Tag: 100-200

Effect of the Cation on the Interactions between Alkyl Methyl Imidazolium Chloride Ionic Liquids and Water was written by Khan, Imran;Taha, Mohamed;Ribeiro-Claro, Paulo;Pinho, Simao P.;Coutinho, Joao A. P.. And the article was included in Journal of Physical Chemistry B in 2014.COA of Formula: C4H7ClN2 This article mentions the following:

A systematic study of the interactions between water and alkyl Me imidazolium chloride ionic liquids at 298.2 K, based on activity coefficients estimated from water activity measurements in the entire solubility range, is presented. The results show that the activity coefficients of water in the studied ILs are controlled by the hydrophilicity of the cation and the cation-anion interaction. To achieve a deeper understanding on the interactions between water and the ILs, COSMO-RS and FTIR spectroscopy were also applied. COSMO-RS was used to predict the activity coefficient of water in the studied ionic liquids along with the excess enthalpies, suggesting the formation of complexes between three mols. of water and one IL mol. On the basis of quantum-chem. calculations, it is found that cation-anion interaction plays an important role upon the ability of the IL anion to interact with water. The changes in the peak positions/band areas of OH vibrational modes of water as a function of IL concentration were investigated, and the impact of the cation on the hydrogen-bonding network of water is identified and discussed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3COA of Formula: C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.COA of Formula: C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Asymmetric Synthesis of Heterocyclic Chloroamines and Aziridines by Enantioselective Protonation of Catalytically Generated Enamines was written by McLean, Liam A.;Ashford, Matthew W.;Fyfe, James W. B.;Slawin, Alexandra M. Z.;Leach, Andrew G.;Watson, Allan J. B.. And the article was included in Chemistry – A European Journal in 2022.Reference of 1632-83-3 This article mentions the following:

A method for the synthesis of chiral vicinal chloroamines RCH(Cl)CH₂NHR¹ [R = 2-quinolyl, quinazolin-2-yl, 1,3-benzothiazol-2-yl, etc.; R¹ = Ph, 4-MeC₆H₄, benzothiophen-5-yl, etc.] via asym. protonation of catalytically generated prochiral chloroenamines using chiral Bronsted acids was reported. The process was highly enantioselective, with the origin of asymmetry and catalyst substituent effects elucidated by DFT calculations The utility of the method showed as an approach to the synthesis of a broad range of heterocycle-substituted aziridines I [R² = 2-quinolyl, quinoxalin-2-yl, 5-cyano-2-pyridyl, etc.; Ar = Ph, 4-MeOC₆H₄, 3-BrC₆H₄, etc.] by treatment of the chloroamines with base in a one-pot process, as well as the utility of the process to allow access to vicinal diamines II [R³ = 4-tert-butoxycarbonylpiperazin-1-yl, morpholino, thiomorpholino]. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Reference of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formylation of 1-methylbenzimidazoles was written by Tertov, B. A.;Koblik, A. V.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1967.SDS of cas: 3012-80-4 This article mentions the following:

To 0.8 g. Na (activated with iso-amyl alc.) in 2.5 ml. HCONMe2 and 45 ml. C6H6, 4 g. 1-methylbenzimidazole was added and the whole stirred under N 1.5 hrs., 5 ml. AcOH in 20 ml. H2O added in one portion, and the mixture worked up to give 0.7 g. 1-methyl 2-formylbenzimidazole (I) m. 109-10°; oxime m. 215-16°. To obtain the Cu salt of 1-methylbenzimidazole-2-carboxylic acid a 5% solution of CuSO4 was added to the reaction mixture to which 80% EtOH was added instead of AcOH to destroy excess Na. From this, the free 1-methylbenzimidazole-2-carboxylic acid (II), m. 90-1°, was obtained. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4SDS of cas: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. SDS of cas: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Catalytic activity of styrene/divinylbenzene copolymeric support immobilized with imidazolium ionic liquids in disproportionation of trichlorosilane was written by Petukhov, A. N.;Vorotyntsev, A. V.;Razov, E. N.;Nyuchev, A.;Makarov, D. A.;Vorotyntsev, V. M.. And the article was included in Journal of Physics: Conference Series in 2018.Formula: C4H7ClN2 This article mentions the following:

For the first time, imidazolium chloride-based ionic liquids (namely 1-methylimidazolium chloride and 1-butyl-3-methylimidazolium chloride) immobilized into macroporous styrene-divinylbenzene copolymer support (5-25 weight% of ionic liquid) were studied as catalysts for trichlorosilane disproportionation in the gas phase in the 293 – 393 K temperature range. In the case of the catalyst containing 15 weight% of the ionic liquid the apparent energy of activation was found to be 67.44 K and the reaction rate constant was found to be 0.2 s^-1 at 393 K. This catalyst was found to be stable up to 408 K, further heating leads to thermal decomposition of the polymer matrix with chloroform as main gas product. The catalytic activity of the catalyst showed to be stable after 3 mo at 393 K. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Formula: C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lanthanoid-Based Ionic Liquids Incorporating the Dicyanonitrosomethanide Anion was written by Chesman, Anthony S. R.;Yang, Mei;Spiccia, Nicolas D.;Deacon, Glen B.;Batten, Stuart R.;Mudring, Anja-Verena. And the article was included in Chemistry – A European Journal in 2012.Reference of 92507-97-6 This article mentions the following:

A series of low-melting-point salts with hexakisdicyanonitrosomethanidolanthanoidate anions has been synthesized and characterized: (C₂mim)₃[Ln(dcnm)₆] (1 Ln; 1 Ln=1 La, 1 Ce, 1 Pr, 1 Nd), (C₂C₁mim)₃[Pr(dcnm)₆] (2 Pr), (C₄C₁pyr)₃[Ce(dcnm)₆] (3 Ce), (N₁₁₁₄)₃[Ln(dcnm)₆] (4 Ln; 4 Ln=4 La, 4 Ce, 4 Pr, 4 Nd, 4 Sm, 4 Gd), and (N_1112OH)₃[Ce(dcnm)₆] (5 Ce) (C₂mim=1-ethyl-3-methylimidazolium, C₂C₁mim=1-ethyl-2,3-dimethylimidazolium, C₄C₁py=N-butyl-4-methylpyridinium, N₁₁₁₄=butyltrimethylammonium, N_1112OH=2-(hydroxyethyl)trimethylammonium=choline). X-ray crystallog. was used to determine the structures of complexes 1 La, 2 Pr, and 5 Ce, all of which contain [Ln(dcnm)₆]^3- ions. Complexes 1 Ln and 2 Pr were all ionic liquids (ILs), with complex 3 Ce melting at 38.1 °C, the lowest m.p. of any known complex containing the [Ln(dcnm)₆]^3- trianion. The ammonium-based cations proved to be less suitable for forming ILs, with complexes 4 Sm and 4 Gd being the only salts with the N₁₁₁₄ cation to have m.ps. below 100 °C. The choline-containing complex 5 Ce did not melt up to 160 °C, with the increase in m.p. possibly being due to extensive hydrogen bonding, which could be inferred from the crystal structure of the complex. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Reference of 92507-97-6).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 92507-97-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The preparation and properties of partially protected 4-amino-1-methylimidazole-2-carboxylic acids to be used as intermediates in the synthesis of analogs of distamycin A was written by Grehn, Leif;Ding, Lu;Ragnarsson, Ulf. And the article was included in Acta Chemica Scandinavica in 1990.Name: Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate This article mentions the following:

Partially protected 4-amino-1-methylimidazole-2-carboxylic acid derivatives I (R = H, R¹ = Et; R = CO₂CMe₃, R¹ = H, CH₂Ph; R = CHO, R¹ = H) have been prepared by a convenient route from the nitro analog. I should serve as suitable precursors for the synthesis of oligoamides related to distamycin A. In addition, several intermediates and side-products have been characterized. In the experiment, the researchers used many compounds, for example, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9Name: Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate).

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Name: Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells was written by Guetzoyan, Lucie J.;Spooner, Robert A.;Boal, Frederic;Stephens, David J.;Lord, J. Michael;Roberts, Lynne M.;Clarkson, Guy J.. And the article was included in Molecular BioSystems in 2010.Product Details of 58442-17-4 This article mentions the following:

The small mol. 4-hydroxy-3-methoxybenzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)hydrazone (Exo2) stimulates morphol. changes at the mammalian Golgi and trans-Golgi network that are virtually indistinguishable from those induced by brefeldin A. Both brefeldin A and Exo2 protect cells from intoxication by Shiga(-like) toxins by acting on other targets that operate at the early endosome, but do so at the cost of high toxicity to target cells. The advantage of Exo2 is that it is much more amenable to chem. modification and here we report a range of Exo2 analogs produced by modifying the tetrahydrobenzothienopyrimidine core, the vanillin moiety and the hydrazone bond that links these two. These compounds were examined for the morphol. changes they stimulated at the Golgi stack, the trans-Golgi network and the transferrin receptor-pos. early endosomes and this activity correlated with their inherent toxicity towards the protein manufacturing ability of the cell and their protective effect against toxin challenge. We have developed derivatives that can sep. organelle morphol., target specificity, innate toxicity and toxin protection. Our results provide unique compounds with low toxicity and enhanced specificity to unpick the complexity of membrane trafficking networks. In the experiment, the researchers used many compounds, for example, 1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4Product Details of 58442-17-4).

1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Product Details of 58442-17-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pathways of the Chemical Reaction of Carbon Dioxide with Ionic Liquids and Amines in Ionic Liquid Solution was written by Kortunov, Pavel V.;Baugh, Lisa Saunders;Siskin, Michael. And the article was included in Energy & Fuels in 2015.Synthetic Route of C4H7ClN2 This article mentions the following:

This paper focuses specifically on certain ionic liquids that are capable of acting as chemisorbents for CO₂ at ambient pressure and temperature This low-pressure approach based on chem. reactivity is more effective than traditional phys. absorption/solubility approaches for CO₂ capture in ionic liquids for higher pressure carbon capture. We describe a class of imidazolium ionic liquids bearing a relatively acidic hydrogen atom at C-2, which upon initial abstraction develops a nucleophilic carbon atom that is carboxylated by CO₂. Basicity of the anion plays a role in the ability to remove the acidic hydrogen to generate the nucleophilic carbon. The yield of carboxylated ionic liquid is not affected by non-aqueous co-solvents but changes as a function of the CO₂ partial pressure, solution temperature, and presence of H₂O in solution CO₂ chemisorption by ionic liquids is particularly efficient in the presence of a non-nucleophilic nitrogenous base that serves to promote ionic liquid carboxylation and stabilize the carboxylic acid product as a salt. Selected ionic liquids are able to stabilize the formation of amine carbamic acids in the ionic liquid solution In this case, each amine captures up to 1 CO₂ mol., which is beneficial for the overall CO₂ capacity in the solution Carboxylation of the ionic liquids themselves is lower because the basic anion of the ionic liquid also stabilizes N-carboxylated products. In-situ ¹³C and ¹H NMR spectroscopy using a built-in micro reactor was used to provide real-time insights on CO₂-ionic liquid and CO₂-amine reaction pathways and product speciation under various conditions. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Synthetic Route of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Synthetic Route of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Determination of the preferred tautomeric form of 4-nitrohistidine was written by Pedoroso, Enrique;Grandas, Anna;Dolors Ludevid, Maria;Giralt, Ernest. And the article was included in Journal of Heterocyclic Chemistry in 1986.Application In Synthesis of 1-Methyl-4-nitroimidazole This article mentions the following:

N^α-Acetyl-4-nitrohistidine Me ester (I) was methylated with CH₂N₂ to give 33% N³-Me derivative II, whereas I was methylated with MeI/KOH in MeOH to give a mixture of 17% II and 11% N¹-Me derivative III. Spectrophotometric pKa determinations of II and III were used to determine the position of the tautomeric equilibrium of I. The N¹-H tautomer is the predominant form with an equilibrium constant K_T of 48. This is supported by the ¹H and ¹³C NMR chem. shifts of the imidazole ring atoms and their changes from neutral to acidic media. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Application In Synthesis of 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application In Synthesis of 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Metalloporphyrin and Ionic Liquid-Functionalized Covalent Organic Frameworks for Catalytic CO₂ Cycloaddition via Visible-Light-Induced Photothermal Conversion was written by Ding, Luo-Gang;Yao, Bing-Jian;Wu, Wen-Xiu;Yu, Zhi-Gao;Wang, Xiao-Yu;Kan, Jing-Lan;Dong, Yu-Bin. And the article was included in Inorganic Chemistry in 2021.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:

We report the construction of a porphyrin and imidazolium-ionic liquid (IL)-decorated and quinoline-linked covalent organic framework (COF, abbreviated as COF-P1-1) via a three-component one-pot Povarov reaction. After post-synthetic metalization of COF-P1-1 with Co(II) ions, the metalized COF-PI-2 is generated. COF-PI-2 is chem. stable and displays highly selective CO₂ adsorption and good visible-light-induced photothermal conversion ability (ΔT = 26°). Furthermore, the coexistence of Co(II)-porphyrin and imidazolium-IL within COF-PI-2 has guaranteed its highly efficient activity for CO₂ cycloaddition Of note, the needed thermal energy for the reactions is derived from the photothermal conversion of the Co(II)-porphyrin COF upon visible-light irradiation More importantly, the CO₂ cycloaddition herein is a “window ledge” reaction, and it can proceed smoothly upon natural sunlight irradiation In addition, a scaled-up CO₂ cycloaddition can be readily achieved using a COF-PI-2@chitosan aerogel-based fixed-bed model reactor. Our research provides a new avenue for COF-based greenhouse gas disposal in an eco-friendly and energy- and source-saving way. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem