Tag: 100-200

Carbon Chain Rupture: Base-Induced Radical C-C Bond Cleavage of Alkylbenzimidazoles was written by Fu, Xuegang;Guo, Dongyang;Yan, Yuting;Marselo, Timotius;Zhang, Mingyu;Zhang, Zhenghan;Li, Siying;Huang, Jianhui. And the article was included in Synthesis in 2022.Recommanded Product: 1632-83-3 This article mentions the following:

A base-mediated aerobic oxidation of alkylbenzimidazoles for the preparation of carboxylic acids was described. A number of aliphatic carboxylic acids are prepared in good to excellent yields via a C-C bond rupture process. Preliminary mechanistic studies suggested the reaction undergoes a radical pathway initiated by strong bases such as potassium amide. This type of transformation provided an alternative strategy for the access of important carboxylic acid moieties. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives as inhibitors of cyclic nucleotide phosphodiesterases was written by Buchman, Russell;Heinstein, Peter F.;Wells, Jack N.. And the article was included in Journal of Medicinal Chemistry in 1974.Recommanded Product: 1H-Imidazole-4-carboxamide This article mentions the following:

Opening the pyrimidine ring of methylxanthines markedly decreased their inhibitory activity toward phosphodiesterases. Four series of imidazole analogs of theophylline were prepared consisting of 1-substituted imidazole-4- and -5-carboxamides, 1,4-disubstituted imidazole-5-carboxamides, and 1-substituted-4-aminoimidazoles. The most potent inhibitors in these series were 4-benzylamino- [53525-67-0]and 4-benzylideneamino-5-(N-methylcarbamoyl)imidazole (I) [53525-53-4]. Substitution of a benzyl group in position 7 of theophylline confirmed some specificity for inhibition of hydrolysis of cyclic GMP. Most of the compounds were prepared by standard methods. 4-Amino-5-(N-methylcarbamoyl)imidazole [53525-66-9] was prepared by reduction of Et α-cyano-α-oximinoacetate [3849-21-6] with Al amalgam, reaction with MeNH2 to form α-amino-α-cyano-N-methylacetamide [50531-01-6], and cyclization with formamidine acetate [3473-63-0]. 4-(N-methylacetamido)-5-(N-methylcarbamoyl)imidazole [53525-54-5] was prepared by ring opening of 7-benzyltheophylline [1807-85-8] with KOH, followed by debenzylation with H2-Pd/C and acetylation. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Recommanded Product: 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synergistic Production of Methyl Lactate from Carbohydrates Using an Ionic Liquid Functionalized Sn-Containing Catalyst was written by Wang, Fenfen;Wen, Yi;Fang, Yanxiong;Ji, Hongbing. And the article was included in ChemCatChem in 2018.COA of Formula: C11H20N2 This article mentions the following:

Considerable progress has been made recently in the catalytic conversion of renewable biomass resources to Me lactate (MLA). However, conceiving eco-friendly and effective catalytic systems for the production of MLA from biomass carbohydrates remains a key challenge. Herein, we report a multifunctional catalyst Sn(salen)/IL, consisting of a Sn(salen) complex and an imidazolium-based ionic liquid (IL), which acts via an intramol. synergistic effect to convert carbohydrates to MLA in methanol. The versatile properties of the resultant catalyst were revealed to be responsible for the conversion of fructose to MLA and the efficient suppression of undesired side reactions. This catalyst displayed outstanding catalytic activity, high selectivity, and excellent recyclability, giving an MLA yield of up to 68.9 % at 160 °C after 2 h. The results of this study will contribute to new approaches for designing synergistic catalysts for producing liquid fuels and chems. from biomass resources. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7COA of Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Highly efficient gel electrolytes by end group modified PEG-based ABA triblock copolymers for quasi-solid-state dye-sensitized solar cells was written by Masud;Kim, Kyeong Min;Kim, Hwan Kyu. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2021.Recommanded Product: 1-Methylbenzimidazole This article mentions the following:

To get highly efficient quasi-solid-state dye-sensitized solar cells (QSS-DSSCs) with long-term stability using polymer gel electrolytes (PGEs), well-defined ABA triblock copolymers ([Poly(Me methacrylate)]₂-block-poly(ethylene glycol)) with different end functionality and components of I^–/I^–₃ liquid electrolytes (LEs) are studied and optimized for the fabrication of PGE-based QSS-DSSCs. Triblock copolymers are synthesized in a one-step reaction using bifunctional PEG-macro chain transfer agent (MCTA) by reversible addition-fragmentation chain transfer (RAFT) polymerization Due to the high reactivity and toxicity of sulfur-containing trithiocarbonate end groups, ABA triblock copolymers prepared from RAFT polymerization are further modified to sulfur-free 2-methylpropionitrile and 4-cyanopentanoic acid end functional triblock copolymers by radical-induced exchange reactions. Dodecyl trithiocarbonate end functional PEG-MCTA and triblock copolymers absorb UV-light in the region of 260-380 nm, whereas sulfur-free carboxylic acid and 2-methylpropionitrile end functional polymers do not absorb in that UV-light region. Among three different end functional polymers, the carboxylic acid end functional triblock copolymer has the highest thermal stability. Based on electrochem. parameters, photovoltaic performance, and long-term stability, 1,2-dimethyl-3-propylimidazolium iodide (DMPII) ionic liquid and 4-tert-butylpyridine (TBP) additive containing acetonitrile-based I^–/I^–₃ LEs are effective for PGEs. The highest power conversion efficiency (PCE) for QSS-DSSCs achieved under simulated 1-sun illumination is up to 10.34%, which is comparable with the highest PCE of 10.39% for LE-DSSCs. Considering the high reactivity, thermal stability, UV-absorption, and the toxicity of the trithiocarbonate end group, the SGT-643-C triblock copolymer with carboxylic acid end group can be a promising candidate as a sulfur-free polymeric matrix for gel electrolytes of QSS-DSSCs. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Stability of Titania Nanomaterials Dispersed in Aqueous Solutions of Ionic Liquids of Different Alkyl Chain Lengths was written by Rouster, Paul;Pavlovic, Marko;Cao, Tianchi;Katana, Bojana;Szilagyi, Istvan. And the article was included in Journal of Physical Chemistry C in 2019.SDS of cas: 35487-17-3 This article mentions the following:

Charging and aggregation of titania nanosheets (TNS) and spherical titania nanoparticles (TNP) were studied in aqueous solutions of ionic liquids The pH and the length of the alkyl chain of the IL cations [1-methylimidazolium (MIM⁺), 1-ethyl-3-methylimidazolium (EMIM⁺), and 1-butyl-3-methylimidazolium (BMIM⁺)] were systematically varied in the experiments No detectable interaction was observed between the IL cations and the pos. charged TNS or TNP surfaces at low pH, where the imidazolium derivatives are the co-ions. For the neg. charged titania nano-objects, significant adsorption of MIM⁺ and EMIM⁺ took place, leading to charge neutralization and overcharging at appropriate concentrations The BMIM⁺ behaved like a simple salt constituent causing charge screening. For both TNS and TNP, the MIM⁺ < EMIM⁺ < BMIM⁺ counterion order was obtained in the critical coagulation concentrations, indicating that MIM⁺ was the most effective in destabilization of the dispersions. The major interparticle forces were of electrostatic origin; however, viscous stabilization was also observed at high IL concentrations The same aggregation mechanism and charging behavior were found for the titania nano-objects irresp. of their shape. The results shed light on the hydrophilic nature of the surface of the TNS and TNP of neg. charge, in contrast to earlier findings with hydrophobic colloidal particles, where the increasing alkyl chain length gave rise to higher destabilization power. The charging properties were governed by specific adsorption of the IL constituents, while the major interparticle forces were qual. well-predicted by the Derjaguin, Landau, Verwey, and Overbeek theory. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3SDS of cas: 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.SDS of cas: 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Combining Organocatalysis with Central-to-Axial Chirality Conversion: Atroposelective Hantzsch-Type Synthesis of 4-Arylpyridines was written by Quinonero, Ophelie;Jean, Marion;Vanthuyne, Nicolas;Roussel, Christian;Bonne, Damien;Constantieux, Thierry;Bressy, Cyril;Bugaut, Xavier;Rodriguez, Jean. And the article was included in Angewandte Chemie, International Edition in 2016.Related Products of 85692-37-1 This article mentions the following:

Suitably substituted enantioenriched 4-aryl-1,4-dihydro-pyridines prepared by an organocatalytic enantioselective Michael addition were oxidized with MnO₂ into axially chiral 4-arylpyridines with central-to-axial chirality conversion. Moderate to complete percentages (cp) were observed, and a model for the conversion of chirality is discussed. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Related Products of 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Related Products of 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

FTIR metabolomic fingerprint reveals different modes of action exerted by active pharmaceutical ingredient based ionic liquids (API-ILs) on Salmonella typhimurium was written by Mester, P.;Jehle, A. K.;Leeb, C.;Kalb, R.;Grunert, T.;Rossmanith, P.. And the article was included in RSC Advances in 2016.Name: 1-ethyl-2,3-dimethylimidazolium chloride This article mentions the following:

Since their incorporation into various chem. and biochem. processes, ionic liquids (ILs) have now been found useful for biomedical applications, including active pharmaceutical ingredients (APIs) such as antimicrobial agents or antibiotics. Recently, synergistic API-ILs with great potential have been reported, which show either increased antimicrobial activity or the ability to overcome bacterial resistance. In this study a total of 19 API-ILs, based on the antibiotic nalidixic acid, combined with different cation species, were investigated for synergistic effects against the important foodborne pathogen Salmonella. Furthermore, 19 resp. ILs with chloride as the anion were used to control the effects of the different cation species. The antimicrobial activities of all 38 ILs against six different Salmonella species, as well as two nalidixic acid-resistant S. typhimurium strains, were determined via the microbroth dilution assay. The response pattern of the main cellular constituents, namely proteins, carbohydrates, and lipids of the bacterial cells to the most promising API-ILs was further investigated by Fourier transform IR (FTIR) spectroscopy. While a number of active API-ILs based on nalidixic acid could be synthesized, no evidence for synergistic effects, such as increased antimicrobial activity or the ability to overcome resistance was found with either microbiol. or spectroscopic methods. However, it could be demonstrated for the first time that while the different IL species ([TC₈MA]⁺ and [TMC₁₆A]⁺) showed similar antimicrobial activity, the FTIR spectral patterns indicated changes in bacterial membrane fluidity suggesting different modes of action. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Name: 1-ethyl-2,3-dimethylimidazolium chloride).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Name: 1-ethyl-2,3-dimethylimidazolium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Toughening Poly(lactic acid) with Imidazolium-based Elastomeric Ionomers was written by Chen, Lu;Hu, Kuan;Sun, Si-Ting;Jiang, Hai;Huang, Dong;Zhang, Kun-Yu;Pan, Li;Li, Yue-Sheng. And the article was included in Chinese Journal of Polymer Science in 2018.Related Products of 21252-69-7 This article mentions the following:

Imidazolium-based elastomeric ionomers (i-BIIR) were facilely synthesized by ionically modified brominated poly(isobutylene-co-isoprene) (BIIR) with different alkyl chain imidazole and thoroughly explored as novel toughening agents for poly(lactic acid) (PLA). The miscibility, thermal behavior, phase morphol. and mech. property of ionomers and blends were investigated through dynamic mech. analyses (DMA), differential scanning calorimetry (DSC), SEM, tensile and impact testing. DMA and SEM results showed that better compatibility between the PLA and i-BIIR was achieved compared to the PLA/unmodified BIIR elastomer. A remarkable improvement in ductility with an optimum elongation at break up to 235% was achieved for the PLA/i-BIIR blends with 1-dodecylimidazole alkyl chain (i-BIIR-12), more than 10 times higher than that of pure PLA. The impact strengths of PLA were enhanced from 1.9 kJ/m² to 4.1 kJ/m² for the PLA/10 wt% i-BIIR-12 blend. Toughening mechanism had been established by systematical anal. of the compatibility, intermol. interaction and phase structures of the blends. Interfacial cavitations initiated massive shear yielding of the PLA matrix owing to a suitable interfacial adhesion which played a key role in the enormous toughening effect in these blends. We believed that introducing imidazolium group into the BIIR elastomer was vital for the formation of a suitable interfacial adhesion. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Related Products of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and pharmacological activity of aroylmethyl derivatives of tricyclic benzimidazole systems containing hydroxy groups in aroyl radicals was written by Anisimova, V. A.;Tolpygin, I. E.;Spasov, A. A.;Kosolapov, V. A.;Stepanov, A. V.;Orlova, A. A.;Naumenko, L. V.. And the article was included in Pharmaceutical Chemistry Journal in 2007.Application of 24134-26-7 This article mentions the following:

The synthesis and pharmacol. properties of a series of hydroxybenzoylmethylimidazo- and pyrimidobenzimidazoles are described. Most of the products exhibit a high antioxidant activity, possess pronounced hemorheol. properties, and influence the blood glucose level. In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Application of 24134-26-7).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application of 24134-26-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Unraveling the antitrypanosomal mechanism of benznidazole and related 2-nitroimidazoles: From prodrug activation to DNA damage was written by Dattani, Ambika;Drammeh, Isatou;Mahmood, Aishah;Rahman, Mahbubur;Szular, Joanna;Wilkinson, Shane R.. And the article was included in Molecular Microbiology in 2021.Application In Synthesis of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid This article mentions the following:

Nitroheterocycles represent an important class of compound used to treat trypanosomiasis. They often function as prodrugs and can undergo type I nitroreductase (NTR1)-mediated activation before promoting their antiparasitic activities although the nature of these downstream effects has yet to be determined Here, we show that in an NTR1-dependent process, benznidazole promotes DNA damage in the nuclear genome of Trypanosoma brucei, providing the first direct link between activation of this prodrug and a downstream trypanocidal mechanism. Phenotypic and protein expression studies revealed that components of the trypanosome′s homologous recombination (HR) repair pathway (TbMRE11, γH2A, TbRAD51) cooperate to resolve the benznidazole-induced damage, indicating that the prodrug-induced lesions are most likely double stand DNA breaks, while the sequence/recruitment kinetics of these factors parallels that in other eukaryotes HR systems. When extended to other NTR1-activated 2-nitroimidazoles, some were shown to promote DNA damage. Intriguingly, the lesions induced by these required TbMRE11 and TbCSB activities to fix leading us to postulate that TbCSB may operate in systems other than the transcription-coupled nucleotide excision repair pathway. Understanding how existing trypanosomal drugs work will aid future drug design and help unlock novel reactions/pathways that could be exploited as targets for therapeutic intervention. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Application In Synthesis of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem