Tag: 100-200

New reactive ionic liquids as carriers in polymer inclusion membranes for transport and separation of Cd(II), Cu(II), Pb(II), and Zn(II) ions from chloride aqueous solutions was written by Szczepanski, Piotr;Guo, Haopeng;Dzieszkowski, Krzysztof;Rafinski, Zbigniew;Wolan, Andrzej;Fatyeyeva, Kateryna;Kujawa, Joanna;Kujawski, Wojciech. And the article was included in Journal of Membrane Science in 2021.Application In Synthesis of 1-Octyl-1H-imidazole This article mentions the following:

Three new reactive ionic liquids (RILs) based on the imidazole derivatives were synthesized and used as carriers in polymer inclusion membranes (PIMs) composed of cellulose triacetate (CTA) as a polymer matrix and o-nitrophenyl octyl ether (NPOE) as a plasticizer. The effect of alkyl chain length (C1, C4, and C8) in the imidazolium cation of RILs on the transport and separation properties was evaluated. From among three synthesized RILs only the RIL with the longest alkyl chain (RILC8_Br) can be successfully applied as the carrier for Cd(II) removal from multicomponent aqueous chloride solution containing also Cu(II), Pb(II), and Zn(II) ions. The effects of the stripping phase composition, HCl concentration in the feed solution, and the carrier content in the membrane on the separation performance and transport effectiveness were studied. The results indicate that the RILC8_Br ionic liquid enables selective transport of Cd(II) ions and their active concentration in the stripping solution with the fluxes reaching a value of 2.7 x 10^-10 mol/cm²s. In the investigated feed solution concentration range, the selectivity order was found to be Cd(II) > Zn(II) > Pb(II) ≫ Cu(II) and it was independent of the exptl. conditions. For a description of the transport kinetics a model similar to the first-order reversible reaction equations was applied and its applicability was proved. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application In Synthesis of 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application In Synthesis of 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enantioselective Hydrogenation of Imidazo[1,2-a]pyridines was written by Schlepphorst, Christoph;Wiesenfeldt, Mario P.;Glorius, Frank. And the article was included in Chemistry – A European Journal in 2018.Reference of 69214-09-1 This article mentions the following:

The enantioselective synthesis of tetrahydroimidazo[1,2-a]pyridines by direct hydrogenation was achieved using a ruthenium/N-heterocyclic carbene (NHC) catalyst. The reaction forgoes the need for protecting or activating groups, proceeds with complete regioselectivity, good to excellent yields, enantiomeric ratios of up to 98:2, and tolerates a broad range of functional groups [e.g., I → II (95.5:4.5 e.r., 99% isolated yield)]. 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridines, which are found in numerous bioactive mols., were directly obtained by this method, and its applicability was demonstrated by the (formal) synthesis of several functional mols. In the experiment, the researchers used many compounds, for example, 5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1Reference of 69214-09-1).

5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 69214-09-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and conversions of 2-formylbenzimidazoles was written by Dalgatov, D. D.. And the article was included in Sb. Aspirantskikh Rabot, Dagestansk. Univ., Estestv, i Fiz.-Mat. Nauk, Makhachkala in 1964.Recommanded Product: 3012-80-4 This article mentions the following:

Methods for synthesis of 2-formylbenzimidazoles (I) and the N-Me (II) and N-Ph (III) derivatives of I were studied. II was condensed with Me ketones and PhCH₂NO₂ (IV) and I and II were condensed with cyclohexanone (V). 1,2-Bis(2-benzimidazolyl)ethylene glycol (2.94 g.) was dissolved in 100 ml. N HCl, 2.3 g. KIO₄ added, the solution kept 2 days at 20°, and 10% Na₂CO₃ added to alkalinity to yield 93% I, m. 235° (alc.) (decomposition). I (1.46 g.), 7 ml. V, and 7 ml. MeOH was heated at 100°, 5-6 drops 20% KOH added, and the mixture cooled after 10-15 min. to yield 75% the 2-(2-benzimidazolylmethylene) derivative of V, sublimes 175-80° (MeOH). KOH (5.6 g.) and 13.2 g. 2-methylbenzimidazole (VI) in 50 ml. alc. was boiled, 17.2 g. PhSO₃Me added after 1 hr., the mixture heated 2 hrs. and filtered, and the filtrate evaporated to give 10.3 g. l-Me derivative (VIa) of VI, m. 112° (H₂O). Oxidation of VIa with SeO₂ in PhMe at 95° yielded 40% II. 1-Methyl-2-(hydroxymethyl)benzimidazole (1.6 g.) was dissolved in 50 ml. 2N H₂SO₄, 0.05 g. AgNO₃ added, the mixture heated to 70° K₂S₂O₈ added after 4 hrs., the mixture filtered, and the filtrate neutralized with Na₂CO₃ solution to yield 0.4 g. II, m. 110°. II (1.6 g.) and 1.49 g. isonicotinic hydrazide in 8 ml. MeOH was boiled 20 min. to yield 2 g. isonicotinoyl hydrazone of II, m. 200-3° (MeOH). 2-(Hydroxymethyl)benzimidazole (VII) (14.8 g.), 21.2 g. unsaturated leukotrone O, and a concentrated solution of 4 g. NaOH was heated 4 hrs., and Me₂NPh steam distilled to yield 12 g. 1-PhCH₂ derivative of VII, m. 186.5-87° (alc.). To 1.6 g. II and 1.99 g. p-bromoacetophenone (VIII) in 3 ml. MeOH was added 2-3 drops 5% KOH to yield 70% 2-[β-(p-bromobenzoyl)vinyl]-1-methylbenzimidazole, m. 159-60° (alc.). II (1.6 g.) and 3.98 g. VIII were dissolved in 10 ml. hot MeOH, 2 ml. 20% KOH added, and the mixture boiled 1 hr. to yield 74% 1-methyl-2-bis(p-bromo-phenacylmethyl)benzimidazole, m. 186.5-87° (MeOH). Analogously was obtained 2-(β-tolylvinyl)-1-methylbenzimidazole, m. 134° (alc.). II (1.6 g.) and 0.98 g. IV in 5 ml. MeOH and 3 drops 10% KOH was boiled 0.5 hr. to yield 1.7 g. 2-(1-methyl-2-benzimidazolylmethylene) derivative of V, m. 237° (CHCl₃). To 1.37 g. IV in 8 ml. alc. was added 1 g. NaOH in 8 ml. H₂O and in portions 1.6 g. of a solution of II in 10 ml. alc. and after 5 hrs. the mixture neutralized with 1:1 aqueous HCl to yield 73% 2-(β-nitro- α-hydroxy-β-phenylethyl)-1-methylbenzimidazole, m. 162-3° (decomposition) (alc.-Me₂CO). To 20.8 g. 2-methyl-1-phenylbenzimidazole in 200 ml. anhydrous PhMe at 95° was added 11.1 g. SeO₂ over 4 hrs., the mixture heated 2 hrs., the PhMe layer separated and steam distilled, and the residue treated with CHCl₃ to yield 35% III (oil); dinitrophenylhydrazone m. 260-1°; semi-carbazone m. 255-6°. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Recommanded Product: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors was written by Li, Kai;Wang, Yang;Yang, Gyongseon;Byun, Soo Young;Rao, Guodong;Shoen, Carolyn;Yang, Hongliang;Gulati, Anmol;Crick, Dean C.;Cynamon, Michael;Huang, Guozhong;Docampo, Roberto;No, Joo Hwan;Oldfield, Eric. And the article was included in ACS Infectious Diseases in 2015.Formula: C11H20N2 This article mentions the following:

The authors synthesized a library of 48 analogs of the Mycobacterium tuberculosis cell growth inhibitor SQ109 in which the ethylenediamine linker was replaced by oxa, thia, or heterocyclic species, and in some cases, the adamantyl group was replaced by a 1,2-carborane or the N-geranyl group by another hydrophobic species. Compounds were tested against M. tuberculosis (H37Rv and/or Erdman), Mycobacterium smegmatis, Bacillus subtilis, Escherichia coli, Saccharomyces cerevisiae, Trypanosoma brucei, and two human cell lines (human embryonic kidney, HEK293T, and the hepatocellular carcinoma, HepG2). The most potent activity was found against T. brucei, the causative agent of human African trypanosomiasis, and involved targeting of the mitochondrial membrane potential with 15 SQ109 analogs being more active than was SQ109 in cell growth inhibition, having IC₅₀ values as low as 12 nM (5.5 ng/mL) and a selectivity index of ∼300. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Asymmetric α-Functionalization of 2-Alkyl Azaarenes: Synthesis of Tertiary Fluorides Having Vicinal Stereogenic Centers was written by Das, Arko;Joshi, Harshit;Singh, Vinod K.. And the article was included in Organic Letters in 2021.Electric Literature of C6H8N2O This article mentions the following:

An enantioselective approach for synthesizing fluorinated azaarenes containing vicinal quaternary-tertiary stereocenters I [R¹ = Ph, CH=CHPh, 2-thienyl, etc.; R² = Me, OMe, OEt, Ph; R³ = 2-pyridyl, benzo[d]thiazol-2-yl] was summarized. The chiral copper(I)-phosphine complex binded with the azaarenes followed by Michael addition to unsaturated acyl imidazoles, resulting in α-functionalized products with an excellent level of enantioselectivities (up to 99%), diastereoselectivities (>20:1), and yields (up to 97%). Furthermore, post-functionalization of the acyl imidazole part had also been demonstrated. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Electric Literature of C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of [¹⁸F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)acetamide], a marker for PET detection of hypoxia was written by Josse, Olivier;Labar, Daniel;Georges, Benoit;Gregoire, Vincent;Marchand-Brynaert, Jacqueline. And the article was included in Bioorganic & Medicinal Chemistry in 2001.Application of 22813-32-7 This article mentions the following:

[¹⁸F]-2-(2-Nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)acetamide ([¹⁸F]-EF3) has been prepared in 65% chem. yield and 5% radiochem. yield by coupling 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1-yl)acetate with [¹⁸F]-3,3,3-trifluoropropylamine. This original radiolabeled key synthon was obtained in 40% overall chem. yield by oxidative [¹⁸F]-fluorodesulfurization of Et N-phthalimido-3-aminopropanedithioate, followed by deprotection with hydrazine of the resulting [¹⁸F]-N-phthalimido-3,3,3-trifluoropropylamine. The process was performed within 90 min, from the [¹⁸F]-HF production in the cyclotron to the purification of the final target. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Application of 22813-32-7).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 22813-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cobalt(II)/(imidazoline-oxazoline)-catalyzed enantioselective Michael addition of 2-acetyl azaarenes to β-CF₃-β-disubstituted nitroalkenes was written by Hao, Xin-Qi;Wang, Cong;Liu, Shuang-Liang;Wang, Xiao;Wang, Li;Gong, Jun-Fang;Song, Mao-Ping. And the article was included in Organic Chemistry Frontiers in 2017.COA of Formula: C6H8N2O This article mentions the following:

A series of chiral (imidazoline-oxazoline) N,N-bidentate ligands derived from 2,2-dimethylmalonic acid were conveniently synthesized and characterized. With the aid of the new ligands, the first Co(II)-catalyzed asym. Michael addition of 2-acetyl azaarenes to β-CF₃-β-disubstituted nitroalkenes was successfully achieved, producing chiral compounds with a trifluoromethylated all-carbon quaternary stereocenter in good yields with enantioselectivities of up to 98% ee. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1COA of Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of 5-fluorouracil, ftorafur and imidazolecarboxamide on the kinetics of the primary immune response in mice was written by Matveev, A. B.;Kudryashov, V. M.. And the article was included in Farmakologiya i Toksikologiya (Moscow) in 1981.SDS of cas: 26832-08-6 This article mentions the following:

Treatment of mice with 5-fluorouracil [51-21-8], ftorafur [17902-23-7], or imidazolecarboxamide [26832-08-6] at 48 or 72 h following immunization with sheep erythrocytes caused an oscillatory-type of response in splenic antibody-forming cells. Each pattern of increases-decreases lasted 8-16 h. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6SDS of cas: 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Product control by halide ions of ionic liquids in the ionothermal syntheses of Ni-(H)BTC metal-organic frameworks was written by Xu, Ling;Yan, Shihai;Choi, Eun-Young;Lee, Jin Yong;Kwon, Young-Uk. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2009.Quality Control of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Ni(OAc)₂-H₃BTC (1,3,5-benzenetricarboxylic acid) system in various imidazolium ionic liquids, [RMI]X (R = Et, Pr, n-butyl; X = Cl, Br, I), produced five MOFs in two structure types; [RMI]₂[Ni₃(BTC)₂(OAc)₂] and [RMI]₂[Ni₃(HBTC)₄(H₂O)₂][RMI]₂. Their relative thermodn. stability varies with the cation size of RMI⁺, and the X^– ions govern the kinetic factors so that their combination effects determine the final product. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Quality Control of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Quality Control of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Density, Viscosity, and Conductivity of Lewis Acidic 1-Butyl- and 1-Hydrogen-3-methylimidazolium Chloroaluminate Ionic Liquids was written by Zheng, Yong;Dong, Kun;Wang, Qian;Zhang, Jianmin;Lu, Xingmei. And the article was included in Journal of Chemical & Engineering Data in 2013.Synthetic Route of C4H7ClN2 This article mentions the following:

To promote the development of Lewis acidic chloroaluminate ionic liquids, it is necessary to get a deeper insight into their physicochem. properties and mol. structure. In this work, the densities, viscosities, and conductivities of acidic 1-butyl- and 1-hydrogen-3-methylimidazolium chloroaluminate with different mole fractions of AlCl₃ were measured in the temperature range from (293.15 to 343.15) K. Meanwhile, excess molar volume and viscosity deviation values for the binary mixtures of 1-butyl-3-methylimidazolium chloroaluminate ionic liquids were also obtained. All of the exptl. data were well-fitted by the empirical equations. Based on the results of d. functional theory calculations, the differences in these properties are attributed to the mol. structure, cation-anion interaction, and hydrogen bonds of ionic liquids It is expected that the present study may be deemed useful for the application of Lewis acidic chloroaluminate ionic liquids in electrochem. and catalysis. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Synthetic Route of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Synthetic Route of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem