain-type cations for protein refolding were diminished. Furthermore, increases in the N’-alkyl chain length to an N’-octyl or N’-dodecyl chain drastically decreased the k_A values, thereby increasing the ratio of k_N to k_A, despite the very small k_N values and resulting in enhanced refolding yields. Thus, by tuning the chem. structure of the N’-substituents of N-methylimidazolium chloride, five effective refolding agents (N’-ethyl-, N’-propyl-, N’-butyl-, N’-pentyl- and N’-isobutyl-N-methylimidazolium chlorides) were successfully obtained, and the kinetic parameters of folding and aggregation during the refolding process could be controlled using three different modes. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Formula: C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Controllable Synthesis of Vacancy-Defect Cu Site and Its Catalysis for the Manufacture of Vinyl Chloride Monomer was written by Wang, Bolin;Jiang, Zhao;Wang, Ting;Tang, Qi;Yu, Mingde;Feng, Tao;Tian, Min;Chang, Renqin;Yue, Yuxue;Pan, Zhiyan;Zhao, Jia;Li, Xiaonian. And the article was included in ACS Catalysis in 2021.Safety of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Designing favorable structures of active sites and clarifying the structure-activity relationship are important to narrow the large activity gap between Cu-based and the noble-metal-based catalytic systems for vinyl chloride production Herein, we report a facile controllable thermal method for fabricating the platform of Cu single-atom catalysts ranging from the standard no-vacancy-defect CuCl₃-N to vacancy-defect CuCl₂V-N (“V” for the vacancy-defect site) and to no-vacancy-defect CuN₄. The gradually released C-Cl derivatives promote the vacancy-defect generation under elevated temperatures, and the activity gap between Cu- and the noble-metal-based systems is found to be dramatically narrowed from classic ~37-fold to ~1.5-fold on the vacancy-defect sites. Kinetic anal. shows that the competitive adsorption between acetylene and hydrogen chloride on the CuCl₂V-N site contributed more to the catalytic performance than the single hydrogen chloride adsorption on site CuCl₃-N or CuN₄. Furthermore, when the CuCl₂V-N site is preoccupied and adsorbed by acetylene, the reaction energy barrier decreases from 35 to 24 kJ/mol, indicating that the single activation of acetylene is more favorable for catalytic activity than that of the dual-activation of acetylene and hydrogen chloride. DFT calculations revealed the specific reaction mechanism catalyzed on the vacancy-defect CuCl₂V-N site, i.e., where the vacancy-defect not only affects the activation behavior of substrates but also regulates the reaction pathway. Excellent catalytic performance can be maintained under the interaction of high concentration of vinyl chloride and H₂S impurity. This work opens a new window for controllable synthesis of vacancy-defect sites of single metallic atoms in catalysis design and enhancing catalytic activity. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Safety of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2 was written by D’Alessandro, Pier L.;Corti, Corrado;Roth, Adelheid;Ugolini, Annarosa;Sava, Anna;Montanari, Dino;Bianchi, Federica;Garland, Stephen L.;Powney, Ben;Koppe, Emma L.;Rocheville, Magalie;Osborne, Greg;Perez, Paloma;de la Fuente, Jesus;De Los Frailes, Maite;Smith, Paul W.;Branch, Clive;Nash, David;Watson, Stephen P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.HPLC of Formula: 3012-80-4 This article mentions the following:

The optimization of an HTS hit series (1) leading to the identification of structurally novel, selective, orally bioavailable mGluR2 pos. modulators GSK1331258 and GSK1331268 is described. Structure-activity relationships, attenuation of dopaminergic activity, and potentiation of mGluR2 responses in rat hippocampal MPP-DG synapses are also reported. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4HPLC of Formula: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A facile and convenient synthesis of new substituted heteroarylchalcones and flavones by microwave irradiated Suzuki-Miyaura cross coupling reaction in aqueous medium was written by Joshi, Vidya;Hatim, Jaywant Govind. And the article was included in Indian Journal of Heterocyclic Chemistry in 2012.COA of Formula: C4H5BrN2 This article mentions the following:

Chalcones I (R = heteroaryl) and corresponding flavones II (same R) having various heteroaryl substituents have been synthesized. The starting compound 5-formyl-2-methoxyphenylboronic acid (III) was prepared by a series of reactions; bromination of 4-methoxybenzaldehyde with catalyst anhydrous AlCl₃ in DCE (1,2-dichloroethane) gave 3-bromo-4-methoxybenzaldehyde. The aldehydic in 3-bromo-4-methoxybenzaldehyde was protected by acetalization with 1,3-propanediol and Et orthoformate with phase transfer catalyst tetrabutylammonium tribromide producing the corresponding 2-(3-bromo-4-methoxyphenyl)-1,3-dioxane, which on treatment with tri-Me borate [(MeO)₃B] in presence of n-butyllithium at 70° gave III. Suzuki-Miyaura coupling of III with different heteroaryl bromides in presence of [(C₆H₅)₃P]₄Pd(0) catalyst, aqueousNa₂CO₃ (2N) as base, and aqueous DMF as solvent and microwave irradiation for 1 to 2.5 min. in a Panasonic microwave set at 1000 W and 80% microwave power yielded 3-heteroaryl-4-methoxybenzaldehydes. Claisen-Schmidt condensation of the latter with 2-hydroxyacetophenone in presence of ethanolic KOH produced 3-heteroaryl-2′-hydroxy-4-methoxychalcones (I, R = heteroaryl). Cyclizing I with a mixture of I₂ and DMSO gave 3′-heteroaryl-4′-methoxyflavones (II, same R). In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9COA of Formula: C4H5BrN2).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C4H5BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem