Tag: 100-200

Synthesis and pharmacological activity of amides of 2,3-dihydroimidazo- and 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazolyl-N-acetic acids was written by Anisimova, V. A.;Spasov, A. A.;Kosolapov, V. A.;Tolpygin, I. E.;Tibir’kova, E. V.;Salaznikova, O. A.;Kuznetsova, V. A.;Gurova, N. A.;Lenskaya, K. V.;Yakovlev, D. S.;Mal’tsev, D. V.;Kolobrodova, N. A.;Mitina, T. M.;Grechko, O. Yu.. And the article was included in Pharmaceutical Chemistry Journal in 2013.Category: imidazoles-derivatives This article mentions the following:

A series of amides of 2,3-dihydroimidazo- and 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazolyl-N-acetic acids were synthesized. Their pharmacol. activity was studied. It was established that the synthesized substances possessed antiaggregant properties and antiarrhythmic activity. Some of these amides exhibited antioxidant and hypoglycemic effects in addition to antagonist activity with respect to serotonin 5-HT₂ and purine P2Y₁ receptors. In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Category: imidazoles-derivatives).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline was written by Casagrande, Manolo;Barteselli, Anna;Basilico, Nicoletta;Parapini, Silvia;Taramelli, Donatella;Sparatore, Anna. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Application of 22600-77-7 This article mentions the following:

With the aim to investigate the effect of different heterocyclic rings linked to the 4-aminoquinoline nucleus on the antimalarial activity, a set of 7-chloro-4-(heteroarylmethylamino)quinoline and 7-chloro-4-(heteroarylamino)quinoline derivatives was synthesized and tested in vitro against D-10 (CQ-S) and W-2 (CQ-R) strains of Plasmodium falciparum. All compounds exhibited from moderate to high antiplasmodial activities. The activity was strongly influenced both by the presence of a methylenic group, as a spacer between the 4-aminoquinoline and the heterocyclic ring, and by the presence of a basic head. The most potent mols. inhibited the growth of both CQ-S and CQ-R strains of P. falciparum with IC₅₀ < 30 nM and were not toxic against human endothelial cells. These results confirm that the presence of an heteroaryl moiety in the side chain of 7-chloro-4-aminoquinoline is useful for the design and development of new powerful antimalarial agents. In the experiment, the researchers used many compounds, for example, (1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7Application of 22600-77-7).

(1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application of 22600-77-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Versatile and Scalable Method for Producing N-Functionalized Imidazoles was written by Bara, Jason E.. And the article was included in Industrial & Engineering Chemistry Research in 2011.Reference of 21252-69-7 This article mentions the following:

A method for producing sodium imidazolate (NaIm) at a scale of ∼400 g from only commodity starting materials has been developed. The NaIm product was then utilized as a starting material to produce 20 different N-functionalized imidazole and bis(imidazole) compounds, with the application of a common procedure involving minimal solvent volumes and straightforward purification via flash chromatog. and solvent evaporation Generating N-functionalized imidazoles “on demand” from NaIm and alkyl halides (or similar compounds) can eliminate the need for hazardous starting materials such as NaH and anhydrous solvents that have typically been employed in their synthesis. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Acylation of benzimidazole by the Regel-Buechel method. 2. Deacylation and dissociation of 1-methyl-3-acyl-2-(1-methyl-2-benzimidazolyl)benzimidazolin-4-ones was written by Khristich, B. I.;Bondarenko, E. V.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1987.Application of 3012-80-4 This article mentions the following:

1-Methyl-3-acyl-2-(1-methylbenzimidazol-2-yl)-2-benzimidazolines with an excess of acyl halide are transformed to unstable 1-methyl-3-acyl-2-(1-methyl-3-acyl-2-benzimidazolin-2-yl)benzimidazolium chlorides, which undergo intramol. oxidation-reduction-decomposition to give 1,1′-dimethyl-2,2′-bibenzimidazolyl and aldehyde, and dissociates at the C-C bond connecting the benzimidazole and benzimidazoline fragments to a carbene-ylide and 1-methyl-3-acylbenzimidazolium chloride. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Application of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Understanding Cellulose Dissolution: Energetics of Interactions of Ionic Liquids and Cellobiose Revealed by Solution Microcalorimetry was written by Nunes de Oliveira, Heitor Fernando;Rinaldi, Roberto. And the article was included in ChemSusChem in 2015.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

In this report, the interactions between fifteen selected ionic liquids (ILs) and cellobiose (CB) were examined by high-precision solution microcalorimetry. The heat of mixing (Δ_mixH) of CB and ILs, or CB and IL/mol. solvent (MS) solutions, provides the first ever-published measure of the affinity of CB with ILs. Most importantly, we found that there is a very good correlation between the nature of the results found for Δ_mixH_(CB) and the solubility behavior of cellulose. This correlation suggests that Δ_mixH_(CB) offers a good estimate of the enthalpy of dissolution of cellulose even in solvents in which cellulose is insoluble Therefore, the current findings open up new horizons for unravelling the intricacies of the thermodn. factors accounting for the spontaneity of cellulose dissolution in ILs or IL/MS solutions In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Aggregation of sodium dodecylbenzene sulfonate: Weak molecular interactions modulated by imidazolium cation of short alkyl chain length was written by Agudelo, Alvaro Javier Patino;Ferreira, Guilherme Max Dias;Ferreira, Gabriel Max Dias;Coelho, Yara Luiza;Hudson, Eliara Acipreste;Pires, Ana Clarissa dos Santos;Mendes da Silva, Luis Henrique. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2020.Electric Literature of C4H7ClN2 This article mentions the following:

Ionic liquids (ILs) can modify cooperative process in aqueous solutions to a large extent, including anionic surfactant aggregation. Here, the micellization of sodium dodecylbenzene sulfonate (SDBS) was evaluated in low concentrations of 1-alkyl-3-methylimidazolium chloride (C_nmimCl, n = 0, 2, and 4) aqueous solutions through fluorescence spectroscopy, isothermal titration calorimetry, dynamic light scattering, and conductometry. The thermodn. stability of SDBS aggregates strongly depended on the IL structure and concentration, following the order C₄mim⁺ > C₀mim⁺ ≈ C₂mim⁺. At 1.0 mmol L^-1 of the ILs, the increase of the hydrophobicity of the imidazolium cation decreased the enthalpic favorableness, changing ΔH^omic from -3.75 ± 0.07 kJ mol^-1, for C₀mim⁺, to -2.69 ± 0.01 kJ mol^-1, for C₄mim⁺. On the other hand, the entropic feasibility showed an opposite trend, i.e., the higher hydrophobicity of C₄mim⁺ overcame the kosmotropic effect of IL cations in the bulks. We suggested that the imidazolium cations interact with the SDBS monomers on the micellar surface, mainly through hydrophobic, π-π, and electrostatic interactions for C₄mim⁺ and C₂mim⁺, and through electrostatic interactions and hydrogen bonds for C₀mim⁺. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Electric Literature of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Amphiphilic Pd^II-NHC Complexes on 1,3-Alternate p-tert-Butylthiacalix[4]arene Platform: Synthesis and Catalytic Activities in Coupling and Hydrogenation Reactions was written by Burilov, Vladimir A.;Gafiatullin, Bulat Kh.;Mironova, Diana A.;Sultanova, Elza D.;Evtugyn, Vladimir G.;Osin, Yuri N.;Islamov, Daut R.;Usachev, Konstantin S.;Solovieva, Svetlana E.;Antipin, Igor S.. And the article was included in European Journal of Organic Chemistry in 2020.Electric Literature of C8H8N2 This article mentions the following:

Herein the authors report the first example of amphiphilic Pd^II-NHC complexes on the thiacalix[4]arene backbone in 1,3-alternate configuration. Relative catalytic activity of synthesized Pd^II-NHC complexes in Suzuki-Miyaura coupling of haloarenes with phenylboronic acid was studied. A combination of micellar and metallocomplex catalysis was observed in Suzuki-Miyaura coupling upon going from pure DMF to water/DMF 3:1: the 2-fold increase of conversion of 4-bromoanisole unlike pure DMF was found. Interesting feature was found using chloroarene in DMF/water: the reaction selectivity changed from heterocoupling to homo coupling of phenylboronic acid. Pd^II-NHC complexes demonstrated a high activity in model hydrogenation reaction of p-nitrophenol using sodium borohydride. The most lipophilic Pd^II-NHC complex is most active, which can be attributed with addnl. p-nitrophenol preconcentration in the aggregates due to larger hydrophobic capacity of macrocycle. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enantioselective Mukaiyama-Michael Reaction Catalyzed by a Chiral Rhodium Complex Based on Pinene-Modified Pyridine Ligands was written by Gong, Jun;Wan, Qian;Kang, Qiang. And the article was included in Chemistry – An Asian Journal in 2018.Name: 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:

The rhodium complex Λ-Rh1 containing chiral pinene-modified pyridine ligands was prepared through a two-step synthetic procedure; it exhibited excellent reactivity and enantiocontrol toward the enantioselective Mukaiyama-Michael reaction of α,β-unsaturated 2-acyl imidazoles with silyl enol ethers, affording enantioenriched 1,5-dicarbonyl compounds such as I [R = n-Bu, SEt, 4-FC₆H₄, etc.; R¹ = i-Pr, Me; R² = cyclopropyl, 2-thienyl, 4O₂NC₆H₄, etc.] in good yields (up to 99 %) with excellent enantioselectivities (up to 99 % ee). In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Name: 1-(1-Methyl-1H-imidazol-2-yl)ethanone).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 1-(1-Methyl-1H-imidazol-2-yl)ethanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

DNA-cellulose: an economical, fully recyclable and highly effective chiral biomaterial for asymmetric catalysis was written by Benedetti, Erica;Duchemin, Nicolas;Bethge, Lucas;Vonhoff, Stefan;Klussmann, Sven;Vasseur, Jean-Jacques;Cossy, Janine;Smietana, Michael;Arseniyadis, Stellios. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Category: imidazoles-derivatives This article mentions the following:

The challenge in DNA-based asym. catalysis is to perform a reaction in the vicinity of the helix by incorporating a small-mol. catalyst anchored to the DNA in a covalent, dative, or non-covalent yet stable fashion in order to ensure high levels of enantio-discrimination. Here, we report the first generation of a DNA-based catalyst bound to a cellulose matrix. The chiral biomaterial is com. available, trivial to use, fully recyclable and produces high levels of enantioselectivity in various Cu(II)-catalyzed asym. reactions including Friedel-Crafts alkylations and Michael additions A single-pass, continuous-flow process is also reported affording fast conversions and high enantioselectivities at low catalyst loadings thus offering a new benchmark in the field of DNA-based asym. catalysis. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Category: imidazoles-derivatives).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A new method for separation and determination of Cr(III) and Cr(VI) in water samples by high-performance liquid chromatography based on anion exchange stationary phase of ionic liquid modified silica was written by Sadeghi, Susan;Moghaddam, Ali Zeraatkar. And the article was included in Environmental Monitoring and Assessment in 2015.HPLC of Formula: 35487-17-3 This article mentions the following:

In this work, N-methylimidazolium-chloride ionic liquid functionalized silica was prepared and used as an anion-exchange stationary phase for separation of chromium species by high-performance liquid chromatog. (HPLC) with UV detection at 200 nm. The Cr(VI) as HCr₂O₇^– and chelated Cr(III) with potassium hydrogen phthalate (PHP) as Cr(PHP)₂^– was retained on the prepared column and separated using a mobile phase composed of 5% methanol in 25 mM phosphate buffer at pH 6.5. Several variables affecting the chelation/separation steps were modeled by response surface methodol. (RSM) using Box-Behnken (BBD) design. The significance of the independent variables and their interactions were tested by the anal. of variances (ANOVA) with 95% confidence limit. Under the optimized conditions, the Cr(III) and Cr(VI) anionic species were well separated with a single peak for each Cr species at retention times of 2.3 and 4.3 min, resp. The relationship between the peak area and concentration was linear in the range of 0.025-30 for Cr(III) and 0.5-20 mg L^-1 for Cr(VI) with detection limits of 0.010 and 0.210 mg L^-1 for Cr(III) and Cr(VI), resp. The proposed method was validated by simultaneous separation and determination of the Cr species in tap and underground water samples without impose to any pretreatment. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3HPLC of Formula: 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.HPLC of Formula: 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem