100-200 Archives - Page 65 of 160 - Imidazoles-derivatives

Choi, Jin Seok et al. published their research in Tetrahedron in 2005 | CAS: 109012-23-9

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 109012-23-9

Orthogonality and compatibility between Tsc and Fmoc amino-protecting groups was written by Choi, Jin Seok;Kang, Hunhui;Jeong, Nakcheol;Han, Hogyu. And the article was included in Tetrahedron in 2005.Reference of 109012-23-9 This article mentions the following:

New deprotection conditions that provide a complete orthogonality between Tsc [2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl] and Fmoc amino-protecting groups are described. The potential of these orthogonal deprotection conditions was then demonstrated by the efficient solid-phase synthesis of branched peptides I (n = 0 or 3) using doubly protected amino acids such as Tsc-Lys(Fmoc)-OH and Fmoc-Lys(Tsc)-OH. In the experiment, the researchers used many compounds, for example, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9Reference of 109012-23-9).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rosenkranz, Herbert S. et al. published their research in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1991 | CAS: 3034-41-1

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 3034-41-1

A re-examination of the genotoxicity and carcinogenicity of azathioprine. Comments was written by Rosenkranz, Herbert S.;Klopman, Gilles. And the article was included in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1991.Product Details of 3034-41-1 This article mentions the following:

CASE, a novel artificial intelligence structure-activity relational method of anal., was used to study the structural basis of carcinogenicity of azathioprine. The criteria that were analyzed predicted azathioprine to be a genotoxic carcinogen. In addition, 6-mercaptopurine and 1-methyl-4-nitroimidazole, both moieties of azathioprine, were predicted to have mutagenic potential. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Product Details of 3034-41-1).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mezzetta, Andrea et al. published their research in Molecules in 2021 | CAS: 1632-83-3

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Electric Literature of C8H8N2

Expanding the Chemical Space of Benzimidazole Dicationic Ionic Liquids was written by Mezzetta, Andrea;Guglielmero, Luca;Mero, Angelica;Tofani, Giorgio;D’Andrea, Felicia;Pomelli, Christian Silvio;Guazzelli, Lorenzo. And the article was included in Molecules in 2021.Electric Literature of C8H8N2 This article mentions the following:

Benzimidazole dicationic ionic liquids (BDILs) have not yet been widely explored in spite of their potential. Therefore, two structurally related families of BDILs, paired with either bromide or bistriflimide anions and bearing alkyl spacers ranging from C3 to C6, have been prepared Their thermal properties have been studied by thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC), while their elec. properties have been assessed by cyclic voltammetry (CV). TG anal. confirmed the higher stability of the bistriflimide BDILs over the bromide BDILs, with minor variation within the two families. Conversely, DSC and CV allowed for ascertaining the role played by the spacer length. In particular, the thermal behavior changed dramatically among the members of the bistriflimide family, and all three possible thermal behavior types of ILs were observed Furthermore, cyclic voltammetry showed different electrochem. window (C₃(C₁BenzIm)₂/2Tf₂N < C₄(C₁BenzIm)₂/2Tf₂N, C₅(C₁BenzIm)₂/2Tf₂N < C₆(C₁BenzIm)₂/2Tf₂N) as well as a reduction peak potential, shape, and intensity as a function of the spacer length. The results obtained highlight the benefit of accessing a more structurally diverse pool of compounds offered by dicationic ILs when compared to the parent monocationic ILs. In particular, gains are to be found in the ease of fine-tuning their properties, which translates in facilitating further investigations toward BDILs as designer solvents and catalysts. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hummel, Michael et al. published their research in Green Chemistry in 2011 | CAS: 79917-89-8

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Name: 1-Methyl-3-propylimidazolium Chloride

Dimethyl phosphorothioate and phosphoroselenoate ionic liquids as solvent media for cellulosic materials was written by Hummel, Michael;Froschauer, Carmen;Laus, Gerhard;Roeder, Thomas;Kopacka, Holger;Hauru, Lauri K. J.;Weber, Hedda K.;Sixta, Herbert;Schottenberger, Herwig. And the article was included in Green Chemistry in 2011.Name: 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

A series of novel ionic liquids comprising two asym. phosphate-derived anions, namely di-Me phosphorothioate and di-Me phosphoroselenoate, and several imidazolium and non-imidazolium-based cations was prepared via a facile synthetic route. Thermal degradation was studied by dynamic thermogravimetric anal. (TGA) revealing a slightly higher stability of the imidazolium ionic liquids and an overall low thermal stability for the phosphoroselenoate salts. Long-term moisture sorption anal. showed correlation with the polarity of the cation and differences in absorption and desorption kinetics. Finally, a Eucalyptus globulus kraft paper grade pulp was dissolved and subsequently regenerated to assess the degradation of the various mol. weight fractions by size exclusion chromatog. In addition, pre-extracted xylan was subjected to the same dissolution procedure to examine the degradation of low-mol. weight components in more detail. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Name: 1-Methyl-3-propylimidazolium Chloride).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Li, Xiaoqian et al. published their research in Green Chemistry in 2019 | CAS: 79917-89-8

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 1-Methyl-3-propylimidazolium Chloride

A facile ionic liquid approach to prepare cellulose-rich aerogels directly from corn stalks was written by Li, Xiaoqian;Lu, Xingmei;Yang, Jiming;Ju, Zhaoyang;Kang, Ying;Xu, Junli;Zhang, Suojiang. And the article was included in Green Chemistry in 2019.Name: 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Aerogels derived from corn stalks are promising materials for wide use, due to their biodegradability and biocompatibility. However, preparation of cellulose-rich aerogels directly from corn stalks is a tedious and complicated process. In this study, generation of cellulose-rich aerogels was achieved by a facile approach relying on an ionic liquid and amido-sulfonic acid used as solvents. By this method, cellulose-rich aerogels were directly obtained from corn stalks through a process whereby lignin was separated from the other components of the corn stalks in one step, an approach simplifying the traditional fabrication processes. The composition, morphol. and thermal stability of the obtained aerogels were investigated as they were related to the ionic liquid solvent systems used. Furthermore, the dye adsorption mechanism of cellulose-rich aerogels was simulated. In the most favorable case, the obtained aerogel was free of lignin and had the cellulose content as high as 88.1%. In addition, the aerogel possessed a porous three-dimensional structure with a high specific area (201 m² g^-1) and good thermal stability. Owing to its excellent properties, this cellulose-rich porous aerogel is expected to have a potential use in dye adsorption and other fields. This aerogel displayed an absorption capacity of 549 mg g^-1 for Congo red and 302 mg g^-1 for Coomassie brilliant blue. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Name: 1-Methyl-3-propylimidazolium Chloride).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

de Pedro, I. et al. published their research in Crystal Growth & Design in 2015 | CAS: 92507-97-6

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Computed Properties of C7H13ClN2

On the Colossal and Highly Anisotropic Thermal Expansion Exhibited by Imidazolium Salts was written by de Pedro, I.;Garcia-Saiz, A.;Dupont, J.;Migowski, P.;Vallcorba, O.;Junquera, J.;Rius, J.;Rodriguez Fernandez, J.. And the article was included in Crystal Growth & Design in 2015.Computed Properties of C7H13ClN2 This article mentions the following:

The imidazolium salts 1-ethyl-2,3-dimethylimidazolium chloride, Edimim[Cl], and bromide, Edimim[Br], exhibit neg. and pos. thermal expansions, as determined by variable-temperature synchrotron powder x-ray diffraction experiments Both compounds crystallize in the same monoclinic centrosym. space group, showing an anisotropic H-bonding network and imidazolium-imidazolium π⁺-π⁺ interactions, which were corroborated by d. functional theory studies. The chloride derivative displays a highly anisotropic thermal expansion with a colossal pos. coefficient along one direction. Replacement of Cl^– by Br^– in the same crystal structure produces an increase of the colossal coefficient and induces a biaxial neg. thermal expansion. By studying the mol. vibration factors and the H-bonding framework in their crystals as a function of temperature, it was possible to rationalize at the mol. level the mechanism for the observed anomalies in thermal expansion. Crystallog. data and at. coordinates are given. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Computed Properties of C7H13ClN2).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wei, Huiqiang et al. published their research in Molecules in 2016 | CAS: 22813-32-7

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Quality Control of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid

Design and synthesis of vandetanib derivatives containing nitroimidazole groups as tyrosine kinase inhibitors in normoxia and hypoxia was written by Wei, Huiqiang;Li, Deguan;Yang, Xiangbo;Shang, Haihua;Fan, Saijun;Li, Yiliang;Song, Dan. And the article was included in Molecules in 2016.Quality Control of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid This article mentions the following:

Sixteen novel epidermal growth factor receptor (EGFR)/vascular endothelial growth factor (VEGF)-2 inhibitors (nitroimidazole-substituted 4-anilinoquinazoline derivatives) I (R¹ = H, CH₃, NO₂; R² = H, NO₂; X¹ = H, F, Cl; X² = H, F, Br, Cl; X³ = H, Br, F, Me, Cl; n = 1, 2, 3) were designed and prepared via the introduction of a nitroimidazole group in the piperidine side chain and modification on the aniline moiety of vandetanib. Preliminary biol. tests showed that comparing with vandetanib, some target compounds exhibited excellent EGFR inhibitory activities and anti-proliferative over A549/H446 cells in hypoxia. Meanwhile, several of the above compounds demonstrated better bioactivity than vandetanib in VEGF gene expression inhibition. Owing to the excellent IC₅₀ value (1.64 μmol/L), the inhibition ratios of compound I (R¹ = H; R² = NO₂; X¹ = F; X² = H; X³ = Br; n = 1) over A549 and H446 cells were 62.01% and 59.86% at the concentration of 0.5 μM in hypoxia, resp. All of these results indicated that compound I (R¹ = H; R² = NO₂; X¹ = F; X² = H; X³ = Br; n = 1) was a potential cancer therapeutic agent in hypoxia and was worthy of further development. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Quality Control of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Stepnowski, Piotr et al. published their research in Journal of Chromatography, A in 2003 | CAS: 79917-89-8

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C7H13ClN2

Reversed-phase liquid chromatographic method for the determination of selected room-temperature ionic liquid cations was written by Stepnowski, Piotr;Muller, Anja;Behrend, Peter;Ranke, Johannes;Hoffmann, Jens;Jastorff, Bernd. And the article was included in Journal of Chromatography, A in 2003.Computed Properties of C7H13ClN2 This article mentions the following:

The separation of selected 1-alkyl- and 1-aryl-3-methylimidazolium-based room temperature ionic liquid cations has been performed using reversed-phase high-performance liquid chromatog. with electrospray ionization mass detection. The RP-HPLC method development started with the selection of a column taking into account especially the resolution of low mol. congeners of the selected group. Mobile phase composition was optimized for peak resolution, sensitivity and high reproducibility of retention values. The results of the method development were applied to the determination of exemplary ionic liquid species present in the medium used in cytotoxicity studies. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Computed Properties of C7H13ClN2).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Jian-Fei et al. published their research in Organic Letters in 2020 | CAS: 85692-37-1

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone

Organocatalytic Enantioselective Conjugate Alkynylation of β-Aminoenones: Access to Chiral β-Alkynyl-β-Amino Carbonyl Derivatives was written by Wang, Jian-Fei;Meng, Xin;Zhang, Chao-Huan;Yu, Chuan-Ming;Mao, Bin. And the article was included in Organic Letters in 2020.Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:

Readily available potassium alkynyltrifluoroborates were used for organocatalytic asym. conjugate alkynylation of β-enaminones. The interception of a modified binaphthol catalyst and in situ generated organodifluoroboranes proved important to access functionalized β-alkynyl-β-amino carbonyls and derivatives with improved chemo-reactivity and enantio-induction. Mechanistic studies revealed the impact of mol. sieves on efficiency and stereocontrol. The products undergo addnl. functionalization to yield a diverse set of valuable β-alkynyl-β-amino carbonyl scaffolds. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sun, Jiahan et al. published their research in RSC Advances in 2015 | CAS: 21252-69-7

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Product Details of 21252-69-7

Synthesis of methylal from methanol and formaldehyde catalyzed by Bronsted acid ionic liquids with different alkyl groups was written by Sun, Jiahan;Li, Hansheng;Song, Haoran;Wu, Qin;Zhao, Yun;Jiao, Qingze. And the article was included in RSC Advances in 2015.Product Details of 21252-69-7 This article mentions the following:

The catalytic reaction of methanol with formaldehyde for the preparation of methylal was investigated in various Bronsted acid ionic liquids with different carbon chain length of alkyl groups. The structures, acidities and properties of ionic liquids were exptl. characterized and theor. analyzed. The Bronsted acidity-viscosity-activity correlation for the ionic liquids was studied. Among all these ionic liquids, [C₆ImBS][HSO₄] exhibited the best catalytic performance, which was ascribed to its strong Bronsted acidity and low viscosity. The catalytic activity of the ionic liquid was near that of concentrated sulfuric acid. The influences of ionic liquid dosage, reaction temperature and molar ratio of methanol to formaldehyde were explored using [C₆ImBS]HSO₄ as the catalyst. Under the optimal conditions of n(methanol) : n(formaldehyde) : n(ILs) = 2.5 : 1 : 0.0258, 60 °C, and 4 h, the conversion of formaldehyde can reach 63.37%. The ionic liquid [C₆ImBS]HSO₄ could be reused. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Product Details of 21252-69-7).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem