Tag: 100-200

Azobenzene-Based Organic Salts with Ionic Liquid and Liquid Crystalline Properties was written by Stappert, Kathrin;Muthmann, Johanna;Spielberg, Eike T.;Mudring, Anja-Verena. And the article was included in Crystal Growth & Design in 2015.Related Products of 21252-69-7 This article mentions the following:

Two sets of new azobenzene-based bromide salts are synthesized, and their thermal photochromic properties are studied. Both sets are based on the imidazolium cation. The first set (1) features a sym. biscation where two imidazolium head groups (Im) with different alkyl chains (Cn) are connected to a central azobenzene unit (Azo): [Azo(C1-Im-Cn)₂]; n = 6, 8, 10, 12, 14. The other one contains an n-alkyl-imidazolium cation (Cn-Im) bearing a terminal azobenzene unit (C1-Azo) substituted with an alkoxy chain (O-Cm) of either two (2) or six (3) carbon atoms: [C1-Azo-O-Cm-Im-Cn]; m = 2, n = 8, 10, 12 and m = 6, n = 8, 10, 12, 14, 16. For both cation classes, the influence of alkyl chains of varying length on the thermal phase behavior was investigated by differential scanning calorimetry (DSC) and polarizing optical microscopy (POM). For five compounds (Azo(-C1-Im-C12)₂ (1d), Azo(-C1-Im-C12)₂ (1e), C1-Azo-O-C2-Im-C10 (2b), C1-Azo-O-C2-Im-C12 (2c), and C1-Azo-O-C6-Im-C16 (3e)), the formation of a liquid crystalline phase was observed The biscationic salts (1) are all comparatively high melting organic salts (180-240 °C), and only the two representatives with long alkylchains (C12 and C14) exhibit liquid crystallinity. The monocationic salts with an O-C2 bridge (2) melt between 140 and 170 °C depending on the alkyl chain length, but from an alkyl chain of 10 and more carbon atoms on they form a smectic A liquid crystalline phase. The representatives of the third set with a O-C6 bridge qualify as ionic liquids with m.ps. less than 100 °C. However, only the representative with a hexadecyl chain forms a liquid crystalline phase. Representative single crystals for all sets of cations could be grown that allowed for single crystal structure anal. Together with small-angle X-ray scattering experiments they allow for a more detailed understanding of the thermal properties. Through irradiation with UV-light (320-366 nm) all compounds undergo trans-cis isomerization, which reverses under visible light (440 nm). In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Related Products of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Related Products of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gemini imidazolium salts comprising Cl^–, BF^–₄, PF^–₆, AuCl^–₄ counterions: synthesis, thermotropic liquid crystal study and use of AuCl^–₄ salt precursor to AuNPs was written by Huang, Roy T. W.;Rondla, Rohini;Wang, Wen-Jwu;Lin, Ivan J. B.. And the article was included in Journal of Molecular Liquids in 2017.Application In Synthesis of 1-Octyl-1H-imidazole This article mentions the following:

The synthesis and thermotropic liquid crystal (LC) properties of gemini imidazolium salts comprising Cl^–, BF^–₄, PF^–₆, AuCl^–₄ counter anions, varied alkenyl spacer lengths and terminal alkyl chains are described. LC properties are investigated by differential scanning calorimetry, polarizing optical microscopy, and powder X-ray diffraction studies. It should be noted that, salts of short spacers favor the formation of mesophase. A SmA with wide mesophase range and high thermal stability are identified. The Cl^– salts have shown an odd-even effect on phase transition temperatures as the length and parity of the spacer is varied. The use of [(CH₂)₄(C₁₈-Im)₂][AuCl₄]₂ salt as precursor for the fabrication of Au nano/micro particles via chem. reduction, photo irradiation, and thermolysis methods is presented. A clear vision of morphol. change is observed in Au structures by varying the reduction method, however the mesophase does not control over the size and morphol. of Au particles in the thermolysis method. The colloidal AuNPs prepared in this study showed remarkable stability for over six months. These results offer great insight into the counter anion and spacer effects on LC nature of gemini Im salts, which broadens the scientific understanding to develop advanced soft materials. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application In Synthesis of 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application In Synthesis of 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of 2,3-dichloropropionitrile from chlorination of acrylonitrile catalyzed by ionic liquids was written by Li, Xuehui;Zheng, Binguo;Zhao, Jinggan. And the article was included in Cuihua Xuebao in 2006.Safety of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Ionic liquids formed by imidazolium and pyridinium cations with Cl^–, Br^–, BF^–₄, and PF^–₆ anions were used for the catalytic synthesis of 2,3-dichloropropionitrile by the chlorination of acrylonitrile. The ionic liquids containing Cl^– and Br^– show good catalytic properties. The Cl^– and Br^– ions act as strong Lewis bases and mol. chlorine is activated by the induction effect of Cl^– and Br^–. Due to the stronger steric hindrance effect of the BF^–₄ and PF^–₆ anions, the chlorination of acrylonitrile is limited in the ionic liquids containing BF^–₄ and PF^–₆ anions. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Safety of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Photoinduced Heterogeneous C-H Arylation by a Reusable Hybrid Copper Catalyst was written by Choi, Isaac;Mueller, Valentin;Lole, Gaurav;Koehler, Robert;Karius, Volker;Vioel, Wolfgang;Jooss, Christian;Ackermann, Lutz. And the article was included in Chemistry – A European Journal in 2020.Application of 1632-83-3 This article mentions the following:

Heterogeneous copper catalysis enabled photoinduced C-H arylations of heteroarenes with aryl halides under exceedingly mild conditions at room temperature to afford aryl heteroarenes such as I [R = H, 6-OMe, 5-Cl, etc.; Ar = Ph, 4-MeC₆H₄, 2-MeOC₆H₄, etc.; X = O, S, NMe]. The hybrid copper catalyst could be reused without significant loss of catalytic efficacy. Detailed studies in terms of TEM, HRTEM and XPS anal. of the hybrid copper catalyst, among others, supported its outstanding stability and reusability. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Combination effect of ligands and ionic liquid components on the structure and properties of manganese metal-organic frameworks was written by Wei, Zhen;Zhang, Zong-Hui;Wang, Meng-Meng;Xu, Ling;Liu, Bing;Jiao, Huan. And the article was included in CrystEngComm in 2017.HPLC of Formula: 79917-89-8 This article mentions the following:

Ionothermal reactions of 1,4-benzenedicarboxylic acid (H₂BDC) and 4,4′-biphenyldicarboxylic (H₂BPDC) with Mn(OAc)₂ resulted in 12 compounds divided into four kinds of structural models: [RMI]₂[Mn₃(BDC)₃X₂] (1–5, type A), [EMI]₂[Mn₃(BPDC)₄] (6, type B), [RMI]₂[Mn₂(BPDC)₃(H₂O)₃] (7–9, type C) and [RMI]₆[Mn₉(BPDC)₉(HBPDC)₂(OAc)₄] (10–12, type D). A combination effect of ligands and IL components can be observed in the structural construction, which also is reflected in the properties of thermal stability and fluorescence. The decomposition temperatures of Mn-BDC compounds are higher than those of Mn-BPDC compounds The decomposition temperatures decrease with the alkyl chain in [RMI]⁺, due to a +I inductive effect. The maximum emissions of compounds 1–5 and 6–12 located at ∼410 or 407 nm are assigned to ILCT of H₂BDC and H₂BPDC ligands, resp. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8HPLC of Formula: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Azo dyes derived from 2-methylbenzimidazole was written by Le Bris, M. Th.;Wahl, H.. And the article was included in Rev. textile-tiba in 1958.SDS of cas: 3012-80-4 This article mentions the following:

Methylation of 2-methyl-5(6)-nitrobenzimidazole gives a mixture containing 53% 1,2-dimethyl-6-nitrobenzimidazole (I), m. 250°, and 47% 1,2-dimethyl-5-nitrobenzimidazole (II), m. 227°. In neutral medium, 58% I is formed. I and II are separated by crystallization from alc. and form a eutectic, m. 198°, at 42% II. Nitration of 1,2-dimethylbenzimidazole gives a mixture of 63% I and 37% II. Methylation of I or II with Me₂SO₄ gives the 1,2,3-trimethyl-5(6)-nitrobenzimidazolium salt (III), m. 198°, very soluble in H₂O; carbinol, m. 176°. Coupling of III with p-O₂NC₆H₄N₂Cl in aqueous pyridine or with p-O₂NC₆H₄NHNO in buffered medium gives a dark green powder, which is not 4-O₂NC₆H₄.N:C(CH₂N₂C₆H₄NO₂-p).NMe (IV), as assumed by Poraǐ-Koshits and Muravich (C.A. 48, 11399e), but a diazo dye 3(4)-O₂NC₆H₄.NMe.C[:C(N₂C₆H₄NO₂-p)₂].NMe. To prepare IV, I or II is oxidized with SeO₂ in PhMe at 95°, the PhMe removed by steam distillation, and the crude aldehyde (V) treated with p-O₂NC₆H₄NHNH₂ to yield yellow needles of IV (from aqueous pyridine). V and PhNHNH₂ give orange red needles of the phenylhydrazone. III and ONC₆H₄NMe₂ in the presence of piperidine give the corresponding azomethine, dark green tablets (from alc.); hydrolysis with dilute HCl and reaction with PhNHNH₂ gives phenylazo-2-methylene-5(6)-nitro-1,3-dimethylbenzimidazoline, violet black rodlets (from aqueous pyridine); hydrochloride, orange red needles (from dilute HCl). Similarly prepared is p-nitrophenylazo-2-methylene-5(6)-nitro-1,3-benzimidazoline, dark red; hydrochloride, needles (from aqueous HCl or AcOH-HCl). In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4SDS of cas: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.SDS of cas: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

NMR Characterization of Hydrate and Aldehyde Forms of Imidazole-2-carboxaldehyde and Derivatives was written by Lazaro Martinez, Juan Manuel;Romasanta, Pablo Nicolas;Chattah, Ana Karina;Buldain, Graciela Yolanda. And the article was included in Journal of Organic Chemistry in 2010.HPLC of Formula: 22600-77-7 This article mentions the following:

The existence and stability of the aldehyde-hydrate form of imidazole-2-carboxaldehyde (4) were studied using FTIR together with solution- and solid-state NMR experiments The results allowed us to conclude that the hydrate form was stable and precipitated at pH = 8.0 and that the aldehyde form was isolated at pH = 6.5 and 9.5. Moreover, the presence of the aldehyde-hydrate form was studied through NMR experiments in D₂O at both alk. and acidic pH. In addition, the tautomeric forms of the 2-substituted imidazole compounds were also analyzed to investigate the influence of the hybridization on the carbon adjacent to the imidazole ring, by ¹³C NMR in DMSO-d₆, acetone-d₆, and CDCl₃. The presence of the syn- and anti-isomers of oxime 8 obtained from 4 were characterized by solid-state NMR and variable-temperature NMR experiments in acetone-d₆. In the experiment, the researchers used many compounds, for example, (1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7HPLC of Formula: 22600-77-7).

(1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 22600-77-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pharmacophore modeling and 3D-QSAR studies on substituted benzothiazole/benzimidazole analogues as DHFR inhibitors with antimycobacterial activity was written by Priyadarsini, R.;Tharani, C. B.;Suganya, Sathya;Kavitha, S.. And the article was included in International Journal of Pharma Sciences and Research in 2012.Safety of 7-Methyl-1H-benzo[d]imidazole This article mentions the following:

The resurgence of tuberculosis and the emergence of multidrug-resistant strains of Mycobacteria drugs has propelled the development of new structural classes of antitubercular agents. The present study was undertaken to investigate the opportunities which the enzyme dihydrofolate reductase, a promising drug target for treatment of Mycobacterial infections offers for the development of new TB drugs. Pharmacophore models were established by using the HipHop and HypoGen algorithms implemented in the Catalyst software package. The best quant. pharmacophore model, consisted of two hydrogen bond acceptor, a hydrophobic aliphatic and a ring aromatic feature which has the highest correlation coefficient (0.93), as well as enrichment factor of 1.75 and Goodness of hit score of 0.73. Based on the pharmacophore model some leads were optimized and some of its derivatives were synthesized and analyzed by following QSAR studies. About 25 compounds of substituted benzothiazole/benzimidazole derivatives were synthesized as potent DHFR inhibitors and screened for antimycobacterial activity. To further explore the structure-activity relationships of all newly synthesized compounds, 3D-QSAR analyses were developed. MFA studies were performed with the QSAR module of Cerius2 using genetic partial least squares (G/PLS) algorithm. The predictive ability of the developed model was assessed using a training set of 25 and a test set of 5 compounds (r2pred = 0.924). The analyzed MFA model demonstrated a good fit, having r2 value of 0.868 and cross validated coefficient r2cv value of 0.771. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Safety of 7-Methyl-1H-benzo[d]imidazole).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of 7-Methyl-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and biological activity of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo- and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and their reduction products was written by Anisimova, V. A.;Tolpygin, I. E.;Spasov, A. A.;Kosolapov, V. A.;Stepanov, A. V.;Kucheryavenko, A. F.. And the article was included in Pharmaceutical Chemistry Journal in 2006.Recommanded Product: 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole This article mentions the following:

A series of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo- and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and products of their reduction has been synthesized and their pharmacol. properties have been studied. Most of the synthesized substances possess weak antioxidant activity. At the same time, they exhibit pronounced antiaggregant and hemorheol. properties, possess spasmolytic activity, and influence the blood glucose level. In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Recommanded Product: 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of 1-Methyl-1H-imidazole Derivatives as Potent Jak2 Inhibitors was written by Su, Qibin;Ioannidis, Stephanos;Chuaqui, Claudio;Almeida, Lynsie;Alimzhanov, Marat;Bebernitz, Geraldine;Bell, Kirsten;Block, Michael;Howard, Tina;Huang, Shan;Huszar, Dennis;Read, Jon A.;Rivard Costa, Caroline;Shi, Jie;Su, Mei;Ye, Minwei;Zinda, Michael. And the article was included in Journal of Medicinal Chemistry in 2014.Formula: C4H5N3O2 This article mentions the following:

Structure based design, synthesis, and biol. evaluation of a novel series of 1-methyl-1H-imidazole, as potent Jak2 inhibitors to modulate the Jak/STAT pathway, are described. Using the C-ring fragment from our first clin. candidate AZD1480 (I), optimization of the series led to the discovery of compound II, a potent, orally bioavailable Jak2 inhibitor. Compound II displayed a high level of cellular activity in hematopoietic cell lines harboring the V617F mutation and in murine BaF3 TEL-Jak2 cells. Compound II demonstrated significant tumor growth inhibition in a UKE-1 xenograft model within a well-tolerated dose range. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Formula: C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem