Tag: 100-200

Effect of temperature on the interactions between low bandgap polymer and ionic liquids was written by Attri, Pankaj;Lee, Seung-Hyun;Hwang, Sun Woo;Kim, Joong Il;Jang, Won;Kim, Young Beom;Park, Jung Ho;Kwon, Gi-Chung;Choi, Eun Ha;Kim, In Tae. And the article was included in Thermochimica Acta in 2014.Synthetic Route of C4H7ClN2 This article mentions the following:

In this paper, we have examined the effect of temperature on the interactions between imidazolium and ammonium based ionic liquids (ILs) and the low bandgap polymer (poly(2-heptadecyl-4-vinylthieno[3,4-d]thiazole) (PHVTT)). With the aim of exploring the utility of low bandgap polymers, we have carried out the interaction studies of the polymer with the ILs and investigated the behavior of polymer in the presence of ILs as the function of temperature Recently, ILs have attracted extensive attention in polymer sciences. In this work, we have studied the temperature dependent interactions between the protic IL (1-methylimidazolium chloride ([Mim]Cl) from imidazolium family) and aprotic ILs (tributylmethylammonium Me sulfate ([N₁₄₄₄][MeSO₄]) from ammonium family and 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) from imidazolium family) with a low bandgap polymer. Our exptl. data of UV-vis spectroscopy, photoluminescence (PL) spectroscopy, FT-IR spectroscopy, d. (ρ) and speed of sound (u) as a function of temperature from 25 to 40° with the interval of 5°, clearly reveal that even at high temperature, [Bmim]Cl interacts strongly with the polymer as compared to other studied ILs. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Synthetic Route of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Controlling selectivity for cycloadditions of nitrones and alkenes tethered by benzimidazoles: combining experiment and theory was written by Meng, Liping;Wang, Selina C.;Fettinger, James C.;Kurth, Mark J.;Tantillo, Dean J.. And the article was included in European Journal of Organic Chemistry in 2009.Related Products of 3012-80-4 This article mentions the following:

A combined exptl./theor. study on the effects of substituents on regio- and stereoselectivity in intramol. 1,3-dipolar cycloadditions of nitrones and alkenes tethered by benzimidazoles. By employing a large substituent at position R² or R³, complete selectivity was achieved for either the fused or bridged cycloadduct, resp. In addition, these cycloadducts were formed as single diastereomers in all of the cycloadditions examined In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Related Products of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Related Products of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic molecules for disruption of the MYC protein-protein interface was written by Jacob, Nicholas T.;Miranda, Pedro O.;Shirey, Ryan J.;Gautam, Ritika;Zhou, Bin;de Orbe Izquierdo, M. Elena;Hixon, Mark S.;Hart, Jonathan R.;Ueno, Lynn;Vogt, Peter K.;Janda, Kim D.. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Synthetic Route of C6H8N2O This article mentions the following:

MYC is a key transcriptional regulator involved in cellular proliferation and has established roles in transcriptional elongation and initiation, microRNA regulation, apoptosis, and pluripotency. Despite this prevalence, functional chem. probes of MYC function at the protein level have been limited. Previously, we discovered 5a, that binds to MYC with potency and specificity, downregulates the transcriptional activities of MYC and shows efficacy in vivo. However, this scaffold posed intrinsic pharmacokinetic liabilities, namely, poor solubility that precluded biophys. interrogation. Here, we developed a screening platform based on field-effect transistor anal. (Bio-FET), surface plasmon resonance (SPR), and a microtumor formation assay to analyze a series of new compounds aimed at improving these properties. This blind SAR campaign has produced a new lead compound of significantly increased in vivo stability and solubility for a 40-fold increase in exposure. This probe represents a significant advancement that will not only enable biophys. characterization of this interaction and further SAR, but also contribute to advances in understanding of MYC biol. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Synthetic Route of C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Synthetic Route of C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design, synthesis and biological evaluation of naphthalene-derived (arylalkyl)azoles containing heterocyclic linkers as new anticonvulsants: A comprehensive in silico, in vitro, and in vivo study was written by Valipour, Mehdi;Naderi, Nima;Heidarli, Elmira;Shaki, Fatemeh;Motafeghi, Farzaneh;Talebpour Amiri, Fereshteh;Emami, Saeed;Irannejad, Hamid. And the article was included in European Journal of Pharmaceutical Sciences in 2021.Name: 1-Methylbenzimidazole This article mentions the following:

In continuation of our research to find strong and safe anticonvulsant agents, a number of (arylalkyl)azoles (AAAs) containing naphthylthiazole and naphthyloxazole scaffolds were designed and synthesized. The in vivo anticonvulsant evaluations in BALB/c mice revealed that some of them had significant anticonvulsant activity in both maximal electroshock (MES) and pentylenetetrazole (PTZ) models of epilepsy. The best profile of activity was observed with compounds containing imidazole and triazole rings (C1, C6, G1, and G6). In particular, imidazolylmethyl-thiazole C1 with median ED (ED₅₀)= 7.9 mg/kg in the MES test, ED₅₀= 27.9 mg/kg in PTZ test, and without any sign of neurotoxicity (in the rotarod test, 100 mg/kg) was the most promising compound The patch-clamp recording was performed to study the mechanism of action of the representative compound C1 on hippocampal dentate gyrus (DG) cells. The results did not confirm any modulatory effect of C1 on the voltage-gated ion channels (VGICs) or GABA_A agonism, but suggested a significant reduction of excitatory postsynaptic currents (EPSCs) frequency on hippocampal DG neurons. Sub-acute toxicity studies revealed that administration of the most active compounds (C1, C6, G1, and G6) at 100 mg/kg bw/day for two weeks did not result in any mortality or significant toxicity as evaluated by assessment of biochem. markers such as lipid peroxidation, intracellular glutathione, total antioxidant capacity, histopathol. changes, and mitochondrial functions. Other pharmacol. aspects of compounds including mechanistic and ADME properties were investigated computationally and/or exptl. Mol. docking on the NMDA and AMPA targets suggested that the introduction of the heterocyclic ring in the middle of AAAs significantly affects the affinity of the compounds The obtained results totally demonstrated that the prototype compound C1 can be considered as a new lead for the development of anticonvulsant agents. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Name: 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of Well-Defined Adenosine Diphosphate Ribose Oligomers was written by Kistemaker, Hans A. V.;Lameijer, Lucien N.;Meeuwenoord, Nico J.;Overkleeft, Herman S.;van der Marel, Gijsbert A.;Filippov, Dmitri V.. And the article was included in Angewandte Chemie, International Edition in 2015.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

The post-translational modification of proteins that is known as ADP ribosylation (ADPr) regulates a wide variety of important biol. processes, such as DNA-damage repair and cellular metabolism This modification is also involved in carcinogenesis and the process of aging. Therefore, a better understanding of the function of ADP-ribosylation is crucial for the development of novel therapeutics. To facilitate the elucidation of the biol. of ADPr, the availability of well-defined fragments of poly(ADP-ribose) is essential. Herein we report a solid-phase synthetic approach for the preparation of ADP-ribose oligomers of exactly defined length. The methodol. is exemplified by the first reported synthesis of an ADP-ribose dimer and trimer. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Green synthesis of acetylated maize starch in different imidazolium carboxylate and choline carboxylate ionic liquids was written by Ren, Fei;Wang, Jinwei;Yu, Jinglin;Zhong, Cheng;Xie, Fengwei;Wang, Shujun. And the article was included in Carbohydrate Polymers in 2022.Recommanded Product: 79917-89-8 This article mentions the following:

This work demonstrates that acetylated maize starches (AMS) with varied degree of substitution (DS, 0.26-2.63) was synthesized in ionic liquids (ILs) (imidazolium chloride, imidazolium carboxylate and choline carboxylate) at 85°C without catalyst. The DS of AMS and reaction efficiency increased with decreasing alkyl chain length of cations or anions, while decreased as the choline cation replaced the imidazolium cation and the chloride anion replaced the acetate anion. The AMS synthesized in imidazolium-based ILs exhibited much higher hydrophobicity and thermal stability than the native starch. Rheol. properties of ILs and ATR-FTIR anal. of acetic anhydride/ILs mixtures indicated that a shorter alkyl side chain or the combination of an imidazolium cation and an acetate anion gave ILs lower viscosities and weaker interactions between acetic anhydride mols., which favored the acetylation of starch. These findings provide insights into the design of green processes to modify starch and the application of acetylated starch. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Recommanded Product: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation and Characterization of Titanium Tetrachloride-Based Ionic Liquids was written by Gao, Lixia;Wang, Lina;Qi, Tao;Chu, Jinglong;Qu, Jingkui. And the article was included in Journal of the Electrochemical Society in 2009.Application of 79917-89-8 This article mentions the following:

TiCl₄-based ionic liquids (ILs) were synthesized by mixing TiCl₄ with quaternary ammonium, pyridinium, and imidazolium chlorogenated salt, resp. The structure and composition of the ILs were studied with Fourier transform ICR mass spectrometry, IR, and Raman spectra. The primary anions of the TiCl₄-based ILs were Ti₂Cl₉^– and TiCl₆^2-, whose amounts were different by variation of the molar ratio of TiCl₄ to organic halogenated salt. The phys. properties such as the phase transition behavior, surface tension, d., viscosity, and conductivity of these ILs were also studied. Temperature-dependent viscosity and conductivity of the ILs followed the Vogel-Tammann-Fulcher equation, and the best-fit parameters had been estimated, together with the linear fitting parameters for the d. The conductivity and viscosity of the TiCl₄-based ILs were controlled by the ion mobility and the availability of voids with suitable dimensions. Hole theory could well explain the physicochem. properties of the TiCl₄-based ILs. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Application of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Oxone-DMSO Triggered Methylene Insertion and C(sp²)-C(sp³)-H-C(sp²) Bond Formation to Access Functional Bis-Heterocycles was written by Kour, Jaspreet;Venkateswarlu, Vunnam;Verma, Praveen K.;Hussain, Yaseen;Dubey, Gurudutt;Bharatam, Prasad V.;Sahoo, Subash C.;Sawant, Sanghapal D.. And the article was included in Journal of Organic Chemistry in 2020.Reference of 1632-83-3 This article mentions the following:

Metal-free insertion of a methylene group was achieved for the construction of a new C(sp²)-C(sp³)-H-C(sp²) bond in order to prepare novel bis-heterocyclic scaffolds. The complete mechanistic investigations included exptl. study and DFT calculations, and various sym. and unsym. bis-pyrazoles as well as other pyrazole-based bis-heterocyclic mols. were prepared in moderate to high yields. Further modification of the bridged methylene group in the unsym. pyrazoles generated a chiral center to extend the scope of this method. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Reference of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hydrogenation sequence of acetophenone on commercial platinum catalyst AP-64 was written by Smirnova, N. A.;Adamyan, V. L.;Edigarova, E. I.. And the article was included in Azerbaidzhanskii Khimicheskii Zhurnal in 1987.Formula: C6H8N2O This article mentions the following:

Cyclohexyl Me carbinol formation from PhCOMe in the title reaction at 100-155° proceeded by parallel formation and hydrogenation of PhCHMeOH (I) and cyclohexyl Me ketone. Small amounts of I were also reduced to PhEt and then to ethylcyclohexane. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Self-Assembly and Complexation of Cellulose/Ionic Liquid at High Cellulose Concentration: Anion Dependence was written by Endo, Takatsugu;Yoshida, Shota;Kimura, Yoshifumi. And the article was included in Crystal Growth & Design in 2020.COA of Formula: C7H13ClN2 This article mentions the following:

The authors studied the state of cellulose that was dissolved in ionic liquid (IL) consisting of 1-Me-3-propylimdiazolium cation ([C₃mim]⁺) paired with acetate ([OAc]^–), dimethylphospate ([DMP]^–), or chloride (Cl^–) anions using wide-angle x-ray scattering (WAXS), particularly focusing on the high cellulose concentration region (10-80 mol %). The anion species considerably altered the WAXS pattern of the cellulose/IL mixtures [C₃mim][OAc] deconstructed cellulose crystal structure up to the 40 mol % cellulose concentration Similar to the previously reported cellulose/1-Et-3-methylimidazolium acetate system ([C₂mim][OAc]), the mixtures of cellulose/[C₃mim][OAc] at 25-60 mol % induced a low angle peak, which corresponds to the self-assembly of the system. For [C₃mim][DMP] and [C₃mim]Cl mixtures, sharp Bragg peaks were observed, which demonstrated the formation of the complex crystal of cellulose/IL. The presence of moisture eventually deconstructed these crystal structures; while for [C₃mim]Cl, an intermediate complex crystal containing H₂O mols. emerged. This work contributes to understanding the cellulose state dissolved in IL at high concentrations and to the development of crystal engineering on this most abundant and recalcitrant biopolymer. Complex crystals formed when cellulose was simply mixed with a certain ionic liquid at high concentrations The complex crystals are sensitive to H₂O; they transformed into a different complex crystal or an amorphous state, depending on anion types used and H₂O concentration contained. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8COA of Formula: C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem