Tag: 100-200

Solvatochromism of heteroaromatic compounds: XXVIII. Factors affecting the nonspecific solvatochromic effect in the UV spectra of aromatic nitro compounds in aprotic protophilic solvents was written by Vokin, A. I.;Shulunova, A. M.;Aksamentova, T. N.;Bozhenkov, G. V.;Turchaninov, V. K.. And the article was included in Russian Journal of General Chemistry in 2006.Reference of 3034-41-1 This article mentions the following:

Examination of the UV spectra of a large series of solvatochromic indicators of the general formula 1-X-4-NO₂-C₆H₄ in aprotic solvents confirmed the proportionality between the dipole moments of these compounds in the ground (μ_g) and first electronically excited (¹A₁, μ_e) states: μ_e = r_μμ_g. The coefficient r_μ was determined by applying the equation of the Bakhshiev-Bilot-Kawski solvatochromism theory both to nonspecifically solvated mols. and to their H complexes with aprotic protophilic solvents. An anisotropy of the electron redistribution was revealed for low-symmetry 1-substituted 2,4-dinitrobenzenes. The r_μ value obtained allowed the calculation of the Kamlet-Taft empirical solvatochromic parameter π* on the basis of generalized characteristics of the solvent. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Reference of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Reference of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer’s Disease Agents was written by Xu, Yixiang;Zhang, Jian;Wang, Huan;Mao, Fei;Bao, Keting;Liu, Wenwen;Zhu, Jin;Li, Xiaokang;Zhang, Haiyan;Li, Jian. And the article was included in ACS Chemical Neuroscience in 2019.Reference of 58442-17-4 This article mentions the following:

Multifunctional agents aiming at cholinesterases (ChEs) and monoamine oxidases (MAOs) are promising therapy for Alzheimer’s disease (AD). Herein, a series of novel propargylamine-modified pyrimidinylthiourea derivatives (1-4) were designed and synthesized as dual inhibitors of ChEs and MAOs with other functions against AD. Most of these derivatives inhibited ChEs and MAOs with IC₅₀ values in the micro- or nanomolar ranges. Compound 1c displayed the dual functional profile of targeting the AChE (IC₅₀ = 0.032 ± 0.007 μM) and MAO-B (IC₅₀ = 2.117 ± 0.061 μM), along with the improved blood-brain barrier (BBB) permeability, antioxidant ability, and good copper chelating property in vitro. Animal studies showed that compound 1c·HCl could inhibit the cerebral AChE/MAO-B activities and alleviate scopolamine-induced cognitive impairment in mice. Combined with good oral bioavailability (F = 45.55%), these findings demonstrated that compound 1c may be a potent brain permeable multifunctional candidate for the treatment of AD. In the experiment, the researchers used many compounds, for example, 1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4Reference of 58442-17-4).

1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Reference of 58442-17-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A new route to imidazo[1,5-a]pyridines and -quinolines was written by Kolar, Patrik;Tisler, Miha. And the article was included in Zeitschrift fuer Naturforschung, B: Chemical Sciences in 1991.Recommanded Product: Ethyl imidazo[1,5-a]pyridine-1-carboxylate This article mentions the following:

A new synthetic approach for imidazo(1,5-a)pyridines, e.g., I, and imidazo(1,5-a)quinolines, e.g., II (R = H, Me) from the corresponding alkyl(pyridyl-2′)- or (quinolyl-2′)glycinates, e.g., III and IV, resp., is described. In the experiment, the researchers used many compounds, for example, Ethyl imidazo[1,5-a]pyridine-1-carboxylate (cas: 119448-87-2Recommanded Product: Ethyl imidazo[1,5-a]pyridine-1-carboxylate).

Ethyl imidazo[1,5-a]pyridine-1-carboxylate (cas: 119448-87-2) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: Ethyl imidazo[1,5-a]pyridine-1-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Regioselective Hydroboration and Hydrosilylation of N-Heteroarenes Catalyzed by a Zinc Alkyl Complex was written by Wang, Xinxin;Zhang, Yu;Yuan, Dan;Yao, Yingming. And the article was included in Organic Letters in 2020.HPLC of Formula: 1632-83-3 This article mentions the following:

Readily available zinc alkyl complexes showed good activity and regioselectivity in catalyzing hydroboration and hydrosilylation of N-heteroarenes. Hydroboration of benzo-fused N-heterocycles gave exclusive 1,2-addition products in 80-97% yields. Reactions of pyridines afforded a mixture of 1,2-, 1,4-, and 1,6-products in yields of 55-95%, with 1,2-dihydropyridine as the main product. Bis-hydrosilylation was observed for quinoline derivatives, generating bis-1,2-hydrosilylation products in 76-96% yields. Kinetic studies and control experiments were conducted to gain some insights into the reaction mechanism. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3HPLC of Formula: 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Intermediates in the Dimroth rearrangement of imidazo[1,2-a]pyridines was written by Jacquier, Robert;Lopez, Helene;Maury, Georges. And the article was included in Journal of Heterocyclic Chemistry in 1973.SDS of cas: 25045-82-3 This article mentions the following:

Imidazo 1,2-a% pyridines, activated by a nitro group at position 6 or 8 undergo the Dimroth rearrangement in aqueous basic media. Intermediates of the rearrangement were detected and their structures investigated spectroscopically. In the experiment, the researchers used many compounds, for example, 6-Nitroimidazo[1,2-a]pyridine (cas: 25045-82-3SDS of cas: 25045-82-3).

6-Nitroimidazo[1,2-a]pyridine (cas: 25045-82-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.SDS of cas: 25045-82-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Development of thermal dissociation atmospheric chemical ionization source for rapid mass spectrometric analysis of ambient samples was written by Han, Jing;Li, Jian-Qiang;Zhang, Xie;Hu, Bin;Luo, Ming-Biao;Chen, Huan-Wen. And the article was included in Fenxi Huaxue in 2011.Reference of 92507-97-6 This article mentions the following:

A novel thermal dissociation atm. chem. ionization source (TDCI) was developed for rapid chem. ionization of ambient analytes in complex matrixes. By coupling the TDCI source to a com. LTQ XL mass spectrometer, the dissociation of chem. reagents such as ionic liquids was systematically investigated using multiple-stage mass spectrometric experiments The primary ions generated through the thermal dissociation process of the ionic liquids were accelerated by the high voltage applied on the repelling electrode of the TDCI source, and then reacted with the analytes present in the matrixes of the raw samples to produce ions of analytes, which were then guided to the LTQ instrument for mass anal. The construction of the TDCI source was detailed in the text. The effects of the exptl. parameters such as the pyrolysis temperature, the distance, and the angles formed between the electrodes were exptl. studied using the signals of characteristic fragments of the ionic liquid Under the optimal exptl. parameters, TDCI was able to directly ionize a wide variety of compounds, including the poplar (e.g., amino acids, doping compounds) and non-polar chems. (e.g, naphthalene) for sensitive detection using LTQ-MS, without any sample pretreatment. The average time for a single sample anal. was less than 30s, and the relative standard deviation of the method was in the range of 5.9%-11.1%; and the LOD for naphthalene was estimated to be 2.93*10^-7g/L. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Reference of 92507-97-6).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 92507-97-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Efficient polymeric catalyst for one-pot synthesis of acenaphtho[1,2-b]pyrroles was written by Goldani, Mohammad Taghi;Sandaroos, Reza;Damavandi, Saman. And the article was included in Research on Chemical Intermediates in 2014.Safety of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Some new derivatives of acenaphtho[1,2-b]furans have been synthesized efficiently by one-pot reaction of (acenaphthylen-1-yloxy)trimethylsilane, various aldehydes, and isocyanides in the presence of silica-supported ionic liquid In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Safety of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Safety of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazolium-based ionic liquids with large weakly coordinating anions was written by Levason, William;Pugh, David;Reid, Gillian. And the article was included in New Journal of Chemistry in 2017.Recommanded Product: 1-ethyl-2,3-dimethylimidazolium chloride This article mentions the following:

Eight imidazolium-based salts with the weakly-coordinating anions [BAr^F]^– and [Al(O^tC₄F₉)₄]^– ([BAr^F]^– = tetrakis{3,5-bis(trifluoromethyl)phenyl}borate) have been synthesized. Characterization by ¹H NMR spectroscopy shows that the salts are fully dissociated in solution Six examples have been further characterized by X-ray crystallog., revealing that weak hydrogen bonds do occur in the solid phase between the imidazolium cations and weakly coordinating anions. Comparison with the bulky [IDiPPH] imidazolium cation (IDiPPH = 1,3-bis{2,6-bis(diisopropyl)phenyl}imidazolium) shows that large steric bulk close to the imidazolium protons can preclude hydrogen bonds from forming. Differential scanning calorimetry of the salts reveal that all are thermally stable up to 200 °C which renders them as potentially suitable background electrolytes for electrochem. processes which take place at elevated temperatures In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Recommanded Product: 1-ethyl-2,3-dimethylimidazolium chloride).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1-ethyl-2,3-dimethylimidazolium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Selective Transport of Cu(II) across a Polymer Inclusion Membrane with 1-Alkylimidazole from Nitrate Solutions was written by Radzyminska-Lenarcik, Elzbieta;Ulewicz, Malgorzata. And the article was included in Separation Science and Technology (Philadelphia, PA, United States) in 2012.Recommanded Product: 21252-69-7 This article mentions the following:

The selective transport of copper(II), zinc(II), cobalt(II), and nickel(II) ions from nitrate solutions across polymer inclusion membranes (PIMs), which consist of cellulose triacetate as polymeric support, o-nitrophenyl pentyl ether as plasticizer, and 1-alkylimidazole (alkyl from hexyl- to decyl) as ion carrier was reported. PIM was characterized by using at. force microscopy (AFM) technique. The results show that Cu(II) can be separated very effectively from other transition metal cations as Zn(II), Co(II), and Ni(II) (at a concentration of 10^-3 mol/dm³ each). Alkyl substituents at position 1 of the imidazole ring have been found to affect the hydrophobic properties and initial flux of the transported metal ions. The efficiency of separation of metal ions by 1-alkylimidazole followed the sequence: Cu(II) > Zn(II) > Co(II) > Ni(II). The highest selectivity coefficient for Cu(II) was found with 1-hexylimidazole and its 1 mol/dm³ solution in PIM. Separation of the ions was more effective for the nitrates(V) than for chlorides. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Recommanded Product: 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fermentable sugars by chemical hydrolysis of biomass was written by Binder, Joseph B.;Raines, Ronald T.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2010.Computed Properties of C7H13ClN2 This article mentions the following:

Abundant plant biomass has the potential to become a sustainable source of fuels and chems. Realizing this potential requires the economical conversion of recalcitrant lignocellulose into useful intermediates, such as sugars. We report a high-yielding chem. process for the hydrolysis of biomass into monosaccharides. Adding water gradually to a chloride ionic liquid-containing catalytic acid leads to a nearly 90% yield of glucose from cellulose and 70-80% yield of sugars from untreated corn stover. Ion-exclusion chromatog. allows recovery of the ionic liquid and delivers sugar feedstocks that support the vigorous growth of ethanologenic microbes. This simple chem. process, which requires neither an edible plant nor a cellulase, could enable crude biomass to be the sole source of carbon for a scalable biorefinery. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Computed Properties of C7H13ClN2).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Computed Properties of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem