Tag: 100-200

Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors was written by Zhao, Xin;Jie, Yanling;Rosenberg, Matthew R.;Wan, Junting;Zeng, Shaogao;Cui, Wei;Xiao, Yiping;Li, Zhiyuan;Tu, Zhengchao;Casarotto, Marco G.;Hu, Wenhui. And the article was included in Antiviral Research in 2012.Related Products of 3012-80-4 This article mentions the following:

The adamantanes are a class of anti-influenza drugs that inhibit the M2 ion channel of the influenza A virus. However recently, the clin. effectiveness of these drugs has been called into question due to the emergence of adamantane-insensitive A/M2 mutants. Although we previously reported (1R,2R,3R,5S)-3-pinanamine 3 as a novel inhibitor of the wild type influenza A virus M2 protein (WT A/M2), limited inhibition was found for adamantane-resistant M2 mutants. In this study, we explored whether newly synthesized pinanamine derivatives were capable of inhibiting WT A/M2 and selected adamantane-resistant M2 mutants. Several imidazole and guanazole derivatives of pinanamine were found to inhibit WT A/M2 to a comparable degree as amantadine and one of these compounds 12 exhibits weak inhibition of A/M2-S31N mutant and it is marginally more effective in inhibiting S31N M2 than amantadine. This study provides a new insight into the structural nature of drugs required to inhibit WT A/M2 and its mutants. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Related Products of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Related Products of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ethyl 3-methyl-5-nitro-1H-imidazole-2-carboxylate was written by Wu, Hai Qiang;An, Lin Kun;Huang, Zhi Shu;Gu, Lian Quan;Zain, Sharifuddin M.;Ng, Seik Weng. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2004.Application In Synthesis of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate This article mentions the following:

The title compound, C₇H₉N₃O₄, exists as a planar mol. whose carboxyethyl fragment is disordered across a crystallog. mirror plane. The fragment is twisted by 15.1(1)° with respect to the plane. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9Application In Synthesis of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate).

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application In Synthesis of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and Antimicrobial Activity of Nitroalkenyl Arenes was written by Nicoletti, Gina;Cornell, Hugh James;Hugel, Helmut Martin;White, Kylie S.;Nguyen, Thu;Zalizniak, Liliana;Nugegoda, Dayanthi. And the article was included in Anti-Infective Agents in 2013.Reference of 58442-17-4 This article mentions the following:

We report here on the synthesis of substituted nitroalkenyl arenes and their evaluation for microbiol. activity and for development as anti-infective drugs. Twenty compounds, based on the nitropropenyl benzene structure (1), were synthesized, chem. characterized and investigated for their min. inhibitory concentration (MIC) to bacteria and fungi and for toxicity to zebrafish eggs and embryos for comparative evaluation of potential mammalian toxicity. The compounds were broadly antimicrobial, with greater activity overall against Gram-pos. bacteria and fungi and less against enteric Gram-neg. rods. The antimicrobial activity spectrum of the compounds varied greatly. Two compounds, 14 (5-[(E)-2-nitroprop-1-enyl]-1,3-benzodioxole) and 9 (4-[(E)-2-nitroprop-1-enyl]-1-fluorobenzene), were the most broadly antimicrobial. The chem. groups most closely associated with microbial toxicity were the β-nitropropenyl side chain, fluoro, methylenedioxy and thiazole substitutions on the benzene ring. Thirteen compounds inhibited hatching of zebrafish eggs at concentrations ≤6 μg/mL. Egg toxicity did not correlate with inhibition of microbial growth or with rodent toxicity where data were available. Four compounds were investigated for effect on zebrafish embryonic development. The major effect observed was reduction of heart rate at 24 h with minimal or no morphol. abnormalities at the highest doses. It is hypothesised that this series of compounds act as tyrosine mimetics, inhibiting protein tyrosine phosphatases (PTP) and interfering with cell signaling in microorganisms. The data confirms the diversity in function and distribution of bacterial PTPs and the potential for the design of further nitroalkenyl arenes active against specific pathogens. In the experiment, the researchers used many compounds, for example, 1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4Reference of 58442-17-4).

1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 58442-17-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reactions of 2-dichloromethylbenzimidazole with certain primary amines was written by Pascal, Robert A. Jr.;Jungk, Steven;Risinger, G. E.. And the article was included in Journal of Heterocyclic Chemistry in 1978.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

An investigation of the reactions of 2-(2,2-dichloromethyl)benzimidazole (I) with primary amines gave 2-(N–tert-butylformimidoyl)benzimidazole, 2-N-(2-phenylethyl)formimdoylbenzimidazole, and 1-(ethoxycarbonylmethyl)-2-(N–tert-butylformimidoyl)benzimidazole. Under mild alkali conditions, I was rapidly converted into a dimer, 6H,13H-pyrazino[1,2-a:4,5-a‘]bisbenzimidazole-6,13-diol. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reactions of N-aryl-N-(4,5-dihydro-1H-imidazol-2-yl)hydroxylamines with methanesulfonyl chloride. Synthesis and acylation of 2,3-dihydro-1H-imidazo[1,2-a]benzimidazoles was written by Saczewski, F.;Debowski, T.. And the article was included in Polish Journal of Chemistry in 1998.Safety of 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole This article mentions the following:

Reactions of N-aryl-N-(4,5-dihydro-1H-imidazo-2-yl)hydroxylamines with methanesulfonyl chloride in the presence of triethylamine afforded 2,3-dihydroimidazo[1,2-a]benzimidazoles. The latter compounds, treated with acetic anhydride, methane or phenylsulfonyl chlorides, gave N-acetyl or N-methane or N-phenylsulfonyl derivatives In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Safety of 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Safety of 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Semi-Transparent and Stable Solar Cells for Building Integrated Photovoltaics: The Confinement Effects of the Polymer Gel Electrolyte inside Mesoporous Films was written by Zhou, Huawei;Cui, Jiawen;Guo, Junxue;Tao, Siwen;Gao, Xiaorui;Liu, Meiqian;Wang, Miaomiao;Yu, Ning;Wang, Xiaojun;Gong, Haoyu;Li, Yanmin;Wang, Ziang;Liu, Tian;Sun, Xun;Chen, Yan;Yin, Jie;Zhang, Xianxi;Zhang, Chunyang;Shi, Yantao. And the article was included in ACS Omega in 2019.Computed Properties of C8H8N2 This article mentions the following:

The semi-transparent solar cells are promising to be applied in building integrated photovoltaic (BIPV) and tandem solar cells. In this study, semi-transparent and stable solar cells are fabricated for BIPV by utilizing a poly (ethylene oxide) electrolyte and controlling the size of TiO₂ nanoparticles and the thickness of the TiO₂ film. The power conversion efficiency of the semi-transparent (> 50% transmittance at 620-750 nm) and quasi-solid solar cells is 5.78% under standard AM1.5G, 100 mW cm^-2. The higher conductivity and smaller diffusion resistance of the quasi-solid electrolyte inside the mesoporous TiO₂ film indicate the confinement effects of the polymer electrolyte inside a mesoporous TiO₂ film. The unsealed semi-transparent and quasi-solid solar cell retains its initial efficiency during 1000 h irradiation in humid air. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and properties of imidazolium-derived biocidals was written by Li, Bingzhen;Li, Yihe;Zhang, Zhe;Xiao, Hua;Jiang, Zhenhua;Li, Gong Yi;Ahn, Kwang-Duk. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2013.Category: imidazoles-derivatives This article mentions the following:

Synthesis and antibacterial activity evaluation of 1-alkyl-3-(4-vinylbenzyl)imidazolium chlorides (alkyl = Me, n-Bu, n-C₆H₁₃, n-C₈H₁₇, n-C₁₂H₂₅) with hydrophobic alkyl substituents are reported. In antibacterial activity study of these imidazolium salts by minimal inhibitory concentrations (MICs) on E. coli., the dodecyl-substituted product showed promising antibacterial activity with MICs at 2.4 μg/mL. It was found that the MIC value of the synthesized imidazole derivatives increased as the number of alkyl substituent carbons increased up to 12 carbons. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Category: imidazoles-derivatives).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ribosides and Ribotide of a Fairy Chemical, Imidazole-4-carboxamide, as Its Metabolites in Rice was written by Choi, Jae-Hoon;Matsuzaki, Nobuo;Wu, Jing;Kotajima, Mihaya;Hirai, Hirofumi;Kondo, Mitsuru;Asakawa, Tomohiro;Inai, Makoto;Ouchi, Hitoshi;Kan, Toshiyuki;Kawagishi, Hirokazu. And the article was included in Organic Letters in 2019.Application In Synthesis of 1H-Imidazole-4-carboxamide This article mentions the following:

The metabolism of imidazole-4-carboxamide (ICA) in plants has been unknown. Two metabolites (1 and 2) were isolated from ICA-treated rice, and their structures were determined by spectroscopic anal. including the single-crystal X-ray diffraction technique and synthesis. The ribotide of ICA (3), whose existence was predicted, was also synthesized and detected from the treated rice by LC-MS/MS. These results indicated that rice might interconvert ICA, 1, and 3 to regulate the biol. activity. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Application In Synthesis of 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Interfacial activity and micellar morphology of an imidazolium ring containing zwitterionic surfactants was written by Ali, Hazrat;Khan, Azim;Ahmad, Tauqeer;Dervisi, Athanasia;Fallis, Ian;Shoetan, Ibrahim O.;Khan, Abbas;Hussain, Arshad;Griffiths, Peter. And the article was included in Journal of Surfactants and Detergents in 2022.Name: 1-Octyl-1H-imidazole This article mentions the following:

Zwitterionic surfactants based on 3-(1-alkyl-3-imidazolio) propane-sulfonate ([ImS3-R] where R is octyl or dodecyl) is an emerging and important class of amphiphile due to their relevance as nano reactors for the synthesis of metallic nanoparticles and accelerated acid hydrolysis. The physicochem. properties of such synthesized imidazolium ring-containing zwitterionic surfactants have been characterized by surface tension and small-angle neutron scattering (SANS) techniques. Surface tension measurements were used to calculate several thermodn. parameters over a range of concentrations and temperatures (298-313 K). The results obtained showed a weak signature representing the critical micelle concentration (CMC) for ImS3-8, however, by increasing the alkyl length of the hydrophobic group to dodecyl, i.e., ImS3-8 to ImS3-12, the signature of the CMC was much more evident. As expected, the CMC for ImS3-12 shifted to a lower concentration An increase in temperature increased the surface activity and decreased the CMC of both zwitterionic surfactants, although the changes were small. Compared to classical surfactants, i.e., sodium dodecyl sulfate and dodecyl trimethylammonium bromide, the CMC of ImS3-12 is much lower. Modeling of SANS data demonstrated that the morphol. of the micelles formed by these amphiphiles may be described by the “classical” model, a central hydrophobic core, with a shell of hydrated headgroups. Due to their widespread applications in colloidal and interfacial science, the present study adds new insight to the fundamental understanding of these interesting imidazolium-based surface-active ionic liquids (ImS3-R). In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Name: 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Additions of Aldehyde-Derived Radicals and Nucleophilic N-Alkylindoles to Styrenes by Photoredox Catalysis was written by Lux, Marcel;Klussmann, Martin. And the article was included in Organic Letters in 2020.Recommanded Product: 1-Methylbenzimidazole This article mentions the following:

The consecutive addition of acyl radicals and N-alkylindole nucleophiles to styrenes was established, as well as some addnl. radical-nucleophile combinations. Both aryl and aliphatic aldehydes give reasonable yields. The reaction proceeds best for α-substituted styrenes, effectively creating a quaternary all-carbon center. Some iridium-based photoredox systems are catalytically active; furthermore, a base is needed in this transformation. Radicals are formed by reductive perester cleavage and hydrogen atom transfer. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem