Tag: 100-200

The effect of an electron-withdrawing group in the imidazolium cation: the case of nitro-functionalized imidazolium salts as acidic catalysts for the acetylation of glycerol was written by Morais, Eduardo M.;Grillo, Igor B.;Stassen, Hubert K.;Seferin, Marcus;Scholten, Jackson D.. And the article was included in New Journal of Chemistry in 2018.Quality Control of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

The acetylation of glycerol was achieved with high conversion and selectivity towards triacetin at low temperatures and short reaction times by using acidic imidazolium salts as catalysts. Moreover, the addition of a nitro group to the imidazolium cation affords a much more competent catalyst, indicating a significant effect provided by the simple electronic change in the imidazolium cation. Theor. calculations revealed increased polarization of the acidic hydrogen bond on the nitrated salts, which may be related to their superior catalytic behavior when compared to the non-functionalized salts. Combining the preliminary exptl. and theor. results, it is possible to suppose that the catalytic activity of acidic imidazolium salts may be better comprehended by its Bronsted acidities, but other parameters such as hardness, electronegativity, electrophilicity and ion-pair binding energy were also evaluated in order to investigate their effects in the acetylation of glycerol promoted by these acidic imidazolium salts. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Quality Control of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Quality Control of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reductive cyclization of o-phenylenediamine with CO₂ and BH₃NH₃ to synthesize 1H-benzoimidazole derivatives was written by Li, Xiao;Zhang, Junhua;Yang, Yue;Hong, Hailong;Han, Limin;Zhu, Ning. And the article was included in Journal of Organometallic Chemistry in 2021.COA of Formula: C8H8N2 This article mentions the following:

A simple and green protocol was developed for the reductive cyclization of o-phenylenediamine with CO₂ and BH₃NH₃ to yield 1H-benzimidazole. The desired 1H-benzimidazole derivatives were produced under mild conditions. Mechanism investigation indicated that the coordination of o-phenylenediamine with the boron atom of BH₃NH₃ promoted the transfer of the formyl group to form a stable intermediate, which facilitated the intramol. nucleophilic addition-elimination for the formation of target product. In this process, BH₃NH₃ served multifunctional roles, acting as a reducing agent and a formylation catalyst. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6COA of Formula: C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effective Interface Defect Passivation via Employing 1-Methylbenzimidazole for Highly Efficient and Stable Perovskite Solar Cells was written by Zheng, Haiying;Liu, Guozhen;Wu, Weiwei;Xu, Huifen;Pan, Xu. And the article was included in ChemSusChem in 2021.Computed Properties of C8H8N2 This article mentions the following:

Although the power conversion efficiencies (PCEs) of perovskite solar cells (PSCs) have made great progress, the surface and interface defects still affect their PCE and stability and hinder the commercialization. To overcome this problem, 1-methylimidazole (1-MIm) and 1-methylbenzimidazole (1-MBIm) were used as the interfacial passivation agents to passivate the defects at surface and interface. The results indicated that, in contrast to 1-MIm, 1-MBIm displayed a stronger Lewis coordination interaction with the uncoordinated Pb²⁺ to reduce the non-radiative recombination and also effectively improved the charge transfer capacity of perovskite films due to its strong Π-Π conjugate interaction, resulting in the better photovoltaic performance. As a result, the PCE of the champion 1-MBIm PSC was improved from 19.48 (pristine) to 21.22 % with a dramatically enhanced open-circuit voltage (V_oc=1.15 V). More importantly, a significant improvement in long-term stability was achieved for 1-MBIm perovskite devices, which was attributed to the high-quality perovskite film caused by the strong passivation effect of 1-MBIm and the hydrogen bond with water mols. The results offers an efficient and facile strategy by interface engineering to fabricate high-performance and stable PSCs for com. application. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Computed Properties of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Experimental study on the pyrolysis of sewage sludge was written by Shen, Boxiong;Zhang, Zenghui;Chen, Jianhong;Hao, Xiaocui;Wen, Jie. And the article was included in Anquan Yu Huanjing Xuebao in 2011.Recommanded Product: 3034-41-1 This article mentions the following:

In this paper, the effect of final pyrolysis temperature on the yield of products from the pyrolysis of sewage sludge was studied. The light fraction from sludge pyrolysis oil was analyzed. The fundamental properties of the pyrolysis residues were also investigated briefly. The results showed that when the final pyrolysis temperature was between 450 °C to 500°C, the yield of liquid product was favorable. With the increase of final pyrolysis temperature, the decreasing trend of pyrolysis residue was similar to the increasing trend of liquid product. Both of them were steep when the temperature was under 450°C and mild when the temperature was higher than 450°C. Meanwhile the uncondensed gas increased smoothly with the increase of final pyrolysis temperature The light fractions of pyrolysis oil obtained at 450°C was mainly consisted of alkanes, alkenes, nitriles and nitrogen-containing heterocyclic compounds as well as MAHs etc. Among them, the concentration of toluene, 4-methyl-phenol, 1-methyl-2, 5-pyrrolidinedione, pyridine, 1-dodecene and pentadecane etc. were significant. The pyrolysis residues of sewage sludge contained low carbon and high ash. However, they still possessed some volatile content. With the increase of final pyrolysis temperature, the surface of pyrolysis residue became more and more looser and rougher. The residue obtained at 450°C exhibited highest pore volume Nevertheless, the residue obtained at 500°C owned maximum sp. surface area in respect that it possessed highest number of micropores. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Carbon Chain Rupture: Base-Induced Radical C-C Bond Cleavage of Alkylbenzimidazoles was written by Fu, Xuegang;Guo, Dongyang;Yan, Yuting;Marselo, Timotius;Zhang, Mingyu;Zhang, Zhenghan;Li, Siying;Huang, Jianhui. And the article was included in Synthesis in 2022.Recommanded Product: 1632-83-3 This article mentions the following:

A base-mediated aerobic oxidation of alkylbenzimidazoles for the preparation of carboxylic acids was described. A number of aliphatic carboxylic acids are prepared in good to excellent yields via a C-C bond rupture process. Preliminary mechanistic studies suggested the reaction undergoes a radical pathway initiated by strong bases such as potassium amide. This type of transformation provided an alternative strategy for the access of important carboxylic acid moieties. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives as inhibitors of cyclic nucleotide phosphodiesterases was written by Buchman, Russell;Heinstein, Peter F.;Wells, Jack N.. And the article was included in Journal of Medicinal Chemistry in 1974.Recommanded Product: 1H-Imidazole-4-carboxamide This article mentions the following:

Opening the pyrimidine ring of methylxanthines markedly decreased their inhibitory activity toward phosphodiesterases. Four series of imidazole analogs of theophylline were prepared consisting of 1-substituted imidazole-4- and -5-carboxamides, 1,4-disubstituted imidazole-5-carboxamides, and 1-substituted-4-aminoimidazoles. The most potent inhibitors in these series were 4-benzylamino- [53525-67-0]and 4-benzylideneamino-5-(N-methylcarbamoyl)imidazole (I) [53525-53-4]. Substitution of a benzyl group in position 7 of theophylline confirmed some specificity for inhibition of hydrolysis of cyclic GMP. Most of the compounds were prepared by standard methods. 4-Amino-5-(N-methylcarbamoyl)imidazole [53525-66-9] was prepared by reduction of Et α-cyano-α-oximinoacetate [3849-21-6] with Al amalgam, reaction with MeNH2 to form α-amino-α-cyano-N-methylacetamide [50531-01-6], and cyclization with formamidine acetate [3473-63-0]. 4-(N-methylacetamido)-5-(N-methylcarbamoyl)imidazole [53525-54-5] was prepared by ring opening of 7-benzyltheophylline [1807-85-8] with KOH, followed by debenzylation with H2-Pd/C and acetylation. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Recommanded Product: 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Novel Mn(II)-Based Metal-Organic Frameworks Isolated in Ionic Liquids was written by Xu, Ling;Kwon, Young-Uk;de Castro, Baltazar;Cunha-Silva, Luis. And the article was included in Crystal Growth & Design in 2013.HPLC of Formula: 79917-89-8 This article mentions the following:

An unprecedented series of Mn²⁺-based metal-organic framework (MOF) materials prepared and isolated in ionic liquids (ILs) is reported. Ionothermal reactions of Mn(OAc)₂ with H₃btc (benzene-1,3,5-tricarboxylic acid) in two groups of [rmi]X (rmi = 1-alkyl-3-methylimidazolium; r = Et or Pr, X = Cl, Br, or I) ILs produced three slightly different 3D MOFs formulated as [rmi][Mn(btc)] [r = Et (1), Pr (2), and (3)], whose architectures can be envisaged as (3,6)-connected pyr topol. nets. Compounds 1–3 are the preferred products when the metal center is half filled d-shelled Mn with the cations of ILs being [emi]⁺ or [pmi]⁺. The comparison of the ionothermal synthesized M-btc systems suggests a significant combinatorial influence of metal-direction and ILs’ cationic template, contrasting with subtle effect of ILs’ halides on the MOF structures. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8HPLC of Formula: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kinetic analysis of the complete mechanochemical synthesis of a palladium(II) carbene complex was written by Allenbaugh, Rachel J.;Zachary, Jonathon R.;Underwood, A. Nicole;Bryson, J. Dillion;Williams, Joseph R.;Shaw, Angela. And the article was included in Inorganic Chemistry Communications in 2020.Recommanded Product: 1632-83-3 This article mentions the following:

Benzimidazoline-2-ylidene complexes of palladium(II) were synthesized mechanochem. in a vibratory ball mill. Complete syntheses began with preparation of benzimidiazolium halides from com. available starting materials. These “greener chem.” syntheses proceed in high yield and require minimal purification using environmentally benign solvents. Kinetic anal. shows that liquid assisted grinding impedes the production to benzimidazolium halides while enhancing the production of the palladium-carbene complex. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A Fairy Chemical, Imidazole-4-carboxamide, is Produced on a Novel Purine Metabolic Pathway in Rice was written by Takemura, Hirohide;Choi, Jae-Hoon;Matsuzaki, Nobuo;Taniguchi, Yuki;Wu, Jing;Hirai, Hirofumi;Motohashi, Reiko;Asakawa, Tomohiro;Ikeuchi, Kazutada;Inai, Makoto;Kan, Toshiyuki;Kawagishi, Hirokazu. And the article was included in Scientific Reports in 2019.Recommanded Product: 1H-Imidazole-4-carboxamide This article mentions the following:

Rings or arcs of fungus-regulated plant growth occurring on the floor of woodlands and grasslands are commonly called “fairy rings”. Fairy chems., 2-azahypoxanthine (AHX), imidazole-4-carboxamide (ICA), and 2-aza-8-oxohypoxanthine (AOH), are plant growth regulators involved in the phenomenon. The endogeny and biosynthetic pathways of AHX and AOH in plants have already been proven, however, those of ICA have remained unclear. We developed a high-sensitivity detection method for FCs including ICA and the endogenous ICA was detected in some plants for the first time. The quant. anal. of the endogenous level of ICA in rice and Arabidopsis were performed using ¹³C-double labeled ICA. In addition, the incorporation experiment and enzyme assay using the labeled compound into rice and partially purified fraction of rice indicated that ICA is biosynthesized from 5-aminoimidazole-4-carboxamide (AICA), a metabolite on the purine metabolic pathway. The relationship between ICA and AHX was also discussed based on quant. anal. and gene expression anal. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Recommanded Product: 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Highly efficient one pot synthesis of benzimidazoles from 2-nitroaniline and PhSiH₃ as reducing agent catalyzed by Pd/C as a heterogeneous catalyst was written by Phatake, Vishal V.;Bhanage, Bhalchandra M.. And the article was included in Tetrahedron Letters in 2021.Electric Literature of C8H8N2 This article mentions the following:

This work reported an efficient route for the synthesis of benzimidazole from o-nitroaniline in the presence of carbon dioxide atm., PhSiH₃ as a reducing agent catalyzed by Pd/C as a catalyst. The more efficient route for the synthesis benzimidazole was developed and various substituted benzimidazoles were synthesized in good to excellent yield. The TBD (1,5,7-Triazabicyclo [4.4.0] dec-5-ene) was selected as a base as it promoted the CO₂ insertion. Benzimidazoles were synthesized through reduction of nitro group followed by cyclization of amine using CO₂ as a carbon source. Moreover, the Pd/C catalyst was recycled upto five recycle run without significant changes in the yield of the product. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem