Tag: 100-200

Perfluoroalkyltricyanoborate and Perfluoroalkylcyanofluoroborate Anions: Building Blocks for Low-Viscosity Ionic Liquids was written by Landmann, Johannes;Sprenger, Jan A. P.;Hennig, Philipp T.;Bertermann, Ruediger;Gruene, Matthias;Wuerthner, Frank;Ignat’ev, Nikolai V.;Finze, Maik. And the article was included in Chemistry – A European Journal in 2018.Name: 1-ethyl-2,3-dimethylimidazolium chloride This article mentions the following:

The K perfluoroalkyltricyanoborates K[C_nF_2 n+1B(CN)₃] [n =1 (1d), 2 (2d)] and the K mono(perfluoroalkyl)cyanofluoroborates K[C_nF_2 n+1BF(CN)₂] [n =1 (1c), 2 (2c)] and [C_nF_2 n+1BF₂(CN)]^– [n =1 (1b), 2 (2b), 3 (3b), 4 (4b)] are accessible with perfect selectivities on multi-gram scales starting from K[C_nF_2 n+1BF₃] and Me₃SiCN. The K⁺ salts are starting materials for the preparation of salts with organic cations, for example, [EMIm]⁺ (EMIm=1-ethyl-3-methylimidazolium). These [EMIm]⁺ salts are hydrophobic room-temperature ionic liquids (RTILs) that are thermally, chem. and electrochem. very robust, offering electrochem. windows ≤5.8 V. The RTILs described herein, exhibit very low viscosities with a min. of 14.0 mPa s at 20° for [EMIm]1c, low m.ps. down to -57° for [EMIm]2b and extraordinary high conductivities ≤17.6 mS/cm at 20° for [EMIm]1 c. The combination of these properties makes these ILs promising materials for electrochem. devices as exemplified by the application of selected RTILs as component of electrolytes in dye-sensitized solar cells (DSSCs, Graetzel cells). The efficiency of the DSSCs was found to increase with a decreasing viscosity of the neat ionic liquid In addition to the spectroscopic characterization, single crystals of the K salts of the anions 1b-d, 2d, 3b and 4c as well as of [nBu₄N]2 c have been studied by x-ray diffraction. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Name: 1-ethyl-2,3-dimethylimidazolium chloride).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Name: 1-ethyl-2,3-dimethylimidazolium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

5-Hydroxymethylfurfural Synthesis in Nonaqueous Two-Phase Systems (NTPS)-PC-SAFT Predictions and Validation was written by Knierbein, Michael;Voges, Matthias;Held, Christoph. And the article was included in Organic Process Research & Development in 2020.COA of Formula: C4H7ClN2 This article mentions the following:

The condensation reaction of fructose to 5-hydroxymethylfurfural (HMF) is acid-catalyzed, and it suffers from thermodn. limitation of the conversion, poor kinetics as well as consecutive reactions such as formation of humins from HMF. Different approaches exist to overcome these limitations. In this work, the combination of a non-aqueous solvent and a suitable extraction system is presented that ensures high reaction selectivity at full conversion, fast kinetics, and high partition selectivity of product HMF over reactant fructose, keeping the temperature as low as 70°C. In a first step of the work, the equation of state PC-SAFT was used to predict solvent effects on the reaction equilibrium of homoge-nous reaction systems. It was found that the two hydrophilic ILs [BMIM]Cl and [MIM]Cl shifted the reaction equilibrium to the product side by factors of 230 and 40, resp., compared to the reaction in water. The predictions were verified by exptl. data, which showed full conversion of fructose to HMF within less than 20 (60) minutes for the reaction in [MIM]Cl ([BMIM]Cl) with high selectivity of up to 80%. Even more, the reaction in [MIM]Cl solvent did not require adding catalyst due to the acidic character of this IL. In a second step of this work, an in-situ extraction of HMF was performed using a non-aqueous two-phase reaction system NTPS that was designed with PC-SAFT. The NTPS contains the reaction phase (either [BMIM]Cl or [MIM]Cl) and the extraction agent, i.e. one of the ketones MEK, MIBK, or Et acetate. These IL+organic solvent NTPSs were analyzed and evaluated towards fructose conversion and partitioning of fructose and of HMF. PC-SAFT predicted that among all systems studied in this work, the NTPS IL+MEK was most promising for the reaction of fructose to HMF and the in-situ removal of HMF from fructose. Exptl. results could validate the PC-SAFT predictions; i.e., IL+MEK NTPSs allowed efficient conversion of fructose to HMF and partition selectivity of HMF over fructose of about 100%. This new NTPS does not require addnl. catalyst due to the acidity of [MIM]Cl; it allows high reaction selectivity of 87% at 20 min and 93% conversion, and it moreover provides high separation efficiency. In sum, these results open the door for further developments of in-situ extraction systems in the future for efficient and fast fructose conversion and HMF separation from the reacting phase keeping temperature as low as possible. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3COA of Formula: C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New molecular hybrids containing benzimidazole, thiazolidine-2,4-dione and 1,2,4-oxadiazole as EGFR directing cytotoxic agents was written by Venu, kudapa;Saritha, B.;Sailaja, B. B. V.. And the article was included in Tetrahedron in 2022.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

Herein, some new mol. hybrids having benzimidazole, thiazolidine-2,4-dione and 1,2,4-oxadiazole scaffolds I (Ar = Ph, 3,5-dibromophenyl, 4-pyridyl, etc.) were synthesized from the com. available 1-methyl-1H-benzo[d]imidazole-2-carbaldehyde using two key methodologies such as Knoevenagel condensation and Vilsmeier reagent mediated one-pot synthesis. Further, all the compounds in their μM concentration were screened for their in vitro cytotoxic activity against three human cancer cell lines which includes MCF-7, A-549 and HepG2. Among all, the compound I (Ar = 3,5-dicyanophenyl) exhibited superior activity against all the cell lines as compared to standard drug erlotinib. Besides, the compounds I (Ar = 4-methoxyphenyl, 3,5-dimethoxyphenyl, 4-cyanophenyl) showed superior activity against MCF-7 and most promising activity against A-549 and HepG2 when compared with the pos. control. As well, the tyrosine kinase EGFR inhibitory activity for the potent compounds I (Ar = 4-methoxyphenyl, 3,5-dimethoxyphenyl, 4-cyanophenyl, 3,5-dicyanophenyl), revealed that the compounds I (Ar = 3,5-dimethoxyphenyl, 3,5-dicyanophenyl) displayed nearly double potency as compared to the erlotinib drug. The mol. docking studies of active compounds I (Ar = 4-methoxyphenyl, 3,5-dimethoxyphenyl, 4-cyanophenyl, 3,5-dicyanophenyl) on EGFR target were also conducted and the results were found to be covenant with the corresponding IC₅₀ values. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

One-pot synthesis of ionic liquid functionalized SBA-15 mesoporous silicas was written by Liu, Yong;Peng, Jiajian;Zhai, Shangru;Yu, Ningya;Li, Meijiang;Mao, Jianjiang;Qiu, Huayu;Jiang, Jianxiong;Lai, Guoqiao. And the article was included in Studies in Surface Science and Catalysis in 2007.Product Details of 79917-89-8 This article mentions the following:

1-Methyl-3-n-propyl-imidazolium chloride (MPImCl) and N-propylpyridinium chloride (PPyCl) ionic liquid functionalized SBA-15 mesoporous materials were successfully synthesized through the co-condensation of tetraethoxysilane (TEOS) with 1-methyl-3-(triethoxysilylpropyl)imidazolium chloride (MTESPImCl) and 3-(triethoxysilylpropyl)-pyridinium chloride (TESPPyCl) using EO₂₀PO₇₀EO₂₀ (Pluronic P123) as surfactant. These organic-inorganic hybrid materials may have potential applications in heterogeneous catalysis reactions. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Product Details of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Magnetic ionic liquids based on transition metal complexes with N-alkylimidazole ligands was written by Chand, Deepak;Farooq, Muhammad Qamar;Pathak, Arjun K.;Li, Jingzhe;Smith, Emily A.;Anderson, Jared L.. And the article was included in New Journal of Chemistry in 2019.Recommanded Product: 21252-69-7 This article mentions the following:

In this study, magnetic ionic liquids (MILs) consisting of Ni(II), Co(II), and Mn(II) and paired with the bis[(trifluoromethyl)sulfonyl]imide [NTf₂^–] anion were synthesized from their water soluble chloride intermediates. The MILs feature low viscosity, high hydrophobicity, and hydrolytic stability making them attractive candidates for a number of highly interdisciplinary applications. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Recommanded Product: 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

110th Anniversary: Properties of Imidazolium-Based Ionic Liquids Bearing Both Benzylic and n-Alkyl Substituents was written by Bara, Jason E.;Finotello, Alexia;Magee, Joseph W.;Qian, Shuai;O’Harra, Kathryn E.;Dennis, Grayson P.;Noble, Richard D.. And the article was included in Industrial & Engineering Chemistry Research in 2019.Safety of 1-Octyl-1H-imidazole This article mentions the following:

Reports of imidazolium ionic liquids (ILs) with at least one benzylic substituent bound to the imidazolium cation are far less common than the ubiquitous 1-alkyl-3-methylimidazolium ILs ([C_nmim][X]). Yet, there is significant motivation to determine structure-property relationships for imidazolium-based ILs with at least one benzylic substituent. Not only are these ILs just as straightforward to synthesize as [C_nmim][X] ILs, but ILs with benzylic substituents are also representative segments of poly(ILs) and ionenes where imidazolium cations with benzylic groups are commonly found. This report focuses on the effects of benzyl and methylbenzyl substituents on the d. and viscosity of a series of imidazolium cations paired with bis[(trifluoromethyl)sulfonyl]imide (more commonly known as bistriflimide) ([Tf₂N]^–) anions. Furthermore, the solubility of CO₂ in 1-benzyl-3-methylimidazolium bistriflimide [Bnmim][Tf₂N] (CAS: 433337-24-7) was measured at 303.15, 318.15, 333.15, and 348.15 K at pressures in the range of 1-9 bar. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Safety of 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chelated Assisted Metal-Mediated N-H Bond Activation of β-Lactams: Preparation of Irida-, Rhoda-, Osma-, and Ruthenatrinems was written by Casarrubios, Luis;Esteruelas, Miguel A.;Larramona, Carmen;Muntaner, Jaime G.;Olivan, Montserrat;Onate, Enrique;Sierra, Miguel A.. And the article was included in Organometallics in 2014.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

2-Azetidinones substituted with pyridine (2a), quinoline (2b), isoquinoline (2c), imidazole (2d), and benzimidazole (2e) at the 4-position of the four-membered ring have been prepared in order to synthesize tribactams containing a transition metal and its associated ligands, L_nM, at the 2-position of the tricyclic skeleton. The developed procedure is compatible with a wide range of transition-metal starting complexes. Thus, the iridium and rhodium dimers [M(η⁵-C₅Me₅)Cl₂]₂ react with 2a–e, in the presence of sodium acetate, to afford irida- and rhodatrinems (1a–j) containing the half-sandwich d⁶ metal fragments M(η⁵-C₅Me₅)Cl (M = Ir, Rh). The reactions of [M(μ-OMe)(η⁴-COD)]₂ (M = Ir, Rh) with 2a lead to irida- and rhodatrinems (1k,l) with the d⁸ moieties M(η⁴-COD). The coordination sphere and oxidation state of the metal center in these compounds can be modified, without affecting the 2-azetidinone backbone, by substitution and oxidative addition reactions. As a proof of concept, metallatrinems with the M(CO)₂ (M = Ir (1m), Rh (1n)) and Ir(Me)I(CO)₂ (1o) units are also reported. Osmatrinems 1p,q containing the d⁴ metal fragment OsH₃(PⁱPr₃)₂ have been obtained starting from the d² hexahydride OsH₆(PⁱPr₃)₂, by reaction with 2a,b, whereas the treatment of the tetrahydroborate complexes MH(η²-H₂BH₂)(CO)(PⁱPr₃)₂ (M = Os, Ru) with 2a yields osma- and ruthenatrinems (1r,s) containing six-coordinate bis(phosphine) d⁶ metal fragments. The IR stretching frequency of the lactamic carbonyl, the bent angle between the five- and four-membered rings of the tricycle, and the N-CO bond length in the lactamic ring are clearly influenced by the L_nM fragment. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Inhibition of guanine deaminase with derivatives of imidazole was written by Kanzawa, Fumihiko;Hoshi, Akio;Kuretani, Kazuo. And the article was included in Chemical & Pharmaceutical Bulletin in 1971.Category: imidazoles-derivatives This article mentions the following:

Inhibition of guanine deaminase by derivatives of 5-amino-4-imidazole-carboxamide (I) was studied. The 5-chloro derivative (II) was the most inhibitory among the halogen derivatives, but was less effective than I. 4-Imidazolecarboximide (III) was the most potent inhibitor found, more active even than I. Imidazole itself was a weak inhibitor. The Et ester instead of the amide, and the 5-chloro-6-carboxamidoxime derivatives were less effective than I, and the 4,5-dicarboxylic acid derivative was almost inactive. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Category: imidazoles-derivatives).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recyclable bifunctional aluminum salen catalyst for CO₂ fixation: the efficient formation of five-membered heterocyclic compounds was written by Luo, Rongchang;Yang, Zhi;Zhang, Wuying;Zhou, Xiantai;Ji, Hongbing. And the article was included in Science China: Chemistry in 2017.Reference of 21252-69-7 This article mentions the following:

A variety of unique Al(salen) complexes functionalized by imidazolium-based ionic liquid (IL) moieties with the salen ligand at the two sides of 3,3′-position have been successfully prepared, rather than familiar 5,5′-position reported previously. The catalytic activity obtained by these bifunctional catalysts could be superior to those of the binary type catalysts in the formation of five-membered heterocyclic compounds from the cycloaddition reaction of CO₂ and three-membered heterocyclic compounds (including terminal epoxides and N-substituted aziridines), presumably due to the distinguished intramolecularly synergistic catalysis, which might lead to perform the cycloaddition reaction at ambient conditions and retain excellent yield and unprecedented chemo- or regioselectivity. Moreover, the polyether-based trifunctional Al(salen) catalysts with the best catalytic performance could be regenerated and reused at least eight times without any obvious decreases in catalytic activity. Finally, the kinetic investigation suggested the structure of catalysts had important influences on the catalytic activity, thereby proposing the possible reaction mechanism. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Diversification of imidazo[1,2-a]pyridines under microwave-assisted palladium-catalyzed Suzuki reaction was written by Lee, Jin-Hee;Park, Seung Yeong;Park, Areum;Yum, Eul Kgun. And the article was included in Journal of the Korean Chemical Society in 2017.Category: imidazoles-derivatives This article mentions the following:

Diversified synthesis of arylated imidazo[1,2-a]pyridines I [R = H, CF₃, C₆H₅, 4-FC₆H₄; R¹ = H, 5-(pyridin-4-yl), 6-(4-H₃COC₆H₄), 7-C₆H₅, etc.; R² = H, C₆H₅, 4-H₃COC₆H₄, 2H-1,3-benzodioxol-5-yl, etc.] via microwave-assisted palladium-catalyzed Suzuki reaction of various bromoimidazo[1,2-a]pyridines II (X = H, 5-Br, 6-Br, 7-Br; Y = H, Br) with substituted arylboronic acids such as pyridin-4-ylboronic acid, (4-ethoxyphenyl)boronic acid, 2H-1,3-benzodioxol-5-ylboronic acid, etc. was described. In the experiment, the researchers used many compounds, for example, 5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1Category: imidazoles-derivatives).

5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem