Tag: 100-200

Asymmetric Michael Addition of 2-Acetyl Azaarenes to β-CF₃-β-(3-indolyl)nitroalkenes Catalyzed by a Cobalt(II)/(imidazoline-oxazoline) Complex was written by Wang, Cong;Li, Nan;Zhu, Wen-Jing;Gong, Jun-Fang;Song, Mao-Ping. And the article was included in Journal of Organic Chemistry in 2019.Computed Properties of C6H8N2O This article mentions the following:

The first enantioselective Michael addition of 2-acetyl azaarenes to β-CF₃-β-(3-indolyl)nitroalkenes has been successfully achieved in the presence of a Co(II)/(imidazoline-oxazoline) complex as the catalyst. The reaction affords a series of CF₃– and 3-indole-containing adducts featuring a trifluoromethylated all-carbon quaternary stereocenter in good to excellent yields (up to 99%) and enantioselectivities (up to 96% ee). Furthermore, the functional groups in the adducts including C=O, NO₂, and the azaarene provide a large variety of useful transformations, leading to the formation of valuable intermediates such as optically active secondary alc., pyrroline, ester, and pyrrolidinone which all contain a 3-substituted indole and a trifluoromethylated all-carbon quaternary stereocenter. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Computed Properties of C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Computed Properties of C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale was written by McCoy, Michael A.;Spicer, Dominique;Wells, Neil;Hoogewijs, Kurt;Fiedler, Marc;Baud, Matthias G. J.. And the article was included in Journal of Medicinal Chemistry in 2022.Synthetic Route of C9H9N3 This article mentions the following:

The canonical Wingless-related integration site signaling pathway plays a critical role in human physiol., and its dysregulation can lead to an array of diseases. β-Catenin is a multifunctional protein within this pathway and an attractive yet challenging therapeutic target, most notably in oncol. This has stimulated the search for potent small-mol. inhibitors binding directly to the β-catenin surface to inhibit its protein-protein interactions and downstream signaling. Here, we provide an account of the claimed (and some putative) small-mol. ligands of β-catenin from the literature. Through in silico anal., we show that most of these mols. contain promiscuous chem. substructures notorious for interfering with screening assays. Finally, and in line with this anal., we demonstrate using orthogonal biophys. techniques that none of the examined small mols. bind at the surface of β-catenin. While shedding doubts on their reported mode of action, this study also reaffirms β-catenin as a prominent target in drug discovery. In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Synthetic Route of C9H9N3).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C9H9N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The ultrasound-assisted synthesis of some novel fused-ring heterocyclic systems bearing structurally diverse benzazoles via a copper-catalyzed cross-coupling reaction was written by Karimi, Nafiseh;Mahboubi-Rabbani, Mohammad;Dastjerdi, Hossein Fasihi;Nematpour, Manijeh;Rezaee, Elham;Tabatabai, Sayyed Abbas. And the article was included in Monatshefte fuer Chemie in 2022.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:

A novel ultrasonic-assisted process involving CuI-catalyzed intra-mol. C-H activation of benzazoles were developed. This methodol. offered affordable starting materials, mild reaction conditions, easy handling of the catalyst, a simple work-up process and short reaction times. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

High-throughput photocapture approach for reaction discovery was written by Bayly, Alison A.;McDonald, Benjamin R.;Mrksich, Milan;Scheidt, Karl A.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2020.Electric Literature of C8H8N2 This article mentions the following:

Modern organic reaction discovery and development relies on the rapid assessment of large arrays of hypothesis-driven experiments The time-intensive nature of reaction anal. presents the greatest practical barrier for the execution of this iterative process that underpins the development of new bioactive agents. Toward addressing this critical bottleneck, the authors report herein a high-throughput anal. (HTA) method of reaction mixtures by photocapture on a 384-spot diazirine-terminated self-assembled monolayer, and self-assembled monolayers for matrix-assisted laser desorption/ionization mass spectrometry (SAMDI-MS) anal. This anal. platform has been applied to the identification of a single-electron-promoted reductive coupling of acyl azolium species. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Regio- and Enantioselective Allylic Amination of Aliphatic MBH Adducts with N-Heteroaromatics was written by Wang, Haixia;Yu, Lulu;Xie, Mingsheng;Wu, Jiang;Qu, Guirong;Ding, Kuiling;Guo, Haiming. And the article was included in Chemistry – A European Journal in 2018.Quality Control of 7-Methyl-1H-benzo[d]imidazole This article mentions the following:

Palladium-catalyzed regio- and enantioselective allylic amination of aliphatic Morita-Baylis-Hillman (MBH) adducts with N-heteroaromatic nucleophiles (e.g., benzimidazole, 4,5-diphenylimidazole, benzotriazole, and purines) was achieved by using a spiroketal-based diphosphine (SKP) ligand, and afforded a range of chiral, branched N-allyl products with high selectivity. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Quality Control of 7-Methyl-1H-benzo[d]imidazole).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of 7-Methyl-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic Liquids Can Significantly Improve Textile Dyeing: An Innovative Application Assuring Economic and Environmental Benefits was written by Bianchini, Roberto;Cevasco, Giorgio;Chiappe, Cinzia;Pomelli, Christian Silvio;Rodriguez Douton, Maria Jesus. And the article was included in ACS Sustainable Chemistry & Engineering in 2015.Safety of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

Owing to economic reasons, the textile dyeing industry generally employs traditional and absolutely no-eco-friendly processes: very large quantities of water are indeed required together with a large number of added chems. which represent dramatic environmental issues. In order to improve the sustainability of the process, we have investigated the dyeing of wool, polyester, and cotton with disperse Red 13 using ionic liquids as the sole additive. The results obtained in isothermal dyeing at 95 °C show an outstanding effect of the ionic liquid 1-(2-hydroxyethyl)-3-methylimidazolium chloride. This ionic liquid assures efficient dyeing of polyester and wool in open vessels, in the absence of whichever auxiliary agent with total dyebath exhaustion, thus allowing in principle the recycling of the dye bath. The environmental benefits arising from the substitution of a number of usually employed auxiliary agents with only an ionic liquid are highlighted together with the economic ones. This article reports for the first time, to the best of our knowledge, dyeing processes for several kinds of fibers (cotton, wool, and polyester) employing exclusively three components: pure disperse dye, water, and an appropriate ionic liquid In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Safety of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Safety of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors was written by Hao, Chenzhou;Zhao, Fan;Song, Hongyan;Guo, Jing;Li, Xiaodong;Jiang, Xiaolin;Huan, Ran;Song, Shuai;Zhang, Qiaoling;Wang, Ruifeng;Wang, Kai;Pang, Yu;Liu, Tongchao;Lu, Tianqi;Huang, Wanxu;Wang, Jian;Lin, Bin;He, Zhonggui;Li, Haitao;Li, Feng;Zhao, Dongmei;Cheng, Maosheng. And the article was included in Journal of Medicinal Chemistry in 2018.HPLC of Formula: 3034-41-1 This article mentions the following:

Herein, we report the discovery and characterization of a novel class of PAK4 inhibitors with a quinazoline scaffold. Based on the shape and chem. composition of the ATP-binding pocket of PAKs, we chose a 2,4-diaminoquinazoline series of inhibitors as a starting point. Guided by X-ray crystallog. and a structure-based drug design (SBDD) approach, a series of novel 4-aminoquinazoline-2-carboxamide PAK4 inhibitors were designed and synthesized. The inhibitors’ selectivity, therapeutic potency, and pharmaceutical properties were optimized. One of the best compounds, 31 (CZh226), showed remarkable PAK4 selectivity (346-fold vs PAK1) and favorable kinase selectivity profile. Moreover, this compound potently inhibited the migration and invasion of A549 tumor cells by regulating the PAK4-directed downstream signaling pathways in vitro. Taken together, these data support the further development of 31 as a lead compound for PAK4-targeted anticancer drug discovery and as a valuable research probe for the further biol. investigation of group II PAKs. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1HPLC of Formula: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.HPLC of Formula: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Alkyl Methyl Imidazolium-Based Ionic Liquids at the Au(111) Surface: Anions and Alkyl Chain Cations Induced Interfacial Effects was written by Kamalakannan, Shanmugasundaram;Prakash, Muthuramalingam;Al-Mogren, Muneerah Mogren;Chambaud, Gilberte;Hochlaf, Majdi. And the article was included in Journal of Physical Chemistry C in 2019.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

The structure, stability, and adsorption mechanism on the Au(111) surface of hydrophilic/hydrophobic ionic liquids (ILs) with various lengths of the alkyl chain group in the cation were studied using 1st-principles approaches including electrostatic potential (ESP), electron d. anal., and dispersion-corrected d. functional theory (DFT-D3) methods. A suitable selection of ILs is considered. Indeed, the authors treat ILs [C_nMIm]⁺[X]^–, where X = Cl^–, PF₆^–, and TFSA^–, MIm = methylimidazolium and where the authors varied the alkyl chain (C_n) length for n = 0, 2, 4, 6, 8, and 10. The adsorption energies (E_ads‘s) of fluorinated ILs are lower (by âˆ?0%) than those of nonfluorinated ILs. Computations show that the nature of the anion within the ILs and the alkyl chain length play a very important role to alter the interfacial interactions between ILs and Au surface. Indeed, the alkyl groups of the cation affect the cation-anion interaction strength within ILs because of specific modes of adsorption of alkyl chains on the Au(111) surface. Also, structural-induced adsorption effects are observed during the variation of alkyl chain and anions. These are due to the modification of the local properties of the Au surface upon IL adsorption, where the authors identify, in some specific cases, an enhancement of the charge transfers between the ILs and the Au(111) surface through van der Waals and dispersive interactions. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Polymer inclusion membranes (PIMs) doped with alkylimidazole and their application in the separation of non-ferrous metal ions was written by Radzyminska-Lenarcik, Elzbieta;Ulewicz, Malgorzata. And the article was included in Polymers (Basel, Switzerland) in 2019.Related Products of 21252-69-7 This article mentions the following:

The study involved the transport of zinc(II), cadmium(II), and nickel(II) ions from acidic aqueous solutions using polymer inclusion membranes (PIMs). PIMs consisted of cellulose triacetate (CTA) as a support; o-nitrophenyl pentyl ether (o-NPPE) as a plasticizer; and 1-octylimidazole (1), 1-octyl-2-methylimidazole (2), 1-octyl-4-methylimidazole (3), or 1-octyl-2,4-dimethylimidazole (4) as ion carriers. The membranes were characterized by means of at. force microscopy (AFM) and SEM (SEM). The results show that Zn(II) and Cd(II) are effectively transported across PIMs, while Ni(II) transport is not effective. The rate of transport of metal ions across PIMs is determined by the diffusion rate of the M(II)-carrier complex across the membrane. The best result achieved for Zn(II) removal after 24 h was 95.5% for the ternary Zn(II)-Cd(II)-Ni(II) solution for PIM doped (4). For this membrane, the separation coefficients for Zn(II)/Cd(II), Zn(II)/Ni(II), and Cd(II)/Ni(II) were 2.8, 104.5, and 23.5, resp. Addnl., the influence of basicity and structure of carrier mols. on transport kinetics was discussed. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Related Products of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Highly Efficient SO₂ Absorption and Its Subsequent Utilization by Weak Base/Polyethylene Glycol Binary System was written by Yang, Zhen-Zhen;He, Liang-Nian;Zhao, Ya-Nan;Yu, Bing. And the article was included in Environmental Science & Technology in 2013.Formula: C11H20N2 This article mentions the following:

A binary system consisting of polyethylene glycol (PEG, proton donor)/PEG-functionalized base with suitable basicity was developed for efficient gas desulfurization (GDS) and is regarded as an alternative approach to circumvent the energy penalty problem in the GDS process. High capacity for SO₂ capture (â‰?.88 mol SO₂/mol base) was achieved, even under low SO₂ partial pressure. SO₂ desorption operates smoothly under mild conditions (N₂, 25°); no significant drop in SO₂ absorption was observed after 5 successive absorption/desorption cycles. SO₂ absorbed by PEG₁₅₀MeIm/PEG₁₅₀, considered the activated form of SO₂, can be directly transformed into value-added chems. under mild conditions, eliminating the energy penalty for SO₂ desorption and simultaneously recycling the absorbents. Thus, this SO₂ capture and utilization process offers an alternative way for GDS and potentially enables SO₂ conversion from flue gas to useful chems. as a value-added process. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem