Tag: 100-200

Tris-imidazolium and benzimidazolium ionic liquids: a new class of biodegradable surfactants was written by Al-Mohammed, Nassir N.;Duali Hussen, Rusnah Syahila;Alias, Yatimah;Abdullah, Zanariah. And the article was included in RSC Advances in 2015.Name: 1-Octyl-1H-imidazole This article mentions the following:

Based on imidazolium and benzimidazolium, two series of novel tris-cationic ionic liquid surfactants containing ester groups were synthesized simply from readily available starting materials in high yields. Biodegradability and surfactants properties of the tris-imidazolium and tris-benzimidazolium ionic liquids were investigated. Some compounds showed assembly behavior in the pure form (i.e. absence of solvent) and in the presence of polar or nonpolar solvents. These surfactants are effectively reducing the surface tension of water in the range of 28-31 mN m^-1. Through using the ‘Closed-Bottle Test’ OECD 301D, the incorporation of alkyl or Ph side chains with ester groups in the same mol. significantly improved the biodegradation compared to sodium n-dodecyl sulfate (SDS) as a reference The aliphatic alkyl side chain, i.e., Bu, hexyl, octyl, decyl and dodecyl, in both imidazolium and benzimidazolium ionic liquids had marked increasing biodegradation and phase behavior results compared to aromatic side-chains. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Name: 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Name: 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lithium chloride-imidazolium chloride melts for the coupling reactions of propylene oxide and CO₂ was written by Nguyen, Ly Vinh;Lee, Bora;Nguyen, Dinh Quan;Kang, Min-Jung;Lee, Hyunjoo;Ryu, Seol;Kim, Hoon Sik;Lee, Je Seung. And the article was included in Bulletin of the Korean Chemical Society in 2008.Formula: C7H13ClN2 This article mentions the following:

A series of lithium chloride-imidazolium chloride (LiCl-[imidazolium]Cl) melts were prepared and their catalytic activities were evaluated for the coupling reactions of propylene oxide and CO₂. At the constant mole of LiCl, the catalytic activities of LiCl-[imidazolium]Cl melts increased with increasing molar ratio of [imidazolium]Cl/LiCl up to 2, but thereafter decreased rapidly. The variation of alkyl groups on the imidazolium ring showed a negligible effect on the catalytic activity, but the number of alkyl groups present on the imidazolium cation exerts a pronounced effect. Catalysis and electrospray ionization tandem mass spectral anal. results of LiCl-[imidazolium]Cl melts imply that the activity of the melt is strongly related to the amount of LiCl₂^– generated from the melt. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Formula: C7H13ClN2).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Formula: C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and Toxicity Evaluation of New Pyrroles Obtained by the Reaction of Activated Alkynes with 1-Methyl-3-(cyanomethyl)benzimidazolium Bromide was written by Ivan, Beatrice-Cristina;Dumitrascu, Florea;Anghel, Adriana Iuliana;Ancuceanu, Robert Viorel;Shova, Sergiu;Dumitrescu, Denisa;Draghici, Constantin;Olaru, Octavian Tudorel;Nitulescu, George Mihai;Dinu, Mihaela;Barbuceanu, Stefania-Felicia. And the article was included in Molecules in 2021.Category: imidazoles-derivatives This article mentions the following:

A series of new pyrrole derivatives I (R = H, methoxycarbonyl, ethoxycarbonyl; R¹ = Bz, methoxycarbonyl, ethoxycarbonyl, (propan-2-yloxy)carbonyl) were designed as chem. analogs of the 1,4-dihydropyridines drugs in order to develop future new calcium channel blockers. The new tri- and tetra-substituted N-arylpyrroles I were synthesized by the one-pot reaction of 1-methyl-3-cyanomethyl benzimidazolium bromide with substituted alkynes RCCR¹ having at least one electron-withdrawing substituent, in 1,2-epoxybutane, acting both as the solvent and reagent to generate the corresponding benzimidazolium N3-ylide. The structural characterization of the new substituted pyrroles I was based on IR, NMR spectroscopy as well as on single crystal X-ray anal. The toxicity of the new compounds was assessed on the plant cell using Triticum aestivum L. species and on the animal cell using Artemia franciscana Kellogg and Daphnia magna Straus crustaceans. The compounds showed minimal phytotoxicity on Triticum rootlets and virtually no acute toxicity on Artemia nauplii, while on Daphnia magna, it induced moderate to high toxicity, similar to nifedipine. This research indicates that the newly synthesized pyrrole derivatives are promising mols. with biol. activity and low acute toxicity. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A Versatile Approach to Ullmann C-N Couplings at Room Temperature: New Families of Nucleophiles and Electrophiles for Photoinduced, Copper-Catalyzed Processes was written by Ziegler, Daniel T.;Choi, Junwon;Munoz-Molina, Jose Maria;Bissember, Alex C.;Peters, Jonas C.;Fu, Gregory C.. And the article was included in Journal of the American Chemical Society in 2013.Formula: C8H8N2 This article mentions the following:

The use of light to facilitate copper-catalyzed cross-couplings of nitrogen nucleophiles can enable C-N bond formation to occur under unusually mild conditions. In this study, we substantially expand the scope of such processes, establishing that this approach is not limited to reactions of carbazoles with iodobenzene and alkyl halides. Specifically, we demonstrate for the first time that other nitrogen nucleophiles (e.g., common pharmacophores such as indoles, benzimidazoles, and imidazoles) as well as other electrophiles (e.g., hindered/deactivated/heterocyclic aryl iodides, an aryl bromide, an activated aryl chloride, alkenyl halides, and an alkynyl bromide) serve as suitable partners. Photoinduced C-N bond formation can be achieved at room temperature using a common procedure with an inexpensive catalyst (CuI) that does not require a ligand coadditive and is tolerant of moisture and a variety of functional groups. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Formula: C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazolium based ionic liquids as solvents for cellulose chemistry was written by Vitz, Juergen;Erdmenger, Tina;Schubert, Ulrich S.. And the article was included in ACS Symposium Series in 2010.HPLC of Formula: 79917-89-8 This article mentions the following:

In recent years, ionic liquids developed to advantageous solvents for the dissolution and homogeneous processing of cellulose. Even if ionic liquids were already known for their capability of efficiently dissolving cellulose for a long time, significant efforts were made in the last years. New candidates were found, but it could be shown, that some ionic liquids are involved in side reactions, too. With the aim for gaining a better insight on the dissolution properties, we screened a wide range of potentially suitable ionic liquids Remarkable results were obtained, for example an odd-even effect was found for different alkyl side chain lengths, both linear and branched, for the imidazolium based ionic liquids with chloride counterions. Furthermore, 1-ethyl-3-methylimidazolium di-Et phosphate showed promising properties for the dissolution of cellulose, e.g. a lower degradation of cellulose than for other ILs, a low m.p., and a low viscosity of the cellulose solution, simplifying the handling. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8HPLC of Formula: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Significant effect of 5,10,15,20-meso-tetraarylporphyrinatoiron(III) chloride/triflate and acidic/neutral/basic imidazolium ionic liquids in catalytic oxidation of phenols was written by Ahmad, Sohail;Gautam, Renu;Singhal, Anchal;Chauhan, S. M. S.. And the article was included in Journal of Molecular Liquids in 2018.Category: imidazoles-derivatives This article mentions the following:

The influence of acidic, neutral and basic ionic liquids and their binary mixture with dichloromethane on the reactivity of iron(III) porphyrins was investigated during oxidation of phenols with hydrogen peroxide catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chloride and 5,10,15,20-tetraarylporphyrinatoiron(III) triflate. The generation of different intermediates of iron(III) porphyrin in different ILs was studied through viscosity, d., UV-Vis and ¹H NMR spectroscopy. The heterolytic cleavage efficiency of (TAP)Fe^III-OOH and formation of quinone using iron(III)porphyrin (TAP)Fe^IIICl with Cl atom as an axial ligand, is influenced by the structure of imidazolium moiety and the counter-anion following the order [(CH₂)₄SO₃HMIm]CF₃COO > [Hmim]CF₃COO > [bmim]TFA >>>> negligible amount in [bmim]CF₃SO₃, [Hmim]CF₃SO₃, [bmim]BF₄, [bmim]PF₆ and [bmim]Cl. On the other hand, the heterolytic cleavage efficiency of (TAP)Fe^III-OOH with iron(III)porphyrin (TAP)Fe^IIICF₃SO₃ with triflate as an axial ligand, was found in the following order [(CH₂)₄SO₃HMIm]CF₃SO₃ > [Hmim]CF₃SO₃ > [(CH₂)₄SO₃HMIm]CF₃COO > [Hmim]CF₃COO > [bmim] CF₃COO > [bmim]PF₆ â‰?[bmim]BF₄ â‰?[bmim]CF₃SO₃, while epoxidation and polymerization were mainly observed in basic and neutral ILs. The reactive intermediates formed by the reaction of monooxygen donors with (TAP)Fe^IIICl varied with ILs, as (TAP)^+·Fe^IV = O intermediate was dominated in acidic ILs, while (TAP)Fe^IV = O was formed in neutral ILs and (TAP)Fe^III-OO^– was formed in basic ILs. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Category: imidazoles-derivatives).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparatory study for the synthesis of the starfish alkaloid imbricatine. Syntheses of 5-arylthio-3-methyl-L-histidines was written by Ohba, Masashi;Mukaihira, Takafumi;Fujii, Tozo. And the article was included in Chemical & Pharmaceutical Bulletin in 1994.SDS of cas: 25676-75-9 This article mentions the following:

Chiral syntheses of 3-methyl-5-(arylthio)-L-histidines I (R = Ph, 1-naphthyl), selected as models for the asteroid alkaloid imbricatine, have been accomplished through a 10-step route starting from 4(5)-bromoimidazole (II). The key steps involved were methylation of II, hydroxymethylation of 4-bromo-1-methyl-1H-imidazole, replacement of the 4-bromo group by an arylthio group, and introduction of a chiral α-amino acid moiety into the chlorides III by the bislactim ether method. The synthesis of 4-(4-methoxybenzyl)thio analog III (R = 4-MeOC₆H₄CH₂), carried out in a similar manner, concluded formal syntheses of ovothiols A and C. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9SDS of cas: 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. SDS of cas: 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study was written by Wang, Li;Bao, Bo-Bo;Song, Guo-Qing;Chen, Cheng;Zhang, Xu-Meng;Lu, Wei;Wang, Zefang;Cai, Yan;Li, Shuang;Fu, Sheng;Song, Fu-Hang;Yang, Haitao;Wang, Jian-Guo. And the article was included in European Journal of Medicinal Chemistry in 2017.Quality Control of Ethyl 2-mercapto-1H-imidazole-4-carboxylate This article mentions the following:

The worldwide outbreak of severe acute respiratory syndrome (SARS) in 2003 had caused a high rate of mortality. Main protease (M^pro) of SARS-associated coronavirus (SARS-CoV) is an important target to discover pharmaceutical compounds for the therapy of this life-threatening disease. During the course of screening new anti-SARS agents, a series of unsym. aromatic disulfides inhibited SARS-CoV M^pro significantly for the first time have been identified. Novel unsym. aromatic disulfides R¹SSR² [R¹ = 1,3-thiazol-2-ylsulfanyl, 1,3,4-oxadiazol-2-ylsulfanyl, pyrimidin-2-ylsulfanyl, etc.; R² = phenylsulfanyl, 4-bromophenylsulfanyl, [2-(methoxycarbonyl)phenyl]sulfanyl, etc.] were synthesized chem. and their biol. activities were evaluated in vitro against SARS-CoV Mpro. These novel compounds displayed excellent IC₅₀ data in the range of 0.516-5.954 μM. Preliminary studies indicated that these disulfides are reversible and competitive inhibitors. A possible binding mode was generated via mol. docking simulation and a comparative field anal. (CoMFA) model was constructed to understand the structure-activity relationships. The present research therefore has provided some meaningful guidance to design and identify anti-SARS drugs with totally new chem. structures. In the experiment, the researchers used many compounds, for example, Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8Quality Control of Ethyl 2-mercapto-1H-imidazole-4-carboxylate).

Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of Ethyl 2-mercapto-1H-imidazole-4-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Novel synthetic methods for N-cyano-1H-imidazole-4-carboxamides and their fungicidal activity was written by Yang, Wen-Chao;Li, Jing;Li, Jun;Chen, Qiong;Yang, Guang-Fu. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Related Products of 26832-08-6 This article mentions the following:

A novel synthetic method for N-cyanoimidazolecarboxamides has been developed with advantages of mild reaction conditions, simpler procedure, and easy reactant-product isolation compared with the existing methods. Thus, a one-step or two-step alkylation of 8-methylimidazo[1,5-d][1,2,4]triazin-1-(2H)-one gave N-cyanocarboxamides. Using this novel method, 16 new N-cyano-1H-imidazole-4-carboxamide derivatives were synthesized and their structures were characterized by spectrum anal. Further antifungal activity study showed that most of the newly synthesized compounds have good antifungal activity selectively against Rhizoctonia solani among the six fungi tested. Particularly, compound I was identified as the most promising candidate with an EC₅₀ of 2.63 μg/mL against R. solani. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Related Products of 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Related Products of 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Leaching separation of taurine and sodium sulfate solid mixture using ionic liquids was written by Gu, Yanlong;Shi, Feng;Yang, Hongzhou;Deng, Youquan. And the article was included in Separation and Purification Technology in 2004.HPLC of Formula: 79917-89-8 This article mentions the following:

The solubilities of taurine [2-aminoethanesulfonic acid (H₂NCH₂CH₂SO₃H)] and sodium sulfate in a series of room temperature ionic liquids were examined, and a novel and greener separation method combined with chlorinated dialkylimidazolium ionic liquid as leaching reagent and organic solvent as precipitating reagent was developed. Using such a process, selective separation of taurine from a solid mixture containing a large amount of sodium sulfate could be realized with 67-98.5% of single separation yield. Recycling of ionic liquid and organic solvent used in this separation process is possible. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8HPLC of Formula: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.HPLC of Formula: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem