Tag: 100-200

How does methylation suppress the electron-induced decomposition of 1-methyl-nitroimidazoles? was written by Kossoski, F.;Varella, M. T. do N.. And the article was included in Journal of Chemical Physics in 2017.Safety of 1-Methyl-4-nitroimidazole This article mentions the following:

The efficient decomposition of nitroimidazoles (NIs) by low energy electrons is believed to underlie their radiosensitizing properties. Recent dissociative electron attachment (DEA) measurements showed that methylation at the N1 site unexpectedly suppresses the electron-induced reactions in 4(5)-NI. We report theor. results that provide a clear interpretation of that astounding finding. Around 1.5 eV, DEA reactions into several fragments are initiated by a 蟺^* resonance, not considered in previous studies. The autoionization lifetime of this anion state, which limits the predissociation dynamics, is considerably shorter in the methylated species, thereby suppressing the DEA signals. On the other hand, the lifetime of the 蟺^* resonance located around 3 eV is less affected by methylation, which explains why DEA is still observed at these energies. Our results demonstrate how even a simple methylation can significantly modify the probabilities for DEA reactions, which may be significant for NI-based cancer therapy. (c) 2017 American Institute of Physics. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Safety of 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Safety of 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Crystal structure of the triclinic modification of 1-methyl-4-nitroimidzole, C₄H₅N₃O₂ was written by Wang, Jianlong;Lian, Pengbao;Chen, Lizhen. And the article was included in Zeitschrift fuer Kristallographie – New Crystal Structures in 2017.Reference of 3034-41-1 This article mentions the following:

C₄H₅N₃O₂, triclinic, P1 (number 1), a = 3.8976(6) 脜, b = 5.7235(8) 脜, c = 6.2670(10) 脜, 伪 = 89.630(12)掳, 尾 = 84.800(13)掳, 纬 = 76.970(13)掳, V = 135.63(4) 脜³, Z = 1, R _gt(F) = 0.0519, wR _ref(F ²) = 0.1303, T = 104.8 K. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Reference of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Copper(II)-catalyzed dehydrogenative cross-coupling between two azoles was written by Qin, Xurong;Feng, Boya;Dong, Jiaxing;Li, Xiaoyu;Xue, Ying;Lan, Jingbo;You, Jingsong. And the article was included in Journal of Organic Chemistry in 2012.Computed Properties of C4H5N3O2 This article mentions the following:

The copper(II)-catalyzed dehydrogenative coupling between two different azoles for the preparation of unsym. biazoles e. g., I has been developed. The current catalytic system can effectively control the chemoselectivity for heterocoupling over homocoupling. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Computed Properties of C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Computed Properties of C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Unusual temperature-promoted carbon dioxide capture in deep-eutectic solvents: the synergistic interactions was written by Shukla, Shashi Kant;Mikkola, Jyri-Pekka. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Formula: C4H7ClN2 This article mentions the following:

A series of novel ethylenediamine (EDA)-based deep-eutectic solvents (DESs) gave rise to unexpectedly large carbon dioxide (CO₂) capture capacities at higher temperatures owing to the “synergistic interaction” between the donor and acceptor moieties. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Formula: C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Substituent Effect of Imidazolium Ionic Liquid: A Potential Strategy for High Coulombic Efficiency Al Battery was written by Yang, Congrong;Wang, Suli;Zhang, Xiaoming;Zhang, Qiang;Ma, Wenjia;Yu, Shansheng;Sun, Gongquan. And the article was included in Journal of Physical Chemistry C in 2019.Name: 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

The chem. structure-effect relationship between imidazolium ion liquid and the properties of electrolyte or Al battery is first completely revealed. First, it is proved that there indeed exsits an interaction between imidazolium cation and chloroaluminate anions (active ions, Al₂Cl₇^– and AlCl₄^–), blocking their reaction in the anode or pos. electrode. Second, by introducing the substituent effect, which could enhance the steric hindrance and change the detailed electronic distribution of imidazolium cations, the intermol. force between imidazolium cations and chloroaluminate anions is effectively weakened. As a result, the electrodeposition achievement, electrodeposition/electrostripping reversibility of aluminum, and intercalation/deintercalation capacity of AlCl₄^– in the pos. electrode are significantly improved. Therefore, the as-assembled battery with AlCl₃/[MPIM]Cl electrolyte shows an 鈭?00% CE. This work provides a potential approach on how to enhance the performance of Al battery by designing the ionic liquid structure. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Name: 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazolium-Catalyzed Formation of Bisphenol A Polycarbonate with a Reduced Level of Branching was written by Tay, Boonying;van Meurs, Martin;Tan, Jozel;Ye, Suming;Borgna, Armando;van Herk, Alexander M.;Selvaratnam, Selvasothi;Wang, Cun;Taniguchi, Shohei;Suzuki, Yousuke;Utsunomiya, Masaru;Ito, Mitsunobu;Monden, Toshiki;Shibata, Hiroki;Tomita, Shohei. And the article was included in Industrial & Engineering Chemistry Research in 2021.Electric Literature of C7H13ClN2 This article mentions the following:

The melt-phase polymerization of bisphenol A (BPA) and di-Ph carbonate (DPC) catalyzed by alk. metal catalysts produces polycarbonates with high branching, which impairs the product’s properties during weather resistance, ductility, and rheol. The use of an imidazolium-type catalyst can result in a reduced amount of branching relative to the benchmark Cs₂CO₃ catalyst. Modification of the imidazolium structure, especially by introducing a substitution at the C2 position, definitely improves the catalyst performance in enhancing the catalyst stability and reducing the branching level in the polycarbonate product. For the best catalyst identified (1,3-Ad₂-2-Ph-Im-BPA), we have shown that at a DPC/BPA ratio of 1.075 and a catalyst loading of 7 ppm, the specifications can be met at the laboratory scale: polymerization time = 125 min, M_n = 11.0 K, OH = 660 ppm, branching = 460 ppm (鈭?5% reduction relative to the Cs₂CO₃ benchmark), and yellowness index = 6.3. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Electric Literature of C7H13ClN2).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Derivatives as Accelerators for Ruthenium-Catalyzed Hydroesterification and Hydrocarbamoylation of Alkenes: Extensive Ligand Screening and Mechanistic Study was written by Konishi, Hideyuki;Muto, Takashi;Ueda, Tsuyoshi;Yamada, Yayoi;Yamaguchi, Miyuki;Manabe, Kei. And the article was included in ChemCatChem in 2015.Related Products of 85692-37-1 This article mentions the following:

Imidazole derivatives are effective ligands for promoting the [Ru₃(CO)₁₂]-catalyzed hydroesterification of alkenes using formates. Extensive ligand screening was performed to identify 2-hydroxymethylated imidazole as the optimal ligand. Neither carbon monoxide gas nor a directing group was required, and the reaction also showed a wide substrate generality. The Ru-imidazole catalyst system also promoted intramol. hydrocarbamoylation to afford lactams. A Ru-imidazole complex was unambiguously analyzed by x-ray crystallog., and it had a trinuclear structure derived from one [Ru₃(CO)₁₂] and two ligands. This complex was also successfully used for hydroesterification. The mechanism was examined in detail by using D- and ¹³C-labeled formates, indicating that the hydroesterification reaction proceeds by a decarbonylation-recarbonylation pathway. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Related Products of 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Related Products of 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and biological evaluation of new benzimidazole-thiazolidinedione hybrids as potential cytotoxic and apoptosis inducing agents was written by Sharma, Pankaj;Srinivasa Reddy, T.;Thummuri, Dinesh;Senwar, Kishna Ram;Praveen Kumar, Niggula;Naidu, V. G. M.;Bhargava, Suresh K.;Shankaraiah, Nagula. And the article was included in European Journal of Medicinal Chemistry in 2016.HPLC of Formula: 3012-80-4 This article mentions the following:

A series of new benzimidazole-thiazolidinedione hybrids was synthesized and evaluated for their cytotoxic potential against a selected human cancer cell lines of prostate (PC-3 and DU-145), breast (MDA-MB-231), lung (A549) and a normal breast epithelial cells (MCF10A). Among the tested compounds, I exhibited promising cytotoxicity with IC₅₀ value of 11.46 卤 1.46 渭M on A549 lung cancer cell line and did not show significant toxicity on normal MCF10A cells. Lung cancer cells (A549) was used to know the mechanism of cell growth inhibition and apoptosis inducing effect with compound I. The treatment of A549 cells with I showed typical apoptotic morphol. like cell shrinkage, chromatin condensation and horseshoe shaped nuclei formation. Flow-cytometry anal. revealed the G2/M phase of cell cycle arrest in a dose dependent manner. Preliminary mechanistic studies suggested that the cell migration was inhibited through the disruption of F-actin protein. Acridine orange-ethidium bromide (AO-EB), DAPI, annexin V-FITC/propidium iodide, rhodamine-123 and MitoSOX assays suggested the induction of apoptosis in A549 cells by compound I. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4HPLC of Formula: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.HPLC of Formula: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis, DNA binding, cytotoxic properties, and structure-activity relationship of a series of head to tail, and tail to tail linked imidazole- and pyrrole-containing analogs of distamycin with N-terminal benzoic acid mustard groups was written by Lee, Moses;Garbiras, Bonnie J.;Young, Chad;Blair, Brian;Wyatt, Michael D.;Hartley, John A.. And the article was included in Medicinal Chemistry Research in 1994.Safety of 1-Methyl-4-nitroimidazole This article mentions the following:

The synthesis and biol. evaluation of the titled compounds are described. Results from an ethidium displacement assay showed that all of these compounds bound strongly to the DNAs studied, and they generally interacted equally well or slightly more strongly to poly(dA-dT) than to poly(dG-dC). Introduction of an aliphatic linker in the head to tail (N to C) compounds significantly decreased their cytotoxicities compared to the oligoimidazole analogs. In the tail to tail (C to C) series of compounds the 1:1 dimeric compounds showed significant improvement in cytotoxicities over their monomeric counterparts, presumably due to their increased ability to produce interstrand crosslinks in the minor groove. The 2:2 dimeric compounds were only slightly more cytotoxic than their monomeric congeners even though their crosslinking abilities were enhanced. This may be due to their poor solubilities in water. There were no significant differences in the cytotoxicities between the tail to tail linked pyrrole- and imidazole-containing compounds In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Safety of 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Safety of 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Heterogeneous polarity and surface acidity of silica-organic materials with fixed 1-n-propyl-3-methylimidazolium chloride as probed by solvatochromic and fluorescent dyes was written by Khristenko, I. V.;Panteleimonov, A. V.;Iliashenko, R. Yu.;Doroshenko, A. O.;Ivanov, V. V.;Tkachenko, O. S.;Benvenutti, E. V.;Kholin, Yu. V.. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2018.Recommanded Product: 79917-89-8 This article mentions the following:

A new silica-organic hybrid material with fixed ionic liquid 1-n-propyl-3-methylimidazolium chloride has been synthesized by the sol-gel method. Its sp. surface area is 22 m² g^-1, average pore diameter is 8 nm and pore volume is 0.05 cm³ g^-1. According to the results of ¹³C NMR spectroscopy, the fixed 1-n-propyl-3-methylimidazolium cationic group is bound with the siloxane framework via one Si-C covalent bond. Properties of the new material were compared with that of its analog, silica with the same modifier covalently grafted at the surface. With the use of the ²⁹Si NMR spectroscopy it was clearly indicated that at the surfaces of both materials silanol groups dominate among all silicon containing groups. The surface polarity was characterized by probing the materials with the solvatochromic Reichardt’s dyes, and the heterogeneous polarity of the near-surface layers has been detected. The values of the normalized Dimroth-Reichardt parameter for three surface regions of different polarities are 0.9-1.0, 0.65 and 0.4. The presence of rather acidic surface silanol groups revealed from probing these materials with solvatochromic dyes was verified with the application of acid-base fluorescent dyes of 2,5-diaryl-1,3-oxazole series having pK_a 4.5-4.8 in ethanol/water medium. The fluorescence spectroscopy experiments have proved unambiguously that surface silanol groups predetermine the possibility of coexistence of the conjugated Bronsted basic and acidic forms of the oxazolic dyes in the near-surface layers. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Recommanded Product: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem