Tag: 100-200

Determination of quinclorac by adsorptive stripping voltammetry in rice samples without sample pretreatment was written by Liberato, Priscila A.;Okumura, Leonardo L.;Silva, Astrea F. S.;Gurgel, Alexandre;Aleixo, Herbert;Silva, Junio G.;de Oliveira, Andre Fernando. And the article was included in Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes in 2021.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

A novel voltammetric method with practically no sample pretreatment was developed for determination of Quinclorac (QNC) in rice samples by using a working Carbon Paste Electrode (CPE) modified with ionic liquid, with deposition potential (ED) of -1.43 V for 30 s in NaOH 0.01 mol L-1. The systematic influence of cations and anions of imidazole ionic liquids on the composition of CPE has evaluated. The best electrode composition was 65% (weight/weight) of graphite powder, 30% (weight/weight) of mineral oil and 5.0% (weight/weight) of C4min+BF4- ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate). The matrixes analyzed were deionized water and extracts of upland rice: white, brown, peel and seed. The limits of quantification ranged between 0.954 mg kg-1 and 3.61 mg kg-1. The recovery percentages of QNC in rice samples ranged between 90% and 121%. The simplicity and good anal. frequency enable the proposed method to be used to obtain preliminary information on the presence of QNC, prior to the implementation of more detailed, costly and elaborate quant. analyses. The technique can be applied in the study and evaluation of sorption mechanisms, metabolization of the herbicide in plants and its persistence and degradation in the environment. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enantioselective Conjugate Addition of 2-Acetyl Azaarenes to β,β-Disubstituted Nitroalkene for the Construction of All-Carbon Quaternary Stereocenters was written by Ma, Hongli;Xie, Lei;Zhang, Zhenhua;Wu, Lin-gang;Fu, Bin;Qin, Zhaohai. And the article was included in Journal of Organic Chemistry in 2017.Safety of 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:

The first highly enantioselective conjugate addition of 2-acetyl azaarenes to α-substituted-β-nitroacrylates was successfully realized under mild conditions by a Ni(II)-bisoxazoline complex, providing the desired adducts bearing an all-carbon quaternary stereocenter in high yield with excellent enantioselectivity. The products obtained in this system could be readily converted into optically active β^2,2-amino esters, succinates, lactones, and lactams. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Safety of 1-(1-Methyl-1H-imidazol-2-yl)ethanone).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Safety of 1-(1-Methyl-1H-imidazol-2-yl)ethanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On the Mesophase Formation of 1,3-Dialkylimidazolium Ionic Liquids was written by Yang, Mei;Mallick, Bert;Mudring, Anja-Verena. And the article was included in Crystal Growth & Design in 2013.Reference of 21252-69-7 This article mentions the following:

A series of seven different 1,3-dialkylimidazolium-based ion-pair salts with the same mol. weight and size but different symmetries was synthesized. For all salts, bromide was chosen as the counterion, giving the series ([CnIMCm][Br]), where IM = imidazolium and Cn and Cm are varying N-alkyl substituents with n + m = 13. Thus, the effect of symmetry on the physicochem. properties, such as thermal transitions, densities and viscosities and particularly mesophase formation, is investigated herein. All salts are fully characterized by NMR spectroscopy and mass spectrometry, and their physicochem. properties such as thermal transitions, densities, and viscosities are reported. Single crystal X-ray structure anal. is reported for 1-tridecylimidazolium bromide ([C0IMC13][Br]) and 1-ethyl-3-undecylimidazolium bromide ([C2IMC11][Br]). Salts 1-tridecylimidazolium bromide ([C0IMC13][Br]) and 1-dodecyl-3-methylimidazolium bromide ([C1IMC12][Br]) exhibit thermotropic liquid crystal behavior, confirmed by differential scanning calorimetry, polarized optical microscopy, and small-angle X-ray diffraction to be the SmA mesophase. A structure with interdigitation of alkyl chains is observed for all of [C0IMC13][Br], [C1IMC12][Br], and [C2IMC11][Br], despite the absence of thermotropic liquid crystalline behavior for the latter (and all other isomers with an alkyl chain length less than 12 carbon atoms). This allows us to draw the conclusion that for the liquid crystal phase of an ionic liquid to exist, not only are the calamitic shape and integral length of a mol. important but a minimal alkyl chain length of n = 12 is also required. Therefore, a dodecyl group could be considered as the functional group responsible for liquid crystalline behavior. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

S-Adenosylhomocysteine Analogue of a Fairy Chemical, Imidazole-4-carboxamide, as its Metabolite in Rice and Yeast and Synthetic Investigations of Related Compounds was written by Ouchi, Hitoshi;Namiki, Takuya;Iwamoto, Kenji;Matsuzaki, Nobuo;Inai, Makoto;Kotajima, Mihaya;Wu, Jing;Choi, Jae-Hoon;Kimura, Yoko;Hirai, Hirofumi;Xie, Xiaonan;Kawagishi, Hirokazu;Kan, Toshiyuki. And the article was included in Journal of Natural Products in 2021.Application In Synthesis of 1H-Imidazole-4-carboxamide This article mentions the following:

During the course of our investigations of fairy chems. (FCs), we found S-ICAr-H I, as a metabolite of imidazole-4-carboxamide (ICA) in rice and yeast (Saccharomyces cerevisiae). In order to determine its absolute configuration, an efficient synthetic method of I was developed. This synthetic strategy was applicable to the preparation of analogs of I. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Application In Synthesis of 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New Schiff bases derived from benzimidazole as efficient mercury-complexing agents in aqueous medium was written by Boulebd, Houssem;Lahneche, Yousra Doria;Khodja, Imene Amine;Benslimane, Meriem;Belfaitah, Ali. And the article was included in Journal of Molecular Structure in 2019.Product Details of 3012-80-4 This article mentions the following:

In this paper, we describe a very fast and efficient synthesis of series of new Schiff bases L1-L5 derived from benzimidazole. It was found that, these compounds react efficiently with mercury ions to afford the corresponding complexes COP1-COP5 in nearly quant. yield. This reaction takes place in water and in most of the usual solvents. The study of the complexation reaction of L1 with other metal ions has been carried out and shown that L1 can efficiently coordinate with Cu²⁺ and Co²⁺. In addition, the reactivity of the benzimidazole Schiff bases has been compared with some reported pyridine analogs and checked with DFT calculations It has been found that both exptl. results and theor. calculations confirm that the benzimidazole Schiff bases are clearly more reactive than their pyridine analogs. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Product Details of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Product Details of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships was written by Deaton, David N.;Haffner, Curt D.;Henke, Brad R.;Jeune, Michael R.;Shearer, Barry G.;Stewart, Eugene L.;Stuart, J. Darren;Ulrich, John C.. And the article was included in Bioorganic & Medicinal Chemistry in 2018.SDS of cas: 22600-77-7 This article mentions the following:

Starting from 4-amino-8-quinoline carboxamide lead 1a and scaffold hopping to the chem. more tractable quinazoline, a systematic exploration of the 2-substituents of the quinazoline ring, utilizing structure activity relationships and conformational constraint, resulted in the identification of 39 novel CD38 inhibitors. Eight of these analogs were 10-100-fold more potent human CD38 inhibitors, including the single digit nanomolar inhibitor 1am (2-(3′-Amino-1’H-spiro[cyclopropane-1,6′-pyrrolo[3,4-c]pyrazol]-5(4H)-yl)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide). Several of these mols. also exhibited improved therapeutic indexes relative to hERG activity. A representative analog 1r ((R)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)-2-(6-methylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)quinazoline-8-carboxamide) exhibited suitable pharmacokinetic parameters for in vivo animal studies, including moderate clearance and good oral bioavailability. These inhibitor compounds will aid in the exploration of the enzymic functions of CD38, as well as furthering the study of the therapeutic implications of NAD enhancement in metabolic disease models. In the experiment, the researchers used many compounds, for example, (1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7SDS of cas: 22600-77-7).

(1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).SDS of cas: 22600-77-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis, characterization and anticancer activity of palladium allyl complexes bearing benzimidazole-based N-heterocyclic carbene (NHC) ligands was written by Scattolin, Thomas;Piccin, Andrea;Mauceri, Matteo;Rizzolio, Flavio;Demitri, Nicola;Canzonieri, Vincenzo;Visentin, Fabiano. And the article was included in Polyhedron in 2021.Name: 1-Methylbenzimidazole This article mentions the following:

The synthesis of twelve new palladium allyl complexes bearing benzimidazole-based NHC (5, NHC = N-heterocyclic carbene) ligands, [(R-MeBzIm)Pd(η³-CH₂CH:CH₂)(L)][ClO₄] (MeBzIm = 1-methylbenzimidazole, R = 3-Me, 3-Ph, 3-ⁱPr, 3-CH₂Py; L = PPh₃, PTA) and [(R¹-BzImCH₂BzIm-R¹)Pd(η³-CH₂CH:CH₂)][ClO₄] [BzImCH₂BzIm = 1,1′-methylenebis(benzimidazole), R¹ = 3-Me, 3-(1-adamantyl)], is reported. All the complexes were characterized by NMR and elemental anal. and, in the case of complex 5c (R = 3-Ph), it was possible to confirm the connectivity by single crystal X-ray diffraction. The cationic palladium allyl complexes were tested toward 5 different cancer lines, with IC₅₀ values generally lower than cisplatin and similar antiproliferative activity in the two ovarian cancer cell lines (A2780 and A2780cis), suggesting a different mechanism of action from classical platinum-based anticancer drugs. Compounds equipped with a pyridine arm or with the NHC/PTA combination (PTA = 1,3,5-triaza-7-phosphaadamantane) showed a lower cytotoxicity on normal cells with respect to cancer ones. By comparing the IC₅₀ values of mixed NHC/PTA complexes reported in this work and their trifluoromethyl congeners recently published by our group, it appears evident that they have very similar antiproliferative activity against cancer cells but the absence of the CF₃ group significantly decreases the selectivity toward them. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Name: 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Name: 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cutaneous irritation in the topical application of 30 antineoplastic agents to New Zealand white rabbits was written by Murphy, James C.;Watson, E. S.;Wirth, P. W.;Skierkowski, Paul;Folk, R. M.;Peck, Gary. And the article was included in Toxicology in 1979.Name: 1H-Imidazole-4-carboxamide This article mentions the following:

Of 30 antineoplastic agents studied for their primary irritation potential in rabbits, 9 showed some potential for irritation. Five of these 9 agents produced a significant dermal irritation. None of the irritation observed was considered to be irreversible skin damage. The study further showed a strong correlation between irritation observed by the Draize method and acute inflammation evaluated histopathol. There was a tendency toward increased epidermal thickness of irritated skin sites. None of the agents produced gross or microscopically visible lesions in the internal organs observed In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Name: 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Name: 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Asymmetric synthesis of cyclic β-amino carbonyl derivatives by a formal [3+2] photocycloaddition was written by Mollari, Leonardo;Valle-Amores, Miguel A.;Martinez-Gualda, Ana M.;Marzo, Leyre;Fraile, Alberto;Aleman, Jose. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Formula: C6H8N2O This article mentions the following:

A visible-light mediated strategy unlocking a family of cyclic β-amino carbonyl derivatives I (R = Me, cyclohexyl, 4-bromophenyl, etc.; R¹ = Ph, naphthalen-2-yl, 4-chlorophenyl, etc.; R² = H, Ts) bearing three contiguous stereogenic centers was introduced. The overall reactivity relies on the performance of the substrate-catalyst complex to assist both the enantiocontrol and the photoredox tasks. This transformation led to an enantioselective [3+2] photocycloaddition between coordinated α,β-unsaturated acyl imidazoles II and cyclopropylamine derivatives III. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of imidazo[1,2-a]benzimidazole and imidazolino-[1,2-a]benzimidazole derivatives was written by Simonov, A. M.;Kochergin, P. M.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1965.Application In Synthesis of 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole This article mentions the following:

Reaction of 1-alkyl-2-aminobenzimidazoles with α-halo ketones and α-halo alcs. gave the corresponding 1,3-disubstituted 2-iminobenzimidazolines, which under the action of dehydrating agents or by heating with mineral or organic acids lost H₂O and gave derivatives of [1,2-a]benzimidazole (I) or the corresponding 2,3-dihydro compounds Thus were obtained: 1-ethyl-3-phenacyl-2-iminobenzimidazoline, m. 120.5° (aqueous MeOH) [hydrobromide m. 2222.5° (decomposition, MeOH)]; 2-phenyl-9-ethylimidazo[1,2-a]benzimidazole, m. 93-3.5° (aqueous EtOH) [picrate m. 238-40° (decomposition, EtOH)]; 1-ethyl-3-(β-hydroxyethyl)-2-iminobenzimidazoline, m. 122.5-23° (C₂H₄Cl₂) [hydrobromide m. 226.5-27° (decomposition, EtOH); picrate m. 182-3° (H₂O)]; and 9-ethylimidazolino[1,2-a]benzimidazole [picrate m. 267-8° (decomposition, AcOH)]. In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Application In Synthesis of 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem