Tag: 100-200

Isonucleosides incorporating universal bases was written by Nair, Vasu;Sosnouski, David S.;Zhu, Qingming. And the article was included in Nucleosides, Nucleotides & Nucleic Acids in 2001.Related Products of 26832-08-6 This article mentions the following:

Enantiomeric isodideoxynucleosides of the (S,S) and (R,R) families with the universal base, imidazole-4-carboxamide as the nucleobase, were synthesized as biol. mimics of anti-HIV active D– and L-related isodideoxyadenosines. In vitro anti-HIV evaluation in CEM cells of these target compounds showed that they were inactive. Further antiviral studies are in progress. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Related Products of 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Protic Ionic-Liquid-Supported Activated Carbon with Hierarchical Pores for Efficient NH₃ Adsorption was written by Yu, Min;Zeng, Shaojuan;Wang, Zongxu;Hu, Zongyuan;Dong, Haifeng;Nie, Yi;Ren, Baozeng;Zhang, Xiangping. And the article was included in ACS Sustainable Chemistry & Engineering in 2019.Quality Control of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

Ionic liquids (ILs) provide a new way for efficient separation and recovery of NH₃ because of low vapor pressure and adjustable properties. However, high viscosity or solid state of functionalized ILs at ambient temperature makes them impossible to use in traditional scrubbing processes. Therefore, combining ILs with porous solid materials to form novel IL-supported materials for NH₃ adsorption is an effective method to solve the above problem. In this work, three protic ILs (PILs) including imidazolium bis(trifluoromethylsulfonyl)imide ([Im][NTf₂]), 1-methylimidazolium bis(trifluoromethylsulfonyl)imide ([1-Mim][NTf₂]), and 2-methylimidazolium bis(trifluoromethylsulfonyl)imide ([2-Mim][NTf₂]) were supported onto activated carbon (AC) to prepare PIL-supported materials. The effects of PILs and AC types, PIL loadings, temperatures, and partial pressures on NH₃ adsorption, as well as the recyclability of the PIL-supported materials, were investigated in detail. Among the investigated PIL-supported materials, 20 weight % [2-Mim][NTf₂]-supported AC-980 exhibits the higher capacity of 68.61 mg of NH₃/g of adsorbent at 303.15 K and 0.10 MPa with good NH₃ selectivity and fast adsorption rate because of the synergistic interaction of hydrogen bonding between the PIL and NH₃ and hierarchical pores, which is 30% higher than that of pure AC. Meanwhile, the PIL-supported material shows good recyclability after five cycles, implying great potentials for NH₃ separation industrial processes. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Quality Control of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Quality Control of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Developing the {M(CO)₃}⁺ Core for Fluorescence Applications: Rhenium Tricarbonyl Core Complexes with Benzimidazole, Quinoline, and Tryptophan Derivatives was written by Wei, Lihui;Babich, John W.;Ouellette, Wayne;Zubieta, Jon. And the article was included in Inorganic Chemistry in 2006.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

Tridentate ligands derived from benzimidazole, quinoline, and tryptophan were synthesized, and their reactions with [NEt₄]₂[Re(CO)₃Br₃] were studied. [Re(CO)₃L]Br (L = L1, L2, L3, L4, L6, L7) (1–4, 6 and 7) exhibit fac-{Re(CO)₃N₃} coordination geometry in the cationic mol. units, while [Re(CO)₃L]Br (L = L5) (5) exhibits fac-{Re(CO)₃N₂O} coordination for the neutral mol. unit, where N₃ and N₂O refer to the ligand donor groups. The ligands bis(1-methyl-1H-benzoimidazol-2-ylmethyl)amine (L1), [bis(1-methyl-1H-benzoimidazol-2-ylmethyl)amino]acetic acid Et ester (L2), [bis(1-methyl-1H-benzoimidazol-2-ylmethyl)amino]acetic acid Me ester (L3), [bis(quinolin-2-ylmethyl)amino]acetic acid Me ester (L4), 3-(1-methyl-1H-indol-3-yl)-2-[(pyridin-2-ylmethyl)amino]propionic acid (L5), 2-[bis(pyridin-2-ylmethyl)amino]-3-(1-methyl-1H-indol-3-yl)propionic acid (L6), and 2-[bis(quinolin-2-ylmethyl)amino]-3-(1-methyl-1H-indol-3-yl)propionic acid (L7) were obtained in good yields and characterized by elemental anal., 1-dimensional and 2-dimensional NMR, and high-resolution mass spectrometry (HRMS). The Re complexes were obtained in 70-85% yields and characterized by elemental anal., 1-dimensional and 2-dimensional NMR, HRMS, IR, UV, and luminescence spectroscopy, as well as x-ray crystallog. for [Re(CO)₃(L1)]Br (1), {[Re(CO)₃(L2)]Br}₂·NEt₄Br·8.5H₂O (3₂·NEt₄Br·8.5H₂O), [Re(CO)₃(L4)]Br (4), and [Re(CO)₃(L6)]Br (6). Crystal data for C₂₁H₁₉BrN₅O₃Re (1): monoclinic, space group P2₁/c, a 13.1851(5), b 16.1292(7), c 10.2689(4) Å, β 99.353(1)°, Z = 4. Crystal data for C₅₆H₇₃Br₃N₁₁O_18.50Re₂ (3₂·NEt₄Br·8.5H₂O): monoclinic, space group C2/c, a 34.7760(19), b 21.1711(12), c 20.3376(11) Å, β 115.944(1)°, Z = 8. Crystal data for C₂₆H₂₁BrN₃O₅Re (4): monoclinic, space group P2₁/c, a 16.6504(6), b 10.1564(4), c 14.6954(5) Å, β 96.739(1)°, Z = 4. Crystal data for C₂₇H₂₄BrN₄O₅Re (6): monoclinic, space group P2₁, a 8.7791(9), b 16.312(2), c 8.9231(9) Å, β 90.030(1)°, Z = 2. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

NMR Quantification of Hydrogen-Bond-Accepting Ability for Organic Molecules was written by Milic, Mira;Targos, Karina;Tellez Chavez, Magda;Thompson, Madison A. M.;Jennings, Julia J.;Franz, Annaliese K.. And the article was included in Journal of Organic Chemistry in 2021.SDS of cas: 1632-83-3 This article mentions the following:

The hydrogen-bond-accepting abilities for more than 100 organic mols. are quantified using ¹⁹F and ³¹P NMR spectroscopy with pentafluorobenzoic acid (PFBA) and phenylphosphinic acid (PPA) as com. available, inexpensive probes. Anal. of pyridines and anilines with a variety of electronic modifications demonstrates that changes in NMR shifts can predict the secondary effects that contribute to H-bond-accepting ability, establishing the ability of PFBA and PPA binding to predict electronic trends. The H-bond-accepting abilities of various metal-chelating ligands and organocatalysts are also quantified. The measured Δδ(³¹P) and Δδ_p(¹⁹F) values correlate strongly with Hammett parameters, pK_a of the protonated HBA, and proton-transfer basicity (pK_BH+). In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3SDS of cas: 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.SDS of cas: 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Study on synthesis and characterization of series functionalized ionic liquids and their physicochemical properties was written by Zhu, Li-ye;Chen, Li-gong;Wang, Ming-qi;Li, Xian-jie;Cao, Shu-han. And the article was included in Gongneng Cailiao in 2011.COA of Formula: C11H20N2 This article mentions the following:

Series functionalized ionic liquids containing ester-group I(n= 1, R = Me, X^– = BF₄^–, Tf₂N^–; n = 1, R = Bu, C₈H₁₇, X^– = Tf₂N^–; n = 2, R = Me, X^– = Tf₂N^–) were synthesized through a typical two-step way and the products were characterized by ¹H-NMR, FT-IR and elemental anal. The basic physicochem. properties and thermal stabilities of the functionalized ionic liquids were studied thoroughly and compared with a traditional nonfunctionalized ionic liquid, 3-methy-1-butylimidazolium terafluoroborate, which had the same alkyl as the functionalized ones. The ester-group functionalized ionic liquids synthesized in this paper have provided new materials and laid a foundation for further study on ionic liquids In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7COA of Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.COA of Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nitroimidazoles. Part III. Ionization constants and tautomerism of imidazoles. A reinvestigation was written by Suwinski, Jerzy;Salwinska, Ewa. And the article was included in Polish Journal of Chemistry in 1981.Formula: C4H5N3O This article mentions the following:

Basic and acidic ionization constants of some simple imidazole derivatives were determined spectrophotometrically as well as potentiometrically or taken from the literature. Tautomeric equilibrium constants of the compounds containing an imino H atom were also calculated Methods and results were discussed with regard to the former literature data. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Formula: C4H5N3O).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Formula: C4H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Palladium-Catalyzed Tandem Ester Dance/Decarbonylative Coupling Reactions was written by Kubo, Masayuki;Inayama, Naomi;Ota, Eisuke;Yamaguchi, Junichiro. And the article was included in Organic Letters in 2022.Recommanded Product: 1-Methylbenzimidazole This article mentions the following:

“Dance reaction” on the aromatic ring is a powerful method in organic chem. to translocate functional groups on arene scaffolds. Notably, dance reactions of halides and pseudohalides offer a unique platform for the divergent synthesis of substituted (hetero)aromatic compounds when combined with transition-metal-catalyzed coupling reactions. Herein, a tandem reaction of ester dance and decarbonylative coupling enabled by palladium catalysis is reported. In this reaction, 1,2-translocation of the ester moiety on the aromatic ring is followed by decarbonylative coupling with nucleophiles to enable the installation of a variety of nucleophiles at the position adjacent to the ester in the starting material. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of transition metal complexes with heteroazomethinic ligands: a comparison of traditional and electrochemical methods was written by Kharisov, B. I.;Blanco, L. M.;Garnovskii, A. D.;Burlov, A. S.;Kuznetsova, L. I.;Korovina, L. V.;Garnovskii, D. A.;Dieck, T.. And the article was included in Polyhedron in 1997.Product Details of 3012-80-4 This article mentions the following:

Transition metal complexes (M = Cu, Ni, Co, Pd, Zn and Cd) containing azomethinic ligands were synthesized by conventional chem. methods and by direct electrochem. dissolution of the sacrificial metal anode. The resulting complexes were characterized by elemental anal., IR and EPR-spectra and magnetochem. data. The influence of the type of metal, the peculiarities of the ligand structure and the methods of synthesis of metal chelates on their physicochem. properties and structure were examined In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Product Details of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Product Details of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Investigations on benzimidazole-absorption spectra and chromiferous properties was written by Mangini, Angelo;Montanari, Fernando;Passerini, Riccardo. And the article was included in Atti accad. nazl. Lincei, Rend. Classe sci. fis., mat. e. nat. in 1952.HPLC of Formula: 4887-83-6 This article mentions the following:

The results are tabulated of absorption-spectrum measurements of derivatives of benzimidazole substituted in either the 4 or 5 position by H, CH₃, Cl, Br, OCH₃, NH₂, or NO₂, and 2-phenylbenzimidazole substituted with various possible combinations of the above substituents in the 4 or 5 positions and in the o, m, or p positions in the phenyl group. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6HPLC of Formula: 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites was written by Oba, Yasuhiro;Takano, Yoshinori;Furukawa, Yoshihiro;Koga, Toshiki;Glavin, Daniel P.;Dworkin, Jason P.;Naraoka, Hiroshi. And the article was included in Nature Communications in 2022.SDS of cas: 26832-08-6 This article mentions the following:

The lack of pyrimidine diversity in meteorites remains a mystery since prebiotic chem. models and laboratory experiments have predicted that these compounds can also be produced from chem. precursors found in meteorites. Here we report the detection of nucleobases in three carbonaceous meteorites using state-of-the-art anal. techniques optimized for small-scale quantification of nucleobases down to the range of parts per trillion (ppt). In addition to previously detected purine nucleobases in meteorites such as guanine and adenine, we identify various pyrimidine nucleobases such as cytosine, uracil, and thymine, and their structural isomers such as isocytosine, imidazole-4-carboxylic acid, and 6-methyluracil, resp. Given the similarity in the mol. distribution of pyrimidines in meteorites and those in photon-processed interstellar ice analogs, some of these derivatives could have been generated by photochem. reactions prevailing in the interstellar medium and later incorporated into asteroids during solar system formation. This study demonstrates that a diversity of meteoritic nucleobases could serve as building blocks of DNA and RNA on the early Earth. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6SDS of cas: 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem