Tag: 100-200

Willgerodt reaction in a series of imidazopyridine derivatives was written by Yutilov, Yu. M.;Shcherbina, L. I.. And the article was included in Zhurnal Organicheskoi Khimii in 1996.Related Products of 52538-09-7 The following contents are mentioned in the article:

The Willgerodt reaction of 2-methylimidazopyridines with aniline and sulfur gave imidazopyridinecarbothioanilides such as I (R = Me, benzyl, Ph, H; R¹ = H, Br). Intramol. versions of this reaction gave tetracyclic products, e.g., II. This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7Related Products of 52538-09-7).

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Related Products of 52538-09-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A direct method for the substitution of imidazo[1,5-a]pyridines at position 5 was written by Blatcher, Philip;Middlemiss, David. And the article was included in Tetrahedron Letters in 1980.Synthetic Route of C10H10N2O2 The following contents are mentioned in the article:

Lithiation of 3-ethylthioimidazo[1,5-a]pyridine (I; R = SEt, R¹ = H) (II) occurred at C-5. Quenching of this anion followed by desulfurization gave 5-substituted imidazo[1,5-a]pyridines. E.g. II reacted with BuLi and PhCHO giving 71% I [R = SEt, R¹ = CH(OH)Ph] which on treatment with Raney Ni gave 65% I [R = H, R¹ = CH(OH)Ph]. This study involved multiple reactions and reactants, such as Ethyl imidazo[1,5-a]pyridine-5-carboxylate (cas: 76292-67-6Synthetic Route of C10H10N2O2).

Ethyl imidazo[1,5-a]pyridine-5-carboxylate (cas: 76292-67-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Synthetic Route of C10H10N2O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New method for synthesis of 2-hetaryl-substituted imidazo[4,5-b]pyridine and imidazo[4,5-c]pyridine was written by Yutilov, Yu. M.;Kovaleva, L. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1977.Reference of 52538-09-7 The following contents are mentioned in the article:

Imidazopyridines I [X = Y = CH, Z = N, R = 6-methyl-2-pyridyl (II), 2-quinolyl (III), imidazo [4,5-c] pyridin-2-yl (IV), R1 = H; X = N, Y = Z = CH, R = II, 2-benzothiazolyl, 2-benzimidazoyl, III, 1-methylimidazo[4,5-c]pyridin-2-yl, R1 = Me; X = Z = CH, Y = N, R = IV, R1 = Me] were obtained in 83-98% yields by treatment of the corresponding diaminopyridine V with MeR 3-8h at 165-200°. This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7Reference of 52538-09-7).

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Reference of 52538-09-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A novel preparation of thiazolo[5,4-c]pyridines and the synthesis of some imidazo[4,5-c]pyridines and oxazolo[4,5-c]pyridines was written by Katner, Allen S.;Brown, Raymond F.. And the article was included in Journal of Heterocyclic Chemistry in 1990.SDS of cas: 52538-09-7 The following contents are mentioned in the article:

Diethoxymethyl acetate was used to cyclize o-disubstituted aminopyridines to oxazolo [4,5-c]pyridines and imidazo[4,5-c]pyridines. All the possible imidazole-methylated imidazo[4,5-c]pyridines were prepared A novel synthesis of 2-substituted thiazolo[5,4-c]pyridines and 4-amino-3-pyridinethiol was discovered. This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7SDS of cas: 52538-09-7).

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).SDS of cas: 52538-09-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A direct method for the substitution of imidazo[1,5-a]pyridines at position 5 was written by Blatcher, Philip;Middlemiss, David. And the article was included in Tetrahedron Letters in 1980.Synthetic Route of C10H10N2O2 The following contents are mentioned in the article:

Lithiation of 3-ethylthioimidazo[1,5-a]pyridine (I; R = SEt, R¹ = H) (II) occurred at C-5. Quenching of this anion followed by desulfurization gave 5-substituted imidazo[1,5-a]pyridines. E.g. II reacted with BuLi and PhCHO giving 71% I [R = SEt, R¹ = CH(OH)Ph] which on treatment with Raney Ni gave 65% I [R = H, R¹ = CH(OH)Ph]. This study involved multiple reactions and reactants, such as Ethyl imidazo[1,5-a]pyridine-5-carboxylate (cas: 76292-67-6Synthetic Route of C10H10N2O2).

Ethyl imidazo[1,5-a]pyridine-5-carboxylate (cas: 76292-67-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Synthetic Route of C10H10N2O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazoles. IX. A new preparation of N-alkylated imidazole compounds was written by Weidenhagen, Rudulf;Train, Gert;Wegner, Hans;Nordstrom, Ludwig. And the article was included in Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen in 1942.Name: 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine The following contents are mentioned in the article:

A solution of 2 g. Cu(OAc)₂, 2 cc. 40% HCHO and 30 cc. H₂O at 0° is treated with 1 g. ο-H₂NC₆H₄NHMe.2HCl in 15 cc. 50% alc. at 0°; the CuCl salt precipitates immediately and the reaction is completed by heating 10 min. at 75°; decomposition with H₂S in dilute HCl gives the HCl salt, which is liberated by K₂CO₃; the yield of 1-methylbenzimidazole (I) is 67%; AcH gives 83% of the 2-Me derivative of I; EtCHO yields the 2-Et derivative, very hygroscopic, m. 61.5-2.5° (containing 0.79 mol. H₂O), m. 54.5-5.5° (anhydrous); picrate, m. 235-6°; iso-PrCHO gives 84% of the 2-iso-Pr derivative, b_0.3 116-18° (picrate, yellow, m. 225-6°); BzH gives 87.5% of the 2-Ph derivative; p-MeOC₆H₄CHO yields 77.5% of the 2-(p-methoxyphenyl) derivative, m. 118°; 2-(p-nitrophenyl) derivative, yellow, m. 213-14°, 88%; 2-(2-furyl) derivative, with 0.5 mol. H₂O, m. 78° (anhydrous, m. 56°), 85%. ο-O₂NC₆H₄NHEt with SnCl₂ in HCl gives 69% of N-ethyl-ο-phenylenediamine (II), m. 185-7° (decomposition). II, HCHO and Cu(OAc)₂ give 71% of 1-ethylbenzimidazole (III); AcH yields 90% of the 2-Me derivative of III, b_0.3 110-12° (picrate, m. 236-7°); EtCHO gives 74% of the 2-Et derivative of III, b_0.2 106.5-7.5° (HCl salt, m. 168.5-9.5°; picrate, m. 207°); BzH yields 82% of the 2-Ph derivative of III; 2-(p-methoxyphenyl) derivative, m. 106-6.5°, 90%; 2-(m-nitrophenyl) derivative, m. 117.5-18°, 46%. ο-ClC₆H₄NO₂ and PrNH₂ in EtOH, heated 7 hrs., give 97% of N-propyl-ο-nitroaniline, red oil; reduction yields 57% of N-propyl-ο-phenylenediamine-2-HCl (IV), m. 172-3° (decomposition). IV, HCHO and Cu(OAc)₂ give 62% of 1-propylbenzimidazole (V), analyzed as the picrate, m. 180-1°; IV and AcH give 92% of the 2-Me derivative of V, hygroscopic oil, b_0.2 111-12° (picrate, m. 218-19°); 2-Et derivative, 85%; picrate, m. 212-12.5°; 2-(p-methoxyphenyl) derivative, m. 67.5-8°. 3-Amino-4-(methylamino)pyridine (VI), m. 169°, results in 95% yield on reduction of the 3-NO₂ compound with Fe in AcOH (picrate, m. 184°; HCl salt, m. 221°). VI (1.8 g.), 1 cc. AcH and 6 g. Cu(OAc)₂ in 50 cc. 50% EtOH, heated 3 hrs. at 150°, give 50% of 1′,2′-dimethylimidazolo-4′,5′,3,4-pyridine (VII), m. 174° (picrate, m. 204-5°); EtCHO gives 48% of the 2′-Et analog of VII, with 1.5 mols. H₂O, m. 76°; 2′-Pr analog, with 1.5 mols. H₂O, m. 64°, 59%; 2′-hexyl analog, a hygroscopic oil, analyzed as the dioxalate, m. 140°, 47%; 2′-Ph analog, m. 149°, 49% (hydrated, m. 79-80°); 2′-(2-furyl) analog, m. 173°, 57%. 3-Amino-4-(ethylamino)pyridine, AcH and Cu(OAc)₂ in EtOH, heated 4.5 hrs. at 150°, give 1′-ethyl-2′-methylimidazolo-4′,5′,3,4-pyridine, m. 84°; with 1 mol. of H₂O, m. 40°; picrate, m. 191°; 2′-Et analog, hygroscopic oil; with 2 mols. H₂O, m. 52°, 54%; 2′-Pr analog, very hygroscopic oil, 39%; with 2 mols. H₂O, m. 68°; 2′-(p-methoxyphenyl) analog, m. 142°, 71%; 2′-(2-furyl) analog, pale yellow, m. 125°, 68%. 3-Nitro-4-(propylamino)pyridine, in nearly theoretical yield by boiling 3-nitro-4-methoxypyridine with PrNH₂ in EtOH; 3-NH₂ derivative, with 1 mol. H₂O, m. 93°, 78%. 1′-Propyl-2′-methylimidazolo-4′,5′,3,4-pyridine, analyzed as the picrate, yellow, m. 156.5-7.5°; 1′-Bu analog, with 2 mols H₂O, m. 47°, 58%. This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7Name: 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine).

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Sisi; Du, Liang; Donmez, Selin; Xin, Yan; Mattoussi, Hedi published an article in 2021, the title of the article was Polysalt ligands achieve higher quantum yield and improved colloidal stability for CsPbBr3 quantum dots.Reference of N-(3-Aminopropyl)-imidazole And the article contains the following content:

Colloidal lead halide perovskite quantum dots (PQDs) are relatively new semiconductor nanocrystals with great potential for use in optoelectronic applications. They also present a set of new scientifically challenging fundamental problems to investigate and understand. One of them is to address the rather poor colloidal and structural stability of these materials under solution phase processing and/or transfer between solvents. In this contribution, we detail the synthesis of a new family of multi-coordinating, bromide-based polysalt ligands and test their ability to stabilize CsPbBr3 nanocrystals in polar solutions The ligands present multiple salt groups involving quaternary cations, namely ammonium and imidazolium as anchors for coordination onto PQD surfaces, along with several alkyl chains with varying chain length to promote solubilization in various conditions. The ligands provide a few key benefits including the ability to repair damaged surface sites, allow rapid ligand exchange and phase transfer, and preserve the crystalline structure and morphol. of the nanocrystals. The polysalt-coated PQDs exhibit near unity PLQY and significantly enhanced colloidal stability in ethanol and methanol. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Reference of N-(3-Aminopropyl)-imidazole

The Article related to cesium lead bromide quantum dot polysalt ligand colloidal stability, Placeholder for records without volume info and other aspects.Reference of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Qu, Shanqiang; Chen, Zhixin; Liu, Bin; Liu, Jin; Wang, Huafu published an article in 2021, the title of the article was N6-methyladenine-related genes affect biological behavior and the prognosis of glioma.Application In Synthesis of N-Methyl-7H-purin-6-amine And the article contains the following content:

Although aberrant expression of N6-methyladenine (m6A) methylation-related genes contribute to tumorigenesis in many solid tumors, the prognostic value of the m6A-related genes and their correlation with clinicopathol. features in gliomas need advanced study. Nine m6A-related genes were identified as independent prognostic factors, which were mostly enriched in RNA splicing, regulation of immune response and vesicle-mediated transport. We constructed risk score of each patient, which was highly associated with clinicopathol. features. Kaplan-Meier curve showed that the prognosis of patients with high-risk scores was significantly worse than that with low-risk scores (HR = 4.30, 95% CI = 3.16-5.85, p < 0.0001). A nomogram was constructed based on the nine m6A-related genes signature and clinicopathol. features with well-fitted calibration curves (c-index = 0.82), showing high specificity and sensitivity (area under the curve for 1-, 3-, and 5-years survival probability = 0.874, 0.918, and 0.934). A nine m6A-related genes signature was identified in gliomas. The m6A-related risk score is a novel prognostic factor for patients with glioma, and is associated with clinicopathol. features. Moreover, the nomogram based on the nine m6A-related genes signature and clinicopathol. features had good efficacy in predicting the survival probability. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Application In Synthesis of N-Methyl-7H-purin-6-amine

The Article related to glioma n6 methyladenine prognosis, neoplasms, nomograms, prognosis, Placeholder for records without volume info and other aspects.Application In Synthesis of N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hardy, Alexis; Matelot, Melody; Touzeau, Amandine; Klopp, Christophe; Lopez-Roques, Celine; Duharcourt, Sandra; Defrance, Matthieu published an article in 2021, the title of the article was DNAModAnnot: a R toolbox for DNA modification filtering and annotation.Safety of N-Methyl-7H-purin-6-amine And the article contains the following content:

Long-read sequencing technologies can be employed to detect and map DNA modifications at the nucleotide resolution on a genome-wide scale. However, published software packages neglect the integration of genomic annotation and comprehensive filtering when analyzing patterns of modified bases detected using Pacific Biosciences (PacBio) or Oxford Nanopore Technologies (ONT) data. Here, we present DNA Modification Annotation (DNAModAnnot), a R package designed for the global anal. of DNA modification patterns using adapted filtering and visualization tools. We tested our package using PacBio sequencing data to analyze patterns of the 6-methyladenine (6mA) in the ciliate Paramecium tetraurelia, in which high 6mA amounts were previously reported. We found P. tetraurelia 6mA genome-wide distribution to be similar to other ciliates. We also performed 5-methylcytosine (5mC) anal. in human lymphoblastoid cells using ONT data and confirmed previously known patterns of 5mC. DNAModAnnot provides a tool-box for the genome-wide anal. of different DNA modifications using PacBio and ONT long-read sequencing data. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Safety of N-Methyl-7H-purin-6-amine

The Article related to deoxyribonucleic acid modification annotation r toolbox filtering, Placeholder for records without volume info and other aspects.Safety of N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 23, 2021, Fallica, Antonino N.; Sorrenti, Valeria; D鈥睞mico, Agata G.; Salerno, Loredana; Romeo, Giuseppe; Intagliata, Sebastiano; Consoli, Valeria; Floresta, Giuseppe; Rescifina, Antonio; D鈥睞gata, Velia; Vanella, Luca; Pittala, Valeria published an article.Product Details of 5036-48-6 The title of the article was Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent In Vitro Antiproliferative Activity. And the article contained the following:

Heme oxygenase-1 (HO-1) promotes heme catabolism exercising cytoprotective roles in normal and cancer cells. Herein, we report the design, synthesis, mol. modeling, and biol. evaluation of novel HO-1 inhibitors. Specifically, an amide linker in the central spacer and an imidazole were fixed, and the hydrophobic moiety required by the pharmacophore was largely modified. In many tumors, overexpression of HO-1 correlates with poor prognosis and chemoresistance, suggesting the inhibition of HO-1 as a possible antitumor strategy. Accordingly, compounds 7i and 7l-p emerged for their potency against HO-1 and were investigated for their anticancer activity against prostate (DU145), lung (A549), and glioblastoma (U87MG, A172) cancer cells. The selected compounds showed the best activity toward U87MG cells. Compound 7l was further investigated for its in-cell enzymic HO-1 activity, expression levels, and effects on cell invasion and vascular endothelial growth factor (VEGF) extracellular release. The obtained data suggest that 7l can reduce cell invasivity acting through modulation of HO-1 expression. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to acetamide derivative heme oxygenase inhibitor preparation cancer, Placeholder for records without volume info and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem