Tag: 100-200

K₂S as Sulfur Source and DMSO as Carbon Source for the Synthesis of 2-Unsubstituted Benzothiazoles was written by Zhu, Xiaoming;Zhang, Fuxing;Kuang, Daizhi;Deng, Guobo;Yang, Yuan;Yu, Jiangxi;Liang, Yun. And the article was included in Organic Letters in 2020.Reference of 1632-83-3 This article mentions the following:

A three-component reaction of o-iodoanilines with K₂S and DMSO that provided 2-unsubstituted benzothiazoles in moderate to good isolated yields with good functional group tolerance. Electron-rich aromatic amines and o-phenylenediamines instead of o-iodoanilines provided 2-unsubstituted benzothiazoles and 2-unsubstituted benzimidazoles with and without K₂S under similar conditions. Notably, DMSO plays three vital roles: carbon source, solvent and oxidant. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Reference of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New Benchmark in DNA-Based Asymmetric Catalysis: Prevalence of Modified DNA/RNA Hybrid Systems was written by Duchemin, Nicolas;Aubert, Sidonie;de Souza, Joao V.;Bethge, Lucas;Vonhoff, Stefan;Bronowska, Agnieszka K.;Smietana, Michael;Arseniyadis, Stellios. And the article was included in JACS Au in 2022.COA of Formula: C6H8N2O This article mentions the following:

By harnessing the chirality of the DNA double helix, chemists have been able to obtain new, reliable, selective, and environmentally friendly biohybrid catalytic systems with tailor-made functions. Nonetheless, despite all the advances made throughout the years in the field of DNA-based asym. catalysis, many challenges still remain to be faced, in particular when it comes to designing a ′universal′ catalyst with broad reactivity and unprecedented selectivity. Rational design and rounds of selection have allowed us to approach this goal. We report here the development of a DNA/RNA hybrid catalytic system featuring a covalently attached bipyridine ligand, which exhibits unmatched levels of selectivity throughout the current DNA toolbox and opens new avenues in asym. catalysis. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1COA of Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.COA of Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides was written by Makosza, Mieczyslaw;Bia-lecki, Maciej. And the article was included in Journal of Organic Chemistry in 1998.Recommanded Product: 1-Methyl-4-nitroimidazole This article mentions the following:

A new reaction of sulfenamides with electrophilic arenes under basic conditions is described. The σ adducts formed from nitroarenes and the anions of sulfenamides undergo elimination of thiol to produce the corresponding o- and/or p-nitroanilines. This reaction is analogous to the known alkylation and hydroxylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen (VNS). The reaction gives access to a wide range of substituted nitroanilines, nitronaphthylamines, and aminoheterocycles. By means of the reaction with N-alkyl- and N-arylsulfenamides, it is possible to obtain N-alkylnitroanilines and nitrodiarylamines. By varying the structure of sulfenamide and the reaction conditions, particularly the nature and concentration of the base, it is possible to control the orientation of amination. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Supported ionic-liquid-phase-stabilized Au(III) catalyst for acetylene hydrochlorination was written by Zhao, Jia;Gu, Shanchuan;Xu, Xiaolong;Zhang, Tongtong;Yu, Yi;Di, Xiaoxia;NI, Jun;Pan, Zhiyan;Li, Xiaonian. And the article was included in Catalysis Science & Technology in 2016.Safety of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

A stable and catalytically active Au(III) complexes was obtained using Supported Ionic Liquid Phase (SILP) technol. The resulting heterogeneous Au-IL/AC catalysts combined the advantages of the catalytic species being stabilized in the Au(III) form by forming a Au(III)-IL complex and the need for a less expensive metal catalyst because the active component could be better developed in a homogeneous reaction medium. When used in acetylene hydrochlorination reaction, this catalyst displayed an excellent specific activity and superior long-term stability. Under the same reaction conditions, the Au(III)-IL/AC catalyst showed higher activity and stability towards the vinyl chloride monomer (VCM) than IL-free Au/AC (C₂H₂ conversion = 72.1% at 180° compared to 16.1% without IL). It also delivered stable performance within the conversion of acetylene, reaching more than 99.4%, and there was only a 3.7% C₂H₂ conversion loss after running for 300 h under the reaction conditions of a temperature of 180° and a C₂H₂ hourly space velocity of 30 h^-1. Its exceptional ability to maintain the high activity and stability further demonstrated the potential for the replacement of Hg-based catalysts for acetylene hydrochlorination. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Safety of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Safety of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic liquids-coordinated Au catalysts for acetylene hydrochlorination: DFT approach towards reaction mechanism and adsorption energy was written by Xu, Hao;Meng, Shijun;Luo, Guohua. And the article was included in Catalysis Science & Technology in 2018.Electric Literature of C7H13ClN2 This article mentions the following:

The addition of various ILs to a Au catalytic system for acetylene hydrochlorination reaction was explored via d. functional theory (DFT) calculations The most common IL cations including imidazolium IL cations, quaternary ammonium IL cations and quaternary phosphonium IL cations were selected and compared. The reaction pathways were explored and the corresponding activation energies were obtained. Adsorption energies of each reactant and product were calculated, which was crucial for predicting the performance of the catalysts. IL addition can significantly change the energy profiles in the reaction pathways and the adsorption energies of each reactant and product, indicating the capacity of ILs for tuning the catalytic properties of Au catalysts in this reaction. Exptl. activation energies were obtained and the data were compared with DFT results. The consistency of computational and exptl. results provides valuable instructions for the design and preparation of high performance non-Hg catalysts for acetylene hydrochlorination. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Electric Literature of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease was written by Helal, Christopher J.;Kang, Zhijun;Lucas, John C.;Gant, Thomas;Ahlijanian, Michael K.;Schachter, Joel B.;Richter, Karl E. G.;Cook, James M.;Menniti, Frank S.;Kelly, Kristin;Mente, Scot;Pandit, Jay;Hosea, Natalie. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Category: imidazoles-derivatives This article mentions the following:

Utilizing structure-based drug design, a 4-aminoimidazole heterocyclic core was synthesized as a replacement for a 2-aminothiazole due to potential metabolically mediated toxicity. The synthetic route utilized allowed for ready synthesis of 1-alkyl-4-(acylamino)imidazoles [alkyl = Me, i-Pr, cyclobutyl, 3-hydroxycyclobutyl, 3-(2-pyridylcarbonylamino)cyclobutyl, etc.; acyl = R²CO; R² = PhCH₂, 4-MeOC₆H₄CH₂, 1-naphthylmethyl]. SAR exploration resulted in the identification of a novel cis-substituted cyclobutyl group that gave improved enzyme and cellular potency against cdk5/p25 with up to 30-fold selectivity over cdk2/cyclin E. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Category: imidazoles-derivatives).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Expedient synthesis of gem-dialkylbenzyl heterocycles through olefinic hydroarylation was written by Lian, Yajing;Burford, Kristen;Londregan, Allyn T.. And the article was included in Tetrahedron in 2015.Name: 4-Bromo-1-methylimidazole This article mentions the following:

A robust approach to gem-dialkylbenzyl heterocycles has been developed through a triflic acid-catalyzed hydroarylation of olefinic heterocycles. A broad range of substrates containing pyridine, quinoline, pyrazole, triazole and imidazole moieties are shown to be highly compatible with this method. This rapid construction of gem-dialkyl groups should be useful in the synthesis of drug-like mols. containing heterocyclic diversity and in the study of the gem-dialkyl effect. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Name: 4-Bromo-1-methylimidazole).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Name: 4-Bromo-1-methylimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Condensed 1,3,5-triazepines – IV. The synthesis of 2,3-dihydro-1H-imidazo[1,2-a][1,3,5]benzotriazepines was written by Agai, B.;Hornyak, G.;Lempert, K.;Simig, G.. And the article was included in Periodica Polytechnica, Chemical Engineering in 1982.Product Details of 24134-26-7 This article mentions the following:

Imidazobenzotriazepines I (R = H, Bu; R¹ = H, Me; R² = H, 8-Cl, 8-BuNHCO) were prepared by cyclizing imines II (R³ = NH₂) (III), obtained by catalytic hydrogenation of II (R³ = NO₂), with R¹C(OEt)₃. I (R = H, Bu; R¹ = SMe; R² = H, 8-MeO, 8-MeO₂C, 8-Cl, 9-Cl, 8-BuNHCO) were prepared by S-methylating the thiones prepared by cyclizing III with Cl₂CS. I (R = H, Bu; R¹ = NHBu, morpholino, 4-methylpiperazino; R² = H, 8-MeO, 8-Cl, 9-Cl, 8-BuNHCO) were obtained by aminating I (R¹ = SMe). In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Product Details of 24134-26-7).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 24134-26-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Aqueous biphasic systems composed of ionic liquids and polypropylene glycol: insights into their liquid-liquid demixing mechanisms was written by Neves, Catarina M. S. S.;Shahriari, Shahla;Lemus, Jesus;Pereira, Jorge F. B.;Freire, Mara G.;Coutinho, Joao A. P.. And the article was included in Physical Chemistry Chemical Physics in 2016.Electric Literature of C7H13ClN2 This article mentions the following:

Novel ternary phase diagrams of aqueous biphasic systems (ABSs) composed of polypropylene glycol with an average mol. weight of 400 g mol^-1 (PPG-400) and a vast number of ionic liquids (ILs) were determined The large array of selected ILs allowed us to evaluate their tuneable structural features, namely the effect of the anion nature, cation core and cation alkyl side chain length on the phase behavior. Addnl. evidence on the mol.-level mechanisms which rule the phase splitting was obtained by ¹H NMR (NMR) spectroscopy and by COSMO-RS (Conductor-like Screening Model for Real Solvents). Some systems, for which the IL-PPG-400 pairs are completely miscible, revealed to be of type “0”. All data collected suggest that the formation of PPG-IL-based ABSs is controlled by the interactions established between the IL and PPG, contrarily to previous reports where a “salting-out” phenomenon exerted by the IL over the polymer in aqueous media was proposed as the dominant effect in ABS formation. The influence of temperature on the liquid-liquid demixing was also evaluated. In general, an increase in temperature favors the formation of an ABS in agreement with the lower critical solution temperature (LCST) phase behavior usually observed in polymer-IL binary mixtures Partition results of a dye (chloroanilic acid, in its neutral form) further confirm the possibility of tailoring the phases’ polarities of IL-PPG-based ABSs. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Electric Literature of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Amino-catalyzed hydrolysis of amides and esters in the fragmentation by electrospray ionization tandem mass spectrometry using an ion trap was written by Yang, Xiaoli;Zhu, Changjin;Cao, Shuxia;Liao, Xinchen;Jiang, Yanfeng;Zhao, Yufen. And the article was included in Rapid Communications in Mass Spectrometry in 2003.Recommanded Product: 169770-25-6 This article mentions the following:

Neutral mass losses from mass-selected precursors in the ESI-MS/MS of monoimidazole polyamine amides and monoimidazole esters were attributed to hydrolysis by water (in the ion trap) and catalyzed by intramol. amino groups. In the experiment, the researchers used many compounds, for example, Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6Recommanded Product: 169770-25-6).

Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 169770-25-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem