Tag: 100-200

Formation of 4(5)-aminoglyoxalines. II. Non-reactivity of the halogen atom in 4(5)-bromoglyoxaline-5(4)-carboxylic acid was written by Balaban, Isidore E.. And the article was included in Journal of the Chemical Society in 1932.Synthetic Route of C4H5N3O This article mentions the following:

Et 2,5-dibromoglyoxaline-4-carboxylate and Na₂SO₃ in H₂O, boiled 3-3.5 hrs., give 69.6% of Et 4(5)-bromoglyoxaline-5(4)-carboxylate, m. 170°; the free acid m. 253°; the acid is recovered unchanged in part or completely destroyed with KCN, Na₂SO₃, Na₂HAsO₃ and CH₂(CO₂Et)₂ in EtOH; Cu bronze gives no satisfactory product and NH₃ in H₂O or EtOH gives only the NH₄ salt, m. 259°. Et glyoxaline-4(5)-carboxylate and NH₄OH (d. 0.880), heated 3-4 hrs. at 150°, give the amide, crystals with 1 mol. H₂O, m. 215° (picrate, yellow, m. 228°); reduction with Na-Hg in EtOH-H₂SO₄ gives 26.2% of 4(5)-hydroxymethylglyoxaline; it could not be converted into the amino derivative by the Hofmann reaction, 60% of the amide being recovered. Br in CHCl₃ gives 30.3% of the 2,5-di-Br derivative, m. 256°. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Synthetic Route of C4H5N3O).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Synthetic Route of C4H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Supported hypochlorites: oxidation in nonaqueous media with sodium and calcium hypochlorite on alumina was written by Ando, Takashi;Cork, David G.;Fujita, Mitsue;Kimura, Takahide. And the article was included in Chemistry Express in 1987.Application of 85692-37-1 This article mentions the following:

Sodium hypochlorite supported on alumina gave an active reagent for convenient oxidation of benzyl and secondary alcs., α,ω-diols and sulfides. Calcium hypochlorite mixed with alumina was effective for the selective oxidation of benzylic alcs. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Application of 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application of 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Asymmetric Synthesis of Multi-Substituted Tetrahydrofurans via Palladium/Rhodium Synergistic Catalyzed [3+2] Decarboxylative Cycloaddition of Vinylethylene Carbonates was written by Ming, Siliang;Qurban, Saira;Du, Yu;Su, Weiping. And the article was included in Chemistry – A European Journal in 2021.Related Products of 85692-37-1 This article mentions the following:

An efficient synergistic catalysis for the diastereo- and enantioselective synthesis of multi-substituted THF derivatives I (R¹ = Me, i-Pr, Ph; R² = Ph, thiophen-2-yl, naphthalen-2-yl, etc.; R³ = Ph, 4-chloropheny, furan-2-yl, etc.) has been developed. Under mild reaction conditions, a series of target mols. with three consecutive stereocenters were synthesized by a palladium(0)/rhodium(III) bimetal-catalyzed asym. decarboxylative [3+2]-cycloaddition of vinylethylene carbonates II with α,β-unsaturated carbonyl compds III. The corresponding adducts were obtained with moderate to high yields (67% ∼ 98%) and excellent stereoselectivities (>20:1 d.r., up to 99% ee). In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Related Products of 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Related Products of 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation of reducing sugar from duckweed catalyzed by heteropolyacid-based ionic liquids was written by Zhang, Xiafei;Cai, Zhenping;Ma, Hao;Wang, Furong;Yu, Yinghao;Li, Xuehui. And the article was included in Huagong Xuebao (Chinese Edition) in 2015.Product Details of 35487-17-3 This article mentions the following:

Reducing sugar was prepared by the hydrolysis of duckweed with a series of acid ionic liquids (ILs). The effects of reaction conditions such as structure of catalyst, dosage of catalyst, reaction temperature and reaction time on the yield of total reducing sugar were investigated. The results showed that, imidazole phosphotungstic ionic liquids had the good performance in hydrolysis of duckweed. The best yield of total reducing sugar is 79.8% under the condition of 140°C, 3 h, 0.4 mmol IL catalyst. The residue and raw material were characterized by using Fourier transform IR spectroscopy (FT-IR), thermogravimetric (TG) and elemental anal. (EA). Furthermore, the IL recovered can be used without significant loss of activity after 5 runs (reducing sugar yield of 70.1%). In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Product Details of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Product Details of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase was written by Juillet, Charlotte;Ermolenko, Ludmila;Boyarskaya, Dina;Baratte, Blandine;Josselin, Beatrice;Nedev, Hristo;Bach, Stephane;Iorga, Bogdan I.;Bignon, Jerome;Ruchaud, Sandrine;Al-Mourabit, Ali. And the article was included in Journal of Medicinal Chemistry in 2021.Computed Properties of C7H5N3O2 This article mentions the following:

Significant inhibition of Aurora B was achieved by the synthesis of simplified fragments of benzosceptrins and oroidin belonging to the marine pyrrole-2-aminoimidazoles metabolites isolated from sponges. Evaluation of kinase inhibition enabled the discovery of a synthetically accessible rigid acetylenic structural analog EL-228, whose structure could be optimized into the potent CJ2-150. Here we present the synthesis of new inhibitors of Aurora B kinase, which is an important target for cancer therapy through mitosis regulation. The biol. oriented synthesis yielded several nanomolar inhibitors. The optimized compound CJ2-150 showed a non-ATP competitive allosteric mode of action in a mixed-type inhibition for Aurora B kinase. Mol. docking identified a probable binding mode in the allosteric site “F” and highlighted the key interactions with the protein. We describe the improvement of the inhibitory potency and specificity of the novel scaffold as well as the characterization of the mechanism of action. In the experiment, the researchers used many compounds, for example, 6-Nitroimidazo[1,2-a]pyridine (cas: 25045-82-3Computed Properties of C7H5N3O2).

6-Nitroimidazo[1,2-a]pyridine (cas: 25045-82-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Computed Properties of C7H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Improvement of the chromatographic separation performance of an imidazolium ionic liquid functionalized silica column by in situ anion-exchange with dodecyl sulfonate and dodecylbenzene sulfonate anions was written by Sun, Min;Feng, Juanjuan;Chen, Wenjie;Li, Leilei;Duan, Huimin;Luo, Chuannan. And the article was included in Journal of Separation Science in 2014.Product Details of 79917-89-8 This article mentions the following:

The anionic part of ionic liquids can provide addnl. interactions during chromatog. separations The chromatog. separation performance of a silica column functionalized with 1-propyl-3-methylimidazolium chloride ionic liquid was improved by in situ anion-exchange from chloride anions to dodecyl sulfonate anions and dodecylbenzene sulfonate anions. The separation performances of these ionic liquid functionalized phases were studied and compared with each other using polycyclic aromatic hydrocarbons, phthalates, parabens, and phenols as model compounds The new columns presented a better chromatog. separation than the original one. This was ascribed retention mechanism from organic anions. The introduction of dodecyl sulfonate anions increased the hydrophobicity of stationary phase. Also, the Ph groups of dodecylbenzene sulfonate anions could provide an enhanced selectivity to aromatic compounds such as polycyclic aromatic hydrocarbons by π-π interactions. Anal. repeatability of the new columns was satisfactory (relative standard deviation of retention time, 0.10-0.40%; relative standard deviation of peak area, 0.66-0.84%). In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Product Details of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hexahalometallate salts of trivalent scandium, yttrium and lanthanum: cation-anion association in the solid state and in solution was written by Champion, Martin J. D.;Levason, William;Pugh, David;Reid, Gillian. And the article was included in New Journal of Chemistry in 2016.Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride This article mentions the following:

The hexahalide salts, [NBu₄]₃[LaCl₆] (1), [BMPYRR]₃[LaCl₆] (2, BMPYRR = 1-butyl-1-methylpyrrolidinium), [EMIM]₃[MX₆] (EMIM = 1-ethyl-3-methylimidazolium; M = La, X = Cl (3), Br (4), I (5); M = Sc (6), Y (7), Ce (8), X = Cl) and [EDMIM]₃[MX₆] (EDMIM = 1-ethyl-2,3-dimethylimidazolium; M = Y (9), X = Cl; M = La, X = Cl (10), I (11)) were prepared and x-ray crystal structures determined for several of them, with a view to probing the effect of varying the trivalent metal ion, the halide and the countercation on the structures adopted in the solid state. The crystal structures of the EMIM and EDMIM salts show extensive H-bonding between the halide ligands and organic cations; based upon the H-bonding distances, this appears to be strongest for the [EMIM]₃[MCl₆] salts, becoming progressively weaker for heavier metal ion or halide. In terms of the cations, changing from EMIM to EDMIM also reduces the strength of the H-bonding. The strength of the cation-anion pairing in solution also was probed in solution via NMR spectroscopy where possible (⁴⁵Sc, ⁸⁹Y and ¹⁸⁹La) and, for the EMIM salts, via the shift of δ(H2) relative to [EMIM]Cl at a standard concentration The trends observed in solution mirror those determined in the solid state. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Simple protic ionic liquid [Et₃NH][HSO₄] as a proficient catalyst for facile synthesis of biscoumarins was written by Patil, Sandip K.;Awale, Deepak V.;Vadiyar, Madagonda M.;Patil, Suryakant A.;Bhise, Sagar C.;Kolekar, Sanjay S.. And the article was included in Research on Chemical Intermediates in 2017.HPLC of Formula: 35487-17-3 This article mentions the following:

Abstract: We have explored a number of protic ionic liquids (PILs) as a catalyst for the synthesis of biscoumarins by condensation of 4-hydroxycoumarin with an aromatic aldehyde. Methylimidazolium- and triethylammonium-based PILs were synthesized by simple neutralization reaction with protic acids. Triethylammonium hydrogen sulfate [Et₃NH][HSO₄] was found to be the best among the studied PILs concerning the yield of products and reaction time period. Different biscoumarin derivatives were synthesized based on 4-hydroxycoumarin and various substituted aromatic aldehydes at optimum reaction conditions. Obtained products were separated just by simple filtration. The facile method does not require addnl. purification for formed products. The catalyst has shown better yields along with outstanding recyclability, providing an environmental benign protocol for the synthesis of biscoumarin derivatives Graphical Abstract: Screening of simple protic ionic liquids as a catalyst in the synthesis of biscoumarins, out of which [Et₃NH][HSO₄] was found to be best among the studied PILs. [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3HPLC of Formula: 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Filling environmental data gaps with QSPR for ionic liquids: Modeling n-octanol/water coefficient was written by Rybinska, Anna;Sosnowska, Anita;Grzonkowska, Monika;Barycki, Maciej;Puzyn, Tomasz. And the article was included in Journal of Hazardous Materials in 2016.Electric Literature of C7H13ClN2 This article mentions the following:

Ionic liquids (ILs) form a wide group of compounds characterized by specific properties that allow using ILs in different fields of science and industry. Regarding that the growing production and use of ionic liquids increase probability of their emission to the environment, it is important to estimate the ability of these compounds to spread in the environment. One of the most important parameters that allow evaluating environmental mobility of compound is n-octanol/water partition coefficient (K_OW). Exptl. measuring of the K_OW values for a large number of compounds could be time consuming and costly. Instead, computational predictions are nowadays being used more often. The paper presents new quant. structure-property relationship (QSPR) model that allows predicting the logarithmic values of K_OW for 335 ILs, for which the exptl. measured values had been unavailable. We also estimated bioaccumulation potential and point out which group of ILs could have neg. impact on environment. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Electric Literature of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors was written by Costales, Abran;Mathur, Michelle;Ramurthy, Savithri;Lan, Jiong;Subramanian, Sharadha;Jain, Rama;Atallah, Gordana;Setti, Lina;Lindvall, Mika;Appleton, Brent A.;Ornelas, Elizabeth;Feucht, Paul;Warne, Bob;Doyle, Laura;Basham, Stephen E.;Aronchik, Ida;Jefferson, Anne B.;Shafer, Cynthia M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Electric Literature of C7H5BrN2 This article mentions the following:

2-Amino-7-substituted benzoxazole analogs were identified by HTS as inhibitors of RSK2. Mol. modeling and medicinal chem. techniques were employed to explore the SAR for this series with a focus of improving in vitro and target modulation potency and physicochem. properties. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-benzoimidazole (cas: 83741-35-9Electric Literature of C7H5BrN2).

4-Bromo-1H-benzoimidazole (cas: 83741-35-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Electric Literature of C7H5BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem