Tag: 100-200

Radiosensitizing, toxicological, and pharmacokinetic properties of hydroxamate analogs of nitroimidazoles as bifunctional radiosensitizers/chemical modifiers was written by Nagasawa, Hideko;Bando, Masahiro;Hori, Hitoshi;Satoh, Tetsuo;Tada, Takuhito;Onoyama, Yasuto;Inayama, Seiichi. And the article was included in International Journal of Radiation Oncology, Biology, Physics in 1992.Category: imidazoles-derivatives This article mentions the following:

The pharmacokinetics were examined of KIH-802, potassium 2-nitroimidazole-1-acetohydroxamate, using its radioisotope-labeled compound and the acute toxicity in mice. The concentration of KIH-802 was very low in the brain and its LD₅₀ was nearly half the value of that of MISO. Here, new 2-nitroimidazole radiosensitizers/chem. modifiers (KIN-804, 811, 831, 841, 844, 821, 823 and 824) were designed to enhance their sensitizing ability intensely by substituting various biol. active groups, such as hydroxamic acids and oximes, with moderate lipophilicity to the aromatic ring, if necessary, through some spacers. The sensitizing effects of all compounds were estimated to be almost equal to or better than that of MISO. The results of their toxicities shows that new hydroxamates KIN-804 and 831 are less toxic than KIH-802 and MISO. Their in vitro enhancement ratios are 2.00 and 1.75, resp., compared with those of KIH-802, MISO and SR-2508, 1.77, 1.72 and 1.72, resp., at each dose of 1 mM for EMT6/KU single cell. It is concluded that they hydroxamic acid analogs to KIH-802 may be superior radiosensitizers. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Category: imidazoles-derivatives).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ru@PsIL-Catalyzed Synthesis of N-Formamides and Benzimidazole by using Carbon Dioxide and Dimethylamine Borane was written by Saptal, Vitthal B.;Sasaki, Takehiko;Bhanage, Bhalchandra M.. And the article was included in ChemCatChem in 2018.Reference of 4887-83-6 This article mentions the following:

The synthesis and characterization of ruthenium nanoparticles (Ru NPs) supported on polymeric ionic liquids (PILs) was reported. This catalyst showed high catalytic activity towards the N-formylation of amines and synthesis of benzimidazoles from 1,2-diamines and carbon dioxide (CO₂) by reductive dehydrogenation of dimethylamine borane. This methodol. showed excellent functional group tolerance with broad substrate scope towards the synthesis of N-formamides and benzimidazoles. Interestingly, this protocol also provided the tandem reduction of 2-nitroamines and CO₂ to synthesize benzimidazoles. It was proposed that the ionic liquid phase of the polymer played pivotal roles such as assisting the stabilization of nanoparticles electrostatically, providing an ionic environment, and controlling the easy access of the substrates/reagents to the active sites. The developed methodol. utilized CO₂ as a C₁ source and water/ethanol as a green solvent system. Addnl., the catalyst was found to be recyclable in nature and showed five consecutive recycling runs without significant loss in its activity. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Reference of 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dialkylimidazolium dimethyl phosphates as solvents and catalysts for the Knoevenagel condensation reaction was written by Zicmanis, Andris;Anteina, Liene. And the article was included in Tetrahedron Letters in 2014.Reference of 21252-69-7 This article mentions the following:

The reaction between benzaldehyde and Et cyanoacetate is investigated in 1,3-dialkylimidazolium salts as solvents. The impact of both ions in these ionic liquids on the yield of the condensation reaction product is examined Potentiometric titrations are employed for quant. anal. of the best ionic liquids, revealing these to be 1,3-dialkylimidazolium di-Me phosphates. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tetracoordinate borates as catalysts for reductive formylation of amines with carbon dioxide was written by Jiang, Xiaolin;Huang, Zijun;Makha, Mohamed;Du, Chen-Xia;Zhao, Dongmei;Wang, Fang;Li, Yuehui. And the article was included in Green Chemistry in 2020.COA of Formula: C8H8N2 This article mentions the following:

We report sodium trihydroxyaryl borates as the first robust tetracoordinate organoboron catalysts for reductive functionalization of CO2. These catalysts, easily synthesized from condensing boronic acids with metal hydroxides, activate main group element-hydrogen (E-H) bonds efficiently. In contrast to BX3 type boranes, boronic acids and metal-BAr4 salts, under transition metal-free conditions, sodium trihydroxyaryl borates exhibit high reactivity of reductive N-formylation toward a variety of amines (106 examples), including those with functional groups such as ester, olefin, hydroxyl, cyano, nitro, halogen, MeS-, ether groups, etc. The over-performance to catalyze formylation of challenging pyridyl amines affords a promising alternative method to the use of traditional formylation reagents. Mechanistic investigation supports electrostatic interactions as the key for Si/B-H activation, enabling alkali metal borates as versatile catalysts for hydroborylation, hydrosilylation, and reductive formylation/methylation of CO2. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3COA of Formula: C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A highly effective sulfamic acid/methanol catalytic system for the synthesis of benzimidazole derivatives at room temperature was written by Zhang, Zhan-Hui;Li, Tong-Shuang;Li, Jian-Jiong. And the article was included in Monatshefte fuer Chemie in 2007.Safety of 7-Methyl-1H-benzo[d]imidazole This article mentions the following:

Sulfamic acid/methanol was an efficient catalytic system for the synthesis of benzimidazole compounds through the condensation of o-phenylenediamines with orthoesters in high yields at room temperature In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Safety of 7-Methyl-1H-benzo[d]imidazole).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Safety of 7-Methyl-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quantum chemical study on nitroimidazole, polynitroimidazole and their methyl derivatives was written by Su, Xinfang;Cheng, Xinlu;Meng, Chuanmin;Yuan, Xiaoli. And the article was included in Journal of Hazardous Materials in 2009.Recommanded Product: 3034-41-1 This article mentions the following:

The insensitive explosive candidates, nitroimidazoles, polynitroimidazoles and their Me derivatives, are studied using d. functional theory (DFT). The homolytic bond dissociation energies (BDEs) corresponding to -NO₂ group removal from C or N site on imidazole ring were calculated at B3P86/6-311G** level, and the weakest bond has been determined A correlation is developed between impact sensitivity h₅₀ and the ratio (BDE/E) of the weakest bond BDE to the total energy E, and we extrapolate this relation to predict the impact sensitivities for compounds where experiments are not available. It is found that most of the title compounds are insensitive towards impact stimuli with their h₅₀ >60.0 cm. Heats of formation (HOFs) for the 21 title compounds at 298 K in gas are also determined both at B3LYP/6-311G** and B3P86/6-311G** levels using isodesmic work reactions. The calculated BDEs and HOFs consistently indicate that C-nitro-substituted imidazole is more stable than the corresponding N-substituted one, and the introduction of Me on C increases the stability whereas the Me attached to N atom decreases the stability. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effectively catalytic hydrolysis of cellulose to glucose in the presence of pyrrolidonium-based acidic ionic liquids was written by Feng, Jianping;Liu, Min;Jia, Songyan;Gong, Yanyan;Song, Chunshan;Guo, Xinwen. And the article was included in Shiyou Xuebao, Shiyou Jiagong in 2012.Name: 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

A series of acidic ionic liquids (methylimidazolium-based acidic ionic liquids and pyrrolidonium-based acidic ionic liquids) were synthesized and characterized. The cellulose hydrolysis into glucose, in which ionic liquid 1-butyl-3-methylimidazolium ([Bmim]Cl) was used as the solvent, in the presence of the synthesized acidic ionic liquids was studied systematically. The influences of water content, procedure of adding water, kinds of catalyst, catalyst dosage, reaction temperature and reaction time on the conversion of cellulose and yield of glucose were investigated. It was shown that pyrrolidonium-based acidic ionic liquids were better in catalyzing the hydrolysis of cellulose into glucose than methylimidazolium-based acidic ionic liquids Under the optimized reaction conditions, which were the reaction temperature of 110掳C, n(catalyst): (glucose unit in cellulose): n(H₂O) = 1:3:210, [Hnmp]CH₃SO₃ as catalyst, with the water addition of once per 10 min in 40 min, and the reaction time of 2 h, the glucose yield of cellulose hydrolysis was 68%. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Name: 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synergy of ionic liquid and confinement in the design of supported palladium catalyst for efficient selective hydrogenation of acetylene was written by Wang, Qingtao;Xu, Yiqi;Zhou, Jing;Xu, Longyu;Yu, Lu;Jiang, Dahao;Lu, Chunshan;Pan, Zhiyan;Zhang, Qunfeng;Li, Xiaonian. And the article was included in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2021.Related Products of 79917-89-8 This article mentions the following:

We present here a novel fabrication of highly effective supported Pd catalysts (Pd@S-1@IL) derived from Pd@S-1 core-shell material coated with ionic liquids (ILs), [Prmim][Cl], for the selective hydrogenation of acetylene. Catalytic testing on Pd@S-1@IL catalyst illustrated a remarkable selectivity towards semi-hydrogenation (over 90% for ethylene, irresp. of conversion level). Moreover, no indications of deactivation were observed after 800 h on stream even under relatively severe conditions. Detailed characterization indicated that the selectivity enhancement was ascribed to the filter effect along with electronic effect on the adsorption/desorption processes arising from the ionic liquids layer. The stability, which has ranked the top reported values over advanced Pd-based catalysts, is attributed to the confinement effect of Pd NPs within the supports thus restricting the migration of metals. The fabrication of core-shell architecture combined with the advantages of ionic liquid layer offers a promising guideline for efficient catalytic transfer of chem. resource. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Related Products of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Two-step redox systems. XV. Vinylogous bibenzimidazoles, bibenzoxazoles, and bibenzothiazoles and their aza derivatives was written by Huenig, Siegfried;Scheutzow, Dieter;Schlaf, Helmut;Schott, Albrecht. And the article was included in Justus Liebigs Annalen der Chemie in 1974.Recommanded Product: 3012-80-4 This article mentions the following:

The bibenzimidazoles and bibenzothiazoles I [Z = (CH:CH)n, n = 1-3, X = NMe or S, A- = e.g. BF4-] were prepared by two-fold ring closure of 2-HXC6H4NHMe with R1CO(CH:CH)nCOR1 (R1 = Cl or Me2CHCH2OCO2). Similarly prepared were I [X = S, Z = CH2(CH:CH)nCH2, n = 0-2]. I (X = O, Z = CH2CH2) was obtained by quaternization of the base. I (X = NMe, O, or S; Z = CH:NN:CH) were prepared by reaction of the heterocyclic aldehydes or the corresponding nitrones with N2H4 followed by quaternization. Coupling the hydrazono compounds II with glyoxal gave the tetraaza analogs III. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Recommanded Product: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Amphiphilic multi-charged cyclodextrins and vitamin K co-assembly as a synergistic coagulant was written by Li, Pei-yu;Chen, Yong;Chen, Chang-hui;Liu, Yu. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Computed Properties of C11H20N2 This article mentions the following:

Balancing and neutralizing heparin dosing after surgeries and hemodialysis treatment is of great importance in medical and clin. fields. In this study, a series of new amphiphilic multi-charged cyclodextrins (AMCD)s as anti-heparin coagulants were designed and synthesized. The AMCD assembly was capable of selective heparin binding through multivalent bonding and showed a better neutralizing effect towards both unfractionated heparin and low mol. weight heparin than protamine in plasma. Meanwhile, an AMCD and vitamin K (VK) co-assembly was prepared to realize heparin-responsive VK release and provide a novel VK deficiency treatment for hemodialysis patients. This AMCD-VK co-assembly for heparin neutralization & vitamin K supplementation synergistic coagulation represents a promising candidate as a clin. anti-heparin coagulant. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Computed Properties of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem